WO2005058295A3 - Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases - Google Patents

Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases Download PDF

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Publication number
WO2005058295A3
WO2005058295A3 PCT/EP2004/014436 EP2004014436W WO2005058295A3 WO 2005058295 A3 WO2005058295 A3 WO 2005058295A3 EP 2004014436 W EP2004014436 W EP 2004014436W WO 2005058295 A3 WO2005058295 A3 WO 2005058295A3
Authority
WO
WIPO (PCT)
Prior art keywords
sphingosine
phosphate
treatment
receptor agonists
degenerative diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/014436
Other languages
French (fr)
Other versions
WO2005058295A2 (en
Inventor
Volker Brinkmann
Nicole Kaneider
Christian J Wiedermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH Austria
Novartis AG
Original Assignee
Novartis Pharma GmbH Austria
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/583,106 priority Critical patent/US20080139662A1/en
Priority to KR1020067011896A priority patent/KR101232934B1/en
Priority to EP04804037A priority patent/EP1713459B1/en
Priority to CN2004800378611A priority patent/CN1893934B/en
Priority to AU2004298760A priority patent/AU2004298760B2/en
Priority to HK07103403.8A priority patent/HK1097458B/en
Priority to BRPI0417203-5A priority patent/BRPI0417203A/en
Priority to KR1020127019200A priority patent/KR101342244B1/en
Priority to MXPA06006924A priority patent/MXPA06006924A/en
Priority to AT04804037T priority patent/ATE474569T1/en
Priority to PL04804037T priority patent/PL1713459T3/en
Application filed by Novartis Pharma GmbH Austria, Novartis AG filed Critical Novartis Pharma GmbH Austria
Priority to CA2545503A priority patent/CA2545503C/en
Priority to DE602004028286T priority patent/DE602004028286D1/en
Priority to JP2006544366A priority patent/JP2007514698A/en
Publication of WO2005058295A2 publication Critical patent/WO2005058295A2/en
Publication of WO2005058295A3 publication Critical patent/WO2005058295A3/en
Anticipated expiration legal-status Critical
Priority to US12/884,953 priority patent/US8519006B2/en
Priority to US13/920,329 priority patent/US20130281541A1/en
Priority to US14/093,975 priority patent/US20140162964A1/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed is the use of sphingosine-1-phosphate (S1P) receptor agonists, preferably 2-amino-2- [2- (4-octylphenyl)ethyl] propane-1,3-diol, in the treatment of progressive dementia or brain degenerative diseases.
PCT/EP2004/014436 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases Ceased WO2005058295A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
PL04804037T PL1713459T3 (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases
EP04804037A EP1713459B1 (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases
CN2004800378611A CN1893934B (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (S1P) receptor agonists for the manufacture of a medicament for the treatment of brain degenerative diseases
AU2004298760A AU2004298760B2 (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (S1P) receptor agonists for the treatment of brain degenerative diseases
HK07103403.8A HK1097458B (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases
BRPI0417203-5A BRPI0417203A (en) 2003-12-19 2004-12-17 use in degenerative brain diseases
KR1020127019200A KR101342244B1 (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases
MXPA06006924A MXPA06006924A (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases.
CA2545503A CA2545503C (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases
US10/583,106 US20080139662A1 (en) 2003-12-19 2004-12-17 Use of Sphingosine-1-Phosphate (S1P) Receptor Agonists For the Treatment of Brain Degenerative Diseases
KR1020067011896A KR101232934B1 (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases
AT04804037T ATE474569T1 (en) 2003-12-19 2004-12-17 USE OF SPHINGOSINE-1 PHOSPHATE (S1P) RECEPTOR AGONISTS FOR THE TREATMENT OF DEGENERATIVE BRAIN DISEASES
DE602004028286T DE602004028286D1 (en) 2003-12-19 2004-12-17 USE OF SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR AGONISTS FOR THE TREATMENT OF DEGENERATIVE BRAIN DISEASES
JP2006544366A JP2007514698A (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (S1P) receptor agonists for the treatment of brain degenerative diseases
US12/884,953 US8519006B2 (en) 2003-12-19 2010-09-17 Use of sphingosine-1 phosphate (S1P) receptor agonists for the treatment of brain degenerative diseases
US13/920,329 US20130281541A1 (en) 2003-12-19 2013-06-18 Use in brain degenerative diseases
US14/093,975 US20140162964A1 (en) 2003-12-19 2013-12-02 Use in brain degenerative diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0329498.0 2003-12-19
GBGB0329498.0A GB0329498D0 (en) 2003-12-19 2003-12-19 Organic compounds

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/583,106 A-371-Of-International US20080139662A1 (en) 2003-12-19 2004-12-17 Use of Sphingosine-1-Phosphate (S1P) Receptor Agonists For the Treatment of Brain Degenerative Diseases
US12/884,953 Continuation US8519006B2 (en) 2003-12-19 2010-09-17 Use of sphingosine-1 phosphate (S1P) receptor agonists for the treatment of brain degenerative diseases

Publications (2)

Publication Number Publication Date
WO2005058295A2 WO2005058295A2 (en) 2005-06-30
WO2005058295A3 true WO2005058295A3 (en) 2005-11-24

Family

ID=30776138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/014436 Ceased WO2005058295A2 (en) 2003-12-19 2004-12-17 Use of sphingosine-1-phosphate (s1p) receptor agonists for the treatment of brain degenerative diseases

Country Status (17)

Country Link
US (4) US20080139662A1 (en)
EP (2) EP2213285B1 (en)
JP (2) JP2007514698A (en)
KR (2) KR101232934B1 (en)
CN (2) CN101791406B (en)
AT (1) ATE474569T1 (en)
AU (1) AU2004298760B2 (en)
BR (1) BRPI0417203A (en)
CA (2) CA2545503C (en)
DE (1) DE602004028286D1 (en)
ES (2) ES2348569T3 (en)
GB (1) GB0329498D0 (en)
MX (1) MXPA06006924A (en)
PL (1) PL1713459T3 (en)
PT (1) PT1713459E (en)
RU (1) RU2379030C2 (en)
WO (1) WO2005058295A2 (en)

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US8415484B2 (en) 2008-08-27 2013-04-09 Arena Pharmaceuticals, Inc. Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
US8580841B2 (en) 2008-07-23 2013-11-12 Arena Pharmaceuticals, Inc. Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
US8853419B2 (en) 2010-01-27 2014-10-07 Arena Pharmaceuticals, Inc. Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
US11555015B2 (en) 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders

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SI3103448T1 (en) * 2006-09-26 2019-11-29 Novartis Ag Pharmaceutical compositions comprising an s1p modulator
EP1905434A1 (en) * 2006-09-26 2008-04-02 Novartis AG Organic compounds comprising an S1P receptor agonist and their therapeutic use
EP2177521A1 (en) 2008-10-14 2010-04-21 Almirall, S.A. New 2-Amidothiadiazole Derivatives
EP2202232A1 (en) 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. 1,2,4-oxadiazole derivatives and their therapeutic use
EP2210890A1 (en) 2009-01-19 2010-07-28 Almirall, S.A. Oxadiazole derivatives as S1P1 receptor agonists
US20120128666A1 (en) * 2009-06-24 2012-05-24 Lpath, Inc. Methods of increasing neuronal differentiation using antibodies to lysophosphatidic acid
AR077969A1 (en) 2009-08-31 2011-10-05 Abbott Healthcare Products Bv DERIVATIVES OF (TIO) MORFOLINA COMOMODULADORES DE S1P
EP2305660A1 (en) 2009-09-25 2011-04-06 Almirall, S.A. New thiadiazole derivatives
EP2343287A1 (en) 2009-12-10 2011-07-13 Almirall, S.A. New 2-aminothiadiazole derivatives
CN107189979B (en) 2010-03-01 2021-05-04 詹森生物科技公司 Methods of purifying cells derived from pluripotent stem cells
CN105503882B (en) 2010-03-03 2019-07-05 艾尼纳制药公司 The method for preparing S1P1 receptor modulators and its crystal form
EP2366702A1 (en) 2010-03-18 2011-09-21 Almirall, S.A. New oxadiazole derivatives
EP2390252A1 (en) 2010-05-19 2011-11-30 Almirall, S.A. New pyrazole derivatives
TW201206893A (en) 2010-07-09 2012-02-16 Abbott Healthcare Products Bv Bisaryl (thio) morpholine derivatives as S1P modulators
TW201643169A (en) 2010-07-09 2016-12-16 艾伯維股份有限公司 Spiro-piperidine derivatives as S1P modulators
TWI522361B (en) 2010-07-09 2016-02-21 艾伯維公司 Fused heterocyclic derivative as S1P regulator
US9388386B2 (en) 2011-12-22 2016-07-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into single hormonal insulin positive cells
RU2482842C1 (en) * 2012-04-26 2013-05-27 Открытое акционерное общество "Новосибхимфарм" Pharmaceutical composition of s1p receptor agonist for treatment of demyelinating diseases (versions) and method of its obtaining
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
RU2687379C2 (en) 2012-12-31 2019-05-13 Янссен Байотек, Инк. Suspending and clustering of human pluripotent cells with the purpose of their differentiation in pancreatic endocrine cells
WO2014105543A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
EP2878339A1 (en) * 2013-12-02 2015-06-03 Siena Biotech S.p.A. SIP3 antagonists
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
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