WO2006012765A1 - Dispositif pour determiner des valeurs de fonction - Google Patents

Dispositif pour determiner des valeurs de fonction Download PDF

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Publication number
WO2006012765A1
WO2006012765A1 PCT/CH2005/000446 CH2005000446W WO2006012765A1 WO 2006012765 A1 WO2006012765 A1 WO 2006012765A1 CH 2005000446 W CH2005000446 W CH 2005000446W WO 2006012765 A1 WO2006012765 A1 WO 2006012765A1
Authority
WO
WIPO (PCT)
Prior art keywords
values
conductivity
skin
distribution
measured values
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CH2005/000446
Other languages
German (de)
English (en)
Inventor
Fritz-Albert Popp
Yan Yu
John Swain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Buehler AG
Original Assignee
Buehler AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Buehler AG filed Critical Buehler AG
Priority to EP05760714A priority Critical patent/EP1776042A1/fr
Publication of WO2006012765A1 publication Critical patent/WO2006012765A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6825—Hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/442—Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/0016—Energy applicators arranged in a two- or three dimensional array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00875—Resistance or impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array

Definitions

  • the invention relates to a device for determining functional values, in particular the regulatory capacity of biological systems, in particular of the human body.
  • thermoregulatory diagnostics Procedures that attempt to include dynamic aspects are known as thermoregulatory diagnostics.
  • temperature values at various parts of the body are measured before and after a defined external influencing of the body.
  • Such measurements can be carried out by means of conventional infrared sensors, and the measured temperature differences of the measuring points before and after the influence are used to investigate the heat regulation capacity of the investigated system.
  • the reproducibility of the methods is low. It has therefore also been proposed, according to DE-A-10132549, to irradiate parts of the body surface with infrared and to determine the resulting photoemission in a time-dependent manner and subsequently to adjust the relaxation function with a hyperbolic function.
  • EP-A-1126271 a method for determining the malignancy and reactivity of tumor tissue is known (EP-A-1126271), in which suitable tissue treatment agents are selected on the basis of measured light emission values of the tissue.
  • the invention is based on the object of providing a device for determining functional values, in particular the regulatory capacity of biological systems, in particular to develop man's, which is easy and reliable applicable.
  • the object is achieved by the features of claim 1.
  • the invention is based on the recognition that the physiological values of healthy people are distributed according to a logarithmic normal distribution, which, however, is subject to a normal distribution by sick people who have lost their ability to be regulated.
  • Well-regulated and disregulating biological systems would therefore be easy to recognize in the distribution of measurements when a large number of measurements are carried out in a short time.
  • the conductivity of the skin is suitable as such a measured value, in particular with regard to electrical resistance values or conductivity values. Electrostatic resistance values and / or electrical conductivity values can be measured quickly and reliably at any number of skin locations. It is then only necessary to compare the actual regulatory capacity of a body with the ideal and the lost regulatory capacity and to conclude on a stage of disease and its development and also to assess a therapy in terms of their effect.
  • Characteristic are measuring electrodes that allow a large number of measured values, in particular the conductivity of the skin, to be determined and evaluated by at least one hand in a short time. Preferably, approximately 500 measured values should be determinable within 10 minutes.
  • Fig. 1 Frequency distribution of a relatively healthy subjects
  • Fig. 2 frequency distribution of a relatively ill subjects
  • Fig. 3 Frequency distribution of a nearly cured subjects
  • Fig. 5 an electrode matrix
  • the device for determining functional values comprises a plate with an electrode matrix 1 onto which a skin area 2, for example a hand, can be laid flat.
  • the electrode matrix 1 has a multiplicity of regularly arranged metal pins 3, which are received in guides 5 and whose upper end face is formed like a head half-round, while the lower end face terminates flatly.
  • the upper area of the metal pins 3 is surrounded between the head end and the electrode matrix 1 by a spring 4 which, in the untensioned state, causes the metal pins 3 to protrude from the upper surface of the metal matrix 1.
  • the metal pins 3 can be pressed against the resistance of the spring 4 so far and into the guides 5 that contact the lower end faces contact points 6 of a counter-plate 15 by electrical Lei ⁇ ter (bundle conductor 10) with a measuring device 11 and further with a reference electrode 13 are connected to another skin site of the measured body. Electro ⁇ denmatrix 1 and counter-plate 15 are spaced from each other by a holder 7 and fixed in position by means of screws 8 and nuts 9.
  • a circuit is built up by the body, the metal pin 3, the measuring device 11 and the reference electrode 13, and the conductivity at the respective home location which touches the metal pin (s) 3 is determined ⁇ measure.
  • the conductivity measurements at the home locations, which contact the metal pins 3, are carried out in sequence.
  • the measured values can then be stored in the EDP 12 and utilized, for example, at the regulation of diagnostics.
  • the spring constants and the geometry are selected so that preferably all the metal pins 3 produce the same back pressure when the contact points 6 are touched.
  • the distribution of the measured values of the conductivity of a subject's skin deviates more or less from the ideal lognormal distribution 2, 3 or 4 and the most unfavorable normal distribution 1.
  • about 500 measured values are recorded, evaluated and plotted in about 10 minutes.
  • a healthy Pro ⁇ band results in a good match to the logarithmic normal distribution 2 of the measured values, with a z.
  • a strong approximation of the distribution 3 to a normal distribution results in a frequency distribution 4 that resembles that of a healthy person.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

L'invention concerne un dispositif pour déterminer des valeurs de fonction de systèmes biologiques, la conductibilité de la peau étant déterminée en particulier comme valeur de fonction. Les valeurs de mesure de la conductibilité sont déterminées au moyen d'une matrice à électrodes (1) dans un appareil de mesure, un circuit électrique étant fermé sur une électrode référence (13) et les valeurs de mesures étant stockées, puis utilisées.
PCT/CH2005/000446 2004-08-02 2005-07-27 Dispositif pour determiner des valeurs de fonction Ceased WO2006012765A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05760714A EP1776042A1 (fr) 2004-08-02 2005-07-27 Dispositif pour determiner des valeurs de fonction

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004037440A DE102004037440A1 (de) 2004-08-02 2004-08-02 Vorrichtung zur Ermittlung von Funktionswerten
DE102004037440.6 2004-08-02

Publications (1)

Publication Number Publication Date
WO2006012765A1 true WO2006012765A1 (fr) 2006-02-09

Family

ID=34979728

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2005/000446 Ceased WO2006012765A1 (fr) 2004-08-02 2005-07-27 Dispositif pour determiner des valeurs de fonction

Country Status (3)

Country Link
EP (1) EP1776042A1 (fr)
DE (1) DE102004037440A1 (fr)
WO (1) WO2006012765A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006054508A1 (de) * 2006-11-20 2008-05-29 Dr.Röhr Medical Solutions GmbH Vorrichtung zur opto-elektrischen Messung von spezifischen Hauptwiderstandsverteilungen
DE102006054509A1 (de) * 2006-11-20 2008-05-29 Dr.Röhr Medical Solutions GmbH Vorrichtung zur Messung von Hautwiderstandsverteilungen
DE102010015608A1 (de) * 2010-04-19 2011-10-20 Ziaja Research Gmbh Verfahren und Vorrichtung zur Bestimmung des Gesundheitszustandes eines Lebewesens
CN104414635A (zh) * 2013-09-04 2015-03-18 上海帝仪科技有限公司 干电极及其制造方法
DE102016001080A1 (de) 2015-02-09 2016-08-11 Stefan Liebelt Verfahren und Diagnosegerät zur Bestimmung von Krebs im menschlichen Körper aufgrund der höheren Eisenkonzentration von malignen Zellen

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3025955A1 (de) * 1980-07-09 1982-01-21 Forschungsgesellschaft für Biomedizinische Technik, 5100 Aachen Ableitelektrode zur aufnahme bioelektrischer aktivitaet von behaarten koerperregionen
US4517983A (en) * 1980-12-31 1985-05-21 Yasuhiro Toyosu Electrode sets with resiliently mounted pin electrodes
EP0538739A1 (fr) * 1991-10-23 1993-04-28 Reinhard, Max Méthode et dispositif destinés à la détermination de l'état de santé d'un être vivant
WO2003079896A1 (fr) * 2002-03-25 2003-10-02 Christian Stockinger Dispositif de mesure et methode pour reduire les erreurs de mesure

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3025955A1 (de) * 1980-07-09 1982-01-21 Forschungsgesellschaft für Biomedizinische Technik, 5100 Aachen Ableitelektrode zur aufnahme bioelektrischer aktivitaet von behaarten koerperregionen
US4517983A (en) * 1980-12-31 1985-05-21 Yasuhiro Toyosu Electrode sets with resiliently mounted pin electrodes
EP0538739A1 (fr) * 1991-10-23 1993-04-28 Reinhard, Max Méthode et dispositif destinés à la détermination de l'état de santé d'un être vivant
WO2003079896A1 (fr) * 2002-03-25 2003-10-02 Christian Stockinger Dispositif de mesure et methode pour reduire les erreurs de mesure

Also Published As

Publication number Publication date
EP1776042A1 (fr) 2007-04-25
DE102004037440A1 (de) 2006-03-16

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