WO2006022220A1 - Dispositif de traitement du cancer avec rayonnement infrarouge lointain - Google Patents

Dispositif de traitement du cancer avec rayonnement infrarouge lointain Download PDF

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Publication number
WO2006022220A1
WO2006022220A1 PCT/JP2005/015202 JP2005015202W WO2006022220A1 WO 2006022220 A1 WO2006022220 A1 WO 2006022220A1 JP 2005015202 W JP2005015202 W JP 2005015202W WO 2006022220 A1 WO2006022220 A1 WO 2006022220A1
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far
infrared
cancer
irradiated
ceramic
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English (en)
Japanese (ja)
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Kikuji Yamashita
Tomoyasu Ishikawa
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BLOODISSUE Inc
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BLOODISSUE Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
    • A61N2005/066—Radiation therapy using light characterised by the wavelength of light used infrared far infrared

Definitions

  • the present invention relates to a cancer treatment instrument that irradiates a cancer affected area with characteristic far infrared rays.
  • the present invention relates to a cancer treatment device that irradiates far-infrared rays that effectively treat each diseased cancer tissue.
  • instruments intended for cancer treatment include a radiation irradiation apparatus and a proton beam irradiation apparatus used for radiation therapy, proton beam therapy, and the like.
  • hyperthermia using cancer cells that are vulnerable to high temperatures has attracted attention, and local thermostats using radio waves, ultrasound, and high frequencies have been developed.
  • whole body thermotherapy using far-infrared rays has come to be used (see Patent Document 1 No. 3).
  • Patent Document 1 JP-A-8-112302
  • Patent Document 2 Japanese Patent Laid-Open No. 2003-126275
  • Patent Document 3 Japanese Patent Laid-Open No. 10-297961
  • the far-infrared radiation wavelength of the far-infrared irradiation device used for conventional thermotherapy includes 3 to 20 ⁇ m, which includes wavelengths that are considered to have a bad influence on the human body.
  • the force has also been pointed out as to its effect V, and it has been pointed out in the past! There is a problem such as /.
  • the ceramic described in this publication also irradiates far-infrared rays having a wide emission spectrum of 2 to 24 m as shown in FIG.
  • the far-infrared radiation of such a wide radiation spectrum does not necessarily heal the cancer affected area in an ideal state.
  • the healing effect can be improved.
  • ceramics that emit far-infrared rays with a specific emission spectrum are difficult to manufacture, and the manufacturing cost is high.
  • the present invention has been developed for the purpose of solving such drawbacks.
  • An important object of the present invention is to efficiently irradiate the cancer affected area with characteristic far-infrared rays and have no side effects, especially for low-healing cancer with low healing rate. To provide equipment.
  • a cancer treatment instrument that radiates far infrared rays is a device that treats cancer by irradiating the cancer affected part 20 with far infrared rays.
  • the cancer treatment instrument includes a far-infrared ray-irradiating ceramic film 1 fixed on the body surface of the cancer affected part 20, a far-infrared source 2 for irradiating this far-infrared ray-absorbing irradiated ceramic film 1 with an excitation far-infrared ray, And a heater 3 for heating the infrared source 2.
  • the far-infrared ray-irradiating ceramic film 1 is a far-infrared ray-absorbing irradiation ceramic that absorbs the excited far-infrared radiation emitted from the far-infrared source 2 and emits far-infrared characteristics that are different from the excited far-infrared radiation that is absorbed. is there.
  • the cancer treatment instrument converts far infrared radiation irradiated from the far infrared source 2 to the far infrared absorbing ceramic film 1 into far infrared absorbing irradiated ceramic film 1 and converts it into a characteristic far infrared having a different emission spectrum. Infrared rays are irradiated to the cancer affected part 20.
  • the above-mentioned cancer treatment device efficiently irradiates the affected area with far-infrared radiation, and has an effective and high healing effect even for cancers that have no side effects and have a low cure rate.
  • the cancer treatment instrument of the present invention is provided with a far-infrared absorption irradiation ceramic film having a radiation spectrum different from that of the far-infrared radiation to be absorbed on the body surface, and the far-infrared absorption irradiation ceramic film is irradiated with excitation far-infrared light from a far-infrared source.
  • the far-infrared absorption irradiated ceramic film converts the wavelength of the far-infrared ray to be absorbed, and irradiates the affected far-infrared ray with a characteristic effective for healing to the cancer affected area.
  • a cancer treatment device of this structure has a far-infrared absorbing ceramic film that is effective for cancer healing as a radiation spectrum whose basic research has shown that proliferation of cancer cells is significantly suppressed. Infrared rays can be irradiated.
  • the cancer treatment instrument of this structure is provided with far-infrared absorption irradiated ceramic films having different emission spectra on a plurality of parts of the body surface, and each far-infrared absorption irradiated ceramic film is heated with a far-infrared source to emit different radiation. It is also possible to irradiate the human body with far infrared rays in the spectrum. For this reason, for example, far-infrared rays having a radiation spectrum excellent in cancer healing can be irradiated to the cancer affected area, and far-infrared rays having a radiation spectrum that comfortably warms the body surface can be irradiated to other portions.
  • the cancer treatment instrument according to claim 2 of the present invention is characterized in that the far-infrared absorbing irradiated ceramic film 1 emits characteristic far-infrared radiation as a characteristic far-infrared absorbing irradiated ceramic.
  • the wavelength can be 7 to 12 ⁇ m, and the radiant intensity at a peak value outside the range of 7 to 12 ⁇ m can be 1Z 10 or less of the radiant intensity at the peak value of 7 to 12 m.
  • the cancer treatment instrument according to claim 3 of the present invention includes a far-infrared irradiation ceramic 4 that emits far-infrared rays when the far-infrared source 2 is heated by the heater 3, and the far-infrared irradiation ceramic 4 emits the far-infrared radiation. And a far-infrared radiation irradiating ceramic film 1 which is focused by the condensing lens 5 can be provided.
  • the far-infrared absorption irradiated ceramic film 1 is a ceramic paste applied to the body surface of the cancer affected part 20, or the body surface of the cancer affected part 20 It can be a ceramic sheet attached to the substrate.
  • the cancer treatment instrument that emits far infrared rays according to claim 6 of the present invention is heated to emit far infrared rays.
  • Far-infrared irradiation ceramics 4 to be irradiated a heater 3 fixed to the far-infrared irradiation ceramics 4 for heating the far-infrared irradiation ceramics 4, and a secondary connected to the heater 3 through a switch 6
  • the battery 11 includes a control circuit 7 that switches the switch 6 on and off with an external force signal, and a case 10 that embeds and insulates the control circuit 7, the switch 6, and the heater 3 in the body.
  • This cancer treatment instrument is implanted in the body and irradiates far-infrared rays to the cancerous part 20 in the body surface.
  • the above cancer treatment devices efficiently irradiate far-infrared rays to the cancerous part of the body, and realize an efficient and high healing effect even for cancers that have no side effects and particularly a low cure rate.
  • the cancer treatment instrument is heated and radiates far infrared radiation, a far infrared irradiation ceramic, a heater that warms the far infrared irradiation ceramic, a secondary battery that heats the heater,
  • a control circuit that controls energization of the vessel is housed in a case and embedded in the vicinity of the cancerous part of the body, and the far-infrared irradiation ceramics also radiates far-infrared radiation to the cancerous part of the body.
  • the cancer therapeutic instrument having this structure can dispose far-infrared irradiation ceramics close to the cancer affected part, and can thus irradiate the cancer affected part with strong far-infrared radiation effectively.
  • the far-infrared energy radiated from the far-infrared irradiated ceramics increases in proportion to the fourth power of the absolute temperature. For this reason, the far-infrared radiation radiated by increasing the temperature of the far-infrared irradiation ceramics can be strengthened.
  • the maximum temperature of far-infrared irradiated ceramics cannot be so high. It also has the power to cause harmful effects such as burns.
  • the temperature of the far-infrared irradiated ceramic determines the peak wavelength of the far-infrared radiation to be emitted.
  • the peak wavelength of far-infrared rays emitted from far-infrared irradiated ceramics is determined by Vienna's displacement law as a function of temperature.
  • the peak wavelength decreases as the temperature of the far-infrared irradiated ceramics increases.
  • the cancer treatment instrument of the present invention brings far-infrared radiation ceramics closer to the cancerous part in the body and intensifies far-infrared radiation to be emitted. For this reason, it is not necessary to increase the temperature of the far-infrared irradiated ceramics to increase the far-infrared radiation. For this reason, it is possible to strongly irradiate the far-infrared temperature of the specific radiation spectrum to the cancer affected part without changing the radiation spectrum. It is also possible to perform cancer treatment by irradiating far-infrared rays that do not supply external force energy to the affected area of the cancer while being implanted in the body.
  • the implantable cancer treatment instrument includes a condensing lens 5 that condenses the far-infrared ray irradiated from the far-infrared irradiation ceramics 4, and the far-infrared ray collected by the condensing lens 5 It is possible to irradiate the cancer affected part 20 in the body locally.
  • the implantable cancer treatment device includes a reed relay that can switch the switch and the control circuit on and off by magnetic force, and a controller that switches on and off the external force of the reed relay.
  • the heater can be energized by switching the reed relay on and off with the controller.
  • the far infrared irradiation ceramics 4 is obtained by adjusting the average current of the heater 3 by changing the duty of the control circuit 7 for switching the switch on and off.
  • the temperature of can be adjusted.
  • the cancer treatment instrument that emits far-infrared rays includes a ceramic-containing infusion solution 13 that is injected into the cancer affected part 20 through the catheter 12 and a ceramic-containing injection that is injected into the cancer affected part 20 through the catheter 12.
  • the far-infrared absorption irradiated ceramics contained in the liquid 13 are provided with a far-infrared source 2 that irradiates far-infrared radiation with an external force excited and a heater 3 that heats the far-infrared source 2.
  • the cancer treatment instrument irradiates far-infrared absorption irradiated ceramics injected into the body with excitation far-infrared radiation from the far-infrared source 2, and the far-infrared absorption irradiation ceramics that absorbs excitation far-infrared rays irradiate the cancer affected part 20 with far-infrared radiation.
  • the above cancer treatment devices also efficiently irradiate far-infrared rays to the cancerous part in the body, and have an effective high healing effect even for cancers that have no side effects and have a low cure rate. Realize. This is because the cancer treatment device injects a ceramic-containing injection solution that emits far-infrared rays when it is heated into the body, and irradiates the ceramic of the ceramic-containing injection solution with far-infrared rays as well. This is because the affected part is irradiated with far infrared rays. Since the cancer treatment device having this structure can inject ceramics very close to the cancer affected part, the ceramics can effectively irradiate the cancer affected part with strong far infrared rays.
  • the cancer treatment instrument shown in FIG. 2 has a far infrared absorption irradiation ceramic film 1 fixed to the body surface of the cancer affected part 20 and a far infrared ray that irradiates this far infrared absorption irradiation ceramic film 1 with an excitation far infrared ray.
  • a source 2 and a heater 3 for heating the far-infrared source 2 are provided.
  • the far-infrared absorbing irradiated ceramic film 1 absorbs the excited far-infrared radiation emitted from the far-infrared source 2 and emits the far-infrared characteristics of the far-infrared absorbing irradiated ceramics having a radiation spectrum different from that of the excited far-infrared to be absorbed. It is.
  • This characteristic far-infrared absorption irradiation ceramic is a ceramic that emits characteristic far-infrared radiation that is effective in cancer healing. This ceramic is produced, for example, by kneading, molding and firing powders of the following components.
  • the characteristic far-infrared absorbing irradiated ceramic produced by the above method absorbs far-infrared rays and emits characteristic far-infrared rays.
  • Figure 3 shows the emission spectrum. This figure shows the emission spectrum when the characteristic far-infrared absorbing ceramics are heated to 55 ° C. This figure shows the radiation scan in the state of heating the characteristic far-infrared absorbing ceramics to 55 ° C. Force indicating vector This characteristic far-infrared absorbing irradiated ceramic emits far-infrared rays and emits far-infrared rays with the same radiation spectrum even if they are absorbed.
  • This is excited by irradiation with far-infrared rays, and is irradiated with a characteristic far-infrared irradiation CO incubator that irradiates the characteristic far-infrared radiation inside the ceramics with the characteristic far-infrared absorption irradiation.
  • the A431 cell is a CO incubator and characteristics far infrared irradiation CO ink
  • HSC3 cells are in a group of characteristic far-infrared irradiated CO incubators after day 4.
  • Sa3 cells are a group of characteristic far-infrared irradiated CO incubators from the 4th day to the 12th day, which suppresses cell growth by 20-25% compared to the CO incubator group.
  • Figure 5 shows the results of the measurement of the number of cells. Suspension characteristics The concentration of far-infrared absorbing ceramics was 200 gZml.
  • the culture was performed in a divided manner. When it reached confluence, it was pulled with a 200ul pipette tip (Nunc). The time at which they were attracted was 0 hour, and A431 and HSC3 cells were observed with a phase contrast microscope after 11 hours, and Sa3 cells were observed with 8 hours later. The result is shown in Fig. 6.
  • CELL CULTURE INSERTS (8um pore size, PE T membrane, 3 x 4 cells per well) 2.5 x 10 4 in a 24-well plate (Nunc) 3 types of squamous cell carcinoma cells (A431, HSC3, Sa3) Becton Dickinson), and 1 ml of a culture solution containing 10% FBS was added to the lower chamber.
  • Matrigel Incubation Chamber 1 at 37 ° C, 5% CO, a group of CO incubators of comparative examples, characteristic far infrared absorption irradiated ceramics
  • Sa3 cells showed a marked suppression of invasion ability.
  • the characteristic far-infrared response gene B mRNA is constantly expressed in A431 cells
  • the characteristic far-infrared absorbing ceramics are fixed on the wall and irradiated with far-infrared rays.
  • the characteristic far-infrared radiation irradiation ceramics irradiates the characteristic far-infrared radiation inside The characteristic far-infrared radiation CO incubator group continued to enhance the expression
  • the rol group and the characteristic far-infrared absorbing ceramic suspension are added, and the far-infrared irradiation group (200 ⁇ g / ml) is irradiated with the far-infrared irradiation of the characteristic far-infrared absorbing ceramic suspension.
  • the culture was performed. After 48 hours of culturing, DNA was extracted using Quick Apoptotic DNA Ladder Detection Kit (BioVision, CA, USA) and electrophoresed on 1% agarose gel. Test results show that all three types of cancer cells In spite of this, DNA ladder, which is an index of apoptosis, was detected in the group irradiated with characteristic far-infrared radiation.
  • squamous cell carcinoma cells (A431, HSC3, Sa3) in 60 mm dish (Nunc) 2 x 10 6 each, and wait for enough cells to attach to the dish, then the characteristic far-infrared absorbing irradiated ceramics A powder suspension (concentration 200 ⁇ g / ml) was added. After 48 hours of culture, the cells were collected and fixed with 70% ethanol for 24 hours. Apo—BrdU In Situ DNA Fragmentation Assay Kit (Bio Vision, Ca, USA) was used for staining the collected cells. For detection of apoptosis, flow cytometry (BECKMAN COULTER, USA) was used.
  • the number of apoptosis-positive cells in the control group of the comparative example was 1.98%, 2.54%, and 3.24% in the A431, HSC3, and Sa3 cells, respectively.
  • 34.4%, 43.9%, and 21.5% significantly induced apoptosis.
  • the far infrared absorption irradiated ceramics having the above characteristics emit far infrared rays having an effect excellent in cancer healing.
  • the cancer treatment instrument of the present invention uses the ceramic of the far infrared absorbing irradiation ceramic film as the above ceramics. Not specified. As far-infrared absorbing ceramic films that are effective for cancer healing, all ceramics that are currently developed or that are effective for cancer healing can be used.
  • the far-infrared absorption irradiated ceramic film 1 irradiates far-infrared rays with a characteristic that has an excellent effect on cancer healing.
  • the far-infrared absorption irradiated ceramic film 1 irradiates excitation far-infrared rays for supplying thermal energy to the far-infrared absorption irradiated ceramic film 1.
  • the far-infrared source 2 does not necessarily need to emit far-infrared rays that have an excellent effect on cancer healing.
  • the far-infrared absorption irradiated ceramic film 1 absorbs the far-infrared ray from the far-infrared radiation source 2 and converts the far-infrared ray that has been absorbed to emit far-infrared rays with an effective spectrum for cancer healing. is there.
  • the far-infrared absorbing and irradiating ceramic film 1 is fixed to the body surface of the cancer affected part 20 and irradiates the cancer affected part 20 with characteristic far infrared rays.
  • the far-infrared absorption irradiated ceramic film 1 can be provided by applying a ceramic paste to the body surface of the cancer affected part 20. Ceramic paste is far away Infrared absorption irradiated ceramics are kneaded into a liquid or paste binder. When the ceramic paste is applied to the body surface, the binder is cured or the binder disappears to form a far infrared ray absorbing irradiated ceramic film 1 on the body surface.
  • the hardened far-infrared absorbing irradiated ceramic film 1 of the binder is removed by peeling off the body surface force after irradiating the cancerous part 20 with the characteristic far-infrared ray.
  • the far infrared ray absorbing irradiated ceramic film 1 can be provided in close contact with the body surface.
  • the far-infrared absorbing irradiated ceramic film 1 can also be fixed to the body surface of the cancerous part 20 in the state of a flexible ceramic sheet.
  • the ceramic sheet is manufactured by applying a ceramic paste to a flexible sheet surface.
  • the ceramic sheet can be fixed at a specific position on the body surface via an adhesive layer (not shown).
  • the far-infrared ray source 2 can be made of any ceramic that emits far-infrared rays by heating.
  • the far-infrared source 2 is manufactured by forming a raw material powder into a plate having a predetermined thickness and firing it.
  • the far-infrared source 2 is enlarged and heated by a heater 3 larger than the far-infrared absorbing irradiated ceramic film 1 to emit far-infrared rays.
  • the far-infrared radiation emitted from the far-infrared source 2 is absorbed by the far-infrared absorbing irradiated ceramic film 1.
  • the far-infrared absorbing and irradiating ceramic film 1 that has absorbed far-infrared rays irradiates the cancer affected part 20 with characteristic far-infrared rays having a specific radiation spectrum after wavelength conversion. Therefore, the far-infrared source 2 does not necessarily need to be in contact with the body surface.
  • Far-infrared source 2 that does not come into contact with the body surface can raise the temperature considerably to 50 ° C or higher. This is because the far-infrared light source 2 that does not come into contact with the body surface does not cause harmful effects such as burns on the human body.
  • Far-infrared source 2 that can raise the temperature can increase the radiant energy of far-infrared rays. This is because the radiant energy increases in proportion to the fourth power of the far-infrared source 2 temperature (absolute temperature).
  • the far-infrared source 2 of the cancer treatment instrument in FIG. 2 includes a far-infrared irradiation ceramic 4 that is heated by a heater 3 and emits far-infrared radiation, and a far-infrared radiation emitted from the far-infrared irradiation ceramic 4.
  • a condensing lens 5 that focuses the light and supplies it to the far-infrared absorbing ceramic film 1.
  • the far-infrared source 2 focuses the far-infrared rays emitted from the far-infrared irradiation ceramics 4 with a condenser lens 5 and supplies the far-infrared rays with high energy density to the far-infrared absorption irradiation ceramic film 1. For this reason, the far infrared rays supplied from the far infrared source 2 are efficient. It can be absorbed by the far-infrared absorbing ceramic film 1.
  • the far-infrared source 2 is heated to a set temperature by the heater 3 and radiates energy.
  • the heater 3 heats the far infrared ray source 2 with Joule heat generated by energization.
  • the heater 3 warms the far infrared radiation source 2 to a constant temperature.
  • the heater 3 is a heater 3A or PTC.
  • Heater 3A is a high-resistance electric wire such as a chrome wire. The heater 3A does not act to keep the temperature of the far infrared ray source 2 constant.
  • FIG. 9 is a circuit diagram of a cancer treatment instrument that maintains the far-infrared ray source 2 at a constant temperature with the heater 3.
  • This heater 3 is a heater 3A, which is connected to a switch 6 in series, and the switch 6 is switched on and off by a control circuit 7.
  • a power supply 8 for supplying power is connected to the heater 3A. That is, the heater 3A and the switch 6 are connected in series and connected to the power source 8.
  • the switch 6 can be a switch having a mechanical contact such as a force relay that uses a semiconductor switching element such as a transistor. In the heater 3, the switch 6 is turned on / off by the control circuit 7, and the far infrared ray source 2 is maintained at a constant temperature.
  • the control circuit 7 is connected to a temperature sensor 9 that detects the temperature of the far infrared ray source 2.
  • the control circuit 7 detects the temperature of the far infrared ray source 2 with the temperature sensor 9 and switches the switch 6 on and off.
  • switch 6 When far-infrared source 2 rises to the set temperature, switch 6 is turned off and heater 3A is de-energized.
  • the switch 6 When the energization is cut off and the temperature of the far infrared ray source 2 falls to the set temperature, the switch 6 is turned on to heat the far infrared ray source 2. This operation is repeated to keep the far-infrared source 2 at a constant temperature.
  • PTC has a characteristic that when the temperature rises to a set temperature, the electrical resistance increases rapidly and substantially cuts off the current. When the temperature is lower than the set temperature, the electric resistance is small and current flows and heat is generated by Joule heat. For this reason, PTC heaters can be connected directly to a power source without the need for temperature sensors or control circuits, and the far-infrared source can be maintained at a constant temperature.
  • the PTC is laminated so as to be in close contact with the far-infrared source, and the far-infrared source and the heater are integrated by holding the far-infrared source at a constant temperature or by mixing the far-irradiated ceramic powder with the PTC. It can also be.
  • the above cancer treatment instrument is used in the state shown in FIG. 2, and irradiates the cancer affected area 20 with characteristic far infrared rays.
  • the body surface of the cancer affected part 20 absorbs far-infrared rays.
  • the collecting ceramic film 1 is fixed.
  • the far-infrared absorbing irradiated ceramic film 1 is fixed by adhering a ceramic sheet to the body surface or by applying a ceramic paste to the body surface of the cancer affected part 20.
  • the far-infrared source 2 is fixed at a position where the far-infrared absorbing irradiated ceramic film 1 is irradiated with far-infrared rays.
  • the far infrared source 2 is heated to a certain temperature by the heater 3 and emits far infrared rays.
  • a condensing lens 5 is disposed between a far-infrared source 2 and a far-infrared absorbing ceramic film 1.
  • the condenser lens 5 is fixed to the far-infrared ray source 2 and irradiates 1 cm of the far-infrared absorbing ceramic film bundled with the far-infrared rays emitted from the far-infrared ray source 2.
  • Far-infrared rays emitted from the far-infrared source 2 are focused by the condenser lens 5 and absorbed by the far-infrared absorbing irradiated ceramic film 1.
  • the far-infrared absorption irradiation ceramic film 1 that has absorbed far-infrared rays converts far-infrared rays that are absorbed, and emits far-infrared rays that have a good healing effect to the cancer affected part 20.
  • the cancer treatment device in FIG. 10 is implanted in the body and irradiates far-infrared rays to the cancer affected part 20 in the body.
  • this cancer treatment instrument is a far-infrared irradiation ceramic 4 that is heated and emits far-infrared radiation, and a far-infrared radiation irradiation ceramic 4 that is fixed to the far-infrared irradiation ceramic 4.
  • the switch 6 and the heater 10 are provided with a case 10 that is embedded and insulated in the body.
  • This cancer treatment instrument can irradiate the cancer affected part 20 with the characteristic far infrared ray having an effect excellent in cancer healing by using the ceramic used for the above-mentioned far infrared absorption irradiation ceramic film for the far infrared irradiation ceramic 4.
  • the implantable cancer treatment instrument shown in FIG. 11 includes a condensing lens 5 that collects far infrared rays irradiated from the far infrared irradiation ceramics 4.
  • This cancer treatment instrument can irradiate far-infrared rays focused by the condenser lens 5 locally to the cancer affected part 20.
  • This cancer treatment instrument also houses a condensing lens 5 in a case 10.
  • Case 10 has a high far-infrared transmittance for the part that transmits far-infrared rays emitted from the condenser lens 5! It is made of glass and plastic.
  • Fig. 12 shows a circuit diagram of a cancer treatment instrument implanted in the body.
  • the cancer treatment instrument in this figure is connected to the secondary battery 11 by connecting the heater 3 and the switch 6 in series.
  • the heater 3 is a heater 3A or PTC, similar to the cancer treatment instrument in FIG.
  • the switch 6 is turned on, the secondary battery 11 heats the heater 3, and the heated heater 3 warms the far-infrared irradiation ceramics 4.
  • the control circuit 7 switches the switch 6 on and off to control the power supplied from the secondary battery 11 to the heater 3.
  • the control circuit 7 receives a radio signal or an ultrasonic signal input from outside the body, or switches the switch 6 on and off with a signal of a built-in timer.
  • the cancer treatment device implanted in the body can have a control circuit and a switch as a relay.
  • a reed relay is a relay that contains a contact point that can be switched on and off by a magnetic field inside a sealed glass tube. The reed relay is switched on by applying a magnetic field from outside the body, and switched off without applying a magnetic field. The reed relay is switched on and off by a controller that controls a magnetic field provided outside the body.
  • the control circuit 7 that controls the temperature of the heater 3 by switching the switch 6 on and off changes the duty for switching the switch 6 on and off, and adjusts the average current flowing through the heater 3 to adjust the temperature of the heater 3
  • the temperature of the far-infrared irradiated ceramic 4 can be controlled with the heater 3 by controlling the temperature.
  • the control circuit 7 changes the duty at which the switch 6 is turned on / off by a signal from the temperature sensor 9 to keep the temperature of the heater 3, that is, the temperature of the far-infrared irradiation ceramics 4 constant.
  • the cancer treatment instrument shown in FIG. 13 is included in a ceramic-containing infusion solution 13 that is injected into the cancer affected part 20 through the catheter 12 and a ceramic-containing infusion solution 13 that is injected into the cancer affected part 20 through the catheter 12.
  • the far-infrared-absorbing irradiated ceramic is provided with a far-infrared source 2 that irradiates far-infrared radiation excited by external force and a heater 3 that heats the far-infrared source 2.
  • This cancer treatment instrument uses the same device as that used in Fig. 2 as the device for irradiating far-infrared absorbing ceramics in the body with far-infrared radiation.
  • the ceramic-containing injection solution 13 is obtained by suspending a fine powder of far-infrared absorption irradiated ceramics in a liquid.
  • the catheter 12 is then injected into the body.
  • the far-infrared absorption irradiation ceramic injected into the body absorbs far-infrared rays irradiated from the outside, converts the wavelength of the absorbed far-infrared rays, and irradiates the cancerous affected part 20 with the characteristic far-infrared rays. Therefore, ceramics that irradiate far-infrared absorbing ceramics that are injected into the body are irradiated with characteristic far-infrared rays that are effective in cancer healing.
  • Somnopentyl (diluted 10-fold) was anesthetized at a rate of 10 mg / kg body weight in skid mice, and 1.5 X 10 6 HSC3 cells were suspended in high-concentration matrigel (Becton Dickinson). Injected subcutaneously in the back. Rats were raised using a far-infrared breeding device that irradiates far-infrared rays inside. The engrafted tumor was measured every 5 days, and the tumor volume was approximated by 1/2 X (major axis) X (minor axis) 2 .
  • the results were as follows. As clearly shown in the photograph in FIG. 14, the transplanted cancer cells (HSC3) were engrafted 4 days after the transplantation (FIG. 14). After transplanting the cancer cells, the tumor volume increased over time as shown in FIGS. However, from the 30th day after transplantation, the far infrared absorption ceramics were injected into the tumor, and the tumor volume decreased over time by using it together with the far infrared irradiation.
  • the cancer treatment instrument of the present invention can be used as an apparatus for effectively treating individual cancer tissues that have developed disease by irradiating a cancerous site with characteristic far infrared rays.
  • FIG. 1 is a graph showing the radiation intensity of a conventional far-infrared radiator.
  • FIG. 2 is a schematic view showing a use state of a cancer treatment device that is useful in one embodiment of the present invention.
  • FIG. 3 is a graph showing a radiation spectrum of characteristic far-infrared absorbing irradiated ceramics.
  • FIG. 4 is a graph showing the results of a characteristic far-infrared irradiated cancer cell growth inhibition test.
  • Characteristic This is a graph showing the results of a far-infrared irradiation cancer cell growth inhibition test.
  • FIG. 6 A micrograph showing the results of a wound healing assay for characteristic far-infrared irradiated cancer cells.
  • FIG. 7 is a fluorescence micrograph showing the result of an invasion of characteristic far-infrared irradiated cancer cells.
  • FIG. 8 shows the results of an expression test of a characteristic far-infrared responsive gene of cancer cells.
  • FIG. 9 is a circuit diagram of the cancer treatment instrument shown in FIG. 2.
  • FIG. 10 is a schematic view showing a use state of a cancer treatment device according to another embodiment of the present invention.
  • FIG. 11 is a schematic configuration diagram of the cancer treatment instrument shown in FIG.
  • FIG. 12 is a circuit diagram of the cancer treatment instrument shown in FIG.
  • FIG. 13 is a schematic view showing a use state of a cancer treatment device according to another embodiment of the present invention.
  • FIG. 15 is a graph showing the results of a characteristic far-infrared cancer suppression test using mice.
  • FIG. 16 is a graph showing the results of a characteristic far-infrared cancer suppression test using mice.

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  • Radiation-Therapy Devices (AREA)

Abstract

L’invention porte sur un dispositif de traitement de cancer par rayonnement infrarouge lointain vers une partie affectée par le cancer (20). Le dispositif de traitement de cancer contient un film céramique d’absorption/de radiation de rayonnement infrarouge lointain (1) disposé au niveau de la partie affectée (20), une source de rayonnement à infrarouge lointain (2) pour irradier le rayonnement infrarouge lointain excité vers le film céramique d’absorption/de radiation de rayonnement infrarouge lointain (1), et un radiateur (3) pour chauffer la source de rayonnement à infrarouge lointain (2). Le film céramique d’absorption/de radiation de rayonnement infrarouge lointain (1) absorbe un rayonnement infrarouge lointain excité irradié depuis la source de rayonnement à infrarouge lointain (2) and émet un rayonnement infrarouge lointain spécial du spectre de radiation différent du rayonnement infrarouge lointain excité absorbé et irradie le rayonnement infrarouge lointain spécial vers la partie affectée (20).
PCT/JP2005/015202 2004-08-23 2005-08-22 Dispositif de traitement du cancer avec rayonnement infrarouge lointain Ceased WO2006022220A1 (fr)

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JP2004-242995 2004-08-23
JP2004242995A JP4653983B2 (ja) 2004-08-23 2004-08-23 遠赤外線を放射する癌治療器具

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WO2006022220A1 true WO2006022220A1 (fr) 2006-03-02

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CN114712725A (zh) * 2022-06-09 2022-07-08 吉林省曹兴堂生物光波科技有限公司 宽频谱痔疮治疗仪
WO2022197743A1 (fr) * 2021-03-16 2022-09-22 Multiple Energy Technologies Llc Compositions biocéramiques pour la récupération post-cancer
US12234191B2 (en) 2012-09-26 2025-02-25 Multiple Energy Technologies Llc Bioceramic compositions

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KR101357529B1 (ko) * 2012-01-04 2014-02-03 울산대학교 산학협력단 성문암 치료용 메가 볼트 엑스-선 산란판 및 이를 이용한 치료방법
CN106902479A (zh) * 2017-02-27 2017-06-30 南京大学 一种红外引导下的测量热塑膜与人体体表吻合度的方法

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JPH08501632A (ja) * 1992-09-14 1996-02-20 エス・アール・アイ・インターナシヨナル レーザー励起技術を用いる生物学的および他の分析のためのアップコンバート性レポータ
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12234191B2 (en) 2012-09-26 2025-02-25 Multiple Energy Technologies Llc Bioceramic compositions
WO2022197743A1 (fr) * 2021-03-16 2022-09-22 Multiple Energy Technologies Llc Compositions biocéramiques pour la récupération post-cancer
CN114712725A (zh) * 2022-06-09 2022-07-08 吉林省曹兴堂生物光波科技有限公司 宽频谱痔疮治疗仪
CN114712725B (zh) * 2022-06-09 2022-08-16 吉林省曹兴堂生物光波科技有限公司 宽频谱痔疮治疗仪

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