WO2006024476A3 - Homogenes verfahren zur bestimmung eines analyten in gegenwart eines überschusses von kreuzreagierenden substanzen - Google Patents

Homogenes verfahren zur bestimmung eines analyten in gegenwart eines überschusses von kreuzreagierenden substanzen Download PDF

Info

Publication number
WO2006024476A3
WO2006024476A3 PCT/EP2005/009284 EP2005009284W WO2006024476A3 WO 2006024476 A3 WO2006024476 A3 WO 2006024476A3 EP 2005009284 W EP2005009284 W EP 2005009284W WO 2006024476 A3 WO2006024476 A3 WO 2006024476A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyte
cross
excess
determining
reacting substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/009284
Other languages
English (en)
French (fr)
Other versions
WO2006024476A2 (de
Inventor
Stefan Teigelkamp
Matthias Ehm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Priority to EP05782650A priority Critical patent/EP1787123A2/de
Publication of WO2006024476A2 publication Critical patent/WO2006024476A2/de
Publication of WO2006024476A3 publication Critical patent/WO2006024476A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Die vorliegende Erfindung betrifft ein homogenes Verfahren, das es unter Verwendung Analyt-spezifischer Bindungspartner, die jeweils mit einer Komponente eines signalbildenden Systems assoziiert sind, ermöglicht, einen Analyten in Gegenwart einer oder mehrerer kreuzreagierender Substanzen zu bestimmen.
PCT/EP2005/009284 2004-08-30 2005-08-29 Homogenes verfahren zur bestimmung eines analyten in gegenwart eines überschusses von kreuzreagierenden substanzen Ceased WO2006024476A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05782650A EP1787123A2 (de) 2004-08-30 2005-08-29 Homogenes verfahren zur bestimmung eines analyten in gegenwart eines überschusses von kreuzreagierenden substanzen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200410042124 DE102004042124B4 (de) 2004-08-30 2004-08-30 Homogenes Verfahren zur Bestimmung eines Analyten in Gegenwart eines Überschusses von kreuzreagierenden Substanzen
DE102004042124.2 2004-08-30

Publications (2)

Publication Number Publication Date
WO2006024476A2 WO2006024476A2 (de) 2006-03-09
WO2006024476A3 true WO2006024476A3 (de) 2006-10-26

Family

ID=35745688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/009284 Ceased WO2006024476A2 (de) 2004-08-30 2005-08-29 Homogenes verfahren zur bestimmung eines analyten in gegenwart eines überschusses von kreuzreagierenden substanzen

Country Status (3)

Country Link
EP (1) EP1787123A2 (de)
DE (1) DE102004042124B4 (de)
WO (1) WO2006024476A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2177624A1 (de) * 2008-10-02 2010-04-21 Siemens Healthcare Diagnostics Products GmbH Blutgerinnungs-Assays
CN114910636B (zh) * 2017-10-26 2025-02-18 科美诊断技术股份有限公司 一种血清总IgE抗体检测试剂盒及其检测方法
CN111781345A (zh) * 2020-06-30 2020-10-16 上海透景生命科技股份有限公司 化学发光标记物标记抗原稳定剂及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006861A1 (en) * 1989-11-06 1991-05-16 Akzo N.V. Immunoassays for and monoclonal antibodies to prothrombin activation peptides and their degradation products
WO2001084157A2 (en) * 2000-05-04 2001-11-08 Dade Behring Marburg Gmbh Compositions for detection of multiple analytes
US20030219845A1 (en) * 1988-02-03 2003-11-27 Ruiz Juan A. Immunoassay for F1.2 prothrombin fragment
WO2005062057A1 (de) * 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Konjugate und deren verwendung in nachweisverfahren

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3633497A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Immunometrisches bestimmungsverfahren
US5512659A (en) * 1989-08-04 1996-04-30 Syntex (U.S.A.) Inc. Compositions useful in heterogeneous immunoassays
EP0984282B1 (de) * 1991-05-22 2003-07-30 Dade Behring Marburg GmbH Partikel, die eine Zusammensetzung beinhalten, die eine chemilumineszierende Verbindung umfassen
CA2170873A1 (en) * 1993-09-03 1995-03-09 Dariush Davalian Fluorescent oxygen channeling immunoassays
DE19521388C2 (de) * 1995-06-13 1997-05-22 Immuno Gmbh Technik zur Bestimmung einer spezifisch-bindefähigen Substanz
WO2001067105A1 (en) * 2000-03-06 2001-09-13 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030219845A1 (en) * 1988-02-03 2003-11-27 Ruiz Juan A. Immunoassay for F1.2 prothrombin fragment
WO1991006861A1 (en) * 1989-11-06 1991-05-16 Akzo N.V. Immunoassays for and monoclonal antibodies to prothrombin activation peptides and their degradation products
WO2001084157A2 (en) * 2000-05-04 2001-11-08 Dade Behring Marburg Gmbh Compositions for detection of multiple analytes
WO2005062057A1 (de) * 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Konjugate und deren verwendung in nachweisverfahren

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CLINICAL CHEMISTRY, vol. 50, no. 6, Suppl. S, Part 2, June 2004 (2004-06-01), 56TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY (AACC); LOS ANGELES, CA, USA; JULY 25-29, 2004, pages A5, ISSN: 0009-9147 *
CLINICAL CHEMISTRY, vol. 50, no. 6, Suppl. S, Part 2, June 2004 (2004-06-01), 56TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY (AACC); LOS ANGELES, CA, USA; JULY 25-29, 2004, pages A59, ISSN: 0009-9147 *
CLINICAL CHEMISTRY, vol. 50, no. 6, Suppl. S, Part 2, June 2004 (2004-06-01), 56TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY (AACC); LOS ANGELES, CA, USA; JULY 25-29, 2004, pages A72, ISSN: 0009-9147 *
CLINICAL CHEMISTRY, vol. 50, no. 6, Suppl. S, Part 2, June 2004 (2004-06-01), 56TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY (AACC); LOS ANGELES, CA, USA; JULY 25-29, 2004, pages A91, ISSN: 0009-9147 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; June 2004 (2004-06-01), BAUER R ET AL: "Quantitation of cardiac markers by LOCI(TM) technology.", XP009069746, Database accession no. PREV200500002978 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; June 2004 (2004-06-01), PIERSON-PERRY J ET AL: "Quantitation of anemia markers by LOCI(TM) technology.", XP009069743, Database accession no. PREV200400468176 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; June 2004 (2004-06-01), ROSENWALD S ET AL: "Quantitation of prostate-specific antigen markers By LOCI(TM) technology.", XP009069744, Database accession no. PREV200400468219 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; June 2004 (2004-06-01), SCHELP C ET AL: "Quantitation of thyroid markers by LOCI(TM) technology", XP009069745, Database accession no. PREV200400468286 *
ULLMAN E.F. ET AL.: "Luminescent oxygen channeling assay (LOCI TM): sensitive, broadly applicable homogeneous immunoassay method", CLIN. CHEM., vol. 42, no. 9, 1996, pages 1518 - 1526, XP002109518, ISSN: 0009-9147 *

Also Published As

Publication number Publication date
EP1787123A2 (de) 2007-05-23
DE102004042124B4 (de) 2006-07-06
DE102004042124A1 (de) 2006-03-02
WO2006024476A2 (de) 2006-03-09

Similar Documents

Publication Publication Date Title
WO2008048970A3 (en) Synthetic antibodies
WO2007109254A3 (en) Stabilized polypeptide compositions
IL176940A (en) An isolated antibody or antigen-binding fragment thereof
DE502005002345D1 (de) Verfahren zur einstellung von sitzkomponenten
IL227753A0 (en) A qualified antibody or antibody residue
WO2005118857A3 (en) Methods and agents for screening for compounds capable of modulating vegf expression
UA94576C2 (ru) Выделенное антитело, которое связывается с igf-1r, композиция, которая его содержит, и способы, которые касаются антител
WO2006058237A3 (en) Polymer-coated substrates for binding biomolecules and methods of making and using thereof
WO2006017274A3 (en) Systems and methods for sample modification using fluidic chambers
WO2007143669A3 (en) Real time micro arrays
WO2009140039A3 (en) Synthetic antibodies
EP1931800A4 (de) Systeme und verfahren zur anreicherung von analyten
EP1956842A4 (de) Verfahren, einrichtung und system zur realisierung von zeitverschiebungs-tv
WO2007033980A3 (de) Verfahren zum bestücken eines teppichs bwz. eines flächenförmigen trägers mit elektronischen bauteilen, vorrichtung hierzu, sowie teppich bzw. flächenförmiger träger mit elektronischen bauteilen
WO2006088700A3 (en) Human ring specific bnp antibodies
WO2007051164A3 (en) Toll like receptor 3 modulators, methods and uses
DE602004022014D1 (de) Rekonfigurierbares Verfahren zur Erfassung von Ereignissen im Fahrzeug
EP1648028A4 (de) Zusammengesetzte elektronische komponente
ATE473290T1 (de) Proteomweite quantifizierung kleiner an zelluläre zielproteine gebundener moleküle
NL1029419A1 (nl) Niveauverschuiver en werkwijze daarvoor.
WO2008024483A3 (en) Array-based analyte detection
ITMI20040858A1 (it) Anticorpi monoclonali ibridomi metodo migliorato per determinare la proteina ptx3 e kit per detta determinazione
GB0403369D0 (en) Devices and methods for testing analytes
DE112004002986A5 (de) Prüfanlage zur zerstörungsfreien Materialprüfung
DE602005010356D1 (de) Verfahren zur elektronischen Konsolidierung von Poststücken

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2005782650

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWP Wipo information: published in national office

Ref document number: 2005782650

Country of ref document: EP