WO2006033995A3 - Thiazolidine-4-ones possedant une activite antihepatite b - Google Patents

Thiazolidine-4-ones possedant une activite antihepatite b Download PDF

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Publication number
WO2006033995A3
WO2006033995A3 PCT/US2005/033038 US2005033038W WO2006033995A3 WO 2006033995 A3 WO2006033995 A3 WO 2006033995A3 US 2005033038 W US2005033038 W US 2005033038W WO 2006033995 A3 WO2006033995 A3 WO 2006033995A3
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WO
WIPO (PCT)
Prior art keywords
hepatitis
thiazolidin
ones
activity
preventing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/033038
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English (en)
Other versions
WO2006033995A2 (fr
Inventor
Robert K Hamatake
Huanming Chen
Anneke Raney
Matthew J Allan
Stanley Lang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeant Research and Development
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Valeant Research and Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valeant Research and Development filed Critical Valeant Research and Development
Publication of WO2006033995A2 publication Critical patent/WO2006033995A2/fr
Publication of WO2006033995A3 publication Critical patent/WO2006033995A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés (I) possédant une structure générale dans laquelle X représente S, O, ou N et X' représente N ou C. Ces composés sont utiles dans la prévention et le traitement d'infections par le virus de l'hépatite B (HBV) chez des mammifères, et dans la prévention et le traitement de maladies associées à cette infection.
PCT/US2005/033038 2004-09-16 2005-09-16 Thiazolidine-4-ones possedant une activite antihepatite b Ceased WO2006033995A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61049404P 2004-09-16 2004-09-16
US60/610,494 2004-09-16

Publications (2)

Publication Number Publication Date
WO2006033995A2 WO2006033995A2 (fr) 2006-03-30
WO2006033995A3 true WO2006033995A3 (fr) 2006-06-01

Family

ID=36090506

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/033038 Ceased WO2006033995A2 (fr) 2004-09-16 2005-09-16 Thiazolidine-4-ones possedant une activite antihepatite b

Country Status (1)

Country Link
WO (1) WO2006033995A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233978B2 (en) 2014-03-07 2016-01-12 Hoffmann-La Roche Inc. 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
US9266904B2 (en) 2013-05-17 2016-02-23 Hoffmann-La Roche Inc. 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
US9856247B2 (en) 2012-03-31 2018-01-02 Hoffmann-La Roche Inc. 4-methyl-dihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection
US11337982B2 (en) 2016-09-13 2022-05-24 Hoffmann-La Roche, Inc. Combined treatment with a TLR7 agonist and an HBV capsid assembly inhibitor
US11771699B2 (en) 2015-03-16 2023-10-03 Hoffmann-La Roche Inc. Combined treatment with a TLR7 agonist and an HBV capsid assembly inhibitor
US11873302B2 (en) 2019-03-25 2024-01-16 Hoffmann-La Roche Inc. Solid forms of a compound of HBV core protein allosteric modifier

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CN103130793B (zh) * 2011-11-30 2016-09-21 中国人民解放军军事医学科学院毒物药物研究所 3-(1-芳基哌啶-4-基)-2-芳基噻唑啉-4-酮类化合物、其制备方法及用途
WO2013144129A1 (fr) 2012-03-31 2013-10-03 F. Hoffmann-La Roche Ag Nouveaux 4-méthyl-dihydropyrimidines pour le traitement et la prophylaxie du virus de l'hépatite b
MX2015002954A (es) 2012-09-10 2015-06-05 Hoffmann La Roche Nuevas 6-aminoacido-heteroarilhidropirimidinas para el tratamiento y profilaxis de la infeccion del virus de la hepatitis b.
CN103664916B (zh) * 2012-09-12 2016-08-24 中国科学院化学研究所 基于联噻吩亚二吡咯及其衍生物的共轭小分子材料及其制备方法与应用
JP2016514164A (ja) 2013-03-14 2016-05-19 エピザイム，インコーポレイティド アルギニンメチルトランスフェラーゼ阻害剤としてのピラゾール誘導体およびその使用
US9447079B2 (en) 2013-03-14 2016-09-20 Epizyme, Inc. PRMT1 inhibitors and uses thereof
WO2014153226A1 (fr) 2013-03-14 2014-09-25 Epizyme, Inc. Inhibiteurs d'arginine méthyltransférase et leurs utilisations
US9394258B2 (en) 2013-03-14 2016-07-19 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9023883B2 (en) 2013-03-14 2015-05-05 Epizyme, Inc. PRMT1 inhibitors and uses thereof
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US20160039767A1 (en) 2013-03-14 2016-02-11 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
EP2970131B1 (fr) 2013-03-14 2017-11-15 Epizyme, Inc. Inhibiteurs de l'arginine méthyltransférase et utilisations de ceux-ci
EP2970136A1 (fr) 2013-03-14 2016-01-20 Epizyme, Inc. Inhibteurs de l'arginine méthyltransférase et utilisations de ceux-ci
EP2970181B1 (fr) 2013-03-14 2017-06-07 Epizyme, Inc. Inhibiteurs d'arginine méthyltransférase et leurs utilisations
US10442788B2 (en) 2015-04-01 2019-10-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2016183266A1 (fr) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Agents antiviraux de l'hépatite b
WO2016202721A1 (fr) 2015-06-16 2016-12-22 F. Hoffmann-La Roche Ag Sels d'acide (s)-4-[(r)-6-(2-chloro-4-fluoro-phényl)-5-méthoxycarbonyl-2-thiazol-2-yl-3,6- dihydro-pyrimidin-4-ylméthyl]-morpholine-3-carboxylique, agent salifiant et leurs procédés de préparation et d'utilisation
US10179131B2 (en) 2015-07-13 2019-01-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017064156A1 (fr) 2015-10-16 2017-04-20 F. Hoffmann-La Roche Ag Nouvelles 2-hétéroaryldihydropyrimidines fusionnées en position 6 pour le traitement et la prophylaxie de l'infection par le virus de l'hépatite b
US10280175B2 (en) 2016-02-02 2019-05-07 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
DK3441389T3 (da) * 2016-04-06 2021-11-08 Shanghai Zhimeng Biopharma Inc Pyrazol-oxazolidinonforbindelse mod anti-hepatitis b-virus
SG11201810834WA (en) 2016-06-10 2018-12-28 Enanta Pharm Inc Hepatitis b antiviral agents
EA202090514A1 (ru) 2017-08-28 2020-06-24 Энанта Фармасьютикалс, Инк. Противовирусное средство против гепатита в
BR112020008765A2 (pt) 2017-11-02 2020-10-20 Aicuris Gmbh & Co. Kg indol-2-carboxamidas pirazolo-piperidina substituídas altamente ativas inovadoras ativas contra o vírus da hepatite b (hbv)
GEAP202115351A (en) 2017-11-02 2021-12-10 Aicuris Gmbh & Co Kg Novel, highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis b virus (hbv)
US10723733B2 (en) 2017-12-06 2020-07-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
TW201927789A (zh) 2017-12-06 2019-07-16 美商因那塔製藥公司 B型肝炎抗病毒試劑
WO2019143902A2 (fr) 2018-01-22 2019-07-25 Enanta Pharmaceuticals, Inc. Hétérocycles substitués utiles en tant qu'agents antiviraux
US10729688B2 (en) 2018-03-29 2020-08-04 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
CA3113235A1 (fr) 2018-09-21 2020-03-26 Enanta Pharmaceuticals, Inc. Heterocycles fonctionnalises utiles en tant qu'agents antiviraux
UY38436A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
PY1991601A (es) 2018-11-02 2020-11-02 Aicuris Gmbh & Co Kg Nuevas 6,7-dihidro-4h-pirazolo [1,5-a] pirazina indole-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
TW202031666A (zh) 2018-11-02 2020-09-01 德商艾庫瑞斯公司 對抗b型肝炎病毒(hbv)之新穎6,7-二氫-4h-噻唑并[5,4-c]吡啶脲活性劑
PY1991611A (es) 2018-11-02 2022-03-14 Aicuris Gmbh & Co Kg Nueva urea 6,7-dihidro-4h-pirazolo [1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb)
PY1991608A (es) 2018-11-02 2022-02-10 Aicuris Gmbh & Co Kg Nueva urea 6,7-dihidro-4h-pirazolo [1,5-a] pirazina activas contra el virus de la hepatitis b (vhb)
PY1991606A (es) 2018-11-02 2022-02-10 Aicuris Gmbh & Co Kg Nueva urea 6,7-dihidro-4h-pirazolo [4,3-c] piridinas activas contra el virus de la hepatitis b (vhb)
IL283190B2 (en) 2018-11-21 2025-08-01 Enanta Pharm Inc Functionalized heterocycles as antiviral agents
CN113748113A (zh) 2019-04-30 2021-12-03 艾库里斯有限及两合公司 具有抗乙型肝炎病毒(hbv)活性的新型吲哚嗪-2-甲酰胺类化合物
EP3962912A1 (fr) 2019-04-30 2022-03-09 AiCuris GmbH & Co. KG Nouvelles urées de phényle et de pyridyle actives contre le virus de l'hépatite b (vhb)
WO2020221826A1 (fr) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Nouveaux indole-2-carboxamides actifs contre le virus de l'hépatite b (vhb)
CU20210090A7 (es) 2019-04-30 2022-06-06 Aicuris Gmbh & Co Kg Compuestos derivados de oxalil piperazinas activos contra el virus de la hepatitis b (vhb)
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2020247575A1 (fr) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Agents antiviraux de l'hépatite b
WO2020247561A1 (fr) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Agents antiviraux de l'hépatite b
WO2021007488A1 (fr) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Hétérocycles substitués utilisés en tant qu'agents antiviraux
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
CN112574188B (zh) * 2019-09-29 2022-05-06 苏州爱科百发生物医药技术有限公司 一种吡唑类化合物及其应用
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
CN114685473B (zh) * 2020-12-25 2024-10-29 杭州百新生物医药科技有限公司 5-烷基-2-吡唑-恶唑烷-4-酮类衍生物及其用途
CN115677680A (zh) * 2021-07-23 2023-02-03 上海挚盟医药科技有限公司 式i化合物的晶型及其制备和应用

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9856247B2 (en) 2012-03-31 2018-01-02 Hoffmann-La Roche Inc. 4-methyl-dihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection
US9266904B2 (en) 2013-05-17 2016-02-23 Hoffmann-La Roche Inc. 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
US9758530B2 (en) 2013-05-17 2017-09-12 Hoffmann-La Roche Inc. 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
US9233978B2 (en) 2014-03-07 2016-01-12 Hoffmann-La Roche Inc. 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
US10081627B2 (en) 2014-03-07 2018-09-25 Hoffmann-La Roche Inc. 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
US10428069B2 (en) 2014-03-07 2019-10-01 Hoffmann-La Roche Inc. 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
US11771699B2 (en) 2015-03-16 2023-10-03 Hoffmann-La Roche Inc. Combined treatment with a TLR7 agonist and an HBV capsid assembly inhibitor
US11337982B2 (en) 2016-09-13 2022-05-24 Hoffmann-La Roche, Inc. Combined treatment with a TLR7 agonist and an HBV capsid assembly inhibitor
US11873302B2 (en) 2019-03-25 2024-01-16 Hoffmann-La Roche Inc. Solid forms of a compound of HBV core protein allosteric modifier

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Publication number Publication date
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