WO2006076265A3 - Procede et dispositif de reduction de la contamination - Google Patents

Procede et dispositif de reduction de la contamination Download PDF

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Publication number
WO2006076265A3
WO2006076265A3 PCT/US2006/000618 US2006000618W WO2006076265A3 WO 2006076265 A3 WO2006076265 A3 WO 2006076265A3 US 2006000618 W US2006000618 W US 2006000618W WO 2006076265 A3 WO2006076265 A3 WO 2006076265A3
Authority
WO
WIPO (PCT)
Prior art keywords
individual
particle
cleanroom
mouthpiece
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/000618
Other languages
English (en)
Other versions
WO2006076265A2 (fr
Inventor
David A Edwards
Mark J Gabrielson
Robert William Clarke
Wesley Hugh Dehaan
Matthew Frederick Brande
Jonathan Chun-Wah Man
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pulmatrix Inc
Original Assignee
Pulmatrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2005/006903 external-priority patent/WO2005084638A2/fr
Application filed by Pulmatrix Inc filed Critical Pulmatrix Inc
Priority to CA002601080A priority Critical patent/CA2601080A1/fr
Priority to JP2007550530A priority patent/JP5075638B2/ja
Priority to EP06717779A priority patent/EP1850749A2/fr
Priority to AU2006205108A priority patent/AU2006205108B2/en
Publication of WO2006076265A2 publication Critical patent/WO2006076265A2/fr
Publication of WO2006076265A3 publication Critical patent/WO2006076265A3/fr
Priority to US11/827,031 priority patent/US8627821B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0816—Measuring devices for examining respiratory frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/087—Measuring breath flow
    • A61B5/0878—Measuring breath flow using temperature sensing means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physiology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des procédés et des dispositifs qui permettent de déterminer le taux de production des particules et la distribution granulométrique des particules produites chez un sujet. Ce dispositif (10) comprend un embout buccal (12), un filtre (14), un clapet de non-retour à faible résolution (16), un compteur de particules (20) et un ordinateur (30). Ce dispositif peut éventuellement comprendre un débitmètre de gaz (22). Les données obtenues au moyen de ce dispositif peuvent servir à déterminer si une formulation de réduction de l'exhalation de particules doit être administrée à l'individu. Ce dispositif est particulièrement utilisé avant et/ou après l'entrée en salle blanche pour respecter les normes de salle blanche. Ce dispositif peut également servir à identifier les animaux et les humains qui ont tendance à exhaler beaucoup d'aérosols (appelés ici surproducteurs, ou superproducteurs, ou superpropagateurs). L'invention concerne en outre des formulations de réduction de la production de particules. La formulation est administrée en quantité suffisante pour modifier les propriétés biophysiques des muqueuses. Après application sur les fluides des muqueuses, la formulation modifie les propriétés physiques telles que les caractéristiques de gel dans l'interface air/liquide, l'élasticité de surface, la viscosité de surface, la tension de surface et la viscosité massive des muqueuses. La formulation est administrée en quantité suffisante pour réduire au minimum la contamination ambiante due à la formation de particules en cas de respiration, de toux, d'éternuement, de parole, ce qui constitue un point très important dans des applications dans des salles blanche. Dans un premier mode de réalisation, la formulation à administrer est une solution non tensioactive. Dans un autre mode de réalisation, les formulations sont conductrices et contiennent des agents conducteurs, tels que sels, tensioactifs ioniques, ou autres substances ionisées ou facilement ionisées dans un environnement solvant aqueux ou organique. De préférence, la formulation est administrée sous forme d'aérosol.
PCT/US2006/000618 2005-01-10 2006-01-10 Procede et dispositif de reduction de la contamination Ceased WO2006076265A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002601080A CA2601080A1 (fr) 2005-01-10 2006-01-10 Procede et dispositif de reduction de la contamination
JP2007550530A JP5075638B2 (ja) 2005-01-10 2006-01-10 汚染を減少させるための方法及び装置
EP06717779A EP1850749A2 (fr) 2005-01-10 2006-01-10 Procede et dispositif de reduction de la contamination
AU2006205108A AU2006205108B2 (en) 2005-01-10 2006-01-10 Method and device for decreasing contamination
US11/827,031 US8627821B2 (en) 2005-01-10 2007-07-10 Method and device for decreasing contamination

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US64264305P 2005-01-10 2005-01-10
US60/642,643 2005-01-10
USPCT/US2005/006903 2005-03-03
PCT/US2005/006903 WO2005084638A2 (fr) 2004-03-05 2005-03-03 Preparations diminuant l'exhalation de particules
US68235605P 2005-05-18 2005-05-18
US60/682,356 2005-05-18

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/008815 Continuation-In-Part WO2007120644A2 (fr) 2005-01-10 2007-04-11 dispositif de diagnostic permettant de déterminer la production de particules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/827,031 Continuation-In-Part US8627821B2 (en) 2005-01-10 2007-07-10 Method and device for decreasing contamination

Publications (2)

Publication Number Publication Date
WO2006076265A2 WO2006076265A2 (fr) 2006-07-20
WO2006076265A3 true WO2006076265A3 (fr) 2006-12-14

Family

ID=36677194

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/000618 Ceased WO2006076265A2 (fr) 2005-01-10 2006-01-10 Procede et dispositif de reduction de la contamination

Country Status (4)

Country Link
EP (1) EP1850749A2 (fr)
AU (1) AU2006205108B2 (fr)
CA (1) CA2601080A1 (fr)
WO (1) WO2006076265A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8627821B2 (en) 2005-01-10 2014-01-14 Pulmatrix, Inc. Method and device for decreasing contamination
CA2701352A1 (fr) * 2007-10-02 2009-04-09 Ann-Charlotte Almstrand Recuperation et mesure de particules exhalees
JP5848608B2 (ja) 2008-12-01 2016-01-27 トリコーンテク コーポレーションＴｒｉｃｏｒｎＴｅｃｈ Ｃｏｒｐｏｒａｔｉｏｎ 喘息、結核及び肺癌の診断及び疾患管理のための呼気分析システム及び方法
US8453601B2 (en) * 2011-05-19 2013-06-04 C-Lock Inc. Vaccine and health-related applications for ruminant breath monitoring system
US11547322B2 (en) 2012-02-08 2023-01-10 Lundin Stefan Device and method for non-invasive analysis of particles during medical ventilation
MX392636B (es) 2014-10-31 2025-03-24 Glaxosmithkline Ip Dev Ltd Formulacion en polvo.
CA3172678A1 (fr) * 2021-09-02 2023-03-02 Klick Inc. Spirometre multivarie, systemes et methodes connexes

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2938856A1 (de) * 1979-09-26 1981-04-16 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Verfahren und vorrichtung zur ermittlung der ablagerung von partikeln im atemtrakt und/oder zur ueberpruefung der funktion des atemtraktes
US5042501A (en) * 1990-05-01 1991-08-27 Battelle Memorial Institute Apparatus and method for analysis of expired breath
US6491872B1 (en) * 1999-09-17 2002-12-10 The United States Of America As Represented By The Secretary Of The Army Method and system for detecting and recording submicron sized particles
US20040077093A1 (en) * 2002-07-12 2004-04-22 Baxter International Inc. Method and apparatus for the detection of the presence of a bacteria in the gastrointestinal tract of a subject
WO2004058064A2 (fr) * 2002-12-20 2004-07-15 Amidex, Inc. Systeme de prelevement et de gestion d'aerosols d'haleine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2938856A1 (de) * 1979-09-26 1981-04-16 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Verfahren und vorrichtung zur ermittlung der ablagerung von partikeln im atemtrakt und/oder zur ueberpruefung der funktion des atemtraktes
US5042501A (en) * 1990-05-01 1991-08-27 Battelle Memorial Institute Apparatus and method for analysis of expired breath
US6491872B1 (en) * 1999-09-17 2002-12-10 The United States Of America As Represented By The Secretary Of The Army Method and system for detecting and recording submicron sized particles
US20040077093A1 (en) * 2002-07-12 2004-04-22 Baxter International Inc. Method and apparatus for the detection of the presence of a bacteria in the gastrointestinal tract of a subject
WO2004058064A2 (fr) * 2002-12-20 2004-07-15 Amidex, Inc. Systeme de prelevement et de gestion d'aerosols d'haleine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EDWARDS DAVID A ET AL: "Inhaling to mitigate exhaled bioaerosols.", 14 December 2004, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 14 DEC 2004, VOL. 101, NR. 50, PAGE(S) 17383 - 17388, ISSN: 0027-8424, XP002392837 *

Also Published As

Publication number Publication date
EP1850749A2 (fr) 2007-11-07
AU2006205108A1 (en) 2006-07-20
WO2006076265A2 (fr) 2006-07-20
CA2601080A1 (fr) 2006-07-20
AU2006205108B2 (en) 2013-01-10

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