WO2006087144A3 - Kontrastmittel für die kernspintomographie unter nutzung des overhauser-effekts - Google Patents

Kontrastmittel für die kernspintomographie unter nutzung des overhauser-effekts Download PDF

Info

Publication number
WO2006087144A3
WO2006087144A3 PCT/EP2006/001199 EP2006001199W WO2006087144A3 WO 2006087144 A3 WO2006087144 A3 WO 2006087144A3 EP 2006001199 W EP2006001199 W EP 2006001199W WO 2006087144 A3 WO2006087144 A3 WO 2006087144A3
Authority
WO
WIPO (PCT)
Prior art keywords
carried out
contrast agents
nuclear spin
overhauser effect
spin tomography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/001199
Other languages
English (en)
French (fr)
Other versions
WO2006087144A2 (de
Inventor
Klaus-Peter Dinse
Andreas Hirsch
Alois Weidinger
Wolfgang Harneit
Martin Rohrer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of WO2006087144A2 publication Critical patent/WO2006087144A2/de
Publication of WO2006087144A3 publication Critical patent/WO2006087144A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/189—Host-guest complexes, e.g. cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Die Erfindung betrifft Kontrastmittel für die Kernspintomographie (oder auch Magnetresonanztomographie, MRT) unter Nutzung des Overhauser-Effekts, die geeignet sind, die magnetische Ausrichtung von Elektronen-Spins auf benachbarte Protonen-Spins zu übertragen.
PCT/EP2006/001199 2005-02-15 2006-02-06 Kontrastmittel für die kernspintomographie unter nutzung des overhauser-effekts Ceased WO2006087144A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005007223.2 2005-02-15
DE102005007223A DE102005007223B4 (de) 2005-02-15 2005-02-15 Verwendung eines endohedrale Fullerene enthaltendes Kontrastmittel für die Kernspintomographie unter Nutzung des Overhauser-Effekts

Publications (2)

Publication Number Publication Date
WO2006087144A2 WO2006087144A2 (de) 2006-08-24
WO2006087144A3 true WO2006087144A3 (de) 2006-11-16

Family

ID=36660178

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/001199 Ceased WO2006087144A2 (de) 2005-02-15 2006-02-06 Kontrastmittel für die kernspintomographie unter nutzung des overhauser-effekts

Country Status (4)

Country Link
US (1) US20070014727A1 (de)
AR (1) AR053679A1 (de)
DE (1) DE102005007223B4 (de)
WO (1) WO2006087144A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100864422B1 (ko) 2007-05-03 2008-10-20 한국생명공학연구원 플러렌 나노구조체에 생체물질을 고정화하는 방법
GB201217228D0 (en) * 2012-09-26 2012-11-07 Pepric Nv Methods and systems for determining a particle distribution
WO2024202899A1 (ja) * 2023-03-31 2024-10-03 国立大学法人九州大学 動的核偏極の偏極源、組成物、動的核偏極用組成物、高偏極化方法およびｎｍｒ測定法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530140A (en) * 1993-04-02 1996-06-25 Nycomed Imaging As Free radicals
US5688486A (en) * 1992-02-11 1997-11-18 Nycomed Salutar, Inc. Use of fullerenes in diagnostic and/or therapeutic agents
WO2003084399A1 (en) * 2002-04-02 2003-10-16 Virginia Tech Intellectual Properties, Inc. Endohedral metallofullerene contrast agents
US20030220518A1 (en) * 2001-10-01 2003-11-27 Bolskar Robert D. Derivatization and solubilization of fullerenes for use in therapeutic and diagnostic applications

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688486A (en) * 1992-02-11 1997-11-18 Nycomed Salutar, Inc. Use of fullerenes in diagnostic and/or therapeutic agents
US5530140A (en) * 1993-04-02 1996-06-25 Nycomed Imaging As Free radicals
US20030220518A1 (en) * 2001-10-01 2003-11-27 Bolskar Robert D. Derivatization and solubilization of fullerenes for use in therapeutic and diagnostic applications
WO2003084399A1 (en) * 2002-04-02 2003-10-16 Virginia Tech Intellectual Properties, Inc. Endohedral metallofullerene contrast agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARDENKJAER-LARSEN J H ET AL: "EPR and DNP Properties of Certain Novel Single Electron Contrast Agents Intended for Oximetric Imaging", JOURNAL OF MAGNETIC RESONANCE, ACADEMIC PRESS, ORLANDO, FL, US, vol. 133, no. 1, July 1998 (1998-07-01), pages 1 - 12, XP004407411, ISSN: 1090-7807 *
GOLMAN K ET AL: "OVERHAUSER-ENHANCED MR IMAGING (OMRI)", ACTA RADIOLOGICA, SE, vol. 39, no. 1, January 1998 (1998-01-01), pages 10 - 17, XP009011937 *
MURTHY C N ET AL: "The water-soluble [beta]-cyclodextrin-[60]fullerene complex", CHEMICAL COMMUNICATIONS 07 JUL 2001 UNITED KINGDOM, vol. 7, no. 13, 7 July 2001 (2001-07-07), pages 1194 - 1195, XP002391852, ISSN: 1359-7345 *
TROGANIS A ET AL: "Experimental Evidence of Specific Solute-Solvent Interactions of Fullerenes C60and C70in Solution: One-Dimensional Steady-State Intermolecular<13>C,<1>H Overhauser Effect Study", JOURNAL OF MAGNETIC RESONANCE, ACADEMIC PRESS, ORLANDO, FL, US, vol. 130, no. 1, January 1998 (1998-01-01), pages 149 - 152, XP004407577, ISSN: 1090-7807 *

Also Published As

Publication number Publication date
DE102005007223A1 (de) 2006-08-24
DE102005007223B4 (de) 2009-01-02
WO2006087144A2 (de) 2006-08-24
AR053679A1 (es) 2007-05-16
US20070014727A1 (en) 2007-01-18

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121 Ep: the epo has been informed by wipo that ep was designated in this application
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
122 Ep: pct application non-entry in european phase

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