WO2006096893A2 - Composition barriere a usage dentaire - Google Patents

Composition barriere a usage dentaire Download PDF

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Publication number
WO2006096893A2
WO2006096893A2 PCT/ZA2006/000036 ZA2006000036W WO2006096893A2 WO 2006096893 A2 WO2006096893 A2 WO 2006096893A2 ZA 2006000036 W ZA2006000036 W ZA 2006000036W WO 2006096893 A2 WO2006096893 A2 WO 2006096893A2
Authority
WO
WIPO (PCT)
Prior art keywords
composition
root canal
carrier
mass
chlorhexadine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ZA2006/000036
Other languages
English (en)
Other versions
WO2006096893A3 (fr
Inventor
Guillaume Marx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARX MANAGEMENT CC
Original Assignee
MARX MANAGEMENT CC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MARX MANAGEMENT CC filed Critical MARX MANAGEMENT CC
Publication of WO2006096893A2 publication Critical patent/WO2006096893A2/fr
Publication of WO2006096893A3 publication Critical patent/WO2006096893A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/52—Cleaning; Disinfecting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/69—Medicaments

Definitions

  • the invention relates to a barrier composition for disinfecting and maintaining sterile a root canal and/or suspending and aiding in removal of particles and lubrication during instrumentation in dental procedures.
  • the inventor is aware that in the preparation of root canal procedures the issue of infection often arises. Sometimes the infection only manifests later and is attributed to a leaky filling or restoration, however, the inventor believes that the infection starts at the time the root canal procedure is being performed as it is very difficult to ensure that the open root canal remains sterile throughout the procedure as well as preventing the entrapment of debri consisting of lipids, antigens, lipopolysaccharides, proteins bacteria etc in an infectious layer.
  • the inventor believes that the problem lies in one or more of the following areas, although there may be other factors present as well.
  • the Gutta Percha points used for sealing may be unsterile as may any other devices used in the process of preparing a root canal, secondly, the tongue or saliva of the patient will often reach out to the tooth being worked on, usually involuntarily, and re-infect a just sterilized area unbeknownst to the dentist. Thirdly, re-infection may occur from contaminated endodontic files.
  • the sterilizing compositions currently in use have a water like low viscosity and drain from the area to which they are applied.
  • the invention provides a dental barrier composition for use in dental procedures, said composition including: one or more microbicidal and/or microbistatic substance or composition; - one or more carrier fluid having a viscosity of between 15 mPa.s and 10 000 mPa.s, said carrier including one or more thickening, gelling, and or suspending agents selected from the group including, but not limited to, hydroxy propyl methyl cellulose; hydroxyl propyl cellulose; - hydroxy ethyl cellulose; methyl cellulose; chitosan; glycerol; silica or fumed silica; - guar gum;
  • Povidone pectin; gelatine; and carob bean gum; provided that where hydroxy ethyl cellulose is used it is used in combination with at least one other carrier.
  • hydroxyl propyl methyl cellulose is believed to be better than hydroxyl ethyl cellulose as it is believed that the propyl groups bind fatty substances which leads to better cleaning of the root canal as well as improving spreadability thereof.
  • the composition may include one or more flavourant, colourant, and diluent.
  • the dental barrier composition may be a temporary dental barrier composition.
  • microbicidal or microbistatic substance may be chlorhexadine or a salt or derivative thereof.
  • the chlorhexadine may be from 0.01% to 5% by mass of the composition.
  • the chlorhexadine may be chlorhexadine digluconate, however other salts or bases could be used.
  • the carrier may be a gel.
  • the gel may include from 0.05% to 50% by mass of one or more thickening, gelling, and or suspending agents.
  • the composition may include non-ionic surfactants.
  • the microbicidal or microbistatic substance may include one or more disinfectants selected from the group including: an amine oxide; a hypochlorite; - an amphoteric surfactant such as a betaine, for example, cocamidopropyl betaine; an anionic surfactant such as sodium laural ether sulphate or sodium laurel sulphate; triclosan; benzalkonium chloride; - bronopol; chlorxylonol; tricresol formaldehyde (tcf); arid chloro phenol - camphor - menthol (cpmcp).
  • an amine oxide such as a hypochlorite
  • - an amphoteric surfactant such as a betaine, for example, cocamidopropyl betaine
  • an anionic surfactant such as sodium laural ether sulphate or sodium laurel sulphate
  • triclosan benzalkonium chloride
  • tcf tricresol
  • Combinations of microbistatic or microbicidal compounds may be used, for example, triclosan and chlorhexadine, chlorxylonol and chlorhexadine, and/or benzalkonium chloride and chlorhexadine.
  • ingredients of the composition include one or more: benzocaine; calcium hydroxide; calcium phosphate; - steroids; anti-inflamatories; and antibiotics.
  • composition may also include flavourants and sweeteners such as aspartame, sorbitol, and the like.
  • the composition may be water soluble and thus the constituents may be water soluble or water solubalized substances for easy wash out and handling characteristics.
  • the composition may include one or more of a local anesthetic, an anti-inflammatory, a pain reliever, or other medically active substance it may be used as an interim root canal medicament, however, the basic composition may be used as a medicament and does not have to contain any of the last mentioned substances.
  • the invention extends to the use of the above composition for disinfecting a root canal during instrumentation and maintaining the sterility thereof until the root canal has been closed up.
  • the invention can be used on both 'milk ' teeth and permanent teeth.
  • the use of the composition may include applying the composition all over the pulpal chamber and surrounding periodontum as well as the root canal.
  • the use of the composition may include applying the composition to periodontum thereby to lower the bacterial count of the periodontum, for example, the periodontal pocket.
  • the use of the composition may include applying the composition to a region of the oral cavity either before or after, or both before and after oral surgery.
  • the use thereof may keep the root canal aseptic while performing other tasks like testing the length (working length) with, for example, a Gutta-Percha (GP) point or any purposefully designed instrument, as well as during the taking of x-ray's
  • GP Gutta-Percha
  • the use prevents excessive saliva contamination and bacteria by serving as a temporary barrier.
  • composition could also be used as a carrier substance for other medicaments, for example, Calcium Hydroxide powder.
  • the use prevents or lowers the risk of formation of a infectious layer or infection prone layer.
  • the use of the composition may result in suspending of particles and dissolving of lipid membranes by the non-ionic surfactants resulting in the suspending of the particles and easier wash out as well as removal of lipids leaving a cleaner root canal
  • composition may be advantageous in that it leads to lubrication of endodontic files leading to better instrumentation and less fracturing of the instruments.
  • composition Another advantage of using the composition is that there is less chance of irritating apical tissue due to the composition being a gel or suspending agent having a high viscosity.
  • compositions are that there is a perceived lower chance of injecting the substance into the periapical area which causes possible irritation and / or necroses and / or inflammation of the surrounding tissue when compared to traditional 1% Sodium Hypo Chloride or peroxide rinses.
  • composition may be used safely with most root canal medicament or sealers.
  • compositions include:
  • microbicide for a wide spectrum anti-bacterial, anti-fungal, and/or anti viral uses that can be applid topicaly, for example, to the vagina, penis, rectum, genitalia or urogenital area, orally or oropharyngeally.
  • Dental / Oral disinfectant for example, for Periodontitis / Gingivitis it can be applied as a gel or a mouth rinse, or by a professional
  • the invention further provides a method of medicating a root canal, said method including applying a dental barrier composition as described above to a root canal and leaving said composition inside the root canal when the root canal procedure is completed.
  • the method may include the steps of applying the composition to the root canal and/or the surrounding perodontium, removing the composition, the reapplying the composition for it to remain there as the root canal procedure is completed.
  • the sensitivity reaction in a normal tooth is due to water movement within the tooth tubili, then it is possible to treat a root canal system with water as the carrier medium, to allow a small enough molecule to diffuse into the tubili, along the path of water and bring about a greater degree of healing and less symptoms associated with root canal treatment. This may be referred to as the wet healing theory.
  • the inventor postulates a greater ability of a root canal system to heal if sterile water is introduced into the root canal at the time of medicating.
  • the substances used in such a wet treatment may be water soluble if diffusion is needed or not water soluble if precipitation is required.
  • tissue e.g. the bone and periodontal ligament area by diffusion of desired molecules.
  • Composition 2 Chlorhexidine (1 mass%)
  • Composition 7 Chlorhexadine 2 mass%
  • This composition had a viscosity of 2920 mPa.s when measured on a Brookfield LVT 1 viscometer with spindle RV6 at a speed of 50.
  • This composition had a viscosity of 4055 mPa.s measured on a Brookfield LVT 1 viscometer on a spindle RV3 at a speed of 20.
  • Triclosan 0.2 m/v% Composition 12
  • This composition has a viscosity of 44 mPa.s when measured on a Brookfield LVT 1 viscometer with a spindle RV 3 at a speed of 50.
  • compositions 1 to 10 examples include, but are not limited to, the following:
  • the gel is applied with e.g. a needle and a syringe (gauge according to the thickness of the gel) inside the root canal or in the pulp chamber.
  • Endodontic hand files / reamers or rotary endodontic file powered by a turbine motor are then inserted into the root canal ( into this gel) for the preparation of the root canal.
  • the gel is washed out, for example with water, or removed via endodontic suction unit, in order to check if the canal is clean /dry (i.e no sign of blood, puss or any undesirable materials). If the dentist thinks the gel is 'dirty" it gets washed out and new gel gets applied until the dentist thinks the canals are clean and debri free — then only is preparation finished.
  • the gel can be applied again when a test measurement is taken with example using a Gutta Percha (GP) point.
  • GP points are usually not sterile / aseptic.
  • the gel is compatible with most dental disinfectants and will not create toxic substances or precipitate, therefore products like CPMCP and TCF could be used in conjunction with this product.
  • compositions 1 to 11 above If a gel as described in Compositions 1 to 11 above is used in conjunction with water the chlorhexidine portion , which is water, soluble, will then diffuse along the path of water , further down the root canal , than where the gel was applied (there has to be a physical connection between the water and the gel however).
  • the penetration ability of calcium hydroxide into the tubili can be greatly enhanced if water is introduced into the root canal prior to applying the medicament ⁇ it is however likely that because of the concentrations that are used it will precipitate and stay in equilibrium of diffusion .

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dental Preparations (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition barrière dentaire, utilisable dans des pratiques dentaires, qui comprend une ou plusieurs substances ou compositions microbicides et/ou microbistatiques; un ou plusieurs fluides vecteurs présentant une viscosité de 15 mPa.s à 10 000 mPa.s, ledit vecteur comprenant un ou plusieurs agents épaississants, gélifiants et/ou de suspension sélectionnés dans le groupe constitué par, mais pas exclusivement, cellulose d'hydroxypropyle-méthyle, cellulose d'hydroxyéthyle, cellulose de méthyle, chitosane, glycérol, silice ou silice sublimée, gomme de guar, povidone, pectine, gélatine et ceratonia, à condition que, lorsque la cellulose d'hydroxyéthyle est utilisée, elle soit associée à au moins un autre vecteur. L'invention concerne en outre l'utilisation de la composition, et un procédé de traitement d'un canal radiculaire.
PCT/ZA2006/000036 2005-03-10 2006-03-09 Composition barriere a usage dentaire Ceased WO2006096893A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA200502024 2005-03-10
ZA2005/2024 2005-03-10

Publications (2)

Publication Number Publication Date
WO2006096893A2 true WO2006096893A2 (fr) 2006-09-14
WO2006096893A3 WO2006096893A3 (fr) 2006-12-14

Family

ID=36954068

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ZA2006/000036 Ceased WO2006096893A2 (fr) 2005-03-10 2006-03-09 Composition barriere a usage dentaire

Country Status (1)

Country Link
WO (1) WO2006096893A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008096022A1 (fr) * 2007-02-07 2008-08-14 Cabanes Vila Jose Composition d'agent d'irrigation conditionneur endodontique
EP1810655A3 (fr) * 2006-01-24 2009-04-08 ITALMED S.r.l. Composition dentaire pour le traitement du canal de racine
WO2013138916A1 (fr) * 2012-03-22 2013-09-26 The Governing Council Of The University Of Toronto Micro multi-fonctionnel et nanoparticules destinées à être utilisées dans des traitements de canal radiculaire
CN116421475A (zh) * 2023-04-19 2023-07-14 桂林凯文彼德科技有限公司 一种无水的用于根管治疗的润滑剂及其制备方法
CN117462416A (zh) * 2023-09-22 2024-01-30 广州贝奥吉因生物科技股份有限公司 一种根管消毒糊剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
JP2566676B2 (ja) * 1990-03-28 1996-12-25 株式会社クラレ 歯科用組成物
MX9101786A (es) * 1990-10-30 1992-06-05 Alza Corp Sistema para el suministro de droga y metodo
JP2894472B2 (ja) * 1993-09-08 1999-05-24 株式会社ビーブランド企画 根管清掃拡大剤
US20030156980A1 (en) * 2002-01-16 2003-08-21 Fischer Dan E. Methods for disinfecting and cleaning dental root canals using a viscous sodium hypochlorite composition

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1810655A3 (fr) * 2006-01-24 2009-04-08 ITALMED S.r.l. Composition dentaire pour le traitement du canal de racine
WO2008096022A1 (fr) * 2007-02-07 2008-08-14 Cabanes Vila Jose Composition d'agent d'irrigation conditionneur endodontique
WO2013138916A1 (fr) * 2012-03-22 2013-09-26 The Governing Council Of The University Of Toronto Micro multi-fonctionnel et nanoparticules destinées à être utilisées dans des traitements de canal radiculaire
US11737955B2 (en) 2012-03-22 2023-08-29 Anil Kishen Multi-functional micro and nanoparticles for use in root canal therapies
CN116421475A (zh) * 2023-04-19 2023-07-14 桂林凯文彼德科技有限公司 一种无水的用于根管治疗的润滑剂及其制备方法
CN117462416A (zh) * 2023-09-22 2024-01-30 广州贝奥吉因生物科技股份有限公司 一种根管消毒糊剂及其制备方法

Also Published As

Publication number Publication date
WO2006096893A3 (fr) 2006-12-14

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