WO2006105199A3 - Compositions et methodes de synthese d'un peptide et d'un conjugue apparente - Google Patents

Compositions et methodes de synthese d'un peptide et d'un conjugue apparente Download PDF

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Publication number
WO2006105199A3
WO2006105199A3 PCT/US2006/011470 US2006011470W WO2006105199A3 WO 2006105199 A3 WO2006105199 A3 WO 2006105199A3 US 2006011470 W US2006011470 W US 2006011470W WO 2006105199 A3 WO2006105199 A3 WO 2006105199A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
synthesis
compositions
methods
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/011470
Other languages
English (en)
Other versions
WO2006105199A2 (fr
Inventor
Stephen Schneider
Catherine J Mader
Brian Bray
Nicolai Tvermoes
Huyi Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trimeris Inc
Original Assignee
Trimeris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trimeris Inc filed Critical Trimeris Inc
Publication of WO2006105199A2 publication Critical patent/WO2006105199A2/fr
Publication of WO2006105199A3 publication Critical patent/WO2006105199A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des fragments de peptide pouvant être utilisés dans une méthode de production d'un peptide synthétique ou d'un conjugué constitué du peptide synthétique lié de manière fonctionnelle à un acide gras. La méthode consiste à lier chimiquement ensemble deux ou plusieurs fragments de peptide, dans un processus d'assemblage, aux fins de produire le peptide synthétique ou le conjugué.
PCT/US2006/011470 2005-03-30 2006-03-28 Compositions et methodes de synthese d'un peptide et d'un conjugue apparente Ceased WO2006105199A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US66665505P 2005-03-30 2005-03-30
US60/666,655 2005-03-30
US70615705P 2005-08-05 2005-08-05
US60/706,157 2005-08-05
US78587506P 2006-03-24 2006-03-24
US60/785,875 2006-03-24

Publications (2)

Publication Number Publication Date
WO2006105199A2 WO2006105199A2 (fr) 2006-10-05
WO2006105199A3 true WO2006105199A3 (fr) 2007-07-12

Family

ID=37054080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/011470 Ceased WO2006105199A2 (fr) 2005-03-30 2006-03-28 Compositions et methodes de synthese d'un peptide et d'un conjugue apparente

Country Status (1)

Country Link
WO (1) WO2006105199A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2291392B1 (fr) * 2008-05-28 2014-03-05 New York Blood Center Molécules bifonctionnelles destinées à inhiber la pénétration du vih
WO2010045613A1 (fr) 2008-10-16 2010-04-22 New York Blood Center Vaccins oligomères contre le vih liés à un stimulateur d'immunité
CN102307588A (zh) 2009-02-09 2012-01-04 纽约血库公司 用于治疗或预防hiv感染的三聚体hiv融合抑制剂
US8828932B2 (en) 2010-05-03 2014-09-09 New York Blood Center, Inc. Bifunctional molecules for inactivating HIV and blocking HIV entry

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750008B1 (en) * 1999-07-09 2004-06-15 Trimeris, Inc. Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission
US20040115774A1 (en) * 2000-09-08 2004-06-17 Kochendoerfer Gerd G Polymer-modified synthetic proteins
US6767993B2 (en) * 1999-07-07 2004-07-27 Brian Bray Methods and compositions for peptide synthesis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767993B2 (en) * 1999-07-07 2004-07-27 Brian Bray Methods and compositions for peptide synthesis
US6750008B1 (en) * 1999-07-09 2004-06-15 Trimeris, Inc. Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission
US20040115774A1 (en) * 2000-09-08 2004-06-17 Kochendoerfer Gerd G Polymer-modified synthetic proteins

Also Published As

Publication number Publication date
WO2006105199A2 (fr) 2006-10-05

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