WO2006106331A3 - Amorces de souris - Google Patents

Amorces de souris Download PDF

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Publication number
WO2006106331A3
WO2006106331A3 PCT/GB2006/001251 GB2006001251W WO2006106331A3 WO 2006106331 A3 WO2006106331 A3 WO 2006106331A3 GB 2006001251 W GB2006001251 W GB 2006001251W WO 2006106331 A3 WO2006106331 A3 WO 2006106331A3
Authority
WO
WIPO (PCT)
Prior art keywords
development
mouse primers
antibodies
mouse
primers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2006/001251
Other languages
English (en)
Other versions
WO2006106331A2 (fr
Inventor
Ralph Adams
Andrew George Popplewell
Patrick Marcel Slocombe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Publication of WO2006106331A2 publication Critical patent/WO2006106331A2/fr
Publication of WO2006106331A3 publication Critical patent/WO2006106331A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des ensembles d'amorces pour isoler des séquences de zones variables d'anticorps de souris. La présente invention porte également sur des anticorps comprenant ces zones, qui sont utiles au développement d'agents thérapeutiques, en particulier, au développement d'anticorps humanisés.
PCT/GB2006/001251 2005-04-06 2006-04-05 Amorces de souris Ceased WO2006106331A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0507046.1 2005-04-06
GB0507046A GB0507046D0 (en) 2005-04-06 2005-04-06 Primers

Publications (2)

Publication Number Publication Date
WO2006106331A2 WO2006106331A2 (fr) 2006-10-12
WO2006106331A3 true WO2006106331A3 (fr) 2007-03-29

Family

ID=34586839

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001251 Ceased WO2006106331A2 (fr) 2005-04-06 2006-04-05 Amorces de souris

Country Status (2)

Country Link
GB (1) GB0507046D0 (fr)
WO (1) WO2006106331A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0675199A2 (fr) * 1994-03-30 1995-10-04 Takara Shuzo Co. Ltd. ADN codant pour la région variable d'un anticorps du virus de la influenza humaine de type A reconnaissant les soustypes H1N1 et H2N2 de l'hémagglutinine
WO2000023087A1 (fr) * 1998-10-21 2000-04-27 Sunol Molecular Corporation Molecules de liaison polyspecifiques et leurs utilisations
US6291161B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
WO2003054016A2 (fr) * 2001-12-21 2003-07-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Procede de clonage de sequences de domaines variables

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291161B1 (en) * 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
EP0675199A2 (fr) * 1994-03-30 1995-10-04 Takara Shuzo Co. Ltd. ADN codant pour la région variable d'un anticorps du virus de la influenza humaine de type A reconnaissant les soustypes H1N1 et H2N2 de l'hémagglutinine
WO2000023087A1 (fr) * 1998-10-21 2000-04-27 Sunol Molecular Corporation Molecules de liaison polyspecifiques et leurs utilisations
WO2003054016A2 (fr) * 2001-12-21 2003-07-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Procede de clonage de sequences de domaines variables

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
"PRIMER DESIGN FOR THE CLONING OF IMMUNOGLOBULIN HEAVY-CHAIN LEADER-VARIABLE REGIONS FROM MOUSE HYBRIDOMA CELLS USING THE PCR", BIOTECHNIQUES, INFORMA LIFE SCIENCES PUBLISHING, WESTBOROUGH, MA, US, vol. 11, no. 2, August 1991 (1991-08-01), pages 152 - 154,156, XP000647450, ISSN: 0736-6205 *
BABCOOK J S ET AL: "A NOVEL STRATEGY FOR GENERATING MONOCLONAL ANTIBODIES FROM SINGLE, ISOLATED LYMPHOCYTES PRODUCING ANTIBODIES OF DEFINED SPECIFICITIES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 93, no. 15, 23 July 1996 (1996-07-23), pages 7843 - 7848, XP000608647, ISSN: 0027-8424 *
DATABASE Geneseq [online] 15 August 2000 (2000-08-15), "F23.1 heavy chain PCR primer JS300.", XP002393358, retrieved from EBI accession no. GSN:AAZ94969 Database accession no. AAZ94969 *
DATABASE Geneseq [online] 9 May 1996 (1996-05-09), "Primer for mouse heavy chain constant region.", XP002393359, retrieved from EBI accession no. GSN:AAT04162 Database accession no. AAT04162 *
DÜBEL S ET AL: "Isolation of IgG antibody Fv-DNA from various mouse and rat hybridoma cell lines using the polymerase chain reaction with a simple set of primers.", JOURNAL OF IMMUNOLOGICAL METHODS. 30 SEP 1994, vol. 175, no. 1, 30 September 1994 (1994-09-30), pages 89 - 95, XP002079907, ISSN: 0022-1759 *
FORD JOHN E ET AL: "Chimeric molecules created by gene amplification interfere with the analysis of somatic hypermutation of murine immunoglobulin genes", GENE (AMSTERDAM), vol. 142, no. 2, 1994, pages 279 - 283, XP002393354, ISSN: 0378-1119 *
GAVILONDO-COWLEY J V ET AL: "SPECIFIC AMPLIFICATION OF REARRANGED IMMUNOGLOBULIN VARIABLE REGION GENES FROM MOUSE HYBRIDOMA CELLS", HYBRIDOMA, LIEBERT, NEW YORK, NY, US, vol. 407 - 417, no. 9, January 1990 (1990-01-01), pages 5, XP008067250, ISSN: 0272-457X *
MAYNARD J ET AL: "ANTIBODY ENGINEERING", ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, ANNUAL REVIEW INCO., PALO ALTO, CA, US, vol. 2, 2000, pages 339 - 376, XP009039750 *
ORLANDI R ET AL: "CLONING IMMUNOGLOBULIN VARIABLE DOMAINS FOR EXPRESSION BY THE POLYMERASE CHAIN REACTION", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 86, no. 10, 1 May 1989 (1989-05-01), pages 3833 - 3837, XP000026475, ISSN: 0027-8424 *
ORUM H ET AL: "Efficient method for constructing comprehensive murine Fab antibody libraries displayed on phage.", NUCLEIC ACIDS RESEARCH. 25 SEP 1993, vol. 21, no. 19, 25 September 1993 (1993-09-25), pages 4491 - 4498, XP002393352, ISSN: 0305-1048 *

Also Published As

Publication number Publication date
WO2006106331A2 (fr) 2006-10-12
GB0507046D0 (en) 2005-05-11

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