WO2007001789A2 - Bouchon pour un flacon contenant des echantillons - Google Patents

Bouchon pour un flacon contenant des echantillons Download PDF

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Publication number
WO2007001789A2
WO2007001789A2 PCT/US2006/022305 US2006022305W WO2007001789A2 WO 2007001789 A2 WO2007001789 A2 WO 2007001789A2 US 2006022305 W US2006022305 W US 2006022305W WO 2007001789 A2 WO2007001789 A2 WO 2007001789A2
Authority
WO
WIPO (PCT)
Prior art keywords
cap
vial
top wall
cap according
connection mechanism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/022305
Other languages
English (en)
Other versions
WO2007001789A3 (fr
Inventor
James Bruno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2007001789A2 publication Critical patent/WO2007001789A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007001789A3 publication Critical patent/WO2007001789A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D41/00—Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
    • B65D41/02—Caps or cap-like covers without lines of weakness, tearing strips, tags, or like opening or removal devices
    • B65D41/04—Threaded or like caps or cap-like covers secured by rotation
    • B65D41/0407—Threaded or like caps or cap-like covers secured by rotation with integral sealing means
    • B65D41/0414—Threaded or like caps or cap-like covers secured by rotation with integral sealing means formed by a plug, collar, flange, rib or the like contacting the internal surface of a container neck
    • B65D41/0421—Threaded or like caps or cap-like covers secured by rotation with integral sealing means formed by a plug, collar, flange, rib or the like contacting the internal surface of a container neck and combined with integral sealing means contacting other surfaces of a container neck
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2231/00—Means for facilitating the complete expelling of the contents
    • B65D2231/02—Precut holes or weakened zones

Definitions

  • This invention relates to caps for vials, and more particularly to caps of the type which permit access to the interior of the vial without removal of the cap.
  • the vials and their caps must not contaminate the specimen; and (ii) must maintain an effective seal so as to prevent contamination and/or loss of the specimen.
  • the vial cap should also permit access to the interior of the vial without necessitating removal of the cap.
  • the caps used to seal a vial have a central opening which is closed off by a special liner or "septum".
  • the septum is configured so that it may be penetrated by a sharp sampling instrument (i.e., a needle), whereby to permit access to the interior of the vial without removing the cap.
  • a sharp sampling instrument i.e., a needle
  • the cap, including its septum component must be constructed so that: (i) it does not itself contaminate the specimen, and (ii) it is able ' to maintain an effective seal with the vial prior to penetration by a needle.
  • the septum is typically formed with two layers, a silicone outer layer and a polytetrafluoroethylene (PTFE) inner layer.
  • the silicone outer layer serves as the sealing agent since the softness of the silicone allows it to "squeeze" against the top of the vial, thereby forming a reliable seal.
  • silicone is reactive with many materials, which could result in contamination of the specimen if the silicone were to come into contact with the specimen, either directly or via the needle during the sampling process.
  • the silicone outer layer is typically lined with an inert inner layer, i.e., the PTFE inner layer.
  • the silicone layer and the PTFE layer are typically bonded together and then "rolled" out into a single, thin, composite layer.
  • septum 15 comprises a composite structure formed by a silicone outer layer 20 and a PTFE inner layer 25. Due to the nature of septum 15, it is possible to pass a sharp sampling needle through the septum, whereby to access the interior of the vial without necessitating the removal of the cap from the vial.
  • Cylindrical side wall 125 includes screw threads 150 formed on inner surface 130. Screw threads 150 mate with counterpart screw threads formed on the top of a vial.
  • an inner seal 155 is provided on the underside of cap 105. More .particularly, inner seal 155 comprises a generally tubular (cylindrical and tapered) structure which extends inwardly from inner surface 115, coaxial with, but radially spaced from, side wall 125. In one preferred form of the invention, inner seal 155 comprises a cylindrical inner surface 160 which extends substantially coaxial with the longitudinal axis of the cap and an outer surface 165 which is inclined, in a frustoconical manner, relative to the longitudinal axis of the cap. - 14 -
  • cap 105 may be secured to a vial 170 by screwing cap 105 onto the top of vial 170, with the cap's screw threads 150 engaging the vial's counterpart screw threads 175, and with (i) the top rim 180 of vial 170 making a secure seal with inner surface 115 of cap 105, and (ii) top inside rim 183 of vial 170 making a secure seal with the inclined outer surface 165 of inner seal 155.
  • cap 105 Due to the geometries selected for cap 105, a reliable seal may be achieved between cap 105 and vial 170 even where cap 105 is formed out of a single, easily moldable material which is non-reactive with the contents of the vial, e.g., an olefin, high density polyethylene, low density polyethylene, polypropylene, PEEK, nylon, etc.
  • the combination of (i) the seal against the underside of the cap, and (ii) the seal against the inner seal 155 of the cap provides a double sealing design, which will effectively seal in even volatile solutions, which are the most difficult to contain. - 15 -
  • a sharp sampling needle 185 is driven through the cap's top wall 110 at the weakened apex 145.
  • the score lines 140 allow the needle to penetrate the top wall of the cap with much less force than would be required if no weakened apex were provided.
  • a cap 205 which generally comprises a top wall 210 having an inner surface 215 and an outer surface 220, and a cylindrical side wall 225 extending substantially coaxial with the cap' s longitudinal axis 227 and having an inner surface 230 and an outer surface 235.
  • Top wall 210 preferably includes score lines 240 which extend inwardly from outer surface 220. Score lines 240 preferably intersect at an apex 245. Score lines - 16 -
  • Cylindrical side wall 225 includes screw threads 250 formed on inner surface 230. Screw threads 250 mate with counterpart screw threads formed on the top of a vial.
  • an inner seal 255 is provided on the underside of cap 205. More particularly, inner seal 255 comprises a generally tubular (cylindrical and tapered) structure which extends inwardly from inner surface 215, coaxial with, but radially spaced from, side wall 225. In one preferred form of the invention, inner seal 255 comprises a cylindrical inner surface 260 which extends substantially coaxial with the longitudinal axis of the cap and an outer surface 265 which is inclined, in a frustoconical manner, relative to the longitudinal axis of the cap.
  • At least the central portion 290 of top wall 210 is domed upward so as to - 17 -
  • cap 205 may be secured to a vial 270 by screwing cap 205 onto the top of vial 270, with the cap's screw threads 250 engaging counterpart screw threads formed on the upper end of vial 270, and with (i) the top rim of vial 270 making a secure seal with inner surface 215 of cap 205, and (ii) the top inside rim of vial 270 making a secure seal with the inclined outer surface 265 of inner seal 255.
  • cap 205 due to the geometries selected for cap 205, a reliable seal may be achieved between cap 205 and vial 270 even where cap 205 is formed out of a single, easily moldable material which is non-reactive with the contents of the vial, e.g., an olefin, high density polyethylene, low density polyethylene, polypropylene, PEEK, nylon, etc.
  • the combination of (i) the seal against the underside of the cap, and (ii) the seal against the inner seal 255 of the cap provides a - 18 -
  • a sharp sampling needle is driven through the cap's top wall 210 at the weakened apex 245.
  • the score lines 240 allow the needle to penetrate the top wall of the cap with much less force than would be required if no weakened apex were provided.
  • a cap 305 which generally comprises a top wall 310 having an inner surface 315 and an outer surface 320, and a cylindrical side wall 325 extending substantially coaxial with the cap's longitudinal axis 327 and having an inner surface 330 and an outer surface 335. - 19 -
  • Top wall 310 preferably includes score lines 340 which extend inwardly from outer surface 320. Score lines 340 preferably intersect at an apex 345. Score lines 340 provide a weakened zone in top wall 310 so as to facilitate penetration of top wall 310 by a sampling needle, as will hereinafter be discussed. Cylindrical side wall 325 includes screw threads 350 formed on inner surface 330. Screw threads 350 mate with counterpart screw threads formed on the top of a vial.
  • an inner seal 355 is provided on the underside of cap 305. More particularly, inner seal 355 comprises a generally tubular (cylindrical and tapered) structure which extends inwardly from inner surface 315, coaxial with, but radially spaced from, side wall 325. In one preferred form of the invention, inner seal 355 comprises a cylindrical inner surface 360 which extends substantially coaxial with the longitudinal axis of the cap and an outer surface 365 which is inclined, in a frustoconical manner, relative to the longitudinal axis of the cap. - 20 -
  • At least the central portion 390 of top wall 310 is domed upward so as to provide additional column strength against the force of a penetrating needle.
  • a projection 395 is formed on inner surface 315 of cap 305, in the region between side wall 325 and inner seal 355.
  • Projection 395 preferably is in the form of an annular ring having a hemispherical cross-section, whereby to form the equivalent of an 0-ring underseal for engagement with the top rim of the vial.
  • cap 305 may be secured to a vial by screwing cap 305 onto the top of the vial, with the cap's screw threads 350 engaging counterpart screw threads formed on the upper end of the vial and with (i) the top rim of the vial making a secure seal with projection 395 and with inner surface 315 of cap 305, and (ii) the top inside rim of the vial making a - 21 -
  • cap 305 due to the geometries selected for cap 305, a reliable seal may be achieved between cap 305 and the vial even where cap 305 is formed out of a single, easily moldable material which is non- reactive with the contents of the vial, e.g., an olefin, high density polyethylene, low density polyethylene, polypropylene, PEEK, nylon, etc.
  • a seal against the underside of the cap, and (ii) the seal against the inner seal 355 of the cap provides a double sealing design, which will effectively seal in even volatile solutions, which are the most difficult to contain.
  • a sharp sampling needle is driven through the cap's top wall 310 at the weakened apex 345.
  • fast and easy penetration of top wall 310 is achieved. More particularly, when the sampling needle applies pressure on the weakened apex 345, the score lines 340 - 22 -
  • a cap 405 which generally comprises a top wall 410 having an inner surface 415 and an outer surface 420, and a cylindrical side wall 425 extending substantially coaxial with the cap' s longitudinal axis 427 and having an inner surface 430 and an outer surface 435.
  • Top wall 410 preferably includes score lines 440 which extend inwardly from outer surface 420. Score lines 440 preferably intersect at an apex 445. Score lines 440 provide a weakened zone in top wall 410 so as to facilitate penetration of top wall 410 by a sampling needle, as will hereinafter be discussed.
  • Cylindrical side wall 425 includes screw threads 450 formed on inner surface 430. Screw threads 450 mate with counterpart screw threads formed on the top of a vial. - 23 -
  • At least the central portion 490 of top wall 410 is domed upward so as to provide additional column strength against the force of a penetrating needle.
  • a projection 495 is formed on inner surface 415 of cap 405, coaxial with, but spaced from, side wall 425.
  • Projection 495 preferably is in the form of an annular ring having a hemispherical cross-section, whereby to form the equivalent of an O-ring underseal for engagement with the top rim of the vial.
  • cap 405 may be secured to vial 470 by screwing cap 405 onto the top of vial 470, with the cap's screw threads 450 engaging counterpart screw threads formed on the upper end of vial 470, and with the top rim of the vial making a secure seal with projection 495 and with inner surface 415 of cap 405.
  • cap 405 and vial 470 may be achieved between cap 405 and vial 470 even where cap 405 is formed out of a single, easily moldable material which is non-reactive with the contents of the vial, e.g., an olefin, high density polyethylene, low density polyethylene, polypropylene, PEEK, nylon, etc.
  • the seal against the underside of the cap provides a reliable seal which will effectively seal in even volatile solutions, which are the most difficult to contain.
  • a sharp sampling needle is driven through the cap's top wall 410 at the weakened apex 445.
  • the score lines 440 allow the needle to penetrate the top wall of the cap with much less force than would be required if no weakened apex were provided.
  • the present invention is typically used with a 9 mm vial, however, it is important to note that the cap of the present invention can be used for vials and other containers of various sizes.
  • the novel cap is described as mounting to the vial with a screw-on connection. However, it should be appreciated that the novel cap may be mounted to the vial with another type of connection, e.g., a snap-on mount, a bayonet-type mount, etc.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Closures For Containers (AREA)

Abstract

Bouchon permettant de fermer hermétiquement un flacon, qui comporte une paroi supérieure pourvue d'une surface interne et d'une surface externe et une paroi latérale cylindrique raccordée à la paroi supérieure et possédant une surface interne et une surface externe, la paroi latérale cylindrique comportant un mécanisme de connexion formé sur la surface interne de la paroi latérale, et le mécanisme de connexion étant configuré pour correspondre à un mécanisme de connexion complémentaire formé sur le flacon. Ledit bouchon est caractérisé en ce qu'un élément d'étanchéité interne est situé sur la face inférieure du bouchon, l'élément d'étanchéité interne comportant une structure généralement tubulaire qui s'étend vers l'intérieur à partir de la surface interne de la paroi supérieure, de manière coaxiale avec la paroi latérale du bouchon, mais située à une certaine distance de cette dernière, ledit élément d'étanchéité interne comportant une surface interne et une surface externe et, lorsque le bouchon est placé sur le flacon, (i) le bord supérieur du flacon formant une fermeture étanche avec la surface interne de la paroi supérieure du bouchon et (ii) le bord intérieur supérieur du flacon formant une fermeture étanche avec la surface externe de l'élément d'étanchéité interne. La présente invention concerne également un bouchon permettant de fermer hermétiquement un flacon, qui comporte une paroi supérieure pourvue d'une surface interne et d'une surface externe et une paroi latérale cylindrique raccordée à la paroi supérieure et possédant une surface interne et une surface externe, la paroi latérale cylindrique comportant un mécanisme de connexion formé sur la surface interne de la paroi latérale, et le mécanisme de connexion étant configuré pour correspondre à un mécanisme de connexion complémentaire formé sur le flacon. Ledit bouchon est caractérisé en ce qu'une saillie est formée sur la surface interne de la paroi supérieure, de manière coaxiale avec la paroi latérale du bouchon, mais située à une certaine distance de ladite paroi, le bord supérieur du flacon formant une fermeture étanche avec ladite saillie et la surface interne de la paroi supérieure lorsque le bouchon est placé sur le flacon. La présente invention concerne encore un bouchon permettant de fermer hermétiquement un flacon, du type qui comporte une extrémité supérieure tubulaire définissant une surface externe cylindrique avec une mécanisme de connexion placé sur ladite extrémité, un bord annulaire supérieur et une surface cylindrique interne. Ledit bouchon comporte une paroi supérieure pourvue d'une surface interne et d'une surface externe et une paroi latérale cylindrique raccordée à la paroi supérieure et possédant une surface interne et une surface externe, la paroi latérale cylindrique comportant un mécanisme de connexion formé sur la surface interne de la paroi latérale, et le mécanisme de connexion étant configuré pour correspondre au mécanisme de connexion formé sur le flacon. Ledit bouchon est caractérisé en ce qu'il comporte un élément d'étanchéité interne pourvu d'une structure tubulaire s'étendant coaxialement à la paroi latérale cylindrique du bouchon, mais radialement espacée de ladite paroi, et, lorsque le bouchon est placé sur le flacon, (i) le bord supérieur du flacon formant une fermeture étanche avec la surface interne de la paroi supérieure du bouchon et (ii) la surface cylindrique interne du flacon formant une fermeture étanche avec la surface externe de la structure tubulaire. La présente invention concerne en outre un ensemble récipient comprenant un flacon et un bouchon permettant de fermer hermétiquement le flacon, qui comporte une paroi supérieure pourvue d'une surface interne et d'une surface externe et une paroi latérale cylindrique raccordée à la paroi supérieure et possédant une surface inte
PCT/US2006/022305 2005-06-08 2006-06-08 Bouchon pour un flacon contenant des echantillons Ceased WO2007001789A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68874605P 2005-06-08 2005-06-08
US60/688,746 2005-06-08

Publications (2)

Publication Number Publication Date
WO2007001789A2 true WO2007001789A2 (fr) 2007-01-04
WO2007001789A3 WO2007001789A3 (fr) 2009-04-23

Family

ID=37595659

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/022305 Ceased WO2007001789A2 (fr) 2005-06-08 2006-06-08 Bouchon pour un flacon contenant des echantillons

Country Status (1)

Country Link
WO (1) WO2007001789A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012030569A1 (fr) * 2010-08-31 2012-03-08 Wheaton Industries, Inc. Flacons cryogéniques à bouchon

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3107022A (en) * 1962-07-10 1963-10-15 James W Wandell Screw cap
US3881627A (en) * 1973-05-09 1975-05-06 Ethyl Dev Corp Vial container and closure
US3980195A (en) * 1974-11-18 1976-09-14 Owens-Illinois, Inc. Tamper-proof closure
US6752965B2 (en) * 1998-03-06 2004-06-22 Abner Levy Self resealing elastomeric closure
US6341706B1 (en) * 2000-06-01 2002-01-29 Color Access, Inc. Snap-on plastic neck for glass containers

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012030569A1 (fr) * 2010-08-31 2012-03-08 Wheaton Industries, Inc. Flacons cryogéniques à bouchon
US8550273B2 (en) 2010-08-31 2013-10-08 Wheaton Industries, Inc. Cryogenic vials

Also Published As

Publication number Publication date
WO2007001789A3 (fr) 2009-04-23

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