WO2007012000A3 - Classificateur de particules presentes dans un liquide utilisant un ejecteur de gouttelettes a grand orifice - Google Patents

Classificateur de particules presentes dans un liquide utilisant un ejecteur de gouttelettes a grand orifice Download PDF

Info

Publication number
WO2007012000A3
WO2007012000A3 PCT/US2006/028014 US2006028014W WO2007012000A3 WO 2007012000 A3 WO2007012000 A3 WO 2007012000A3 US 2006028014 W US2006028014 W US 2006028014W WO 2007012000 A3 WO2007012000 A3 WO 2007012000A3
Authority
WO
WIPO (PCT)
Prior art keywords
liquid sample
particles
liquid
droplets
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/028014
Other languages
English (en)
Other versions
WO2007012000A2 (fr
Inventor
Steven Clyde Hill
Richard Kounai Chang
Hermes Chi-Yuan Huang
Yongle Pan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2007012000A2 publication Critical patent/WO2007012000A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007012000A3 publication Critical patent/WO2007012000A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G01N15/1492—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties within droplets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/019—Biological contaminants; Fouling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1481—Optical analysis of particles within droplets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un classificateur de particules présentes dans un liquide, qui permet de classer les particules étudiées d'un échantillon liquide selon une propriété optique desdites particules. Le classificateur comprend: (a) un éjecteur de gouttelettes à grand orifice qui contient l'échantillon liquide et éjecte des gouttelettes de celui-ci, les gouttelettes éjectées étant plusieurs fois inférieures à tout orifice entourant l'échantillon, à l'interface liquide-air, de sorte que le risque d'obturation de l'orifice par les particules présentes dans l'échantillon liquide est réduit; et (b) un sous-système de mesure de gouttelettes en suspension dans l'air, qui permet de mesurer une propriété optique de chacune des gouttelettes de l'échantillon liquide, la propriété optique de n'importe quelle particule étudiée dans les gouttelettes de l'échantillon pouvant être estimée à partir de cette mesure. Les gouttelettes de l'échantillon liquide pouvant être très petites, ce système permet de mesurer avec une grande sensibilité les particules étudiées, l'une après l'autre, comme en cytométrie de flux, avec peu de risques de boucher le dispositif, même si on n'utilise pas d'écoulement en gaine.
PCT/US2006/028014 2005-07-19 2006-07-19 Classificateur de particules presentes dans un liquide utilisant un ejecteur de gouttelettes a grand orifice Ceased WO2007012000A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70079605P 2005-07-19 2005-07-19
US60/700,796 2005-07-19

Publications (2)

Publication Number Publication Date
WO2007012000A2 WO2007012000A2 (fr) 2007-01-25
WO2007012000A3 true WO2007012000A3 (fr) 2008-12-04

Family

ID=37669542

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/028014 Ceased WO2007012000A2 (fr) 2005-07-19 2006-07-19 Classificateur de particules presentes dans un liquide utilisant un ejecteur de gouttelettes a grand orifice

Country Status (1)

Country Link
WO (1) WO2007012000A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017212067A1 (en) * 2016-01-26 2018-08-02 Ricoh Company, Ltd. Droplet forming device and dispensing device

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230031A (en) * 1978-04-26 1980-10-28 Coulter Electronics, Inc. Biohazard containment apparatus and method
US5032381A (en) * 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US5292499A (en) * 1990-09-11 1994-03-08 University Of Wales College Of Cardiff Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
US5698397A (en) * 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US6827287B2 (en) * 2002-12-24 2004-12-07 Palo Alto Research Center, Incorporated High throughput method and apparatus for introducing biological samples into analytical instruments
US20050127206A1 (en) * 2003-12-10 2005-06-16 Xerox Corporation Device and system for dispensing fluids into the atmosphere

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230031A (en) * 1978-04-26 1980-10-28 Coulter Electronics, Inc. Biohazard containment apparatus and method
US5032381A (en) * 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US5292499A (en) * 1990-09-11 1994-03-08 University Of Wales College Of Cardiff Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
US5698397A (en) * 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US6827287B2 (en) * 2002-12-24 2004-12-07 Palo Alto Research Center, Incorporated High throughput method and apparatus for introducing biological samples into analytical instruments
US20050127206A1 (en) * 2003-12-10 2005-06-16 Xerox Corporation Device and system for dispensing fluids into the atmosphere

Also Published As

Publication number Publication date
WO2007012000A2 (fr) 2007-01-25

Similar Documents

Publication Publication Date Title
EP3429862B1 (fr) Systèmes et procédés d'impression à jet d'encre de précision
Javadi et al. Delayed capillary breakup of falling viscous jets
Verkouteren et al. Inkjet metrology: high-accuracy mass measurements of microdroplets produced by a drop-on-demand dispenser
WO2015015199A3 (fr) Dispositifs et systèmes microfluidiques
EP2727969A3 (fr) Encre d'enregistrement à jet d'encre et système d'enregistrement à jet d'encre
WO2015173710A3 (fr) Système de séparation de particules individuelles à base d'un mems
WO2009111431A3 (fr) Processus d’interface avec un dispositif microfluidique numérique
WO2006001024A3 (fr) Dispositifs de mesure en continu du glucose dans des fluides corporels
AU2016229870A1 (en) Spray characterization by optical image analysis
WO2006124340A3 (fr) Systeme microfluidique permettant d'identifier ou de calibrer des particules individuelles circulant dans un canal
WO2009051949A3 (fr) Dispositif d'éjection de fluide
GB2556703A (en) Systems and methods
WO2014146063A3 (fr) Systèmes et procédés d'hématologie
WO2008027070A3 (fr) Système de caractérisation de l'eau dans un nuage
WO2007000710A3 (fr) Capteur de particules ultrafines
JP2010531730A5 (fr)
DE102015202574A1 (de) Vorrichtung und Verfahren zum Dispensieren von unter Verwendung eines akustischen Felds ausgerichteten Partikeln in frei fliegenden Tropfen
EP3378563A3 (fr) Appareil de distribution de gouttelettes
EP2075134A3 (fr) Dispositif d'enregistrement à jet d'encre
ATE370788T1 (de) Pipettenspitze, pipetiervorrichtung, pipettenspitzenbetätigungsvorrichtung und verfahren zum pipetieren im nl-bereich
JP2013210287A5 (fr)
WO2008140722A3 (fr) Mécanisme de déflecteur d'imprimante comprenant un flux de liquide
EP2434273A3 (fr) Quantification et analyse de gouttelettes éjectées par un dispositif à jet d'encre
CN101349631B (zh) 粒径分布测定装置
FR3040948B1 (fr) Procede et dispositif de degivrage d’une vitre de vehicule

Legal Events

Date Code Title Description
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06787843

Country of ref document: EP

Kind code of ref document: A2