WO2007013893A3 - Compositions immunogenes contenant un antigene de l'anthrax, des microparticules de polymeres biodegradables, et un adjuvant immunologique contenant un polynucleotide - Google Patents

Compositions immunogenes contenant un antigene de l'anthrax, des microparticules de polymeres biodegradables, et un adjuvant immunologique contenant un polynucleotide Download PDF

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Publication number
WO2007013893A3
WO2007013893A3 PCT/US2005/041107 US2005041107W WO2007013893A3 WO 2007013893 A3 WO2007013893 A3 WO 2007013893A3 US 2005041107 W US2005041107 W US 2005041107W WO 2007013893 A3 WO2007013893 A3 WO 2007013893A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotide
biodegradable polymer
immunogenic compositions
polymer microparticles
immunological adjuvant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/041107
Other languages
English (en)
Other versions
WO2007013893A2 (fr
Inventor
Derek T O'hagan
Manmohan Singh
Dennis M Klinman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Novartis Vaccines and Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics Inc
Priority to US11/667,642 priority Critical patent/US9107813B2/en
Priority to ES05858489T priority patent/ES2434029T3/es
Priority to CA2588089A priority patent/CA2588089C/fr
Priority to EP05858489.7A priority patent/EP1812056B1/fr
Priority to AU2005334819A priority patent/AU2005334819B2/en
Publication of WO2007013893A2 publication Critical patent/WO2007013893A2/fr
Publication of WO2007013893A3 publication Critical patent/WO2007013893A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/07—Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

L'invention porte sur des compositions et trousses immunogènes, sur des méthodes de stimulation de réponses immunitaire, et sur des méthodes d'immunisation les utilisant. Lesdites compositions et trousses comprennent: (a) un antigène dérivant du Bacillus anthracis; (b) des microparticules de polymères dont un polymère biodégradable; et (c) un adjuvant immunologique contenant un polynucléotide.
PCT/US2005/041107 2004-11-15 2005-11-15 Compositions immunogenes contenant un antigene de l'anthrax, des microparticules de polymeres biodegradables, et un adjuvant immunologique contenant un polynucleotide Ceased WO2007013893A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US11/667,642 US9107813B2 (en) 2004-11-15 2005-11-15 Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant
ES05858489T ES2434029T3 (es) 2004-11-15 2005-11-15 Composiciones inmunogénicas que contiene antígeno de antrax, micropartículas de polímero biodegradable, y adyuvante inmunológico que contiene polinucleótido
CA2588089A CA2588089C (fr) 2004-11-15 2005-11-15 Compositions immunogenes contenant un antigene de l'anthrax, des microparticules de polymeres biodegradables, et un adjuvant immunologique contenant un polynucleotide
EP05858489.7A EP1812056B1 (fr) 2004-11-15 2005-11-15 Compositions immunogenes contenant un antigene de l'anthrax, des microparticules de polymeres biodegradables, et un adjuvant immunologique contenant un polynucleotide
AU2005334819A AU2005334819B2 (en) 2004-11-15 2005-11-15 Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62804904P 2004-11-15 2004-11-15
US60/628,049 2004-11-15

Publications (2)

Publication Number Publication Date
WO2007013893A2 WO2007013893A2 (fr) 2007-02-01
WO2007013893A3 true WO2007013893A3 (fr) 2007-04-19

Family

ID=37564361

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/041107 Ceased WO2007013893A2 (fr) 2004-11-15 2005-11-15 Compositions immunogenes contenant un antigene de l'anthrax, des microparticules de polymeres biodegradables, et un adjuvant immunologique contenant un polynucleotide

Country Status (6)

Country Link
US (1) US9107813B2 (fr)
EP (1) EP1812056B1 (fr)
AU (1) AU2005334819B2 (fr)
CA (1) CA2588089C (fr)
ES (1) ES2434029T3 (fr)
WO (1) WO2007013893A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481043B2 (en) * 2001-06-22 2013-07-09 Cpex Pharmaceuticals, Inc. Nasal immunization
JP5191740B2 (ja) 2005-01-28 2013-05-08 ガレンバイオ、インコーポレイテッド 免疫学的に活性な組成物
AU2007221154A1 (en) 2006-02-24 2007-09-07 Novartis Ag Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
JP2010502747A (ja) * 2006-09-08 2010-01-28 ベクトン・ディキンソン・アンド・カンパニー ミョウバン吸着ワクチンの安定粉末製剤
BR122016015627A2 (pt) * 2007-10-19 2018-10-30 Novartis Ag kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica
EP2244695A1 (fr) * 2007-12-07 2010-11-03 Novartis AG Compositions utilisées pour induire des réponses immunitaires
WO2010138192A2 (fr) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Nanotransporteurs dont les composants présentent des vitesses de libération différentes
CN102905728B (zh) 2010-05-26 2015-11-25 西莱克塔生物科技公司 具有不偶合的佐剂的纳米载体组合物
US11291635B2 (en) * 2010-07-06 2022-04-05 Glaxosmithkline Biological Sa Virion-like delivery particles for self-replicating RNA molecules
US20130028857A1 (en) 2011-07-29 2013-01-31 Selecta Biosciences, Inc. Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents
EP4093873A4 (fr) 2020-01-24 2024-07-10 AIM ImmunoTech Inc. Procédés, compositions et vaccins pour le traitement d'une infection virale

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003028661A2 (fr) * 2001-10-03 2003-04-10 Chiron Corporation Compositions de meningocoque assorties d'un adjuvant
WO2004065578A2 (fr) * 2003-01-14 2004-08-05 Chiron Corporation Microparticules presentant une espece contenant des polynucleotides adsorbes

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
ATE252894T1 (de) 1995-01-05 2003-11-15 Univ Michigan Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
US6884435B1 (en) 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
EP0991403B1 (fr) 1997-01-30 2003-04-02 Chiron Corporation Utilisation de microparticules contenant un antigene adsorbe dans le but de stimuler les reponses immunitaires
ATE215385T1 (de) 1997-12-16 2002-04-15 Chiron Corp Verwendung von mikropartikeln mit submikron öl/wasser emulsionen
AU763975B2 (en) 1998-07-29 2003-08-07 Novartis Vaccines And Diagnostics, Inc. Microparticles with adsorbent surfaces, methods of making same, and uses thereof
US20040022814A1 (en) 2000-06-15 2004-02-05 O'hagan Derek Microparticles with adsorbent surfaces, methods of making same, and uses thereof
MXPA03002640A (es) 2000-09-28 2003-06-19 Chiron Corp Microparticulas para la distribucion de acidos nucleicos heterologos.
WO2002026212A2 (fr) 2000-09-28 2002-04-04 Chiron Corporation Compositions de microparticules et procede de fabrication desdites compositions
US7838015B2 (en) 2001-10-03 2010-11-23 Novartis Vaccines And Diagnostics, Inc. Adjuvanted meningococcus compositions
US7501134B2 (en) 2002-02-20 2009-03-10 Novartis Vaccines And Diagnostics, Inc. Microparticles with adsorbed polypeptide-containing molecules
US20040082530A1 (en) 2002-04-11 2004-04-29 Schmaljohn Connie S. Nucleic acid immunization
EP1572122A4 (fr) 2002-11-01 2008-04-09 Us Gov Health & Human Serv Procede de prevention d'infections a partir d'agents de terrorisme biologique avec des oligonucleotides cpg immunostimulateurs
DE602004020189D1 (de) 2003-01-30 2009-05-07 Novartis Vaccines & Diagnostic Adjuvante influenza-vakzine
JP5557415B2 (ja) 2003-06-02 2014-07-23 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003028661A2 (fr) * 2001-10-03 2003-04-10 Chiron Corporation Compositions de meningocoque assorties d'un adjuvant
WO2004065578A2 (fr) * 2003-01-14 2004-08-05 Chiron Corporation Microparticules presentant une espece contenant des polynucleotides adsorbes

Non-Patent Citations (3)

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Title
FLICK-SMITH H C ET AL: "MUCOSAL OR PARENTERAL ADMINISTRATION OF MICROSPHERE-ASSOCIATED BACILLUS ANTHRACIS PROTECTIVE ANTIGEN PROTECTS AGAINST ANTHRAX INFECTION IN MICE", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 70, no. 4, April 2002 (2002-04-01), pages 2022 - 2028, XP002977234, ISSN: 0019-9567 *
KLINMAN D M ET AL: "CpG oligonucleotides improve the protective immune response induced by the anthrax vaccination of rhesus macaques", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 22, no. 21-22, 29 July 2004 (2004-07-29), pages 2881 - 2886, XP004520426, ISSN: 0264-410X *
SINGH M ET AL: "Cationic microparticles are an effective delivery system for immune stimulatory CpG DNA", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 18, no. 10, October 2001 (2001-10-01), pages 1476 - 1479, XP002976979, ISSN: 0724-8741 *

Also Published As

Publication number Publication date
US9107813B2 (en) 2015-08-18
AU2005334819A1 (en) 2007-02-01
CA2588089A1 (fr) 2007-02-01
ES2434029T3 (es) 2013-12-13
CA2588089C (fr) 2015-06-23
US20080317784A1 (en) 2008-12-25
AU2005334819B2 (en) 2011-11-24
EP1812056A2 (fr) 2007-08-01
WO2007013893A2 (fr) 2007-02-01
EP1812056B1 (fr) 2013-08-07

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