WO2007083101A3 - Traitement du cancer - Google Patents

Traitement du cancer Download PDF

Info

Publication number
WO2007083101A3
WO2007083101A3 PCT/GB2007/000125 GB2007000125W WO2007083101A3 WO 2007083101 A3 WO2007083101 A3 WO 2007083101A3 GB 2007000125 W GB2007000125 W GB 2007000125W WO 2007083101 A3 WO2007083101 A3 WO 2007083101A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
cancer
pdi
medicament
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/000125
Other languages
English (en)
Other versions
WO2007083101A2 (fr
Inventor
Mark Birch-Machin
Penny Lovat
Christopher Redfern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Technology Ltd
Original Assignee
Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Technology Ltd filed Critical Cancer Research Technology Ltd
Publication of WO2007083101A2 publication Critical patent/WO2007083101A2/fr
Publication of WO2007083101A3 publication Critical patent/WO2007083101A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne l'utilisation d'au moins un agent qui induit un stress du réticulum endoplasmique (RE) accompagné d'au moins un agent qui provoque l'inhibition de la protéine disulfure isomérase (PDI) ou de la fonction de la GRP78 pour la préparation d'un médicament, plus particulièrement d'un médicament destiné au traitement du cancer. L'invention concerne également des compositions pharmaceutiques comprenant une quantité efficace d'au moins un agent qui induit un stress du RE accompagné d'au moins un agent qui provoque l'inhibition de la PDI ou de la fonction de la GRP78 et qui ont ensemble un effet thérapeutique.
PCT/GB2007/000125 2006-01-17 2007-01-17 Traitement du cancer Ceased WO2007083101A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0600903.9A GB0600903D0 (en) 2006-01-17 2006-01-17 Treatment of cancer
GB0600903.9 2006-01-17

Publications (2)

Publication Number Publication Date
WO2007083101A2 WO2007083101A2 (fr) 2007-07-26
WO2007083101A3 true WO2007083101A3 (fr) 2007-09-20

Family

ID=35998168

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/000125 Ceased WO2007083101A2 (fr) 2006-01-17 2007-01-17 Traitement du cancer

Country Status (2)

Country Link
GB (1) GB0600903D0 (fr)
WO (1) WO2007083101A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9907828B2 (en) 2012-06-22 2018-03-06 The University Of Vermont And State Agricultural College Treatments of oxidative stress conditions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568665A (en) * 1982-06-25 1986-02-04 Mitchell David C Protein compounds
US6719750B2 (en) * 2000-08-30 2004-04-13 The Johns Hopkins University Devices for intraocular drug delivery
EP1444989A1 (fr) * 2003-02-07 2004-08-11 Giorgio Dr. Stassi Sensibilisation de cellules à l'apoptose par bloquage selective de cytokines
US20050043215A1 (en) * 2003-02-19 2005-02-24 Tamara Minko Complex drug delivery composition and method for treating cancer
US20060068012A1 (en) * 2004-09-29 2006-03-30 Bausch & Lomb Incorporated Process for preparing poly (vinyl alcohol) drug delivery devices with humidity control

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568665A (en) * 1982-06-25 1986-02-04 Mitchell David C Protein compounds
US6719750B2 (en) * 2000-08-30 2004-04-13 The Johns Hopkins University Devices for intraocular drug delivery
EP1444989A1 (fr) * 2003-02-07 2004-08-11 Giorgio Dr. Stassi Sensibilisation de cellules à l'apoptose par bloquage selective de cytokines
US20050043215A1 (en) * 2003-02-19 2005-02-24 Tamara Minko Complex drug delivery composition and method for treating cancer
US20060068012A1 (en) * 2004-09-29 2006-03-30 Bausch & Lomb Incorporated Process for preparing poly (vinyl alcohol) drug delivery devices with humidity control

Also Published As

Publication number Publication date
WO2007083101A2 (fr) 2007-07-26
GB0600903D0 (en) 2006-02-22

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