WO2007085676A1 - Procédé de fabrication d'une solution à base de polyéthylèneglycol avec des électrolytes, produit obtenu et son application - Google Patents

Procédé de fabrication d'une solution à base de polyéthylèneglycol avec des électrolytes, produit obtenu et son application Download PDF

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Publication number
WO2007085676A1
WO2007085676A1 PCT/ES2007/000043 ES2007000043W WO2007085676A1 WO 2007085676 A1 WO2007085676 A1 WO 2007085676A1 ES 2007000043 W ES2007000043 W ES 2007000043W WO 2007085676 A1 WO2007085676 A1 WO 2007085676A1
Authority
WO
WIPO (PCT)
Prior art keywords
solution
prepared
weight
incorporation
polyethylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2007/000043
Other languages
English (en)
Spanish (es)
Inventor
Daniel Tabuenca Navarro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LABORATORIOS CASEN-FLEET SL
Original Assignee
LABORATORIOS CASEN-FLEET SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LABORATORIOS CASEN-FLEET SL filed Critical LABORATORIOS CASEN-FLEET SL
Publication of WO2007085676A1 publication Critical patent/WO2007085676A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Definitions

  • the present specification refers to a process of manufacturing a solution based on polyethylene glycol with electrolytes, product obtained and use, by means of which procedure the product based on polyethylene glycol and electrolytes is obtained in a gel state presenting a better solubility facilitating its absorption, better organoleptic properties and a greater predisposibility in the organism.
  • the solutions manufactured based on polyethylene glycol and electrolytes are presented in powder for dissolution in water and administered orally, being applied as an osmotic laxative and as an intestinal evacuator for the previous preparation, for example, to colonoscopy, surgery , radiology and other colorectal and genitourinary examinations.
  • solutions based on polyethylene glycol and electrolytes are obtained by the homogeneous mixture of its components resulting in a powder product for dissolution in water and oral administration.
  • oral solutions based on polyethylene glycol as an osmotic agent and electrolytes are hypertonic solutions, so that it facilitates the outflow of water to the intestinal lumen and therefore the laxative / evacuating effect.
  • auxiliary reactor of 150 I. 0.3% by weight of the batch of solution to be prepared of orange flavor has been dissolved in 100 I. (approximately 2% of the batch to be prepared) of purified water, the mixture being incorporated into the main reactor.
  • half of the hydroxyethylcellulose is mixed in each of them, that is, approximately 0.5% by weight of the solution to be prepared and half of the anhydrous sodium sulfate, that is , approximately, 1.6% by weight of the solution to be prepared, proceeding to its incorporation into the main reactor, so that the content of one of the vessels is first introduced and once dissolved, the content of the second will be introduced container.
  • the product obtained in a gel state has a pH between 7 and 9.5 and a viscosity between 500 and
  • the product obtained is applicable as an osmotic laxative - A - for the treatment of constipation and as an intestinal evacuator for prior preparation in color and genitourinary examinations.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Conductive Materials (AREA)
  • Primary Cells (AREA)

Abstract

Procédé de fabrication de polyéthylèneglycol avec des électrolytes, permettant d'obtenir un produit à base de polyéthylèneglycol et d'électrolytes sous forme de gel. Ce produit se caractérise par une meilleure solubilité, ce qui facilite son absorption, de meilleures propriétés organoleptiques et une meilleure biodisponibilité.
PCT/ES2007/000043 2006-01-30 2007-01-29 Procédé de fabrication d'une solution à base de polyéthylèneglycol avec des électrolytes, produit obtenu et son application Ceased WO2007085676A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200600198 2006-01-30
ES200600198A ES2278537B1 (es) 2006-01-30 2006-01-30 Procedimiento de fabricacion de una solucion a base de polietilenglicol con electrolitos, producto obtenido y uso.

Publications (1)

Publication Number Publication Date
WO2007085676A1 true WO2007085676A1 (fr) 2007-08-02

Family

ID=38308886

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2007/000043 Ceased WO2007085676A1 (fr) 2006-01-30 2007-01-29 Procédé de fabrication d'une solution à base de polyéthylèneglycol avec des électrolytes, produit obtenu et son application

Country Status (3)

Country Link
ES (1) ES2278537B1 (fr)
SA (1) SA07280014B1 (fr)
WO (1) WO2007085676A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9468686B2 (en) 2009-07-30 2016-10-18 Norgine Bv Solutions comprising polyethylene glycol and electrolytes

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987000754A1 (fr) * 1985-08-01 1987-02-12 Braintree Laboratories, Inc. Laxatif a faible teneur en sodium et compositions de lavage
WO2003092589A2 (fr) * 2002-04-30 2003-11-13 Braintree Laboratories, Inc. Solution saline pour le nettoyage du côlon
WO2004037292A1 (fr) * 2002-10-25 2004-05-06 Norgine Europe Bv Compositions de nettoyage du colon
WO2005049049A1 (fr) * 2003-11-17 2005-06-02 Braintree Laboratories, Inc. Concentre de solution peg therapeutique
WO2005102364A1 (fr) * 2004-04-23 2005-11-03 Norgine Europe Bv Compositions pharmaceutiques comprimees comprenant peg et des electrolytes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987000754A1 (fr) * 1985-08-01 1987-02-12 Braintree Laboratories, Inc. Laxatif a faible teneur en sodium et compositions de lavage
WO2003092589A2 (fr) * 2002-04-30 2003-11-13 Braintree Laboratories, Inc. Solution saline pour le nettoyage du côlon
WO2004037292A1 (fr) * 2002-10-25 2004-05-06 Norgine Europe Bv Compositions de nettoyage du colon
WO2005049049A1 (fr) * 2003-11-17 2005-06-02 Braintree Laboratories, Inc. Concentre de solution peg therapeutique
WO2005102364A1 (fr) * 2004-04-23 2005-11-03 Norgine Europe Bv Compositions pharmaceutiques comprimees comprenant peg et des electrolytes

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9468686B2 (en) 2009-07-30 2016-10-18 Norgine Bv Solutions comprising polyethylene glycol and electrolytes

Also Published As

Publication number Publication date
SA07280014B1 (ar) 2009-12-22
ES2278537A1 (es) 2007-08-01
ES2278537B1 (es) 2008-09-16

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