WO2007101248A2 - Appareil de pompage jetable base sur des recipients flexibles dans des contenants sous pression - Google Patents

Appareil de pompage jetable base sur des recipients flexibles dans des contenants sous pression Download PDF

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Publication number
WO2007101248A2
WO2007101248A2 PCT/US2007/062976 US2007062976W WO2007101248A2 WO 2007101248 A2 WO2007101248 A2 WO 2007101248A2 US 2007062976 W US2007062976 W US 2007062976W WO 2007101248 A2 WO2007101248 A2 WO 2007101248A2
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
flexible
vessel
interior
rigid container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/062976
Other languages
English (en)
Other versions
WO2007101248A3 (fr
Inventor
Alexandre N. Terentiev
Sergey Terentyev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Levtech Inc
Original Assignee
Levtech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Levtech Inc filed Critical Levtech Inc
Publication of WO2007101248A2 publication Critical patent/WO2007101248A2/fr
Publication of WO2007101248A3 publication Critical patent/WO2007101248A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
    • F04B43/10—Pumps having fluid drive
    • F04B43/113—Pumps having fluid drive the actuating fluid being controlled by at least one valve
    • F04B43/1136—Pumps having fluid drive the actuating fluid being controlled by at least one valve with two or more pumping chambers in parallel
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
    • F04B43/10—Pumps having fluid drive
    • F04B43/113—Pumps having fluid drive the actuating fluid being controlled by at least one valve
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C5/00—Methods or apparatus for filling containers with liquefied, solidified, or compressed gases under pressures
    • F17C5/06—Methods or apparatus for filling containers with liquefied, solidified, or compressed gases under pressures for filling with compressed gases
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C9/00—Methods or apparatus for discharging liquefied or solidified gases from vessels not under pressure
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2203/00—Vessel construction, in particular walls or details thereof
    • F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
    • F17C2203/068—Special properties of materials for vessel walls
    • F17C2203/0685—Special properties of materials for vessel walls flexible
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/01—Mounting arrangements
    • F17C2205/0123—Mounting arrangements characterised by number of vessels
    • F17C2205/013—Two or more vessels
    • F17C2205/0134—Two or more vessels characterised by the presence of fluid connection between vessels
    • F17C2205/0146—Two or more vessels characterised by the presence of fluid connection between vessels with details of the manifold
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
    • F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
    • F17C2205/0323—Valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
    • F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
    • F17C2205/0341—Filters
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2205/00—Vessel construction, in particular mounting arrangements, attachments or identifications means
    • F17C2205/03—Fluid connections, filters, valves, closure means or other attachments
    • F17C2205/0302—Fittings, valves, filters, or components in connection with the gas storage device
    • F17C2205/0352—Pipes
    • F17C2205/0364—Pipes flexible or articulated, e.g. a hose
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2221/00—Handled fluid, in particular type of fluid
    • F17C2221/05—Ultrapure fluid
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/01—Propulsion of the fluid
    • F17C2227/0128—Propulsion of the fluid with pumps or compressors
    • F17C2227/0135—Pumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/01—Propulsion of the fluid
    • F17C2227/0128—Propulsion of the fluid with pumps or compressors
    • F17C2227/0135—Pumps
    • F17C2227/0142—Pumps with specified pump type, e.g. piston or impulsive type
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/01—Propulsion of the fluid
    • F17C2227/0128—Propulsion of the fluid with pumps or compressors
    • F17C2227/0157—Compressors
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
    • F17C2227/01—Propulsion of the fluid
    • F17C2227/0128—Propulsion of the fluid with pumps or compressors
    • F17C2227/0171—Arrangement
    • F17C2227/0185—Arrangement comprising several pumps or compressors
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2250/00—Accessories; Control means; Indicating, measuring or monitoring of parameters
    • F17C2250/06—Controlling or regulating of parameters as output values
    • F17C2250/0605—Parameters
    • F17C2250/0636—Flow or movement of content
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2270/00—Applications
    • F17C2270/02—Applications for medical applications
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2270/00—Applications
    • F17C2270/05—Applications for industrial use

Definitions

  • the present invention relates generally to fluid pumping and, more particularly, to a disposable pumping apparatus.
  • Typical upstream pumping applications include: buffer preparation, media preparation, bioreactor media feed and supplement addition.
  • Typical downstream applications include pumping the cell suspensions, protein solutions or buffers to or through purification devises such as centrifuges, filters, membranes, chromatography columns or formulation and fill vessels.
  • disposable pumps it is advantageous to use disposable pumps in the above pumping applications in an effort to eliminate cross contamination risks between the batches, as well as to reduce cleaning and validation downtime and overall manufacturing cost for biopharmaceuticals.
  • One popular disposable pumping technology in the bioprocess industry is a peristaltic pump.
  • a peristaltic pump In one form, such as is shown in U.S. Patent No. 3,737,251 (the disclosure of which is incorporated herein by reference to the extent not inconsistent with the present teachings), such a pump uses a flexible tube as a pumping chamber, as well as the pumping line to move the fluid from one location to another. Compressing the tube with a driving head produces the desired pumping action.
  • an apparatus for intended use in pumping a fluid under sterile conditions comprises a first rigid container having an interior capable of being pressurized (either positively or negatively).
  • a first flexible vessel is positioned at least partially within the interior of the first rigid container, and includes an outlet for discharging the fluid.
  • At least one pressure source such as a gas cylinder, compressor, or even a vacuum pump, is provided for pressurizing the interior of the rigid container to cause the fluid to move through the outlet of the flexible vessel.
  • the apparatus further includes a feed vessel connected to an inlet of the first flexible vessel, as well as a pump for delivering the fluid from the feed vessel to an inlet of the first flexible vessel.
  • a filter may also be provided for receiving fluid from the outlet of the first flexible vessel, along with a return line for delivering fluid from the filter to the feed vessel.
  • the pressure created in the interior of the first rigid container comprises hydrostatic pressure to create a substantially constant flow of fluid through the outlet of the first flexible vessel.
  • the apparatus may further comprise a second container having an interior capable of being pressurized by the pressure source, as well as a second flexible vessel for positioning at least partially within the second container.
  • the second flexible vessel further includes an outlet for discharging the fluid to a line in common with the outlet of the first flexible vessel.
  • the pressure source alternately pressurizes the first and second containers, such as through the use of valves.
  • an apparatus for intended use in pumping a fluid comprises at least two containers, each having an interior capable being pressurized.
  • a flexible vessel is positioned at least partially within the interior of each container and is capable of receiving and holding the fluid.
  • Each flexible vessel further includes an outlet.
  • At least one pressure source is provided for selectively pressurizing the interiors of the containers to cause the fluid to move through the outlets of the corresponding flexible vessels.
  • the pressure source alternatively pressurizes the containers.
  • the apparatus may further include a common line connected to the outlets of the flexible vessels, or a feed vessel for feeding fluid to the inlets of the flexible vessels, hi the latter case, a filter may receive fluid from the outlet of one or both of the flexible vessels, and a return line may be provided for returning fluid from the filter to the feed vessel.
  • a chromatography column may be provided for receiving fluid from the outlets of the flexible vessels.
  • a method of pumping a fluid comprises providing the fluid in a first flexible vessel positioned at least partially within a first rigid container, and pressurizing an interior of the first rigid container to pump the fluid from the first flexible vessel.
  • the method may further include the steps of at least partially relieving the pressure in the first rigid container, allowing fluid to enter the first flexible vessel through an inlet, and then pressurizing the interior of the first rigid container.
  • the method may further include the steps of delivering the fluid to a second flexible vessel positioned at least partially within a second rigid container, and pressurizing an interior of the second rigid container to pump the fluid from the second flexible vessel.
  • a method of pumping a fluid comprises delivering the fluid to a first flexible vessel positioned at least partially within an interior of a first rigid container; pressurizing the interior of the first rigid container to move fluid through an outlet of the first flexible vessel; delivering the fluid to a second flexible vessel positioned at least partially within an interior of a second rigid container; and pressurizing the interior of the second rigid container to move fluid through an outlet of the second flexible vessel.
  • the step of delivering the fluid to the second flexible vessel is concurrent with the step of pressurizing the first rigid container.
  • the delivering step may comprise delivering step comprises delivering fluid from a common feed vessel.
  • the method may further include the step of delivering the fluid from the outlet of the first or second flexible vessel to a filter, and then delivering the fluid to a vessel for feeding either the first or second flexible vessel.
  • the pressurizing steps are performed to create a substantially constant flow of fluid along a common line associated with the outlets of the flexible vessels.
  • Figure 1 is a schematic diagram of one pumping apparatus forming one aspect of the invention
  • FIG. 2 is a schematic diagram of a pumping apparatus forming another aspect of the invention.
  • Figures 3 a and 3 b are graphical illustrations of the flow rate versus time created from the use of a pumping apparatus of Figure 1 or 2;
  • FIGS 4, 5, and 6 schematically illustrate various configurations usable with the disclosed pumping apparatus.
  • the general nature of the proposed pumping apparatus comprises a container capable of being pressurized, such as for example with a periodically oscillating internal pressure.
  • the pressure is of a hydrostatic nature and maybe created by introducing gas or fluid media to the interior of the pressure container.
  • a hermetically closed or sealed collapsible container such as a flexible bag, is placed at least parti ally and preferably entirely inside the pressure container.
  • the outer surface of the flexible vessel is in contact with pressure transferring media and need not be sterile, but the inner surface of the flexible vessel maybe in contact with the pumped sterile fluid so it must also be sterile.
  • the flexible vessel When the pressure container is periodically or selectively pressurized, the flexible vessel then works as a fluid pumping chamber.
  • the flexible vessel and the chamber have an inlet port and a discharge port.
  • the pumped fluid is introduced into the flexible vessel by an inlet port connected to an inlet line (such as flexible tubing) via an inlet valve.
  • the pumped fluid discharges from the flexible vessel via the discharge port connected to a discharge line by a discharge valve.
  • These lines may penetrate into the pressure container, which may be hermetically sealed from the outside environment in the entire range of the pressure developed inside the container.
  • one embodiment of the pumping apparatus 10 includes two flexible vessels 11, 12, such as disposable plastic bags, that create pumping chambers.
  • These flexible vessels 11, 12 are preferably hermetically sealed and at least partially (and most preferably) fully contained within separate rigid pressure containers 13, 14 capable of being pressurized (positively or negatively). Both pressure containers 13, 14 are preferably connected with an external pressure source
  • the pressure source P can be a compressed gas cylinder, a gas compressor, a hydraulic press, or the like.
  • the media producing hydrostatic pressure to the bag chambers is preferably air, but can be any suitable gas or liquid capable of creating the desired hydrostatic pressure.
  • valves 15, 16 open and close the outlets of the flexible vessels 11, 12, while valves 17, 18 open and close the associated inlets.
  • Vent valves 19, 20 open or close the lines connecting the internal volume or space of the rigid pressure containers 13, 14 with the atmosphere.
  • a feeding vessel V may contain the fluid to be pumped, and a low pressure pump 23 may be used to fill the pumping chambers 11, 12 with fluid prior to high pressure pumping action.
  • this pump 21 may comprise a peristaltic pump.
  • the pumping chamber formed by one of the flexible vessels 11 is filled with a fluid, such as a liquid, preferably to capacity.
  • Pumping chamber formed by the other flexible vessel 12 may be initially empty. Fluid valves 16 and 17 are closed while valves 15 and 18 are open. The vent valve 20 is open, while vent valve 19 is closed.
  • pressure valve 22 is open while valve 21 is closed. Accordingly, pressure developed in pressure container 13 results in the discharge of the fluid from the vessel 11 through the outlet line. Since the pressure in the container 13 remains constant, the flow rate of the fluid pumped is also constant until all the fluid from the vessel 11 is pumped out and it collapses. During this cycle, the other pressure chamber within vessel 12 may be filled to capacity with fluid by the pump 23.
  • valves 16 and 17 are opened while valves 15 and 18 are closed. Furthermore, vent valve 20 is closed while valve 19 is opened, and pressure valve 22 is closed while valve 21 is open.
  • the pressure developed in the rigid container 14 results in discharge of the fluid from the pressure chamber of vessel 12 through the outlet line.
  • pressure chamber of vessel 11 is filled to capacity with fluid, such as by the pump 23.
  • valves 25 and 26 are controlled by valves 25 and 26.
  • negative pressure within the containers 13, 14 thus forces the fluid to exit through the corresponding outlet(s) of the flexible vessels 11, 12 (provided, of course, the associated valves 15, 16 are selectively opened).
  • Figure 3 b shows the resultant flow rate in the discharge line D of the pumping apparatus 10 (see also Figure 1 ).
  • the resultant flow rate is constant as long as the spikes resulting from switching from one pumping chamber to another can be minimized by proper synchronization of the valves.
  • FIG 4 an illustration is provided of a pre-sterilized (by means of gamma radiation or other methods) disposable flexible bag assembly 40 consisting of the feed bag serving as the vessel V containing the fluid to be pumped and two pumping vessels 11, 12.
  • the two pumping vessels 11, 12 forming the pressure chambers of this assembly 40 may be introduced into the two rigid pressure containers 13, 14 of the pumping apparatus 10 shown on Figure 1 or Figure 2 to pump the fluid from the feed bag.
  • FIG 5 shows a pre-sterilized (by means of gamma radiation or other methods) disposable bag assembly 50 consisting of a bag as the feed vessel V with the fluid to be pumped, two flexible pumping vessels 11, 12 forming the pressure chambers and a filter F, such as for example a tangential flow filter.
  • a re-circulating, disposable filtration loop is described.
  • the two pumping vessels 11, 12 of the assembly 50 maybe introduced into the pressure containers 13, 14 of the pumping apparatus 10 shown in Figure 1 or Figure 2 for re- circulation of the fluid from the feed bag serving as the feed vessel V, through the filter F, and back again.
  • Illustrated in Figures 6 is a disposable bag assembly 60 connected to a chromatography column C.
  • the bag serving as the feed vessel V contains the fluid to be processed.
  • Flexible vessels 11, 12 may be introduced in the pumping apparatus 10 shown in Figure 1 or Figure 2 to activate the pumping of the fluid through the chromatography column C.
  • the chromatography column C can be re-usable.
  • the bag assembly 60 and the column C are single use components.
  • the pumping apparatus 10 is based on two chambers created by separate flexible vessels 11, 12. However, pumping with a single vessel having chamber is also possible.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Reciprocating Pumps (AREA)

Abstract

L'invention concerne un appareil destiné à être utilisé pour le pompage d'un fluide dans des conditions stériles. Dans un mode de réalisation, un premier contenant rigide est intérieurement mis sous pression pour pomper du fluide au travers d'un premier récipient flexible à l'intérieur du contenant rigide. Dans un autre mode de réalisation, un premier contenant et un deuxième contenant sont mis en œuvre, chacun destiné à recevoir des récipients flexibles qui créent des chambres de pompage indépendantes lors de la mise sous pression interne sélective ou périodique des contenants. L'invention concerne également des aspects et procédés connexes.
PCT/US2007/062976 2006-02-28 2007-02-28 Appareil de pompage jetable base sur des recipients flexibles dans des contenants sous pression Ceased WO2007101248A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77737606P 2006-02-28 2006-02-28
US60/777,376 2006-02-28

Publications (2)

Publication Number Publication Date
WO2007101248A2 true WO2007101248A2 (fr) 2007-09-07
WO2007101248A3 WO2007101248A3 (fr) 2008-03-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/062976 Ceased WO2007101248A2 (fr) 2006-02-28 2007-02-28 Appareil de pompage jetable base sur des recipients flexibles dans des contenants sous pression

Country Status (2)

Country Link
US (1) US20070201993A1 (fr)
WO (1) WO2007101248A2 (fr)

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US11602617B2 (en) * 2019-04-18 2023-03-14 Michael Bonnette Pumpless thrombectomy system
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