WO2007102797A3 - Conjugues de polysaccharides-proteines derivatises meningococciques multivalents et vaccin - Google Patents

Conjugues de polysaccharides-proteines derivatises meningococciques multivalents et vaccin Download PDF

Info

Publication number
WO2007102797A3
WO2007102797A3 PCT/US2005/046886 US2005046886W WO2007102797A3 WO 2007102797 A3 WO2007102797 A3 WO 2007102797A3 US 2005046886 W US2005046886 W US 2005046886W WO 2007102797 A3 WO2007102797 A3 WO 2007102797A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein conjugates
derivatized polysaccharide
polysaccharide
vaccine
derivatized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/046886
Other languages
English (en)
Other versions
WO2007102797A2 (fr
Inventor
Robert P Ryall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Inc
Original Assignee
Sanofi Pasteur Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Pasteur Inc filed Critical Sanofi Pasteur Inc
Priority to CNA2005800486574A priority Critical patent/CN101443454A/zh
Priority to PCT/US2005/046886 priority patent/WO2007102797A2/fr
Priority to MX2007007790A priority patent/MX2007007790A/es
Priority to JP2008547192A priority patent/JP2009521434A/ja
Priority to BRPI0516372-2A priority patent/BRPI0516372A/pt
Priority to EP05858729A priority patent/EP1963522A4/fr
Priority to AU2007203489A priority patent/AU2007203489A1/en
Publication of WO2007102797A2 publication Critical patent/WO2007102797A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007102797A3 publication Critical patent/WO2007102797A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des conjugués de polysaccharides-protéines dérivatisés, une composition comprenant un ou plusieurs desdits conjugués, et des procédés d'immunisation de patients humains avec lesdits conjugués. Lesdits conjugués sont des polysaccharides capsulaires purifiés de sérogroupes de Neisseria meningitidis A, C, W-135, et/ou Y, dérivatisés, chimiquement activés et sélectivement fixés sur une protéine-support au moyen d'une liaison chimique covalente. Ces polysaccharides capsulaires purifiés constituent ainsi des conjugués de polysaccharides-protéines capables de procurer une immunité durable à diverses souches de N. meningitidis.
PCT/US2005/046886 2005-12-22 2005-12-22 Conjugues de polysaccharides-proteines derivatises meningococciques multivalents et vaccin Ceased WO2007102797A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CNA2005800486574A CN101443454A (zh) 2005-12-22 2005-12-22 多价脑膜炎球菌衍生化的多糖-蛋白质缀合物和疫苗
PCT/US2005/046886 WO2007102797A2 (fr) 2005-12-22 2005-12-22 Conjugues de polysaccharides-proteines derivatises meningococciques multivalents et vaccin
MX2007007790A MX2007007790A (es) 2005-12-22 2005-12-22 Conjugados y vacuna de proteina con polisacarido derivado meningococcal multivalente.
JP2008547192A JP2009521434A (ja) 2005-12-22 2005-12-22 髄膜炎菌由来の誘導体化多糖類−タンパク質の多価コンジュゲートおよびワクチン
BRPI0516372-2A BRPI0516372A (pt) 2005-12-22 2005-12-22 conjugados de polissacarìdeo-proteìna derivatizados meningocócicos multivalentes e vacina
EP05858729A EP1963522A4 (fr) 2005-12-22 2005-12-22 Conjugues de polysaccharides-proteines derivatises meningococciques multivalents et vaccin
AU2007203489A AU2007203489A1 (en) 2005-12-22 2007-07-23 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2005/046886 WO2007102797A2 (fr) 2005-12-22 2005-12-22 Conjugues de polysaccharides-proteines derivatises meningococciques multivalents et vaccin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2007203489A Division AU2007203489A1 (en) 2005-12-22 2007-07-23 Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine

Publications (2)

Publication Number Publication Date
WO2007102797A2 WO2007102797A2 (fr) 2007-09-13
WO2007102797A3 true WO2007102797A3 (fr) 2009-04-16

Family

ID=38475284

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/046886 Ceased WO2007102797A2 (fr) 2005-12-22 2005-12-22 Conjugues de polysaccharides-proteines derivatises meningococciques multivalents et vaccin

Country Status (6)

Country Link
EP (1) EP1963522A4 (fr)
JP (1) JP2009521434A (fr)
CN (1) CN101443454A (fr)
BR (1) BRPI0516372A (fr)
MX (1) MX2007007790A (fr)
WO (1) WO2007102797A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102327605B (zh) * 2011-08-25 2013-01-30 成都康华生物制品有限公司 四价脑膜炎球菌多糖疫苗的制备工艺
CN102809656B (zh) * 2012-08-26 2014-09-03 云南沃森生物技术股份有限公司 一种脑膜炎球菌多糖结合疫苗成品各群游离多糖含量的测定方法
SG11201700089QA (en) * 2014-07-25 2017-02-27 Biosynth Srl Glycoconjugate vaccines comprising basic units of a molecular construct expressing built-in multiple epitopes for the formulation of a broad-spectrum vaccine against infections due to enteropathogenic bacteria
CN104383532A (zh) * 2014-12-02 2015-03-04 云南沃森生物技术股份有限公司 一种用乙肝表面抗原为载体蛋白的细菌多糖蛋白结合物疫苗及其制备方法
BR112019003992A2 (pt) 2016-09-02 2019-05-28 Sanofi Pasteur Inc vacina contra neisseria meningitidis
WO2025224732A1 (fr) * 2024-04-26 2025-10-30 Techinvention Lifecare Private Limited Vaccin combiné hexavalent méningococcique

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425946A (en) * 1992-08-31 1995-06-20 North American Vaccine, Inc. Vaccines against group C Neisseria meningitidis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998058670A1 (fr) * 1997-06-24 1998-12-30 Chiron Corporation Procedes permettant d'immuniser des adultes grace a des compositions de vaccins anti-meningococcique
BRPI0410423A (pt) * 2003-05-07 2006-06-06 Sanofi Pasteur Inc processo de imunogenicidade melhorada para vacinação meningocócica

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425946A (en) * 1992-08-31 1995-06-20 North American Vaccine, Inc. Vaccines against group C Neisseria meningitidis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CAMPBELL J.D.: "Safety, Reactogenicity and Immunogenicity of a Tetravalent Meningococcal Polysaccharide-Diphtheria Toxoid Conjugate Vaccine Given to Healthy Adults.", J. INFECT. DIS., vol. 186, 2002, pages 1848 - 1851, XP008015583 *
MITCHELL L.A.: "Analysis of Meningococcal Serogroup C-specific Antibody Levels in British Columbian Children and Adolescents.", J. INFECT DIS., vol. 173, April 1996 (1996-04-01), pages 1009 - 1013, XP008120564 *
See also references of EP1963522A4 *
SNAPE. M.D.: "Meningococcal Polysaccharide-Protein Conjugate Vaccines.", LANCET INFECT. DIS., vol. 5, January 2005 (2005-01-01), pages 21 - 30, XP004835479 *
TROTTER C.L.: "Effectiveness of Meningococcal Serogroup C Conjugate Vaccine 4 years After Introduction.", LANCET, vol. 364, July 2004 (2004-07-01), pages 365 - 367, XP004747133 *

Also Published As

Publication number Publication date
CN101443454A (zh) 2009-05-27
MX2007007790A (es) 2009-06-05
EP1963522A4 (fr) 2010-05-12
EP1963522A2 (fr) 2008-09-03
JP2009521434A (ja) 2009-06-04
WO2007102797A2 (fr) 2007-09-13
BRPI0516372A (pt) 2008-09-02

Similar Documents

Publication Publication Date Title
WO2004103400A3 (fr) Conjugues de polysaccharides-proteines derivatises meningococciques multivalents et vaccin correspondant
AP1897A (en) Multivalent Meningococcal polysaccharide-Protein Conjugate Vaccine.
EP2364725A3 (fr) Procédé d'immunisation contre les sérogroupes A et C de Neisseria Meningitidis
JP2007533729A5 (fr)
EA200801368A1 (ru) Конъюгатные вакцины
MX337528B (es) Composición inmunogénica que comprende un sacárido capsular estafilocócico o-acetilado y una proteína estafilocócica.
EP2382986A3 (fr) Vaccin contre streptococcus pneumoniae
EP2886551A3 (fr) Polypeptides fHbp méningococciques
EP2687228A3 (fr) Vaccin contenant des conjugues de polysaccharide capsulaire de streptococcus pneumoniae vaccin
ATE552844T1 (de) Injizierbarer impfstoff gegen multiple meningokokken-serogruppen
WO2007026249A3 (fr) Vaccination multiple comprenant des meningocoques du serogroupe c
WO2003094834A3 (fr) Vaccins muqueux avec adjuvant de chitosane et/ou antigenes meningococciques
WO2005004909A3 (fr) Methode permettant d'obtenir une immunogenicite amelioree par rapport a la vaccination meningococcique
WO2005105140A3 (fr) Integration d'une vaccination conjuguee antimeningococcique
WO2010109325A3 (fr) Combinaisons comprenant un saccharide de pneumocoque sérotype 14
WO2006034320A3 (fr) Conjugues polysaccharide/proteine menogococciques multivalents derivatises et vaccin
WO2006026689A3 (fr) Conjugues polysaccharide/proteine derivatises de meningocoque multivalents et vaccin
WO2006004390A3 (fr) Methode de preparation et d'utilisation d'un vaccin bivalent contre la dependance a la morphine/heroine
WO2007102797A3 (fr) Conjugues de polysaccharides-proteines derivatises meningococciques multivalents et vaccin
MX382165B (es) Una vacuna conjugada contra n. meningitidis para usarse en la prevención o tratamiento de enfermedades por n. meningitidis.
PE20120262A1 (es) Procedimiento para la preparacion de inmunoconjugados que comprenden polisacarido u oligosacarido capsular de s. aureus junto con la proteina portadora
UA99703C2 (en) Use of streptococcus pneumoniae immunogenic composition

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200580048657.4

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2008547192

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 184154

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: MX/A/2007/007790

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 3253/CHENP/2007

Country of ref document: IN

Ref document number: 1020077017010

Country of ref document: KR

Ref document number: 1020077017011

Country of ref document: KR

Ref document number: 2005858729

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: PI0516372

Country of ref document: BR