WO2007129184A3 - Procédé amélioré de préparation de sodium de phénytoïne - Google Patents

Procédé amélioré de préparation de sodium de phénytoïne Download PDF

Info

Publication number
WO2007129184A3
WO2007129184A3 PCT/IB2007/001130 IB2007001130W WO2007129184A3 WO 2007129184 A3 WO2007129184 A3 WO 2007129184A3 IB 2007001130 W IB2007001130 W IB 2007001130W WO 2007129184 A3 WO2007129184 A3 WO 2007129184A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
phenytoin sodium
phenytoin
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/001130
Other languages
English (en)
Other versions
WO2007129184A2 (fr
Inventor
Siripragada Mahender Rao
Padmanabhan Ramar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchid Pharma Ltd
Original Assignee
Orchid Chemicals and Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals and Pharmaceuticals Ltd filed Critical Orchid Chemicals and Pharmaceuticals Ltd
Publication of WO2007129184A2 publication Critical patent/WO2007129184A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007129184A3 publication Critical patent/WO2007129184A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention concerne un procédé amélioré de préparation de sodium de phénytoïne de formule (I). Ce procédé consiste à faire réagir de la phénytoïne avec une solution aqueuse d'hydroxyde de sodium en présence de chlorure de sodium aqueux.
PCT/IB2007/001130 2006-05-04 2007-05-02 Procédé amélioré de préparation de sodium de phénytoïne Ceased WO2007129184A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN806/CHE/2006 2006-05-04
IN806CH2006 2006-05-04

Publications (2)

Publication Number Publication Date
WO2007129184A2 WO2007129184A2 (fr) 2007-11-15
WO2007129184A3 true WO2007129184A3 (fr) 2009-06-04

Family

ID=38668137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/001130 Ceased WO2007129184A2 (fr) 2006-05-04 2007-05-02 Procédé amélioré de préparation de sodium de phénytoïne

Country Status (1)

Country Link
WO (1) WO2007129184A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111978258B (zh) * 2020-08-13 2021-05-25 山西新宝源制药有限公司 制备苯妥英钠的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109456271B (zh) * 2018-11-20 2022-06-21 宁波职业技术学院 一种苯妥英钠的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245917B1 (en) * 1998-03-20 2001-06-12 Warner-Lambert Company Crystalline sodium phenytoin monohydrate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245917B1 (en) * 1998-03-20 2001-06-12 Warner-Lambert Company Crystalline sodium phenytoin monohydrate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NI, N. ET AL.: "Estimation of the effect of NaCl on the solubility of organic compounds in aqueous solutions", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 89, no. ISS.12, 17 October 2000 (2000-10-17), pages 1620 - 1625 *
SWABRICK, J ET AL., ENCYCLOPEDIA OF PHARMACEUTICAL TECHNOLOGY, vol. 20, no. SUPPLE, 2001, pages 500, ISBN: 082472819X, Retrieved from the Internet <URL:http://books.google.com/books?id=gJYv8mdG0iEC8&pg=PP1&dq=Encyclopedia+of+Pharmaceutical+Technology:+Volume+20+-+Supplement+3&client=firefox-a> *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111978258B (zh) * 2020-08-13 2021-05-25 山西新宝源制药有限公司 制备苯妥英钠的方法

Also Published As

Publication number Publication date
WO2007129184A2 (fr) 2007-11-15

Similar Documents

Publication Publication Date Title
PH12012500634A1 (en) Processes for preparing of glucopyranosyl -substituted benzyl -benzene derivatives
WO2007035629A3 (fr) Inhibiteurs de dipeptidylpeptidase
WO2008085575A3 (fr) Polypeptides et voies de synthèse biologique destinés à la production de stéréoisomères de monatine et de leurs précurseurs
WO2007133183A3 (fr) Polypeptides et voies de synthèse biologique destinés à produire des stéréoisomères de monatine et leurs précurseurs
CL2012000929A1 (es) Proceso para la obtencion de derivados de glucosa por acoplamiento entre un compuesto organometalico de zinc y un derivado de glucosa protegido y su posterior desproteccion.
MX2009003823A (es) Nueva difenilazetidinona sustituida con acido piperazina-1-sulfonico y que tiene propiedades farmacologicas mejoradas.
AU2013380573A8 (en) A process for sodium salt of (2S, 5R)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane
WO2010150211A3 (fr) Utilisation de dérivés d&#39;indoles dans le traitement du cancer
MX2011007301A (es) Dabigatran liofilizado.
MX2007014172A (es) Procedimiento para la produccion de 4-bifenililacetidina-2-onas fenolicos.
WO2008053334A3 (fr) Procédé amélioré de préparation de rosuvastatine calcique
MX2011011011A (es) Preparacion solida.
MX2010006787A (es) Análogos halogenados de agentes anti-fibroticos.
UA101835C2 (uk) Спосіб отримання похідних 1-(2-галогенбіфеніл-4-іл)-циклопропанкарбонової кислоти
MX2011009898A (es) Proceso para la obtencion de derivados de acido propionico.
WO2009138847A3 (fr) Procédé de préparation amélioré de céfozoprane
WO2008075205A3 (fr) Procédé amélioré de préparation de la voriconazole
WO2008077035A3 (fr) Procédés de préparation de lévétiracétam
WO2008015703A3 (fr) Procédé pour la préparation de montelukast et de ses sels
MX2010001864A (es) Metodo para la preparacion de acido montelukast en un medio liquido ionico.
WO2007108011A3 (fr) Procede de preparation de donepezile de grande purete
AR114133A2 (es) Sal de citrato de 11-(2-pirrolidin-1-il-etoxi)-14,19-dioxa-5,7,26-triaza-tetraciclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaeno
MX2010009926A (es) Nuevo proceso para la preparacion de derivados de acido ciclohexancarboxilico.
MX2010009876A (es) Nuevo proceso para la preparacion de derivados de acido ciclohexanocarboxilico por medio del derivado de ciclohexanocarboxamida correspondiente.
WO2009113098A3 (fr) Procédé de préparation de 2-cyanoimino-1,3-thiazolidine

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07734447

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07734447

Country of ref document: EP

Kind code of ref document: A2