WO2007134533A8 - Intermédiaire médical soluble de 20(r)-ginsenoside rg3 et procédé correspondant - Google Patents

Intermédiaire médical soluble de 20(r)-ginsenoside rg3 et procédé correspondant

Info

Publication number
WO2007134533A8
WO2007134533A8 PCT/CN2007/001634 CN2007001634W WO2007134533A8 WO 2007134533 A8 WO2007134533 A8 WO 2007134533A8 CN 2007001634 W CN2007001634 W CN 2007001634W WO 2007134533 A8 WO2007134533 A8 WO 2007134533A8
Authority
WO
WIPO (PCT)
Prior art keywords
ginsenoside
soluble intermediate
dissolving
water
medicinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2007/001634
Other languages
English (en)
Chinese (zh)
Other versions
WO2007134533A1 (fr
Inventor
Li Fu
Qi Lu
Hong Liu
Mingming Lu
Seong Tae Cho
Wanzhe Cui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2007134533A1 publication Critical patent/WO2007134533A1/fr
Anticipated expiration legal-status Critical
Publication of WO2007134533A8 publication Critical patent/WO2007134533A8/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un intermédiaire médical soluble dans l'eau, employé pour la préparation d'injections, est préparé par dissolution de 20(R)-ginsenoside Rg3 dans un solvant organique, dissolution de 2-hydroxypropyl-β-cyclodextrine dans de l'eau afin d'obtenir une solution aqueuse, chauffage à 40-100°C, mélange avec instillation d'une solution de ginsenoside, récupération du solvant et dissolution dans de l'eau pour injection.
PCT/CN2007/001634 2006-05-22 2007-05-18 Intermédiaire médical soluble de 20(r)-ginsenoside rg3 et procédé correspondant Ceased WO2007134533A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200610046618.7 2006-05-22
CNA2006100466187A CN1895220A (zh) 2006-05-22 2006-05-22 20(R)－人参皂苷Rg3药用水溶性中间体及制备方法

Publications (2)

Publication Number Publication Date
WO2007134533A1 WO2007134533A1 (fr) 2007-11-29
WO2007134533A8 true WO2007134533A8 (fr) 2008-12-04

Family

ID=37607958

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2007/001634 Ceased WO2007134533A1 (fr) 2006-05-22 2007-05-18 Intermédiaire médical soluble de 20(r)-ginsenoside rg3 et procédé correspondant

Country Status (2)

Country Link
CN (1) CN1895220A (fr)
WO (1) WO2007134533A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102091114B (zh) * 2009-12-15 2014-11-26 河北以岭医药研究院有限公司 一种中药冻干注射剂及其制备方法
CN103705926A (zh) * 2012-10-08 2014-04-09 贾力 预防原发性肿瘤在手术切除后再转移的药用组合物
CN103845348B (zh) * 2012-11-30 2016-07-13 富力 20(R)-人参皂苷Rg3在制备痛经药物中的应用
CN104561219A (zh) * 2014-12-16 2015-04-29 江南大学 一种酶促合成人参皂苷Rh2的方法
CN110547465A (zh) * 2019-08-06 2019-12-10 上海麒稷健康科技有限公司 一种大脑神经营养组合物及制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1167734C (zh) * 2001-07-02 2004-09-22 董英杰 人参皂甙Rg3羟丙基-β-环糊精包合物及制剂和制备方法
CN1526405A (zh) * 2003-01-06 2004-09-08 山东绿叶天然药物研究开发有限公司 抗肿瘤的人参皂苷Rg3注射剂及其制备方法
CN1569011A (zh) * 2003-07-24 2005-01-26 山东绿叶天然药物研究开发有限公司 20（R）－人参皂苷－Rg3在制备治疗或预防心脑血管疾病的药物中的应用
CN1569012A (zh) * 2003-07-24 2005-01-26 山东绿叶天然药物研究开发有限公司 20(R)－人参皂苷－Rg3在制备治疗或预防高血压的药物中的应用

Also Published As

Publication number Publication date
CN1895220A (zh) 2007-01-17
WO2007134533A1 (fr) 2007-11-29

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