WO2007138198A3 - Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait - Google Patents

Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait Download PDF

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Publication number
WO2007138198A3
WO2007138198A3 PCT/FR2007/000908 FR2007000908W WO2007138198A3 WO 2007138198 A3 WO2007138198 A3 WO 2007138198A3 FR 2007000908 W FR2007000908 W FR 2007000908W WO 2007138198 A3 WO2007138198 A3 WO 2007138198A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
milk
phase
lipid
extraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2007/000908
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English (en)
Other versions
WO2007138198A2 (fr
Inventor
Alain Lejars
Michel Nogre
Michel Tellier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LFB Biotechnologies SAS
Original Assignee
LFB Biotechnologies SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/300,495 priority Critical patent/US20100047428A1/en
Application filed by LFB Biotechnologies SAS filed Critical LFB Biotechnologies SAS
Priority to AU2007266951A priority patent/AU2007266951C1/en
Priority to BRPI0712005-2A priority patent/BRPI0712005A2/pt
Priority to CN200780020173.8A priority patent/CN101501059B/zh
Priority to KR1020147034304A priority patent/KR101593494B1/ko
Priority to JP2009512640A priority patent/JP5279087B2/ja
Priority to EP07788820A priority patent/EP2038296A2/fr
Priority to CA2652495A priority patent/CA2652495C/fr
Publication of WO2007138198A2 publication Critical patent/WO2007138198A2/fr
Priority to IL195183A priority patent/IL195183A0/en
Anticipated expiration legal-status Critical
Publication of WO2007138198A3 publication Critical patent/WO2007138198A3/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/303—Extraction; Separation; Purification by precipitation by salting out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un procédé d'extraction d'au moins une protéine présente dans du lait, ladite protéine présentant une affinité pour les ions calcium complexés ou non dudit lait, comprenant les étapes suivantes consistant à : a) libérer la protéine par la précipitation de composés de calcium obtenue par mise en contact du lait avec un sel soluble, dont l'anion est choisi pour son aptitude à former dans un tel milieu lesdits composés de calcium insolubles, pour ainsi obtenir une phase liquide enrichie en la protéine, b) séparer la phase liquide enrichie en la protéine du précipité de composés de calcium, ladite phase liquide étant en outre séparée en une phase lipidique et en une phase aqueuse non lipidique comprenant la protéine, et c) récupérer la phase aqueuse non lipidique comprenant la protéine.
PCT/FR2007/000908 2006-05-31 2007-05-31 Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait Ceased WO2007138198A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA2652495A CA2652495C (fr) 2006-05-31 2007-05-31 Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
AU2007266951A AU2007266951C1 (en) 2006-05-31 2007-05-31 Method for the extraction of one or several proteins present in milk
BRPI0712005-2A BRPI0712005A2 (pt) 2006-05-31 2007-05-31 método de extração de uma ou várias proteìnas no leite
CN200780020173.8A CN101501059B (zh) 2006-05-31 2007-05-31 奶中一种或多种蛋白的提取方法
KR1020147034304A KR101593494B1 (ko) 2006-05-31 2007-05-31 우유에 존재하는 하나 이상의 단백질을 추출하는 방법
US12/300,495 US20100047428A1 (en) 2006-05-31 2007-05-31 Method for the extraction of one or several proteins in milk
EP07788820A EP2038296A2 (fr) 2006-05-31 2007-05-31 Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
JP2009512640A JP5279087B2 (ja) 2006-05-31 2007-05-31 母乳中に存在する１つ又は複数のタンパク質を抽出する方法
IL195183A IL195183A0 (en) 2006-05-31 2008-11-09 Method for the extraction of one or several proteins present in milk

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0604864A FR2901796A1 (fr) 2006-05-31 2006-05-31 Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
FR0604864 2006-05-31

Publications (2)

Publication Number Publication Date
WO2007138198A2 WO2007138198A2 (fr) 2007-12-06
WO2007138198A3 true WO2007138198A3 (fr) 2009-04-23

Family

ID=37441903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/000908 Ceased WO2007138198A2 (fr) 2006-05-31 2007-05-31 Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait

Country Status (13)

Country Link
US (1) US20100047428A1 (fr)
EP (1) EP2038296A2 (fr)
JP (2) JP5279087B2 (fr)
KR (2) KR101593494B1 (fr)
CN (2) CN103910779A (fr)
AR (2) AR061429A1 (fr)
AU (1) AU2007266951C1 (fr)
BR (1) BRPI0712005A2 (fr)
CA (1) CA2652495C (fr)
FR (1) FR2901796A1 (fr)
IL (1) IL195183A0 (fr)
TW (1) TWI394534B (fr)
WO (1) WO2007138198A2 (fr)

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FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
WO2011037957A2 (fr) * 2009-09-24 2011-03-31 U.S. Foods & Pharmaceuticals, Inc. Compositions et procédés pour réparation, maintenance et régénération osseuse
JP5883849B2 (ja) * 2010-04-29 2016-03-15 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 陰イオン交換樹脂を用いる二価カチオン結合タンパク質の精製方法
CN101885755B (zh) * 2010-06-09 2012-07-04 中国热带农业科学院热带生物技术研究所 一种巴西橡胶胶乳蛋白的提取方法
CN102127164B (zh) 2010-12-20 2013-01-30 武汉禾元生物科技有限公司 一种从水稻种子中提取重组人血清白蛋白的方法
CN102532254B (zh) 2010-12-24 2015-06-24 武汉禾元生物科技股份有限公司 一种从水稻种子中分离纯化重组人血清白蛋白的方法
EP2729164A4 (fr) * 2011-07-07 2015-05-06 Lfb Usa Inc Formulations stabilisant des protéines
LT2748179T (lt) 2011-10-14 2022-04-11 Takeda Pharmaceutical Company Limited Baltymų gryninimas anijonų mainų chromatografija
EP2748180B1 (fr) 2011-10-14 2018-08-15 Baxalta GmbH Purification de protéines par chromatographie par echange d'anions
CN102746394A (zh) * 2012-01-05 2012-10-24 暨南大学 一种离子交换色谱分离乳源αs-酪蛋白的方法
AU2013202191A1 (en) * 2012-06-20 2014-01-16 Massey University Micronutrient Fortification Process and its Uses
EP2687595B1 (fr) 2012-07-19 2018-05-30 Laboratoire Français du Fractionnement et des Biotechnologies Procédé de purification de facteur VII transgénique
AU2013204858B2 (en) * 2012-10-08 2015-06-25 Saputo Dairy Australia Pty Limited Improved process for purifying milk proteins and products thereof
AU2013204850B2 (en) * 2012-10-08 2015-06-25 Murray Goulburn Co-Operative Co. Limited Improved process for purifying milk proteins and products thereof
CN103880947B (zh) 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
TR201808584T4 (tr) 2013-03-15 2018-07-23 Baxalta GmbH Anyon değişimi kromotografisi aracılığıyla k vitaminine bağlı proteinler için saflaştırma yöntemi.
US10611826B2 (en) 2013-07-05 2020-04-07 Laboratoire Français Du Fractionnement Et Des Biotechnologies Affinity chromatography matrix
AT516149B1 (de) 2014-12-15 2016-03-15 MAN Truck & Bus Österreich AG Verfahren zum Steuern einer Motorbremsvorrichtung sowie Motorbremsvorrichtung
CN107373012B (zh) * 2017-08-15 2021-07-23 临邑禹王植物蛋白有限公司 一种大豆乳清蛋白的生产工艺
CN110623243B (zh) * 2019-09-11 2023-03-31 内蒙古蒙牛乳业（集团）股份有限公司 高钙盐类复合物及其制备方法
CN118909086B (zh) * 2024-10-12 2025-01-24 安徽天凯生物科技有限公司 一种分离α-乳白蛋白、β-乳球蛋白的方法

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Also Published As

Publication number Publication date
AR106315A2 (es) 2018-01-03
AU2007266951B2 (en) 2012-05-31
AR061429A1 (es) 2008-08-27
JP5279087B2 (ja) 2013-09-04
CA2652495C (fr) 2017-02-14
KR20150008455A (ko) 2015-01-22
JP2013163689A (ja) 2013-08-22
WO2007138198A2 (fr) 2007-12-06
TWI394534B (zh) 2013-05-01
AU2007266951A1 (en) 2007-12-06
CA2652495A1 (fr) 2007-12-06
KR20090028694A (ko) 2009-03-19
CN101501059A (zh) 2009-08-05
IL195183A0 (en) 2011-08-01
CN101501059B (zh) 2014-05-14
CN103910779A (zh) 2014-07-09
US20100047428A1 (en) 2010-02-25
EP2038296A2 (fr) 2009-03-25
BRPI0712005A2 (pt) 2012-02-14
AU2007266951C1 (en) 2013-02-28
KR101593494B1 (ko) 2016-02-15
FR2901796A1 (fr) 2007-12-07
JP2009538884A (ja) 2009-11-12
TW200808188A (en) 2008-02-16
KR101579811B1 (ko) 2015-12-24

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