WO2007140584A1 - ProcÉdÉ et appareil de traitement de l'apnÉe et des ronflements pendant le sommeil - Google Patents

ProcÉdÉ et appareil de traitement de l'apnÉe et des ronflements pendant le sommeil Download PDF

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Publication number
WO2007140584A1
WO2007140584A1 PCT/CA2007/000966 CA2007000966W WO2007140584A1 WO 2007140584 A1 WO2007140584 A1 WO 2007140584A1 CA 2007000966 W CA2007000966 W CA 2007000966W WO 2007140584 A1 WO2007140584 A1 WO 2007140584A1
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WO
WIPO (PCT)
Prior art keywords
stimulation signal
pulses
episode
person
snoring
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2007/000966
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English (en)
Inventor
William Toderan
Franco Villa
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Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2007140584A1 publication Critical patent/WO2007140584A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
    • A61F5/56—Devices for preventing snoring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs

Definitions

  • This invention relates to apparatus for treating snoring and obstructive sleep apnea, or either of them, and also relates to a method of treatment of these conditions, using electrical stimulation. Background of the invention
  • Snoring is a condition commonly caused by a partial obstruction of the upper airway, in which the airflow causes the obstructing tissue to resonate, resulting in characteristic and well-known snoring sounds.
  • Snoring can be a major disruptive agent in relationships where one person is subjected to the sleep disturbing effects which the snoring partner causes.
  • Obstructive sleep apnea is a more serious medical condition caused by a more pronounced obstruction such that the airflow during breathing is severely restricted or is completely interrupted. This condition causes a degraded sleep pattern and reduced blood oxygenation and is believed to have the potential for producing serious medical problems, including cardiovascular complications.
  • the invention provides an apparatus for treating an obstruction of the upper airway of a person, such condition causing an episode of either snoring or obstructive sleep apnea, said apparatus comprising: a) a sensor for sensing the onset of a said episode, b) a stimulation signal generator coupled to said sensor and responsive thereto for generating a stimulation signal for application to said person, said stimulation signal comprising a series of pulses, c) said generator including a ramping device for initiating the generation of said stimulation signal at a selected intensity and then for increasing said intensity with time as said stimulation signal is applied to said person, d) a sensor for detecting the end of said episode and being coupled to said generator for terminating the application of said stimulation signal to said person following the end of said episode.
  • the invention provides a method of treating a person having an obstruction of the upper airway causing the onset of either a snoring or an obstructive sleep apnea episode, comprising:
  • Fig. 1 is a plan view of the front part of a neck strap which supports components of a system according to the invention;
  • Fig. 2 is a block diagram of the detection part of a circuit for the
  • FIG. 3 is a block diagram of a pulse generating and shaping part of the Fig. 1 system
  • FIG. 4 is a plan view of the front part of a chest strap housing components of a system according to the invention.
  • Fig. 5 is a block diagram of the detection part of the circuit of the
  • Fig. 6 is a block diagram of the pulse generating and shaping part of the circuit of the Fig. 4 system. Detailed description of preferred embodiments
  • Fig. 1 is a plan view of a neck strap 10 for use with the present invention.
  • the neck strap 10 includes a main substrate 12 of woven material with a sufficiently open weave to allow for evaporation of skin moisture.
  • the neck strap 10 supports conductive pads 14, 16 in spaced apart relation, a microphone 18, a battery 20, and an electronic circuit module 22 with a slide power switch 24 on one side of the module.
  • the neck strap 10 does not need to apply more than a gentle pressure on the skin, since voltages may be used which are sufficiently elevated to overcome high resistivity in the pad-to-skin contacts.
  • Fig. 2 is a block diagram of a detection circuit 30 which forms part of the circuit module 22.
  • the detection circuit 30 detects snoring and sleep apnea episodes.
  • signal from the microphone 18 is amplified by an amplifier 32 and is then applied in two branches to bandpass filters 34, 36 which extract telltale signatures respectively of snoring and breathing activity.
  • bandpass filters 34, 36 which extract telltale signatures respectively of snoring and breathing activity.
  • Various types of signal processing are well-known to those skilled in the art to detect snoring activity and breathing activity and to filter out extraneous signal components.
  • the snoring signal is directed to full wave rectifier 38 and then to internally referenced comparator 40, which outputs a logic one if snoring is sensed.
  • the breathing signal from bandpass filter 36 is rectified by full wave rectifier 44, the output of which is directed to internally referenced comparator 46 which outputs logic one if the acoustic signature of airflow is detected.
  • the output of the comparator 46 is used to reset a timer 48, the output of which is set to go high after an interval of 4-6 seconds following any reset. Respiration cycles are typically 4-6 seconds, and therefore the timer 48 is reset every equivalent time interval (i.e. every respiration cycle). Thus, the timer 48 will output a logic one signal if a breathing pattern is not detected for more than six seconds.
  • Snoring and apnea events characterized by output high or logic one from the comparator 46 and the timer 48 are directed to the inputs of OR gate 54, which outputs a signal at terminal 56 for a pulse generator (to be described) to initiate stimulation of the subject person.
  • Fig. 3 is a block diagram of the pulse generating and shaping part 58 of the electronic circuit module 22.
  • Information to initiate stimulation namely, a logic one signal at terminal 56, sets astable oscillator 60 running and generating a square wave 62 with a pulse repetition rate of 3-10 pulses per second.
  • the square wave 62 is applied to a Schmitt inverter 64 via an RC network of capacitor 70 and resistor 72, with a time constant ranging preferably between 40 microseconds and 200 milliseconds.
  • the output of inverter 64 is a square wave pulse train 74 with pulse width equivalent to the time constant of the input network.
  • the pulse train 74 is directed to the input of another Schmitt inverter 76 which inverts the phase of its input pulses and outputs a pulse train 78.
  • the two phases 74, 78 are applied to photo MOS network 80 to process the high voltage applied to the network at connection 82 (as will be described).
  • capacitor 84 through a resistor 86, the values of these components being chosen so that a time constant of 3-6 seconds is achieved.
  • the rising voltage at capacitor 84 is applied to the negative input of a comparator 90, the output of which is directed to control the start-stop mode of a high voltage inverter 92, which runs when its control is at logic zero.
  • inverter 92 When inverter 92 is operational, its output is rectified by diode 94 and is stored in capacitor 96 which may typically have a value of 0.22 microfarad.
  • the resultant DC high voltage at terminal 82 is presented to photo MOS switches 80, which output pulses of alternating polarity having the frequency and width of the controlling pulses from Schmitt inverters 64, 76 and having the amplitude of the input DC high voltage at terminal 82.
  • the outputs 98 of the switches 80 are connected to the stimulating pads 14, 16.
  • High voltage at terminal 82 is also connected to a voltage divider consisting of resistors 100, 102.
  • the output terminal 104 of the voltage divider is connected to the positive input of comparator 90, thus forming a feedback circuit.
  • This feedback circuit will lock the value of the high voltage at terminal 82 to that of the voltage at capacitor 84, with the relationship of 1 to
  • the detection circuit 30 outputs a logic zero and the stimulation signal is interrupted (by ceasing to rise, and instead decreasing), thus minimizing the disturbance to the subject person's sleep.
  • the conductive pads 14, 16 through which the stimulation is applied preferably each have an active surface area of 1-5 cm 2 and are preferably positioned approximately 5-10 cm apart symmetrically to the muscle group to be stimulated. However, these parameters are not critical.
  • the system is tolerant of axial offset between the stimulated region and the position of the pads, although preferably the offset is made equivalent to the spacing between the pads.
  • the stimulation pulses applied to the subject person may be of relatively high voltage
  • the short duration of the pulses ensures that the overall integrated energy of each pulse is limited to values that are a fraction of a millijoule.
  • the high surface area of the pads 14, 16 ensures that the current density at skin level will be kept sufficiently low to avoid disturbing the subject person with the perception of an electric shock.
  • the stimulation pulses are of alternating polarity, they will not cause electrolytic polarization in the subject person's tissue, which would gradually desensitize the subject person's physiological response to the stimulus.
  • the neck strap 10 may be fastened by any desired means, e.g. hook and loop pads (not shown) attached to the ends of the strap.
  • the components described may be attached to a chest strap 10' as shown in Fig. 4, the chest strap 10' being fastened (by any desired means) around the chest of the subject.
  • the main substrate 12' of the chest strap is preferably a woven material with sufficiently open weave to allow skin moisture to evaporate.
  • the center portion 112 of the chest strap may be of stretchable material, to allow for mechanical loading of a strain gauge 112 which is preferably connected to the non-stretchable material at 114, at each side of the stretchable patch 110.
  • Fig. 4 Unlike the Fig. 1 embodiment, where the same microphone 18 is used for detection of both snoring and sleep apnea conditions, in the Fig. 4 embodiment only snoring is detected by the microphone 18. The presence or absence of breathing is detected by strain gauge 112 in response to chest movements. The output of strain gauge 112 is sent directly to the positive input of comparator 44' shown in Fig. 5. The negative input of the comparator 44' is connected to an integrating network of resistor 116 and capacitor 118 having a time constant of 120 seconds. The output of this network supplies the comparator 44' with a baseline reference which tracks variations in the mechanical bias of the strain gauge 112.
  • timer 48' the output of which becomes high six seconds following reset, thus outputting a logic one signal if inhalation does not occur for more than six seconds.
  • the output of timer 48" is connected to one input of AND gate 120 and the other input 122 is connected to the output of another timer 124, which outputs a logic one signal 120 seconds following circuit power-up.
  • This arrangement disables apnea sensing for the initial 120 seconds after circuit power up, in order for baseline reference at capacitor 118 to stabilize. After the initial delay, a breathing interruption of more than six seconds will cause the output of AND gate 120 to be high. Circuit and sleep apnea information are thus present at terminal 56', at the output of OR gate 54'.
  • Fig. 5 is the part of the circuit which generates and shapes stimulation pulses for application to the subject person and is identical to the circuit of Fig. 3 except for the use of primed reference numerals.
  • the device of the invention may be attached to an appropriate garment, such as a t-shirt.
  • Different processing means may be used, e.g. appropriate integrated logic chips in place of the discrete circuit components shown.
  • Various muscles or muscle groups may be stimulated to terminate snoring or a sleep apnea episode.
  • the stimulation signal applied may, when the snoring or sleep apnea episode has ended, be decreased to zero or a low level over a short time (as described), or it may be rapidly totally switched off. Further changes may be made without departing from the scope of the present invention.

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Nursing (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)

Abstract

L'invention concerne un procédé et un dispositif pour le traitement des ronflements et de l'apnée obstructive pendant le sommeil, dans lesquels un ou plusieurs détecteurs détectent l'apparition d'un épisode de ronflement ou d'apnée pendant le sommeil et entraînent la production d'un signal électrique de stimulation constitué d'un train d'impulsions alternées. L'intensité des impulsions augmente progressivement d'un niveau bas à un niveau suffisamment élevé pour arrêter l'épisode. La fin de l'épisode est détectée et le signal de stimulation est ensuite progressivement diminué ou débranché. Par conséquent, lorsque l'intensité du signal de stimulation est devenue suffisamment élevée pour arrêter l'épisode indésirable, l'intensité n'augmente pas au-delà de ce qui est nécessaire dans ce but. Par conséquent, le signal de stimulation est moins susceptible de perturber le sommeil de la personne traitée.
PCT/CA2007/000966 2006-06-02 2007-05-31 ProcÉdÉ et appareil de traitement de l'apnÉe et des ronflements pendant le sommeil Ceased WO2007140584A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81017406P 2006-06-02 2006-06-02
US60/810,174 2006-06-02

Publications (1)

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WO2007140584A1 true WO2007140584A1 (fr) 2007-12-13

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Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7725195B2 (en) 2006-02-16 2010-05-25 Imthera Medical, Inc. RFID-based apparatus, system, and method for therapeutic treatment of obstructive sleep apnea
US8428725B2 (en) 2008-10-09 2013-04-23 Imthera Medical, Inc. Method of stimulating a Hypoglossal nerve for controlling the position of a patient's tongue
US8886322B2 (en) 2009-11-10 2014-11-11 Imthera Medical, Inc. System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue
WO2016094390A1 (fr) * 2014-12-08 2016-06-16 Coats Andrew Justin Stewarts Dispositif anti-ronflement à induction magnétique
US9849288B2 (en) 2007-10-09 2017-12-26 Imthera Medical, Inc. Apparatus, system, and method for selective stimulation
WO2019014715A1 (fr) 2017-07-17 2019-01-24 Health Apps Pty Ltd Système d'aide à la détection et à la prise en charge précoces de troubles associés à la respiration
US11185690B2 (en) 2016-05-23 2021-11-30 BTL Healthcare Technologies, a.s. Systems and methods for tissue treatment
US11247039B2 (en) 2016-05-03 2022-02-15 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11247063B2 (en) 2019-04-11 2022-02-15 Btl Healthcare Technologies A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US11253718B2 (en) 2015-07-01 2022-02-22 Btl Healthcare Technologies A.S. High power time varying magnetic field therapy
US11253717B2 (en) 2015-10-29 2022-02-22 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
US11266852B2 (en) 2016-07-01 2022-03-08 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
US11464993B2 (en) 2016-05-03 2022-10-11 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11464994B2 (en) 2016-05-10 2022-10-11 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11484727B2 (en) 2016-07-01 2022-11-01 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11491342B2 (en) 2015-07-01 2022-11-08 Btl Medical Solutions A.S. Magnetic stimulation methods and devices for therapeutic treatments
US11491329B2 (en) 2020-05-04 2022-11-08 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11534619B2 (en) 2016-05-10 2022-12-27 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11612758B2 (en) 2012-07-05 2023-03-28 Btl Medical Solutions A.S. Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields
US11633596B2 (en) 2020-05-04 2023-04-25 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11896816B2 (en) 2021-11-03 2024-02-13 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US12064163B2 (en) 2021-10-13 2024-08-20 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US12156689B2 (en) 2019-04-11 2024-12-03 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US12274494B2 (en) 2016-08-16 2025-04-15 Btl Healthcare Technologies A.S. Treatment device
US12558146B2 (en) 2019-04-11 2026-02-24 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US12564726B1 (en) 2024-10-08 2026-03-03 Btl Medical Solutions A.S. Devices and methods for application of a magnetic field to the nervous system
US12611545B2 (en) 2023-08-01 2026-04-28 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient

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Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7937159B2 (en) 2006-02-16 2011-05-03 Imthera Medical Inc. Apparatus, system and method for therapeutic treatment of obstructive sleep apnea
US7725195B2 (en) 2006-02-16 2010-05-25 Imthera Medical, Inc. RFID-based apparatus, system, and method for therapeutic treatment of obstructive sleep apnea
US9849288B2 (en) 2007-10-09 2017-12-26 Imthera Medical, Inc. Apparatus, system, and method for selective stimulation
US11351364B2 (en) 2007-10-09 2022-06-07 Imthera Medical, Inc. Apparatus, system, and method for selective stimulation
US10646714B2 (en) 2007-10-09 2020-05-12 Imthera Medical, Inc. Apparatus, system, and method for selective stimulation
US9884191B2 (en) 2007-10-09 2018-02-06 Imthera Medical, Inc. Apparatus, system, and method for selective stimulation
US10279185B2 (en) 2008-10-09 2019-05-07 Imthera Medical, Inc. Method of stimulating a hypoglossal nerve for controlling the position of a patient's tongue
US9895541B2 (en) 2008-10-09 2018-02-20 Imthera Medical, Inc. Method of stimulating a hypoglossal nerve for controlling the position of a patients tongue
US8428725B2 (en) 2008-10-09 2013-04-23 Imthera Medical, Inc. Method of stimulating a Hypoglossal nerve for controlling the position of a patient's tongue
US9579505B2 (en) 2008-10-09 2017-02-28 Imthera Medical, Inc. Method of stimulating a hypoglossal nerve for controlling the position of a patient's tongue
US8751005B2 (en) 2008-10-09 2014-06-10 Imthera Medical, Inc. Method of stimulating a hypoglossal nerve for controlling the position of a patients tongue
US9314641B2 (en) 2008-10-09 2016-04-19 Imthera Medical, Inc. Method of stimulating a hypoglossal nerve for controlling the position of a patient's tongue
US9031654B2 (en) 2008-10-09 2015-05-12 Imthera Medical, Inc. Method of stimulating a hypoglossal nerve for controlling the position of a patient's tongue
US8886322B2 (en) 2009-11-10 2014-11-11 Imthera Medical, Inc. System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue
US10195436B2 (en) 2009-11-10 2019-02-05 Imthera Medical, Inc. System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue
US9662497B2 (en) 2009-11-10 2017-05-30 Imthera Medical, Inc System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue
US9339651B2 (en) 2009-11-10 2016-05-17 Imthera Medical, Inc. System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue
US11612758B2 (en) 2012-07-05 2023-03-28 Btl Medical Solutions A.S. Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields
WO2016094390A1 (fr) * 2014-12-08 2016-06-16 Coats Andrew Justin Stewarts Dispositif anti-ronflement à induction magnétique
US11491342B2 (en) 2015-07-01 2022-11-08 Btl Medical Solutions A.S. Magnetic stimulation methods and devices for therapeutic treatments
US11266850B2 (en) 2015-07-01 2022-03-08 Btl Healthcare Technologies A.S. High power time varying magnetic field therapy
US11253718B2 (en) 2015-07-01 2022-02-22 Btl Healthcare Technologies A.S. High power time varying magnetic field therapy
US11253717B2 (en) 2015-10-29 2022-02-22 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
US11464993B2 (en) 2016-05-03 2022-10-11 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11247039B2 (en) 2016-05-03 2022-02-15 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
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US11484727B2 (en) 2016-07-01 2022-11-01 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
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US11679270B2 (en) 2016-07-01 2023-06-20 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11497925B2 (en) 2016-07-01 2022-11-15 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11794029B2 (en) 2016-07-01 2023-10-24 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11266852B2 (en) 2016-07-01 2022-03-08 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
US11524171B2 (en) 2016-07-01 2022-12-13 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US12274494B2 (en) 2016-08-16 2025-04-15 Btl Healthcare Technologies A.S. Treatment device
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WO2019014715A1 (fr) 2017-07-17 2019-01-24 Health Apps Pty Ltd Système d'aide à la détection et à la prise en charge précoces de troubles associés à la respiration
CN111200997A (zh) * 2017-07-17 2020-05-26 健康应用程序有限公司 一种呼吸相关疾病的辅助早期检测和管理系统
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