WO2007146261A3 - Biomolecule-linked biomimetic scaffolds - Google Patents

Biomolecule-linked biomimetic scaffolds Download PDF

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Publication number
WO2007146261A3
WO2007146261A3 PCT/US2007/013736 US2007013736W WO2007146261A3 WO 2007146261 A3 WO2007146261 A3 WO 2007146261A3 US 2007013736 W US2007013736 W US 2007013736W WO 2007146261 A3 WO2007146261 A3 WO 2007146261A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomolecule
linked
covalently
biomimetic scaffolds
nanofiber polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/013736
Other languages
French (fr)
Other versions
WO2007146261A2 (en
Inventor
Craig Hashi
Song Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2007/061253 external-priority patent/WO2007090102A2/en
Priority to EP07795989A priority Critical patent/EP2023852A4/en
Priority to MX2008015695A priority patent/MX2008015695A/en
Priority to RU2009100654/14A priority patent/RU2009100654A/en
Priority to CA002654840A priority patent/CA2654840A1/en
Priority to AU2007258379A priority patent/AU2007258379A1/en
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Priority to JP2009514426A priority patent/JP2009540878A/en
Publication of WO2007146261A2 publication Critical patent/WO2007146261A2/en
Publication of WO2007146261A3 publication Critical patent/WO2007146261A3/en
Priority to IL195801A priority patent/IL195801A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A61L33/0082—Chemical modification of the substrate by reacting with an organic compound other than heparin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

The invention provides a composition comprising a nanofiber polymer in which the fibers of the nanofiber polymer are aligned, and a molecule is covalently attached, either directly or through a linker, to the nanofiber polymer. This molecule is capable of either covalently or non-covalently attaching to a member selected from an extracellular matrix component, a growth factor, and combinations thereof. The invention also provides methods of making the composition and methods of using the compositions to add new tissue to a subject, such as a human.
PCT/US2007/013736 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds Ceased WO2007146261A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2009514426A JP2009540878A (en) 2006-06-09 2007-06-11 Biomimetic scaffolds with biomolecules attached
MX2008015695A MX2008015695A (en) 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds.
RU2009100654/14A RU2009100654A (en) 2006-06-09 2007-06-11 BIOMIMETIC FRAMES WITH ATTACHED BIOMOLECULES
CA002654840A CA2654840A1 (en) 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds
AU2007258379A AU2007258379A1 (en) 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds
EP07795989A EP2023852A4 (en) 2006-06-09 2007-06-11 BIOMIMETIC SKELETONS RELATED TO A BIOMOLECULE
IL195801A IL195801A0 (en) 2006-06-09 2008-12-08 Biomolecule-linked biomimetic scaffolds

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US80435006P 2006-06-09 2006-06-09
US60/804,350 2006-06-09
US86178006P 2006-11-30 2006-11-30
US60/861,780 2006-11-30
PCT/US2007/061253 WO2007090102A2 (en) 2006-01-27 2007-01-29 Biomimetic scaffolds
USPCT/US2007/016253 2007-01-29
US11/668,448 US20070269481A1 (en) 2006-01-27 2007-01-29 Biomimetic Scaffolds
US11/668,448 2007-01-29
US92492607P 2007-06-05 2007-06-05
US60/924,926 2007-06-05

Publications (2)

Publication Number Publication Date
WO2007146261A2 WO2007146261A2 (en) 2007-12-21
WO2007146261A3 true WO2007146261A3 (en) 2008-12-04

Family

ID=40243723

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/013736 Ceased WO2007146261A2 (en) 2006-06-09 2007-06-11 Biomolecule-linked biomimetic scaffolds

Country Status (9)

Country Link
EP (1) EP2023852A4 (en)
JP (1) JP2009540878A (en)
KR (1) KR20090024249A (en)
AU (1) AU2007258379A1 (en)
CA (1) CA2654840A1 (en)
IL (1) IL195801A0 (en)
MX (1) MX2008015695A (en)
RU (1) RU2009100654A (en)
WO (1) WO2007146261A2 (en)

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WO2007090102A2 (en) * 2006-01-27 2007-08-09 The Regents Of The University Of California Biomimetic scaffolds
EP2341865A4 (en) 2008-10-07 2014-01-08 Nanonerve Inc Multilayer fibrous polymer scaffolds, methods of production and methods of use
WO2010065265A2 (en) 2008-11-25 2010-06-10 Edwards Lifesciences Corporation Apparatus and method for in situ expansion of prosthetic device
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
WO2011127478A1 (en) 2010-04-09 2011-10-13 Nanovasc, Inc. Sleeve for graft and method
BR112012026882A2 (en) * 2010-05-17 2015-09-22 Pall Corp systems for sowing cells on three-dimensional supports
US9090863B2 (en) 2010-05-17 2015-07-28 Pall Corporation System for seeding cells onto three dimensional scaffolds
EP2412798A1 (en) * 2010-07-27 2012-02-01 Gambro Lundia AB Biomimetic membrane for cell expansion
EP2646065A4 (en) 2010-12-05 2016-03-23 Nanonerve Inc Fibrous polymer scaffolds having diametrically patterned polymer fibers
EP2661243B1 (en) * 2011-01-06 2022-10-12 Humacyte, Inc. Tissue-engineered constructs
CN102698323B (en) * 2012-05-14 2014-07-23 西南交通大学 Preparation method of anticlotting materials
ES2470495B1 (en) 2012-12-19 2015-05-14 Universidad De Castilla La Mancha Materials, methods and devices to stimulate and direct the proliferation and migration of neural progenitors and axonal and dendritic growth
KR101526308B1 (en) * 2013-01-23 2015-06-09 아주대학교산학협력단 Biomaterials containing contrast agent for tracing polymer in vivo and method for preparing the same
CN106103821B (en) 2014-02-14 2018-03-02 日产化学工业株式会社 Active ester group-containing fiber production composition and cell culture scaffold material using the same
CN104153123B (en) * 2014-07-30 2016-08-24 东华大学 A kind of flexible TiOx nano fibrous membrane and preparation method thereof
CN104153124B (en) * 2014-07-30 2016-11-02 东华大学 A kind of flexible rare-earth oxide nanofiber film and preparation method thereof
WO2016022797A1 (en) 2014-08-06 2016-02-11 Edwards Lifesciences Corporation Multi-lumen cannulae
KR102772441B1 (en) 2015-08-17 2025-02-26 더 존스 홉킨스 유니버시티 Mesenchymal cell-bound composite materials for tissue restoration
WO2017031171A1 (en) * 2015-08-17 2017-02-23 The Johns Hopkins University In situ forming composite material for tissue restoration
CA2995855C (en) 2015-09-02 2024-01-30 Edwards Lifesciences Corporation Spacer for securing a transcatheter valve to a bioprosthetic cardiac structure
WO2017062375A1 (en) * 2015-10-05 2017-04-13 The Regents Of The University Of California Thermoreversible polymers and methods of use thereof
US10456245B2 (en) 2016-05-16 2019-10-29 Edwards Lifesciences Corporation System and method for applying material to a stent
SG11201809053UA (en) * 2016-05-16 2018-11-29 Edwards Lifesciences Corp System and method for applying material to a stent
USD846122S1 (en) 2016-12-16 2019-04-16 Edwards Lifesciences Corporation Heart valve sizer
WO2019147497A1 (en) 2018-01-23 2019-08-01 Edwards Lifesciences Corporation Prosthetic valve holders, systems, and methods
KR20210034544A (en) 2018-05-09 2021-03-30 더 존스 홉킨스 유니버시티 Nanofiber-hydrogel composite material for improved soft tissue replacement and regeneration
JP2021522938A (en) 2018-05-09 2021-09-02 ザ ジョンズ ホプキンス ユニバーシティ Nanofiber-hydrogel complex for cell and tissue delivery
USD908874S1 (en) 2018-07-11 2021-01-26 Edwards Lifesciences Corporation Collapsible heart valve sizer
EP4009906A1 (en) 2019-08-05 2022-06-15 Edwards Lifesciences Corporation Heart valve deployment aid
CN110548187A (en) * 2019-09-16 2019-12-10 生纳科技(上海)有限公司 Instant puncture dialysis type nanofiber artificial blood vessel
CA3143382A1 (en) 2019-09-27 2021-04-01 Edwards Lifesciences Corporation Modified prosthetic heart valve stent
CN121371320A (en) * 2025-12-23 2026-01-23 四川大学华西医院 Bionic tissue equivalent patch based on nano CRISPR assistance, preparation method and application

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US5607475A (en) * 1995-08-22 1997-03-04 Medtronic, Inc. Biocompatible medical article and method
US5990379A (en) * 1994-11-15 1999-11-23 Kenton W. Gregory & Sisters Of Providence Prosthetic devices including elastin or elastin-based materials
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WO2007090102A2 (en) * 2006-01-27 2007-08-09 The Regents Of The University Of California Biomimetic scaffolds

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US5990379A (en) * 1994-11-15 1999-11-23 Kenton W. Gregory & Sisters Of Providence Prosthetic devices including elastin or elastin-based materials
US5607475A (en) * 1995-08-22 1997-03-04 Medtronic, Inc. Biocompatible medical article and method
US6889082B2 (en) * 1997-10-09 2005-05-03 Orqis Medical Corporation Implantable heart assist system and method of applying same
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6753311B2 (en) * 2000-06-23 2004-06-22 Drexel University Collagen or collagen-like peptide containing polymeric matrices
US6893431B2 (en) * 2001-10-15 2005-05-17 Scimed Life Systems, Inc. Medical device for delivering patches

Also Published As

Publication number Publication date
CA2654840A1 (en) 2007-12-21
EP2023852A2 (en) 2009-02-18
AU2007258379A1 (en) 2007-12-21
EP2023852A4 (en) 2012-06-27
KR20090024249A (en) 2009-03-06
IL195801A0 (en) 2009-09-01
MX2008015695A (en) 2009-02-06
WO2007146261A2 (en) 2007-12-21
RU2009100654A (en) 2010-07-20
JP2009540878A (en) 2009-11-26

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