WO2008008024A3 - Formes polymorphes de chlorhydrate de spirapril - Google Patents

Formes polymorphes de chlorhydrate de spirapril Download PDF

Info

Publication number
WO2008008024A3
WO2008008024A3 PCT/GB2007/002653 GB2007002653W WO2008008024A3 WO 2008008024 A3 WO2008008024 A3 WO 2008008024A3 GB 2007002653 W GB2007002653 W GB 2007002653W WO 2008008024 A3 WO2008008024 A3 WO 2008008024A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymorphic forms
spirapril hydrochloride
spirapril
hydrochloride
new polymorphic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/002653
Other languages
English (en)
Other versions
WO2008008024A9 (fr
WO2008008024A2 (fr
Inventor
Aleksandar Danilovski
Maja Devcic
Marina Marinkovic
Ernest Mestrovic
Tina Mundofer
Petar Tudja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Hrvatska doo
Original Assignee
Pliva Hrvatska doo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Hrvatska doo filed Critical Pliva Hrvatska doo
Priority to EP07848377A priority Critical patent/EP2069360A2/fr
Publication of WO2008008024A2 publication Critical patent/WO2008008024A2/fr
Publication of WO2008008024A9 publication Critical patent/WO2008008024A9/fr
Publication of WO2008008024A3 publication Critical patent/WO2008008024A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des nouvelles formes polymorphes de chlorhydrate de spirapril, des procédés de préparation de ces nouvelles formes polymorphes, des compositions pharmaceutiques contenant ces nouvelles formes polymorphes, l'utilisation thérapeutique de celles-ci ainsi que des méthodes de traitement les faisant intervenir.
PCT/GB2007/002653 2006-07-13 2007-07-13 Formes polymorphes de chlorhydrate de spirapril Ceased WO2008008024A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07848377A EP2069360A2 (fr) 2006-07-13 2007-07-13 Formes polymorphes de chlorhydrate de spirapril

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0613927.3 2006-07-13
GBGB0613927.3A GB0613927D0 (en) 2006-07-13 2006-07-13 Pharmaceutically acceptable salt and polymorphic forms

Publications (3)

Publication Number Publication Date
WO2008008024A2 WO2008008024A2 (fr) 2008-01-17
WO2008008024A9 WO2008008024A9 (fr) 2008-03-13
WO2008008024A3 true WO2008008024A3 (fr) 2009-02-12

Family

ID=36955585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002653 Ceased WO2008008024A2 (fr) 2006-07-13 2007-07-13 Formes polymorphes de chlorhydrate de spirapril

Country Status (4)

Country Link
EP (1) EP2069360A2 (fr)
DE (2) DE202007019054U1 (fr)
GB (1) GB0613927D0 (fr)
WO (1) WO2008008024A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4470972A (en) * 1981-04-28 1984-09-11 Schering Corporation 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
US4847384A (en) * 1987-03-12 1989-07-11 Sandoz Pharm. Corp. Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403593A (en) 1991-03-04 1995-04-04 Sandoz Ltd. Melt granulated compositions for preparing sustained release dosage forms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4470972A (en) * 1981-04-28 1984-09-11 Schering Corporation 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
US4847384A (en) * 1987-03-12 1989-07-11 Sandoz Pharm. Corp. Process for the preparation of certain nitrogen-containing mono- and bicyclic ace inhibitors, and novel intermediates useful therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SMITH E M ET AL: "ANGIOSTENSIN CONVERTING ENZYME INHIBITOR: SPIRAPRIL AND RELATED COMPOUNDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 32, no. 7, 1989, pages 1600 - 1606, XP000961168, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
DE102007032613A1 (de) 2008-01-24
EP2069360A2 (fr) 2009-06-17
GB0613927D0 (en) 2006-08-23
WO2008008024A9 (fr) 2008-03-13
WO2008008024A2 (fr) 2008-01-17
DE202007019054U1 (de) 2010-05-12

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