WO2008020332A3 - Procédé de préparation de tartrate de (r)-tolterodine - Google Patents

Procédé de préparation de tartrate de (r)-tolterodine Download PDF

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Publication number
WO2008020332A3
WO2008020332A3 PCT/IB2007/003377 IB2007003377W WO2008020332A3 WO 2008020332 A3 WO2008020332 A3 WO 2008020332A3 IB 2007003377 W IB2007003377 W IB 2007003377W WO 2008020332 A3 WO2008020332 A3 WO 2008020332A3
Authority
WO
WIPO (PCT)
Prior art keywords
tolterodine
formula
order
reacted
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/003377
Other languages
English (en)
Spanish (es)
Other versions
WO2008020332A2 (fr
Inventor
Sanchez Patricia Flores
Quevedo Salvador Adrian Avila
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Uquifa Mexico SA de CV
Original Assignee
Uquifa Mexico SA de CV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uquifa Mexico SA de CV filed Critical Uquifa Mexico SA de CV
Publication of WO2008020332A2 publication Critical patent/WO2008020332A2/fr
Publication of WO2008020332A3 publication Critical patent/WO2008020332A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procédé de préparation de tartrate de (R)-tolterodine qui comprend la réduction d'une benzopyranone de formule 1 avec du borohydrure de sodium afin d'obtenir un dialcool de formule 12; la réaction des groupes hydroxyle du dialcool avec du chlorure de mésyle afin d'introduire deux groupes de méthane sulfonyle et former un composé dimésylé avec un di-isopropylamine sous pression, puis avec un hydroxyde de sodium afin d'obtenir une tolterodine de base à partir du brome hydrate et la réaction ultérieure de celle-ci avec un acide (+)- tartarique afin d'obtenir le tartrate de (R)-tolterodine.
PCT/IB2007/003377 2006-07-04 2007-06-29 Procédé de préparation de tartrate de (r)-tolterodine Ceased WO2008020332A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXPA06007686A MXPA06007686A (es) 2006-07-04 2006-07-04 Proceso para la obtencion del tartrato de tolterodina.
MXPA/A/2006/007686 2006-07-04

Publications (2)

Publication Number Publication Date
WO2008020332A2 WO2008020332A2 (fr) 2008-02-21
WO2008020332A3 true WO2008020332A3 (fr) 2008-05-29

Family

ID=39031182

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003377 Ceased WO2008020332A2 (fr) 2006-07-04 2007-06-29 Procédé de préparation de tartrate de (r)-tolterodine

Country Status (3)

Country Link
ES (1) ES2291135B1 (fr)
MX (1) MXPA06007686A (fr)
WO (1) WO2008020332A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010046801A2 (fr) * 2008-10-21 2010-04-29 Alembic Limited Procédé de préparation de tartrate de tolterodine
CN101445462B (zh) * 2008-12-29 2011-05-25 药源药物化学（上海）有限公司 托特罗定及其酒石酸盐的制备方法
EP2476665A1 (fr) 2011-01-17 2012-07-18 Cambrex Profarmaco Milano S.r.l. Procédé pour la préparation de N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine et ses sels démarrant à partir d'un nouvel intermédiaire
WO2012098044A1 (fr) 2011-01-17 2012-07-26 Cambrex Profarmaco Milano S.R.L. Procédé pour la préparation de n,n-diisopropyl-3-(2-hydroxy-5-méthylphényl)-3-phénylpropylamine et de ses sels à partir d'un nouvel intermédiaire

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014060A1 (fr) * 2001-08-03 2003-02-20 Ranbaxy Laboratories Limited Procede de preparation de tolterodine
CZ293791B6 (cs) * 2003-06-05 2004-07-14 Zentiva, A.S. Způsob výroby N,N-diisopropyl-3-(2-hydroxy-5-methylfenyl)-3-fenylpropylaminu v jeho racemické nebo opticky aktivní formě
US20060079716A1 (en) * 2004-10-11 2006-04-13 Chemi Spa Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine
US20060094904A1 (en) * 2004-10-28 2006-05-04 Sundaram Venkataraman Process for preparing tolterodine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014060A1 (fr) * 2001-08-03 2003-02-20 Ranbaxy Laboratories Limited Procede de preparation de tolterodine
CZ293791B6 (cs) * 2003-06-05 2004-07-14 Zentiva, A.S. Způsob výroby N,N-diisopropyl-3-(2-hydroxy-5-methylfenyl)-3-fenylpropylaminu v jeho racemické nebo opticky aktivní formě
US20060079716A1 (en) * 2004-10-11 2006-04-13 Chemi Spa Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine
US20060094904A1 (en) * 2004-10-28 2006-05-04 Sundaram Venkataraman Process for preparing tolterodine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CAS [online] LUPIN LMT; 9 June 2006 (2006-06-09), accession no. cas on stn Database accession no. (2007:397369) *

Also Published As

Publication number Publication date
WO2008020332A2 (fr) 2008-02-21
ES2291135A1 (es) 2008-02-16
MXPA06007686A (es) 2008-01-07
ES2291135B1 (es) 2008-12-16

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