WO2008021048A3 - Procédés et compositions fondés sur l'adp-ribosyltransférase - Google Patents

Procédés et compositions fondés sur l'adp-ribosyltransférase Download PDF

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Publication number
WO2008021048A3
WO2008021048A3 PCT/US2007/017461 US2007017461W WO2008021048A3 WO 2008021048 A3 WO2008021048 A3 WO 2008021048A3 US 2007017461 W US2007017461 W US 2007017461W WO 2008021048 A3 WO2008021048 A3 WO 2008021048A3
Authority
WO
WIPO (PCT)
Prior art keywords
adp
ribosyltransferase
compositions
based methods
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/017461
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English (en)
Other versions
WO2008021048A2 (fr
Inventor
David A Sinclair
Ron Firestein
Basil Hubbard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of WO2008021048A2 publication Critical patent/WO2008021048A2/fr
Publication of WO2008021048A3 publication Critical patent/WO2008021048A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91142—Pentosyltransferases (2.4.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des procédés permettant d'identifier des agents qui modulent l'activité des ADP-ribosyltransférases de type sirtuine, notamment la Sirt4 et la Sirt6. L'invention concerne également des procédés permettant de traiter une maladie hyperproliférative, consistant, par exemple, à administrer à un sujet nécessitant des soins un agent qui réduit l'activité ou le niveau protéique d'une ADP-ribosyltransférase, notamment la Sirt6.
PCT/US2007/017461 2006-08-07 2007-08-06 Procédés et compositions fondés sur l'adp-ribosyltransférase Ceased WO2008021048A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83603506P 2006-08-07 2006-08-07
US83600806P 2006-08-07 2006-08-07
US60/836,035 2006-08-07
US60/836,008 2006-08-07

Publications (2)

Publication Number Publication Date
WO2008021048A2 WO2008021048A2 (fr) 2008-02-21
WO2008021048A3 true WO2008021048A3 (fr) 2008-09-04

Family

ID=39082544

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017461 Ceased WO2008021048A2 (fr) 2006-08-07 2007-08-06 Procédés et compositions fondés sur l'adp-ribosyltransférase

Country Status (1)

Country Link
WO (1) WO2008021048A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100137345A1 (en) * 2007-05-14 2010-06-03 Universite Libre De Bruxelles Prophylactic and therapeutic use of sirtuin inhibitors in tnf-alpha mediated pathologies
KR102043303B1 (ko) * 2013-03-08 2019-11-12 한국화학연구원 Sirt7단백질의 탈아세틸화 활성을 정량분석하는 방법 및 상기 방법을 이용한 활성을 저해하는 억제제의 스크리닝 방법
US9063420B2 (en) 2013-07-16 2015-06-23 Rohm And Haas Electronic Materials Llc Photoresist composition, coated substrate, and method of forming electronic device
US8933239B1 (en) 2013-07-16 2015-01-13 Dow Global Technologies Llc Bis(aryl)acetal compounds
US9410016B2 (en) 2013-07-16 2016-08-09 Dow Global Technologies Llc Aromatic polyacetals and articles comprising them
US8962779B2 (en) 2013-07-16 2015-02-24 Dow Global Technologies Llc Method of forming polyaryl polymers
CN114958960B (zh) * 2022-01-07 2025-07-25 河南省人民医院 一种靶向组蛋白去乙酰化酶sirt6调节剂的药物筛选方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FRYE ET AL.: "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity", BIOCHEM. BIPHYS. RES. COMMUN., vol. 260, no. 1, 24 June 1999 (1999-06-24), pages 273 - 279, XP002963940 *
HONES ET AL.: "Studies of enzyme-ligand complexes using dynamic fluorescence anisotropy. II. The coenzyme-binding site of malate dehydrogenase", BIOL. CHEM. HOPPE SEYLER, vol. 367, no. 2, February 1986 (1986-02-01), pages 103 - 108 *

Also Published As

Publication number Publication date
WO2008021048A2 (fr) 2008-02-21

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