WO2008024288A3 - Non-invasive methods of using spectral information in determining analyte concentrations - Google Patents

Non-invasive methods of using spectral information in determining analyte concentrations Download PDF

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Publication number
WO2008024288A3
WO2008024288A3 PCT/US2007/018310 US2007018310W WO2008024288A3 WO 2008024288 A3 WO2008024288 A3 WO 2008024288A3 US 2007018310 W US2007018310 W US 2007018310W WO 2008024288 A3 WO2008024288 A3 WO 2008024288A3
Authority
WO
WIPO (PCT)
Prior art keywords
raman
fluorescence
spectral information
analyte concentrations
invasive methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/018310
Other languages
French (fr)
Other versions
WO2008024288A2 (en
Inventor
Mihailo V Rebec
Michael P Houlne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Bayer Healthcare LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Priority to JP2009525575A priority Critical patent/JP2010501252A/en
Priority to CA002661952A priority patent/CA2661952A1/en
Priority to EP07837020A priority patent/EP2056716A2/en
Publication of WO2008024288A2 publication Critical patent/WO2008024288A2/en
Publication of WO2008024288A3 publication Critical patent/WO2008024288A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

A non-invasive method of determining the concentration of an analyte uses Raman or fluorescence spectral information. A high-intensity band of light is applied to one side of skin tissue. The high-intensity light enters the skin tissue and generates a Raman or fluorescence signal. A Raman-generating material or fluorescence-generating material is placed in a location nearest the other side of skin tissue. The Raman-generating or fluorescence- generating material is located generally opposite of the entry of the applied high-intensity light. The Raman or fluorescence signal is collected and the analyte concentration is determined using the collected Raman signal.
PCT/US2007/018310 2006-08-22 2007-08-17 Non-invasive methods of using spectral information in determining analyte concentrations Ceased WO2008024288A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009525575A JP2010501252A (en) 2006-08-22 2007-08-17 Non-invasive method to determine analyte concentration using spectral information
CA002661952A CA2661952A1 (en) 2006-08-22 2007-08-17 Non-invasive methods of using spectral information in determining analyte concentrations
EP07837020A EP2056716A2 (en) 2006-08-22 2007-08-17 Non-invasive methods of using spectral information in determining analyte concentrations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83929906P 2006-08-22 2006-08-22
US60/839,299 2006-08-22

Publications (2)

Publication Number Publication Date
WO2008024288A2 WO2008024288A2 (en) 2008-02-28
WO2008024288A3 true WO2008024288A3 (en) 2008-11-13

Family

ID=39107321

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018310 Ceased WO2008024288A2 (en) 2006-08-22 2007-08-17 Non-invasive methods of using spectral information in determining analyte concentrations

Country Status (5)

Country Link
EP (1) EP2056716A2 (en)
JP (1) JP2010501252A (en)
CA (1) CA2661952A1 (en)
TW (1) TW200819732A (en)
WO (1) WO2008024288A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0606891D0 (en) 2006-04-05 2006-05-17 Council Cent Lab Res Councils Raman Analysis Of Pharmaceutical Tablets
US9662047B2 (en) * 2010-08-05 2017-05-30 Massachusetts Institute Of Technology Portable raman diagnostic system
KR101207695B1 (en) * 2010-08-11 2012-12-03 서울대학교산학협력단 Medical imaging method for simultaneous detection of multiplex targets using fluorescent and raman signal and apparatus for simultaneously detecting multiplex targets of fluorescent and raman signal using therof
CN102821688A (en) * 2011-04-12 2012-12-12 松下电器产业株式会社 Method for measuring concentration of biological component contained in living body
US8509868B2 (en) 2011-04-12 2013-08-13 Panasonic Corporation Method for measuring a concentration of a biogenic substance contained in a living body
JP6212303B2 (en) * 2013-06-28 2017-10-11 景博 内田 Diabetes marker measurement method
CN103529013A (en) * 2013-10-18 2014-01-22 福建师范大学 Method for rapidly detecting seminal plasma fructose based on DCDR spectrum technique
KR101651659B1 (en) * 2015-02-12 2016-08-30 한국광기술원 System and method for quantification of pigmented skin lesion using oct
CN114295522B (en) * 2021-12-28 2024-03-29 华东理工大学 Analysis method for penetration depth and spatial concentration distribution based on vibration spectrum imaging
TWI890642B (en) * 2024-12-27 2025-07-11 恆達光電股份有限公司 Non-invasive method for estimating blood glucose and the device thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6070093A (en) * 1997-12-02 2000-05-30 Abbott Laboratories Multiplex sensor and method of use
US20030120137A1 (en) * 2001-12-21 2003-06-26 Romuald Pawluczyk Raman spectroscopic system with integrating cavity
WO2006127766A1 (en) * 2005-05-25 2006-11-30 Bayer Healthcare Llc Methods of using raman spectral information in determining analyte concentrations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6070093A (en) * 1997-12-02 2000-05-30 Abbott Laboratories Multiplex sensor and method of use
US20030120137A1 (en) * 2001-12-21 2003-06-26 Romuald Pawluczyk Raman spectroscopic system with integrating cavity
WO2006127766A1 (en) * 2005-05-25 2006-11-30 Bayer Healthcare Llc Methods of using raman spectral information in determining analyte concentrations

Also Published As

Publication number Publication date
EP2056716A2 (en) 2009-05-13
CA2661952A1 (en) 2008-02-28
JP2010501252A (en) 2010-01-21
TW200819732A (en) 2008-05-01
WO2008024288A2 (en) 2008-02-28

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