WO2008024459A3 - Compositions et procédés pour la modification de propriétés cellulaires - Google Patents

Compositions et procédés pour la modification de propriétés cellulaires Download PDF

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Publication number
WO2008024459A3
WO2008024459A3 PCT/US2007/018699 US2007018699W WO2008024459A3 WO 2008024459 A3 WO2008024459 A3 WO 2008024459A3 US 2007018699 W US2007018699 W US 2007018699W WO 2008024459 A3 WO2008024459 A3 WO 2008024459A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
cellular properties
modifying cellular
recombinant protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/018699
Other languages
English (en)
Other versions
WO2008024459A2 (fr
WO2008024459A9 (fr
Inventor
Joseph Shiloach
Pratik Jaluria
Michael Betenbaugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Priority to US12/438,706 priority Critical patent/US20110200987A1/en
Publication of WO2008024459A2 publication Critical patent/WO2008024459A2/fr
Publication of WO2008024459A9 publication Critical patent/WO2008024459A9/fr
Publication of WO2008024459A3 publication Critical patent/WO2008024459A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne d'une manière générale des compositions et des procédés servant à la modulation de propriétés cellulaires et à l'amélioration des rendements en protéines recombinantes. En particulier, les compositions et procédés peuvent conduire à des cellules ayant des caractéristiques de croissance altérées, comprenant une adhésion, une vitesse de prolifération, une croissance à une densité de cellule particulière et un taux d'expression de protéine recombinante altérés.
PCT/US2007/018699 2006-08-24 2007-08-24 Compositions et procédés pour la modification de propriétés cellulaires Ceased WO2008024459A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/438,706 US20110200987A1 (en) 2006-08-24 2007-08-24 Compositions and methods for modifying cellular properties

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84038106P 2006-08-24 2006-08-24
US60/840,381 2006-08-24
US93143907P 2007-05-23 2007-05-23
US60/931,439 2007-05-23

Publications (3)

Publication Number Publication Date
WO2008024459A2 WO2008024459A2 (fr) 2008-02-28
WO2008024459A9 WO2008024459A9 (fr) 2008-07-31
WO2008024459A3 true WO2008024459A3 (fr) 2008-10-02

Family

ID=39107425

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018699 Ceased WO2008024459A2 (fr) 2006-08-24 2007-08-24 Compositions et procédés pour la modification de propriétés cellulaires

Country Status (2)

Country Link
US (1) US20110200987A1 (fr)
WO (1) WO2008024459A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120039939A1 (en) * 2008-04-11 2012-02-16 The Johns Hopkins University Compositions and methods for vaccine and virus production
EP3218514B1 (fr) * 2014-11-12 2019-07-24 LEK Pharmaceuticals d.d. Méthode de prédiction de production de protéines recombinées génétiquement stables au stade précoce de développement de lignées cellulaires
CN109097391A (zh) * 2018-07-11 2018-12-28 个体化细胞治疗技术国家地方联合工程实验室（深圳） 一种大规模生产蜕膜间充质干细胞活性因子的方法及其应用
WO2023172495A2 (fr) * 2022-03-07 2023-09-14 Mazef Biosciences Llc Méthodes et compositions pour la production de substances biologiques dans une cellule génétiquement modifiée

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004007754A2 (fr) * 2002-07-12 2004-01-22 Rigel Pharmaceuticals, Inc. Modulateurs de la proliferation cellulaire
WO2005072470A2 (fr) * 2004-01-28 2005-08-11 Exelixis, Inc Genes mbm en tant que modificateurs de la morphogenese de ramification et methodes d'utilisation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004007754A2 (fr) * 2002-07-12 2004-01-22 Rigel Pharmaceuticals, Inc. Modulateurs de la proliferation cellulaire
WO2005072470A2 (fr) * 2004-01-28 2005-08-11 Exelixis, Inc Genes mbm en tant que modificateurs de la morphogenese de ramification et methodes d'utilisation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHANG GIN-WEN ET AL: "Multiple changes in gene expression are associated with normal cell-induced modulation of the neoplastic phenotype", CANCER RESEARCH, vol. 58, no. 19, 1 October 1998 (1998-10-01), pages 4445 - 4452, XP002481598, ISSN: 0008-5472 *
MILASINCIC DEBRA J ET AL: "Anchorage-dependent control of muscle-specific gene expression in C-2C-12 mouse myoblasts", IN VITRO CELLULAR AND DEVELOPMENTAL BIOLOGY ANIMAL, vol. 32, no. 2, 1996, pages 90 - 99, XP002481599, ISSN: 1071-2690 *
NAGATO S ET AL: "DOWNREGULATION OF LAMININ ALPHA4 CHAIN EXPRESSION INHIBITS GLIOMA INVASION IN VITRO AND IN VIVO", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 117, no. 1, 20 October 2005 (2005-10-20), pages 41 - 50, XP008054255, ISSN: 0020-7136 *
TANAKA RYOICHI ET AL: "Cloning and expression of the ccdA-associated thiol-disulfide oxidoreductase (catA) gene from Brevibacillus choshinensis: Stimulation of human epidermal growth factor production.", JOURNAL OF BIOTECHNOLOGY, vol. 103, no. 1, 12 June 2003 (2003-06-12), pages 1 - 10, XP002481597, ISSN: 0168-1656 *

Also Published As

Publication number Publication date
US20110200987A1 (en) 2011-08-18
WO2008024459A2 (fr) 2008-02-28
WO2008024459A9 (fr) 2008-07-31

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