WO2008024471A2 - Gestion d'informations de laboratoire utilisant une identification par radio fréquence - Google Patents

Gestion d'informations de laboratoire utilisant une identification par radio fréquence Download PDF

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Publication number
WO2008024471A2
WO2008024471A2 PCT/US2007/018742 US2007018742W WO2008024471A2 WO 2008024471 A2 WO2008024471 A2 WO 2008024471A2 US 2007018742 W US2007018742 W US 2007018742W WO 2008024471 A2 WO2008024471 A2 WO 2008024471A2
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WO
WIPO (PCT)
Prior art keywords
laboratory
radio frequency
frequency identification
action
receivers
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Ceased
Application number
PCT/US2007/018742
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English (en)
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WO2008024471A3 (fr
Inventor
Kevin Lloyd
Greg Ferguson
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Individual
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Individual
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Publication of WO2008024471A2 publication Critical patent/WO2008024471A2/fr
Publication of WO2008024471A3 publication Critical patent/WO2008024471A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis

Definitions

  • the present invention relates generally to the effective and efficient management of intra- laboratory activities by using RFED tags within a LIMS, across a plurality of users, a plurality of objects, and a plurality of intra- laboratory locations.
  • the preserve-the-chain-of-custody concept In a regulated laboratory environment, like those involved in drug development, or forensic chemistry, or even environmental testing, the preserve-the-chain-of-custody concept generally is extended to any component of a laboratory test, project, or study. Properly and appropriately tracking all of the components of a complex, multiple-year, multiple-location clinical trial, for instance may create millions of data points. Each of those data points in a manual tracking system is subject to error, decreasing the value of the study, and ultimately increasing the risk associated with the use of the datum. Managing data of this level of importance, and of this magnitude, is the reason behind the development of a LIMS as a concept.
  • RFID tags, LIMS and various manual tracking systems are known in the art.
  • prior art does not integrate the use of RFDD tag technologies into current LIMS software.
  • This invention provides a mechanism for laboratory management to minimize the risk associated with manual tracking systems by using RFDD tags as data-entry devices within existing LIMS software.
  • the present invention enables laboratory management to monitor the custody of any given specimen or sample; to monitor the movement of specimens, samples, or any other laboratory device or expendable through the laboratory; to document which employee moved a given specimen, or used a given reagent; to demonstrate that specimens or waste have been disposed properly; and to associate such events with particular laboratory tests, projects, or studies by the use of RFDD tags.
  • a relational database was developed within a LIMS.
  • the database structure includes information about a given object, and how it is analyzed within a project or study, including all components of said project or study.
  • RFDD tags were applied to various objects such as specimens, laboratory devices, laboratory expendables, and employee identity badges.
  • RFDD antennae were positioned around the doorways of refrigerators, freezers, and specific laboratory areas. RFDD receivers were also positioned around waste disposal containers; on laboratory bench tops; and handheld wireless RFED receivers were also employed.
  • Any change in any object tagged with an RFDD tag can then detected or recorded automatically, by use of the RFID receiver.
  • the receiver is integrated into a LIMS by the current invention, and a unique data point is created which corresponds to a change in a tagged object.
  • FIGS 1 through 7 illustrate the structure, logic and components of the present invention, according to one embodiment of the invention, which is a system for documenting laboratory activity via RFED tags and incorporating the data within a LEMS. Note that this is not the only embodiment of the invention; other, different embodiments of this invention may be made without departing from the spirit of the invention.
  • Figure 1 illustrates the general conceptual structure and relationship of the invention components and their relationship to the RFED tags and the LIMS.
  • Figure 2 represents how an action on an object by an individual changes the object within the context of this invention.
  • FIG 3 represents an action on an object by an individual creates an Internal Chain of Custody ("ICOC") event within the context of this invention.
  • ICOC Internal Chain of Custody
  • Figure 4 represents how an ICOC event is captured in the LEMS by means of manual recording.
  • Figure 5 represents the RFED-based capture of ICOC events.
  • Figure 6 represents how RFED transmitters and receivers are used to track physical relocation of objects and to record that data in the LIMS.
  • Figure 7 represents how an ICOC event is triggered when the LEMS polls an RFED receiver.
  • Figure 1 represents a conceptual overview of the structure and relationship between objects that may be tagged with RFID transmitters and/or receivers and the LIMS. Any desired number or type of objects may be tagged or identified for incorporation into the RFID-LIMS combination. As depicted in Figures 1 and 2, an "object” can be:
  • Each such sample- or specimen-related item is identified with a distinct RFID tag.
  • an "object” may be:
  • a laboratory supply or laboratory expendable such as: a) Reagent b) Sample preparation device (e.g., solid phase extraction [SPE] device) c) Laboratory-prepared solutions d) Laboratory container (tube, vial, well-plate) e) Dispensing device f) Safety equipment (e.g., latex gloves, flammable spill clean-up kit) g) Measuring devices (e.g., pipettes, syringes) h) Chromatography columns (e.g., LC, GC, IC)
  • an "object” may be:
  • a laboratory device or instrument or associated with a laboratory device or instrument, such as: a) Analytical instrument (e.g., GC, GC-MS, HPLC, ICP-MS, LC/MS/MS) b) Preparation instrument (e.g., mill, chopper) c) Analytical balance
  • an "object” may be: 4) a collection of items, such as: a) Collection of sample extract vials (e.g., 100 HPLC a ⁇ tosampler vials) b) Collection of primary or secondary standards
  • an "object” may be:
  • a reference or comparison material such as: a) Primary reference standard b) Secondary reference standard c) Mixed reference standard d) Fortification standard solution e) Laboratory reference material f) Laboratory control material g) Reagent control or blank
  • an "object” may be:
  • a laboratory waste / disposal collection container or associated with such containers, such as: a) Waste solvent drums b) Trash cans or barrels c) Glass collection drums d) Quarantined items intended to be disposed
  • Each such waste collection container is identified with a distinct RFID tag.
  • an "object” may be:
  • a monitored area, room, compartment, chamber, container, or other enclosed area such as: a) room b) freezer c) refrigerator d) incubator e) any temperature-controlled storage area f) building or facility doorways or gates through which sample custody flow occurs g) waste container or, an "object" may be:
  • an individual such as an employee generally, an employee specifically authorized to perform specific tasks, a robotic device, or a visitor within a laboratory or other facility.
  • an action on an object (as defined above) by an individual changes the object.
  • An “action” is any change in any object created by any individual, including: 1) change in location
  • An “individual” may be:
  • FIG. 3 graphically represents that an "ICOC event” ("Internal Chain of Custody event”) occurs whenever an object is changed by the action of an individual.
  • ICOC events may be captured in the LIMS by manual recording of the event and associated data entry into the LIMS database structure.
  • manual recording of data is prone to errors and is not as accurate as RFED-based capture of ICOC events.
  • This invention improves current practice and reduces recording errors by using RFID-based capturing of ICOC events,
  • ICOC events are "captured" (i.e., become data points in the relational database of a LIMS) when an object bearing an RFID tag is interrogated by an RFID receiver at the entrance of an object which is a monitored area, room, compartment, chamber, container, or other enclosed area, such as a room; a freezer; a refrigerator; an incubator; any temperature-controlled storage area; a waste container; or a building or facility entrance, doorway, portal or gate through which sample custody flow occurs.
  • FIG. 6 illustrates a specific example of the current invention in which an RFID-tagged specimen is physically moved from one location to a new location, and where each location possesses an Rt ID-receiver connected to a LIMS.
  • both the specimen and the location are "objects".
  • the location-as-object is communicated to the LIMS through an RFID-receiver.
  • An RFTD-receiver-antenna is placed around the doorway to a location.
  • the LIMS records that entrance.
  • the LIMS records that removal. No other activity is required by the individual. Moving the specimen through the doorway triggers the change in status.
  • This change in status is a recordable ICOC event, and is automatically recorded in the LIMS.
  • the individual moves the specimen from one location to another.
  • location 1 in this example
  • the specimen and the individual both pass through a second RF field generated by a second RFID-receiver-antenna.
  • This action creates a new data point in the LIMS, indicating that the specimen is now in location 1, and that the relocation was conducted by the individual. Again, no other documentation is required by the individual.
  • the RFTD antenna detects both the specimen RFID tag and the individual's RFTD badge, both at the entrance to location 0, and the entrance to location 1.
  • an access to "object” i.e., a controlled substance freezer
  • An RFED-receiver detects the RFID employee- badge-tag; determines whether the employee is permitted access to the freezer, and prompts (on-screen) the employee to verify that he or she wishes to enter the controlled space. On "yes", the door is unlocked.
  • ICOC events occur when: 1) the badge is detected; 2) when there is a positive response to the prompt; 3) when tagged objects leave the freezer; and 4) then the door is relocked.
  • Figure 7 graphically illustrates how the LEMS and RFID systems interact.
  • the invention comprises an object (i.e., a specimen, a sample, an individual, a container, a location, etc.) to which an RFID tag is attached or applied in some mechanical fashion; an RFID antenna within proximity to a controlled or secured location; an RFID receiver which is capable of interrogating the RFID tag in combination with the antenna, and which contains a storage device capable of storing data received from the RFID tag; and a LIMS which includes a relational database in which both the RFID tag data and the RFID receiver data can be stored.
  • an object i.e., a specimen, a sample, an individual, a container, a location, etc.
  • an RFID antenna within proximity to a controlled or secured location
  • an RFID receiver which is capable of interrogating the RFID tag in combination with the antenna, and which contains a storage device capable of storing data received from the RFID tag
  • a LIMS which includes a relational database in which both the RFID tag data and the RFID receiver data can be stored.
  • the RFID receiver interrogates the RFID chip (a storage device retaining the unique identity of the device). The data acquired from this interrogation is stored within the buffer of the RFED receiver.
  • the identity data (including specimen ID, location ID, and individual ID) are downloaded to, and stored within the buffer of the RFID receiver.
  • the LIMS "polls" the buffer of the RFID receiver and downloads any newly acquired data into the relational database of the LIMS. This polling can be accomplished either through a hardwired or wireless connection.
  • Each polling of the RFID receiver buffer can create an ICOC event if, during the interval between pollings, movement of an RFID device has been detected by the RFID receiver.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
  • Public Health (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention est un procédé pour une utilisation par une pluralité d'utilisateurs pour gérer et documenter des activités à l'intérieur d'un environnement de laboratoire utilisant des marqueurs d'identification par radio fréquence (RFID) en tant que dispositifs d'entrée de données à l'intérieur d'un système de gestion d'informations de laboratoire (LEMS). Des marqueurs RFID standard ou personnalisés sont liés à n'importe quel nombre ou type d'objets désirés, comprenant, mais sans être limité, des échantillons ou éprouvettes; des instruments de laboratoire; des réactifs de laboratoire; des fourniture fongibles de laboratoire; et des zones de stockage (comprenant des congélateurs, des réfrigérateurs, des incubateurs, etc.). Des personnes travaillant dans le laboratoire portent également des badges d'identification incorporant les marqueurs RFID. Toute activité de laboratoire peut être surveillée et documentée de manière automatique de cette manière.
PCT/US2007/018742 2006-08-24 2007-08-24 Gestion d'informations de laboratoire utilisant une identification par radio fréquence Ceased WO2008024471A2 (fr)

Applications Claiming Priority (2)

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US83980806P 2006-08-24 2006-08-24
US60/839,808 2006-08-24

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WO2008024471A2 true WO2008024471A2 (fr) 2008-02-28
WO2008024471A3 WO2008024471A3 (fr) 2008-05-08

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Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2270722A1 (fr) * 2009-07-01 2011-01-05 Biogemma Dispositif de collecte et de traitement d'informations relatives à l'exposition d'une ou plusieurs personnes à un ou plusieurs produits d'origine chimique ou biologique et procédé d'utilisation d'un tel dispositif
ITPD20100252A1 (it) * 2010-08-03 2012-02-04 Syntesys S A S Di Rinaldo R & C Sistema di tracciabilità tramite tecnologia rfid uhf di contenitori per materiali di origine organica umana e/o animale
CN102760317A (zh) * 2012-07-18 2012-10-31 东北农业大学 高校实验室信息化管理系统
EP2502190A4 (fr) * 2009-11-20 2014-11-05 Versus Technology Inc Procédé et système en temps réel pour commander des procédés de distribution de soins de santé dans un environnement clinique
WO2016040593A1 (fr) 2014-09-11 2016-03-17 Deroyal Industries, Inc. Système pour suivre de l'utilisation et de la consommation d'articles médicaux dans un établissement médical et pour tenir à jour une chaîne de garde sur la base de celui-ci
CN105468931A (zh) * 2016-01-06 2016-04-06 广东省人民医院 一种急性肾损伤电子预警系统
EP3182310A1 (fr) * 2015-12-18 2017-06-21 Roche Diagnostics GmbH Procédé de stockage temporaire de données dans une mémoire d'une étiquette rfid associée à un consommable d'un instrument de laboratoire et système comprenant un instrument de laboratoire, un consommable et une étiquette rfid
US10152688B2 (en) 2014-05-15 2018-12-11 Deroyal Industries, Inc. System for sensing and recording information regarding medical items in a medical facility
WO2019050697A1 (fr) * 2017-09-06 2019-03-14 Siemens Healthcare Diagnostics Inc. Intégration d'application passive activée par alerte
WO2020016123A1 (fr) 2018-07-20 2020-01-23 Bayer Business Services Gmbh Système de gestion de laboratoire
CN112270392A (zh) * 2020-10-28 2021-01-26 茅台学院 融合rfid和wsn定位技术的高校实验室管理系统
US10922647B2 (en) 2014-10-02 2021-02-16 Deroyal Industries, Inc. System for prevention of fraud in accounting for utilization of medical items
US10973226B2 (en) 2018-10-05 2021-04-13 TMRW Life Sciences, Inc. Apparatus to preserve and identify biological samples at cryogenic conditions
USD951481S1 (en) 2020-09-01 2022-05-10 TMRW Life Sciences, Inc. Cryogenic vial
CN114722791A (zh) * 2022-02-14 2022-07-08 宏佳永晟(北京)科技有限公司 一种实验室操作行为智能识别与记录系统
USD963194S1 (en) 2020-12-09 2022-09-06 TMRW Life Sciences, Inc. Cryogenic vial carrier
US11607691B2 (en) 2019-10-29 2023-03-21 TMRW Life Sciences, Inc. Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
CN117041292A (zh) * 2023-08-11 2023-11-10 三亚汉烯石墨烯技术研究所有限公司 一种基于rfid的智能实验室事件管理系统及方法
US11817187B2 (en) 2020-05-18 2023-11-14 TMRW Life Sciences, Inc. Handling and tracking of biological specimens for cryogenic storage
US12017227B2 (en) 2020-12-10 2024-06-25 TMRW Life Sciences, Inc. Specimen holder with wireless transponder for attachment to specimen collection body
US12099890B2 (en) 2020-10-02 2024-09-24 TMRW Life Sciences, Inc. Interrogation device and/or system having alignment feature(s) for wireless transponder tagged specimen containers and/or carriers
US12259399B2 (en) 2021-01-13 2025-03-25 TMRW Life Sciences, Inc. Systems, apparatus and methods to pick and/or place specimen containers
US12285009B2 (en) 2020-09-24 2025-04-29 TMRW Life Sciences, Inc. Workstation and apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
CN120632604A (zh) * 2025-08-18 2025-09-12 青岛大数华创科技有限公司 一种实验室数据分析方法
US12527318B2 (en) 2021-10-08 2026-01-20 TMRW Life Sciences, Inc. Systems, apparatus and methods to pick and/or place specimen containers

Family Cites Families (2)

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US6816075B2 (en) * 2001-02-21 2004-11-09 3M Innovative Properties Company Evidence and property tracking for law enforcement
WO2005113147A2 (fr) * 2004-04-08 2005-12-01 Biomatrica, Inc. Integration du stockage et de la gestion d'echantillons pour les sciences de la vie

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2270722A1 (fr) * 2009-07-01 2011-01-05 Biogemma Dispositif de collecte et de traitement d'informations relatives à l'exposition d'une ou plusieurs personnes à un ou plusieurs produits d'origine chimique ou biologique et procédé d'utilisation d'un tel dispositif
WO2011000875A1 (fr) * 2009-07-01 2011-01-06 Biogemma Dispositif pour la collecte et le traitement d'informations concernant l'exposition d'une ou plusieurs personnes à un ou plusieurs produits d'origine chimique ou biologique, et procédé d'utilisation de ce dispositif
FR2947654A1 (fr) * 2009-07-01 2011-01-07 Biogemma Fr Methode de collecte d'informations relatives a l'exposition d'une ou plusieurs personnes a un ou plusieurs produits d'origine chimique ou biologique et dispositif de mise en oeuvre d'une telle methode
US9043157B2 (en) 2009-07-01 2015-05-26 Biogemma Device for the collection and processing of information relating to the exposure of one or more persons to one or more products of chemical or biological origin and method for the use of such a device
EP2502190A4 (fr) * 2009-11-20 2014-11-05 Versus Technology Inc Procédé et système en temps réel pour commander des procédés de distribution de soins de santé dans un environnement clinique
ITPD20100252A1 (it) * 2010-08-03 2012-02-04 Syntesys S A S Di Rinaldo R & C Sistema di tracciabilità tramite tecnologia rfid uhf di contenitori per materiali di origine organica umana e/o animale
WO2012017275A1 (fr) * 2010-08-03 2012-02-09 Syntesys Sas Système de traçabilité utilisant une technologie rfid uhf pour des récipients de matière organique d'origine humaine et/ou animale
CN102760317A (zh) * 2012-07-18 2012-10-31 东北农业大学 高校实验室信息化管理系统
US10152688B2 (en) 2014-05-15 2018-12-11 Deroyal Industries, Inc. System for sensing and recording information regarding medical items in a medical facility
EP3192048A4 (fr) * 2014-09-11 2018-03-21 DeRoyal Industries, Inc. Système pour suivre de l'utilisation et de la consommation d'articles médicaux dans un établissement médical et pour tenir à jour une chaîne de garde sur la base de celui-ci
WO2016040593A1 (fr) 2014-09-11 2016-03-17 Deroyal Industries, Inc. Système pour suivre de l'utilisation et de la consommation d'articles médicaux dans un établissement médical et pour tenir à jour une chaîne de garde sur la base de celui-ci
US10922647B2 (en) 2014-10-02 2021-02-16 Deroyal Industries, Inc. System for prevention of fraud in accounting for utilization of medical items
EP3182310A1 (fr) * 2015-12-18 2017-06-21 Roche Diagnostics GmbH Procédé de stockage temporaire de données dans une mémoire d'une étiquette rfid associée à un consommable d'un instrument de laboratoire et système comprenant un instrument de laboratoire, un consommable et une étiquette rfid
US10185850B2 (en) 2015-12-18 2019-01-22 Roche Diagnostics Operations, Inc. Method for storing temporary data in a memory of an RFID tag associated with a consumable of a laboratory instrument and system comprising a laboratory instrument, consumable and RFID tag
CN105468931A (zh) * 2016-01-06 2016-04-06 广东省人民医院 一种急性肾损伤电子预警系统
WO2019050697A1 (fr) * 2017-09-06 2019-03-14 Siemens Healthcare Diagnostics Inc. Intégration d'application passive activée par alerte
CN111066038A (zh) * 2017-09-06 2020-04-24 美国西门子医学诊断股份有限公司 警报使能的被动应用整合
US11334060B2 (en) 2017-09-06 2022-05-17 Siemens Healthcare Diagnostics Inc. Alert-enabled passive application integration
WO2020016123A1 (fr) 2018-07-20 2020-01-23 Bayer Business Services Gmbh Système de gestion de laboratoire
US11252956B2 (en) 2018-10-05 2022-02-22 TMRW Life Sciences, Inc. Apparatus to preserve and identify biological samples at cryogenic conditions
US10973226B2 (en) 2018-10-05 2021-04-13 TMRW Life Sciences, Inc. Apparatus to preserve and identify biological samples at cryogenic conditions
US12290816B2 (en) 2019-10-29 2025-05-06 TMRW Life Sciences, Inc. Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
US11607691B2 (en) 2019-10-29 2023-03-21 TMRW Life Sciences, Inc. Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
US11817187B2 (en) 2020-05-18 2023-11-14 TMRW Life Sciences, Inc. Handling and tracking of biological specimens for cryogenic storage
US12354716B2 (en) 2020-05-18 2025-07-08 TMRW Life Sciences, Inc. Handling and tracking of biological specimens for cryogenic storage
USD951481S1 (en) 2020-09-01 2022-05-10 TMRW Life Sciences, Inc. Cryogenic vial
US12285009B2 (en) 2020-09-24 2025-04-29 TMRW Life Sciences, Inc. Workstation and apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
US12099890B2 (en) 2020-10-02 2024-09-24 TMRW Life Sciences, Inc. Interrogation device and/or system having alignment feature(s) for wireless transponder tagged specimen containers and/or carriers
CN112270392A (zh) * 2020-10-28 2021-01-26 茅台学院 融合rfid和wsn定位技术的高校实验室管理系统
USD963194S1 (en) 2020-12-09 2022-09-06 TMRW Life Sciences, Inc. Cryogenic vial carrier
USD1002868S1 (en) 2020-12-09 2023-10-24 TMRW Life Sciences, Inc. Cryogenic vial carrier
US12017227B2 (en) 2020-12-10 2024-06-25 TMRW Life Sciences, Inc. Specimen holder with wireless transponder for attachment to specimen collection body
US12383905B2 (en) 2020-12-10 2025-08-12 TMRW Life Sciences, Inc. Specimen holder with wireless transponder for attachment to specimen collection body
US12259399B2 (en) 2021-01-13 2025-03-25 TMRW Life Sciences, Inc. Systems, apparatus and methods to pick and/or place specimen containers
US12527318B2 (en) 2021-10-08 2026-01-20 TMRW Life Sciences, Inc. Systems, apparatus and methods to pick and/or place specimen containers
CN114722791B (zh) * 2022-02-14 2024-10-15 宏佳永晟(北京)科技有限公司 一种实验室操作行为智能识别与记录系统
CN114722791A (zh) * 2022-02-14 2022-07-08 宏佳永晟(北京)科技有限公司 一种实验室操作行为智能识别与记录系统
CN117041292A (zh) * 2023-08-11 2023-11-10 三亚汉烯石墨烯技术研究所有限公司 一种基于rfid的智能实验室事件管理系统及方法
CN117041292B (zh) * 2023-08-11 2024-06-04 三亚汉烯石墨烯技术研究所有限公司 一种基于rfid的智能实验室事件管理系统、方法、计算机设备及终端
CN120632604A (zh) * 2025-08-18 2025-09-12 青岛大数华创科技有限公司 一种实验室数据分析方法

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