WO2008070014A3 - Pipéridines à substitution cétonique de biaryle - Google Patents

Pipéridines à substitution cétonique de biaryle Download PDF

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Publication number
WO2008070014A3
WO2008070014A3 PCT/US2007/024717 US2007024717W WO2008070014A3 WO 2008070014 A3 WO2008070014 A3 WO 2008070014A3 US 2007024717 W US2007024717 W US 2007024717W WO 2008070014 A3 WO2008070014 A3 WO 2008070014A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted piperidines
cgrp
compounds
methods
biaryl ketone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/024717
Other languages
English (en)
Other versions
WO2008070014A2 (fr
Inventor
Rajagopal Bakthavatchalm
Bertrand L Chenard
Scott M Capitosti
Alan J Hutchison
Robert Ohliger
John M Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of WO2008070014A2 publication Critical patent/WO2008070014A2/fr
Publication of WO2008070014A3 publication Critical patent/WO2008070014A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Cette invention concerne des pipéridines à substitution cétonique de biaryle de formule suivante, où les variables sont telles que décrites ici. Ces composés peuvent être utilisés pour moduler l'activité des récepteurs du CGRP (calcitonin gene-related peptide) in vivo ou in vitro, et sont particulièrement utiles dans le traitement des affections sensibles à la modulation du CGRP chez l'homme, chez l'animal domestique et chez l'animal d'élevage, y compris les céphalées comme la migraine. L'invention propose aussi des compositions pharmaceutiques et des procédés permettant de les utiliser pour traiter ces affections, ainsi que des procédés permettant d'utiliser ces composés pour des études de localisation des récepteurs et pour diverses études in vitro.
PCT/US2007/024717 2006-12-04 2007-11-28 Pipéridines à substitution cétonique de biaryle Ceased WO2008070014A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86836606P 2006-12-04 2006-12-04
US60/868,366 2006-12-04
US88717107P 2007-01-30 2007-01-30
US60/887,171 2007-01-30

Publications (2)

Publication Number Publication Date
WO2008070014A2 WO2008070014A2 (fr) 2008-06-12
WO2008070014A3 true WO2008070014A3 (fr) 2009-04-02

Family

ID=39492822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/024717 Ceased WO2008070014A2 (fr) 2006-12-04 2007-11-28 Pipéridines à substitution cétonique de biaryle

Country Status (1)

Country Link
WO (1) WO2008070014A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100091972A (ko) 2007-10-18 2010-08-19 베링거 인겔하임 인터내셔날 게엠베하 Ｃｇｒｐ 길항제
EP2065381A1 (fr) 2007-10-18 2009-06-03 Boehringer Ingelheim Pharma GmbH & Co. KG Antagonistes du CGRP
US8829006B2 (en) 2007-11-22 2014-09-09 Boehringer Ingelheim International Gmbh Compounds
AU2011236155B2 (en) 2010-04-06 2014-01-16 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and method for producing same
AU2014201036B2 (en) * 2010-04-06 2015-07-16 Nippon Soda Co., Ltd Nitrogen-containing heterocyclic compound and method for producing same
MX2012013128A (es) * 2010-05-13 2013-03-20 Amgen Inc Compuestos heterociclicos de nitrogeno como inhibidores de la fosfodiesterasa 10.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268474B1 (en) * 1998-04-30 2001-07-31 Creighton University Peptide antagonists of CGRP-receptor superfamily and methods of use
WO2001066248A2 (fr) * 2000-02-22 2001-09-13 University Of New Orleans Research And Technology Foundation Systeme catalyseur comprenant un metal de transition et de l'imidazoline-2-ylidene ou de l'imidazolidine-2-ylidene et son utilisation dans des reactions de couplage
WO2004091514A2 (fr) * 2003-04-15 2004-10-28 Merck & Co., Inc. Antagonistes des recepteurs de cgrp
WO2006052378A1 (fr) * 2004-11-03 2006-05-18 Bristol-Myers Squibb Company Composes a cycle tendu en tant qu'antagonistes des recepteurs cgrp

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268474B1 (en) * 1998-04-30 2001-07-31 Creighton University Peptide antagonists of CGRP-receptor superfamily and methods of use
WO2001066248A2 (fr) * 2000-02-22 2001-09-13 University Of New Orleans Research And Technology Foundation Systeme catalyseur comprenant un metal de transition et de l'imidazoline-2-ylidene ou de l'imidazolidine-2-ylidene et son utilisation dans des reactions de couplage
WO2004091514A2 (fr) * 2003-04-15 2004-10-28 Merck & Co., Inc. Antagonistes des recepteurs de cgrp
WO2006052378A1 (fr) * 2004-11-03 2006-05-18 Bristol-Myers Squibb Company Composes a cycle tendu en tant qu'antagonistes des recepteurs cgrp

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CONNER ET AL.: "The Second Intracellular Loop of the Calcitonin Gene-related Peptide Receptor Provides Molecular Determinants for Signal Transduction and Cell Surface Expression.", J. BIOL. CHEM., vol. 281, no. 3, 20 January 2006 (2006-01-20), pages 1644 - 1651, XP008109007, DOI: doi:10.1074/jbc.M510064200 *

Also Published As

Publication number Publication date
WO2008070014A2 (fr) 2008-06-12

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