WO2008075376A8 - Formes polymorphes du bortézomibe et leur procédé de préparation - Google Patents

Formes polymorphes du bortézomibe et leur procédé de préparation Download PDF

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Publication number
WO2008075376A8
WO2008075376A8 PCT/IN2007/000561 IN2007000561W WO2008075376A8 WO 2008075376 A8 WO2008075376 A8 WO 2008075376A8 IN 2007000561 W IN2007000561 W IN 2007000561W WO 2008075376 A8 WO2008075376 A8 WO 2008075376A8
Authority
WO
WIPO (PCT)
Prior art keywords
bortezomib
preparation
polymorphic forms
forms
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2007/000561
Other languages
English (en)
Other versions
WO2008075376A1 (fr
Inventor
Janaki Rama Rao Ravi
Muddasani Pulla Reddy
Bhujanga Rao Adibatla Kali Satya
Nannapaneni Venkaiah Chowdary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Natco Pharma Ltd
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of WO2008075376A1 publication Critical patent/WO2008075376A1/fr
Anticipated expiration legal-status Critical
Publication of WO2008075376A8 publication Critical patent/WO2008075376A8/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur deux nouvelles formes polymorphes stables du bortézomibe (formes I et II) et sur leur procédé de préparation. Le bortézomibe (1) est un agent anti-néoplasique utilisé dans le traitement du myélome multiple.
PCT/IN2007/000561 2006-12-18 2007-12-03 Formes polymorphes du bortézomibe et leur procédé de préparation Ceased WO2008075376A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2348/CHE/2006 2006-12-18
IN2348CH2006 2006-12-18

Publications (2)

Publication Number Publication Date
WO2008075376A1 WO2008075376A1 (fr) 2008-06-26
WO2008075376A8 true WO2008075376A8 (fr) 2010-04-15

Family

ID=39327992

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000561 Ceased WO2008075376A1 (fr) 2006-12-18 2007-12-03 Formes polymorphes du bortézomibe et leur procédé de préparation

Country Status (1)

Country Link
WO (1) WO2008075376A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010539183A (ja) * 2007-09-12 2010-12-16 ドクター・レディーズ・ラボラトリーズ・リミテッド ボルテゾミブおよびその生成のためのプロセス
WO2011099018A1 (fr) * 2010-02-15 2011-08-18 Hetero Research Foundation Polymorphes de bortézomib
WO2011107912A1 (fr) 2010-03-04 2011-09-09 Ranbaxy Laboratories Limited Formes polymorphes de bortézomib
US8263578B2 (en) 2010-03-18 2012-09-11 Innopharma, Inc. Stable bortezomib formulations
AU2011227083B2 (en) 2010-03-18 2013-07-18 Innopharma, Inc. Stable bortezomib formulations
EP2624818B1 (fr) 2010-10-05 2017-04-05 Fresenius Kabi USA, LLC Formulations de bortézomib stabilisées par de l'acide borique
US8497374B2 (en) 2011-05-12 2013-07-30 Scinopharm Taiwan, Ltd. Process for preparing and purifying bortezomib
CA2784240C (fr) 2012-03-27 2014-07-08 Innopharma, Inc. Formulations stables a base de bortezomib
CA2891822A1 (fr) 2012-11-16 2014-05-22 Shilpa Medicare Limited Procede de preparation de bortezomib cristallin
WO2014097306A1 (fr) 2012-12-21 2014-06-26 Natco Pharma Limited Forme polymorphe stable et pure du bortézomib
CA2909519A1 (fr) * 2013-04-16 2014-10-23 Cipla Limited Procede pour la preparation d'ester de mannitol du bortezomib
KR101763106B1 (ko) * 2014-02-14 2017-08-01 주식회사 경보제약 보르테조밉(Bortezomib)의 신규한 결정형 및 그의 제조방법
JP2018500299A (ja) 2014-11-25 2018-01-11 バイオエクセル コーポレーション 神経線維腫症２型に関連する腫瘍の治療のためのユビキチン−プロテアソーム系阻害剤の使用
EP3031811A1 (fr) 2014-12-09 2016-06-15 Teva Pharmaceuticals Ltd. Esters d'acide malique de bortézomib
CN110312727A (zh) 2017-02-17 2019-10-08 费森尤斯卡比肿瘤学有限公司 一种改进的制备硼酸酯的方法
WO2019151133A1 (fr) * 2018-02-01 2019-08-08 日本化薬株式会社 Procédé de fabrication de cristaux de bortézomib
CN110642881A (zh) * 2019-10-18 2020-01-03 扬子江药业集团上海海尼药业有限公司 一种硼替佐米晶型m及其制备方法和用途
US11964993B2 (en) 2021-07-03 2024-04-23 Shilpa Pharma Lifesciences Limited Crystalline bortezomib process

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME01975B (fr) * 2004-03-30 2015-05-20 Millennium Pharm Inc Synthese d'ester borique et de composes acides
WO2006101535A1 (fr) * 2005-03-23 2006-09-28 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Inhibition de la fonction du proteasome pour renforcer l’activite proapoptotique et antitumorale des cytokines

Also Published As

Publication number Publication date
WO2008075376A1 (fr) 2008-06-26

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