WO2008079543A2 - Compositions de matériaux mésoporeux et méthodes permettant de les utiliser pour améliorer l'apparence de surfaces biologiques - Google Patents

Compositions de matériaux mésoporeux et méthodes permettant de les utiliser pour améliorer l'apparence de surfaces biologiques Download PDF

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Publication number
WO2008079543A2
WO2008079543A2 PCT/US2007/084614 US2007084614W WO2008079543A2 WO 2008079543 A2 WO2008079543 A2 WO 2008079543A2 US 2007084614 W US2007084614 W US 2007084614W WO 2008079543 A2 WO2008079543 A2 WO 2008079543A2
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Prior art keywords
appearance
skin
improving
composition
mesoporous material
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PCT/US2007/084614
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WO2008079543A9 (fr
WO2008079543A3 (fr
Inventor
Prithwiraj Maitra
John C. Brahms
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Avon Products Inc
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Avon Products Inc
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Priority claimed from US11/714,516 external-priority patent/US20080220026A1/en
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Publication of WO2008079543A2 publication Critical patent/WO2008079543A2/fr
Publication of WO2008079543A9 publication Critical patent/WO2008079543A9/fr
Publication of WO2008079543A3 publication Critical patent/WO2008079543A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/242—Gold; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A61K2800/43—Pigments; Dyes
    • A61K2800/434—Luminescent, Fluorescent; Optical brighteners; Photosensitizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

Definitions

  • This invention generally relates to cosmetic, dermatological, and pharmaceutical compositions and their use, and more particularly to cosmetic compositions and their use in improving the appearance of biological surfaces.
  • Aging skin is characterized by poor elasticity and the accentuation of lines and wrinkles due to reduced oil gland activity.
  • Collagen a fundamental protein in the composition of skin, plays a primary role in elasticity and hydration. As the aging process occurs, the collagen structure weakens, and skin loses its firmness becoming ineffective in retaining moisture. The breakdown of collagen and its precursors contributes to wrinkling and creates the appearance of sagging skin. Though reversing the aging process is not possible, the appearance of fine lines and wrinkles can be diminished. Topical application of products which make fine lines and wrinkles appear more smooth and plump are contemplated.
  • compositions and methods of use thereof to improve the aesthetic appearance of skin. Therefore, safe and effective compositions that provide a translucent appearance in a film with uniform coloring, smooth and even biological surfaces, with no apparent imperfections would be advantageous for the formulation of treatments and products for biological surfaces, including the skin.
  • the mesoporous material of the composition is a metal oxide such as TiO 2 , ZnO, AI2O3, a mesoporous silica, and combinations thereof,
  • a further object of the invention is to provide a composition having a mesoporous material with empty pores or loaded with material, including for example, metal nanocrystals, such as noble metal nanocryslals, and fluorescent materials, which further produce unique optical effects on skin.
  • a method of improving the aesthetic or natural appearance of a biological surface by applying to the biological surface a composition having a mesoporous material and carrier in an amount effective to improve the aesthetic or natural appearance of the biological surface.
  • the composition is applied such that the appearance of dermatological signs of damaged or chronologically-aged, hormonally- aged, actinically- aged, photo-aged skin, such as fine lines, wrinkles, and sagging skin, surface imperfections, and discoloration is diminished.
  • Another object provides a method for forming a film on a biological surface, such as but not limited to a keratinous surface by contacting the surface with a mesoporous material and carrier composition, thereby forming a film on the keratinous surface, where the film produces blurring effect to reduce both color and textural imperfections and to improve the natural appearance of the keratinous surfaces.
  • Mesoporous materials can produce these effects by achieving a balance between diffused transmittance and opacity and thus retaining natural translucency of biological tissues.
  • compositions having a mesoporous material and combinations thereof are achieved by compositions having a mesoporous material and combinations thereof, and methods of using such compositions for topical application in order to improve the aesthetic and natural appearance of a biological surface, including for example, skin.
  • FIG. 1 shows the effects of percent solid loadings with respect to percent diffused transmittance or percent reflectance of mesoporous Ti ⁇ 2 , compared to that of pigment grade TiO 2 .
  • FIG- 2 shows the effects of film thickness with respect to percent diffused transmittance of mesoporous T1O 2 , compared to that of pigment grade T1O 2 , at a 2.5% solid loading.
  • the invention overcomes deficiencies associated with the prior art by providing compositions comprising at least one mesoporous material, and an acceptable vehicle, which improves the aesthetic appearance of biological surface resulting from, for example., the chronological aging process, environmental damage to the biological surface, or other imperfections.
  • the composition and methods thereof once applied to a biological surface or synthetic biological surface, enhances the appearance of the surface by altering the appearance of a biological surface by enhancing diffused transmiltance and reflective properties, thereby improving the aesthetic appearance of the biological surface.
  • the aesthetic appearance of the biological surface including but not limited to, keratinous tissues, skin, hair, and nails, may be achieved by topical application of the inventive composition to the biological surface on a daily basis or when a natural appearance is desired.
  • the composition embraces a mesoporous material having several properties that enhance diffused transmittance and results in a film with high blurring effect upon application of a thin film of the mesoporous material composition to a biological surface.
  • the film is about 0.2 microns to about 50 microns in thickness; and preferably about 1 micron to about 20 microns.
  • Mesoporous materials may be of an ordered or disordered structure of pores, providing transparent and more preferably translucent properties when formed in a film.
  • the pores may be loaded with another material in order to enhance the optical properties of the mesoporous material by altering the resulting refractive index.
  • the pores may also be loaded, or simply empty but for air. or loaded with air.
  • the mesoporous material and the material that is loaded in the pores of the mesoporous material are capable of altering the scattering behavior of visible light, thereby providing soft focus or blurring effects useful in cosmetic compositions which camouflage wrinkles, fine lines, or imperfections of biological surfaces.
  • any mesoporous material of the inventive composition producing the desired effects may be used, non-limiting examples of which include a metal oxide, for example, titanium oxide (TiO 2 ) such as AEROXIDE® TiO 2 P25 (Degussa Corporation; Parsippany. NJ) aluminum oxide, and iron oxide, mesoporous silica, or combinations thereof.
  • the mesoporous material may be a hybrid, for example, a metal oxide and polymer. Combinations, hybrids or mixtures of a metal oxide and a polymer may be used as the film forming components of the composition described herein.
  • Non-limiting examples of polymers include homopolymers and copolymers of : (1) synthetic polymers including vinyl esters that are produced by the polymerization of vinyl ethers (e.g., polyvinyl acetate, produced by free-radical initiated polymerization or vinyl acetate); (2) acrylic acid esters and methacryUc acid esters, readily combine with themselves or other monomers (e.g..
  • acrylic acid esters and methacrylic acid esters include, but not limited to, methyl acrylate, ethyl acrylate, butyl acrylate, 2-ethyhexyl acrylate, methyl methacrylate, ethyl niethacrylate and butyl melhacrylate ; and (3) mono and di-ethylene unsaturated hydrocarbons, such as ethylene iso-butylene, styrene and aliphatic dunes, such as butadiene, isoprene and chloroprene.
  • polyhedral oligosilsesquioxane is an example of hybrid mesoporous material.
  • the polyhedral oligosilsesquioxane has randomly linked arrays of polycyclic cages of bridged polysilsesquioxanes by means of sol-gel polymerization may be used as well.
  • These network polymers may be porous xerogels and aerogels, or non-porous polymers depending on whether the organic spacer is a rigid arylene group or a flexible alkylene group.
  • Monolithic gels containing organic dyes have been prepared for waveguide, NLO (Non-linear optical), and laser applications.
  • mesoporous TiCh has a large fraction of pores, about 50-80%, empty or filled with trapped air.
  • mesoporous T1O2 has greater light diffusing properties compared to non-porous materials. Light scattering is reduced and the film comprising mesoporous materials appears more translucent than that of the non-porous materials. This film produces a blurred effect, reducing both color and textural imperfections and improving the natural appearance of the keralinous surfaces.
  • Mesoporous materials can produce these effects by achieving a balance between diffused transmittance and reflectance and opacity, and thus retaining natural translucency of biological tissues.
  • High reflectance provides optimal coverage, thereby obscuring discoloration and hyperpigmentation.
  • These qualities combined result in a composition which may reduce the appearance of lines, wrinkles, creases, crow's feet, suborbital lines, periorbital lines, hyperpigmentation, skin discoloration, blemishes, sagging skin, skin fragility, skin atrophy and/or the like. These attributes are extremely important in achieving a blurring effect but also to improve the natural appearance of skin with good coverage.
  • the balance between reflectance and diffused transmittance is essential for obtaining a mesoporous material which provides good coverage with optical blurring resulting in a natural appearance.
  • a mesoporous material having a balance of these properties is optimal.
  • a film of the mesoporous material has a reflectance of less than about 55% providing sufficient co ⁇ erage and a diffused transmittance of greater than about 18% providing optical blurring enables a good balance as determined by the method described in Example 1.
  • the method uses a film that contains 5% mesoporous material and has a thickness of 10 microns.
  • Other mesoporous material equivalents are also contemplated should they have the desired characteristics described herein.
  • the mesoporous material has a high pore density and volume. These qualities in combination with the refractive index enable the composition to produce a blurring effect by enhancing diffused transmiitance and thereby improving the appearance of the biological surface onto which the composition was applied. Without wishing to be bound by theory, the efficiency of the blurring and soft focus effect or the ability to camouflage fine lines and wrinkles is believed to be a function of the diffused transmittance parameter ("'Quantification of the Soft Focus Effect", Cosmetics & Toiletries, 111:57, 1996). Diffused transmittance is known as the portion of light that is scattered or diffuse by irregularities.
  • Haze and clarity characteristics are both a measure of the degree of scatter and in combination make up diffused transmittance. While haze is a measure of wide- angle scattering, which causes a loss of contrast, clarity is the measure of narrow-angle scattering. Clarity and details are lost when an object is viewed through another material, such as a film, or when the object is further away. Accordingly, the higher the haze, the lower the clarity, and thus more diffusion occurs.
  • any mesoporous material that produces high diffused transmittance would be beneficial in a cosmetic formulation or preparation for producing a blurring effect, improving the natural appearance of the biological surface to which the cosmetic is applied, and overcoming the drawbacks of typical cosmetics that are opaque, unnatural and chalky., and those that settle in fine lines and wrinkles.
  • the pore volume is about 0. lcm ? /g to about 2 cm 3 /g; more preferably about 0.1 cnvVg to about 1.8 cmVg; and most preferably about 0.2 cm 3 /g to about 1.6 cmVg, while the refractive index of the mesoporous material is about 1.38 to about 3.52. More preferably, the refractive index is about 1.40 to about 3.50; and most preferably about 1.42 to about 3.40. Because the refractive index of human skin is about 1.55, a preferred refractive index range of around the skin refractive index is useful for modifying the optical properties of skin.
  • the refractive indices of various materials may be calculated using a refractometer.
  • a refractometer See, for example, hypertext transfer protocol :// ⁇ vorld wide web2.ups.edu/faculty/hanson/labtechniques/refractometry/interpret.hlm
  • the diameter of a pore is about 2 nanometers to about 70 nanometers; and preferably about 5 nanometers to about 60 nanometers.
  • the mesoporous material has a pore size such that the wavelength of the light that enters the pore has a wavelength less than that of visible light.
  • a mesoporous material having a surface area in the range of 20 m 2 /g to 700 m 2 /g and preferably about 35 m 2 /g to about 500 m 2 /g is most useful in the inventive composition for producing a blurring and soft focus effect.
  • the advantages of the inventive composition include, bul are not limited to, the simplicity of at least one mesoporous material to provide optical blurring and "coverage" without the drawbacks of pigments or dyes, such as pigmented T1O 2 , which produces a chalky white residue thereby losing the soft focus effects and inadvertently accentuating the fine lines or wrinkles into which pigments settle.
  • Non-mesoporous materials including traditional commercial soft focus materials such as PMMA, PE, and spherical silica, provide soft blurring effects. However, they have a low refractive index, which result in a sheer film thereby providing little or no coverage.
  • nanocrystals or nanoparticles may be loaded in the ordered or disordered pores of the mesoporous material.
  • nanoparticles can also refer to nanoclusters. clusters, particles, dots, quantum dots, small particles, nanostruclured materials. These nanocrystals may be either placed or formed in situ in the pores of the mesoporous material using electrical and/or van der Waals interactions. Depending on the size of active ingredients typically used in cosmetic formulations, they should not be trapped in the mesoporous material pores because these pores are very small. However, should these pores be loaded with materials other than air, then these materials would alter the optical properties of the compositions.
  • One embodiment of the invention relates to mesporous material pores loaded with (noble) metal nanocrystals, including but not limited to, precious metals, gold, silver, copper, platinum, palladium, tantalum, and iridium.
  • the optical spectra of noble metal clusters are known to demonstrate apparent resonance lines resulting from collective excitations of electrons. These electron excitations are known as particle plasmons, Mie plasmons or surface plasmons.
  • a further embodiment loads any metal that is resistant to corrosion or oxidation and results in the absorption of light at specific wave lengths through the Mie plasmon effect thereby producing non-linear optical properties.
  • the mesoporous materials loaded with, for example, (noble) metal nanocrystals exhibit plasmon resonance effects resulting from non-linear optical properties which, would be useful as an alternative to cosmetic colorants, pigments, or dyes.
  • Fluorescent materials are known to produce visible or invisible light as a result of incident light of a shorter wavelength (i.e. X-rays, UV-rays, etc.). The effect ceases as soon as the source of excitement is removed. Fluorescent materials are also contemplated as one of the materials to load in the pores of the mesoporous material of the inventive composition. Non-limiting examples of fluorescent materials include zinc sulfide. Fluorescein isothiocyanate (FITC), and fluorescein derivatives, such as Oregon Green. Tokyo Green, SNAFL, and carboxynapthofiuorescein.
  • FITC Fluorescein isothiocyanate
  • fluorescein derivatives such as Oregon Green. Tokyo Green, SNAFL, and carboxynapthofiuorescein.
  • the mesoporous material comprises particles that are extremely small, for example, less than or about 100 nanometers, then the films and coatings may be produced that also provide ultraviolet (UV) protection.
  • UV ultraviolet
  • Another advantage of the mesoporous material is that it absorbs oil, sebum, and moisture, for example.
  • a yet further embodiment of the invention provides a mesoporous material composition with or without (empty /air) loaded pores, that has optical properties which enhance the aesthetic and natural appearance of a biological surface, while minimizing or eliminating the use of pigments or dyes for coverage, and yet resulting in optical blurring and diffuse light transmittance, light scattering and reflection, thereby reducing the appearance of dermatological signs of chronological aging, photo-aging, hormonal aging, and/or actinic aging; reducing the appearance of lines and/or wrinkles; reducing the noticeability of facial lines and wrinkles, facial wrinkles on (he cheeks, forehead, perpendicular wrinkles between the eyes, horizontal wrinkles above the eyes, and around the mouth, marionette lines, and particularly deep wrinkles or creases; reducing the appearance and/or depth of lines and/or wrinkles: improving the appearance of suborbital lines and/or periorbital lines; reducing the appearance of crow's feet; improving the appearance of rejuvenating and/or revitalizing skin, decreasing the
  • Another embodiment of the invention relates to a method of improving the aesthetic or natural appearance of a biological surface comprising applying to the biological surface, including but not limited to, keratinous tissue, skin, hair and nails, the inventive composition comprising a mesoporous material having the characteristics and properties described herein, in an amount effective to improve the aesthetic or natural appearance of the biological surface.
  • the biological surface including but not limited to, keratinous tissue, skin, hair and nails
  • the inventive composition comprising a mesoporous material having the characteristics and properties described herein, in an amount effective to improve the aesthetic or natural appearance of the biological surface.
  • skin thickness variations associated with aging decreases with loss of estrogen.
  • glycosaminoglycans, procollagens, and procollagens precursors of collagen
  • collagen all extracellular matrix components in the skin, production and presence are important for softening fine lines, wrinkles, dimpling, blemishes, sagging, resulting in the appearance of thicker healthier skin.
  • Keratinous surfaces may be mottled with folds, wrinkles, creases, dimples, sagging, and relaxed cutaneous tissue resulting from physiological aging, cutaneous senescence, photo-induced actinic aging, as elastic fibers become looser and fibroblasts become less active and/or as the appearance of keratinization and oxydative stress (free radicals) results in a diminished cutaneous vascular network.
  • the biological surface may be any surface to which cosmetics, personal care products, dermatological, and pharmaceutical compositions are typically applied, including but not limited to skin, lips, hair, nails, and the like.
  • the composition that is applied to biological surfaces improves or enhances the aesthetic appearance of skin by camouflaging the natural aging process, discoloration, chronic and cumulative damage to biological surfaces, and imperfections on the surface.
  • Embodiments of the invention relate to the discovery that mesoporous materials with pores loaded or empty /unloaded in a composition or formulation camouflage fine lines, wrinkles, pores, sagging, or other conditions due to aging.
  • mesoporous materials with pores loaded or empty /unloaded in a composition or formulation camouflage fine lines, wrinkles, pores, sagging, or other conditions due to aging.
  • By relying on the optical properties of the inventive composition enables one to camouflage the signs of aging, dermalological degeneration of biological surfaces, and imperfections of biological surfaces, thereby improving the aesthetic and natural appearance of skin.
  • One embodiment of the invention relates to methods of applying the mesoporous material composition that is loaded or unloaded (air) to an affected area of the skin.
  • composition is preferably applied topically at least once daily, preferably twice a day, and remains on the affected area of the skin, where the affected area of the skin includes, but is not limited to, the face, neck, legs and thighs, scalp, and overall body.
  • Topical compositions preferably have the aforementioned mesoporous material, loaded or unloaded, which improves the cosmetic and/or aesthetic appearance of skin, particularly of aging and/or inflamed skin.
  • the composition may have a mesoporous material in an amount from about 0.1% to about 50%, preferably from about 0.2% to about 20%, and more preferably from about 0.3% to about 10%, based on the total weight of the composition, where the composition is useful in improving the natural and aesthetic appearance of, for example, skin.
  • the mesoporous material composition is useful in improving the natural and aesthetic appearance of a biological surface, including skin, lips, hair, and nails, when applied, preferably topically in a daily manner to the biological surface.
  • the composition of the invention may also include, in addition to a carrier or vehicle, non-limiting examples of active ingredients useful in reducing, diminishing, or camouflaging medical and/or cosmetic conditions associated with aging, inflammation, and degeneration of the biological surface.
  • Such conditions commonly include, but are not limited to, dermatological aging (chronological aging, hormonal aging and/or actinic aging), dermatitis, skin and hair fragility, hirsutism, rosacea, skin blemishes, sensitive skin, hyperpigmentation or hypopigmentation, thinning skin, roughness, keratosis, skin atrophy, wrinkles, lines, hyperplasia, fibrosis, and any combinations thereof.
  • the active components of the present invention may also be useful in enhancing lhe general health, vitality, condition, and aesthetic appearance of the skin.
  • compositions comprising mesoporous materials having the desired properties, whether loaded with a compatible material or with air, may be useful in topically applied formulations, anti-oxidants, antiinflammatories, sunscreens, cosmetics, including makeup, and formulations for reducing dermatological signs of aging, including wrinkles, fine lines, and sagging skin, and the like.
  • additional constituents in a composition may be formulated in a variety of product forms.
  • the compositions may be prepared in targeted deliver)' systems, e.g. creams, lotions, moisturizers, gels, toners, serums, sprays, foams, powders, and the like, particularly for topical application and administration.
  • the present invention further provides the compositions comprising the loaded and unloaded mesoporous material, preferably for topical administration or for targeted delivery without inducing significant irritation.
  • the inventive compositions are suitable for all skin types, such as sensitive, normal, dry, or oily, preferably sensitive to dry skin, as well as mature skin.
  • the compositions may be suitable for dry skin.
  • the compositions are applied to the skin for a period of time sufficient to enhance the natural and aesthetic appearance of skin.
  • the compositions may be applied topically once, twice, or more daily to biological surfaces, including but not limited to skin, lips, and hair.
  • the daily application may be applied for a period of one week, two weeks, four weeks, or more.
  • the preferred composition or formulation may be applied and left on the affected area once daily.
  • the consumer could preferably apply the inventive composition at a frequency and duration in which to accomplish and reflect a flawless, natural look.
  • compositions may be formulated into liposomes which may comprise other additives or substances, and/or which may be modified to more specifically reach or remain at a site following administration.
  • the compositions of embodiments of the present invention yield improvements to the aesthetic appearance of skin by camouflaging or improving upon at least one of the previously described conditions, or combinations thereof.
  • cosmetic treatments comprising compositions containing mesoporous materials loaded with or without additional materials, such as (noble) metal nanocrystals of the invention may be carried out, for example, by topically applying the cosmetic composition as described herein according to the routine technique for administering such compositions.
  • the topical cosmetic, dermatological, or pharmaceutical composition preferably is applied once daily for a period of at least one week, but may include a period of about 2, 4, 8, 12 or more weeks.
  • the cosmetic composition is preferably applied to the face and neck, but may be applied to any area of skin in need of aesthetic improvement, where the cosmetic composition remains on the affected area of skin, and preferably not removed or rinsed off the skin.
  • Routine and commonly practiced techniques encompass the application of creams, lotions, gels, sera, ointments, makeup, sunscreen compositions, or the like, to the skin.
  • the cosmetic composition is a topical leave on formulation, where spraying as a form of application is also envisioned.
  • compositions comprising a cosmetically, dermaiologically, or pharmaceutically acceptable formulation which is suitable for contact with living mammalian tissue, including human tissue, or synthetic equivalents thereof, with virtually no adverse physiological effect to the user.
  • compositions embraced by this invention can be provided in any cosmetically and/or dermaiologically suitable form, preferably as a lotion or cream, but also in an anhydrous or aqueous base, as well as in a sprayable liquid form.
  • compositions of this invention include but are not limited to, for example, an emulsion, a cream, a balm, a gloss, a lotion, a foam, a mask, a serum, a toner, an ointment, a mousse, a patch, a pomade, a solution, a spray, a wax-based slick, or a towelette.
  • compositions contemplated by this invention can include one or more compatible cosmetically acceptable adjuvants commonly used and known by the skilled practitioner, such as fragrances, emollients, humectants, preservatives, vitamins, chelators, thickeners, perilla oil or perilla seed oil (WO 01/66067 to a "Method of Treating a Skin Condition.” incorporated herewith) and the like, as well as other botanicals such as aloe, chamomile, and the like, and as further described below. Pigments, dyes, and colorants would not be required or necessary, but could be used if so desired and if they do not interfere with the optical blurring and reflective properties of the composition.
  • compatible cosmetically acceptable adjuvants commonly used and known by the skilled practitioner, such as fragrances, emollients, humectants, preservatives, vitamins, chelators, thickeners, perilla oil or perilla seed oil (WO 01/66067 to a "Method of Treating a Skin
  • the mesoporous material in a cosmetic application would be used as an alternative to colorants, pigments, or dyes because the mesoporous material provides increased light diffusion properties comparable to light diffusing pigments, such as but not limited to nylon, PMMA, etc. while maintaining relatively high reflectance.
  • mesoporous materials which provide color such as, for example, mesoporous iron oxide, may be used to in combination with the mesoporous Ti ⁇ 2 to match skin tone. Both of these mesoporous materials would have high reflectance and diffused transmittance properties.
  • the mesoporous materials, either loaded or unloaded, of the present invention may be contained in a cosmetically, dematologically, physiologically, and pharmaceutically acceptable vehicle, medium, diluent or earner, for use in reducing, ameliorating, or preventing the dermatological signs associated with aging and inflammation of biological surfaces.
  • the compositions of this invention comprise a medium (vehicle, diluent or carrier) that is compatible with mammalian biological surfaces, including skin, lips, hair and nails.
  • compositions can be formulated as an aqueous phase, an oil phase, alcohol, or aqueous/alcohol -based solutions, ointments, creams, lotions, gels, a wax-in-water emulsion, or water-in-oil, oil-in-water, of water-oil- water triple emulsions having the appearance of a cream or gel, microemulsions, or aerosols.
  • the aqueous phase is a mixture of one or more water soluble or water dispersible ingredient, which can be liquid, semi-solid or solid at room temperature (25 0 C).
  • the vehicle comprises or can be in the form of a suspension, dispersion or solution in water or an aqueous-alcoholic vehicle, which may contain a thickener or gellant.
  • a person skilled in the art can select the appropriate cosmetic form, the ingredients contained therein, as well as the method for preparing it, on the basis of the knowledge that the skilled artisan possesses.
  • the composition may include an aqueous phase which may contain water or a mixture of water and at least one hydrophilic organic solvent in particular an alcohol, especially a linear or branched lower monoaicohol containing from 2 to 5 carbon atoms, e.g., ethanol or propanol; a polyol, e.g., propylene glycol., sorbitol, glycerol, diglycerol, panthenol, or polyethylene glycol, and mixtures thereof.
  • This aqueous phase may represent from about 0.5 weight % to about 99.99 weight %, based upon the total weight of the composition.
  • composition of the invention when in the form of an emulsion, the composition may also optionally comprise a surfactant, preferably in an amount of from about 0.1 weight % to about 30 weight %, and in particular, from about 1 weight % to about 20 weight %, based upon the total weight of the composition.
  • a surfactant preferably in an amount of from about 0.1 weight % to about 30 weight %, and in particular, from about 1 weight % to about 20 weight %, based upon the total weight of the composition.
  • the composition may also comprise a thickening polymer such as an amphiphilic polyurethane. a polyacrylic homopolymer or copolymer, a polyester, or a hydrocarbon-based resin.
  • a thickening polymer such as an amphiphilic polyurethane. a polyacrylic homopolymer or copolymer, a polyester, or a hydrocarbon-based resin.
  • Non-limiting polymers include, homopolymers or copolymers of: vinyl esters of an aliphatic aid having 1 to 18 carbon atoms, such as vinyl acetate; acrylic acid esters and melhacrj lie acid esters of an alcohol having 1 to 18 carbon atoms, such as methyl acrylate, ethyl acrylate, butyl aery late, 2-ethyhexyl acrlate, methyl methacrylate, ethyl methacrylate and butyl methacrylate; and mono and di- ethylenically unsaturated hydrocarbons, including ethylene iso-butylene, styrene and aliphatic dunes, including butadiene, isoprene and chloroprene.
  • vinyl esters of an aliphatic aid having 1 to 18 carbon atoms such as vinyl acetate
  • acrylic acid esters and melhacrj lie acid esters of an alcohol having 1 to 18 carbon atoms, such as
  • composition of the invention which may also comprise an oil phase containing oil soluble or oil dispersible ingredients that are liquid at room temperature (25 0 C) and/or oily or waxy substances that are solid at room temperature, such as waxes, semi-solids, gums, and mixtures thereof.
  • This oily phase may also contain organic solvents.
  • oils include hydrocarbon-based oils of animal origin such as perhydrosqualene; hydrocarbon-based plant oils such as liquid triglycerides of fatty acids of 4 to 10 carbon atoms .
  • heptanoic or octanoic acid triglycerides or oils such as sunflower oil, corn oil, soybean oil, grapeseed oil, castor oil, avocado oil, caprylic/capric acid triglycerides, jojoba oil; linear or branched hydrocarbons of mineral or synthetic origin such as liquid paraffins and derivatives thereof, petroleum jelly; synthetic esters and ethers, in particular esters of fatty alcohols, namely; for example, isopropyl myristate, 2-ethylhexyl palmitate.
  • the oil phase of the composition of the invention may also comprise one or more cosmetically acceptable organic solvents. These solvents are present in an amount of about 0 weight % to about 60 weight %, preferably about 1 weight % to about 30 weight %, based on the total weight of the composition, and may be selected from the group consisting of lipophilic organic solvents, amph philic organic solvents and mixtures thereof.
  • Suitable solvents which may be used in the composition of the invention include acetic acid esters such as methyl, ethyl, butyl, amyl or 2-methoxyethyl acetate; isopropyl acetate; hydrocarbons such as toluene, xylene, p-xylene, hexane or heptane; ethers containing at least 3 carbon atoms, and mixtures thereof.
  • composition of the invention may further comprise any ingredient conventionally used in the cosmetics field.
  • ingredients include preserving agents, aqueous phase thickeners (polysaccharide biopolymers, synthetic polymers) and fatty-phase thickeners, fragrances, hydrophilic and lipophilic active agents, and mixtures thereof.
  • the amounts of these various ingredients are those conventionally used in the cosmetics field to achieve their intended purpose, and range typically from about 0.01 weight % to about 20 weight %, based upon the total weight of the composition. The nature of these ingredients and their amounts must be compatible with the production of the compositions of the invention.
  • the composition of the invention may also comprise an additional particulate phase, typically present in an amount of about 0 weight % to about 30 weight %, based upon the total weight of the composition, preferably from about 0.05 weight % to about 20 weight %, and which can comprise pearlescent agents and/or fillers used in cosmetic compositions.
  • Suitable pearlescenl agents include mica coated with titanium oxide or with iron oxide.
  • Fillers are normally present in an amount of about 0 weight % to about 30 weight %, based on the total weight of the composition, preferably about 0.5 weight % to about 15 weight %.
  • Suitable fillers include talc, silica, zinc stearate, mica, kaolin, nylon (in particular orgasol) powder, polyethylene powder.
  • compositions of the invention are preferably utilized without colorants, pigments, or dyes as they may alter the desired optical properties, it is also contemplated that compositions may contain colorants, pigments, or dyes such that their presence which alters optical properties will be compensated in order to produce a desired blurring effect, enhanced diffused transmittance, and optimal reflection.
  • Suitable inorganic pigments include, but are not limited to, titanium oxide, zirconium oxide and cerium oxide, as well as zinc oxide, iron oxide, chromium oxide and ferric blue.
  • Suitable organic pigments include, but barium, strontium, calcium, and aluminium lakes and carbon black.
  • the oil phase of the compositions of the invention may comprise one or more waxes, gums, or mixtures thereof.
  • the waxes include hydrocarbon-based waxes, fluoro waxes and/or silicone waxes and can be of plant, mineral, animal and/or synthetic origin. In particular, the waxes have a melting point of greater than 25 0 C, preferably greater than 45 0 C.
  • the compositions of the present invention may contain from about 0 weight % to about 20 weight % waxes, based upon the total weight of the composition.
  • the gums are generally high molecular weight polydimethylsiloxanes
  • compositions of the present invention may contain from about 0 weight % to about 20 weight % gums, based upon the total weight of the composition, typically from about 0.1 weight % to about 10 weight %.
  • compositions for topical application can be in the form of a protective care composition for the skin, preferably for the face, the neck, the hands, the feet, or other areas of the body.
  • a protective care composition for the skin preferably for the face, the neck, the hands, the feet, or other areas of the body.
  • Non-limiting examples include day creams or lotions, night creams or lotions, moisturizer, salves, sunscreen creams, fluid lotions, oils, ointments, gels, body milks, makeup (a foundation, a bronzer), artificial tanning compositions, emulsifiers, or a solid which is poured or cast as a stick or a dish, for example.
  • the mesoporous materials are ideal for use in a foundation product because it could achieve high camouflage and blurring effects to result in the perception of a natural appearance.
  • the topical compositions of the present invention may also include one or more of the following: a skin penetration enhancer, an emollient, a skin plumper, an optical diffuser, a sunscreen, an exfoliation promoter, and an antioxidant. Details with respect to these and other suitable cosmetic ingredients can be found in the International Cosmetic Ingredient Dictionary and Handbook, 10th Edition (2004)("INCI”), published by the Cosmetic, Toiletry, and Fragrance Association (CTFA), at pp. 2177-2299, which is herein incorporated by reference in its entirely.
  • CTFA Cosmetic, Toiletry, and Fragrance Association
  • An emollient provides the functional benefits of enhancing skin smoothness, reducing the appearance of fine lines and coarse wrinkles, and moisturizing.
  • Non-limiting examples include isopropyl myristate, petrolatum, isopropyl lanolate, silicones (e.g., methicone, dimethicone), oils, mineral oils, fatty acid esters, or any mixtures thereof.
  • the emollient is preferably present from about 0.1 weight % to about 50 weight % of the total weight of the composition.
  • a skin plumper serves as a collagen enhancer to the skin.
  • An example of a suitable, and preferred, skin plumper is palmitoyl oligopeptide.
  • Other skin plumpers are collagen and/or glycosaminoglycan (GAG) enhancing agents.
  • the skin plumper is preferably present from about 0.1 weight % to about 20 weight % of the total weight of the composition.
  • optical diffusers examples include, but are not limited to, boron nitride, mica, nylon, polymethylmethacrylate (PMMA), polyurethane powder, seriate, silica, silicone powder, talc, Teflon, titanium dioxide, zinc oxide, or any mixtures thereof.
  • the optical diffuser is preferably present from about 0.01 weight % to about 20 weight % of the total weight of the composition.
  • a sunscreen protects the skin from damaging ultraviolet rays.
  • the sunscreen would provide both UVA and UVB protection, by using either a single sunscreen or a combination of sunscreens.
  • the sunscreens that can be employed in the present compositions are avobenzone, cinnamic acid derivatives (such as octylmethoxy cinnamate), octyl salicylate, oxybenzone, non-mesoporous titanium dioxide, zinc oxide, or any mixtures thereof.
  • the sunscreen may be present from about 1 weight % to about 30 weight % of the total weight of the composition.
  • the addition of a sunscreen may protect the skin from ultraviolet radiation.
  • compositions of the invention having sunscreen bring about additional improvements to the aesthetic appearance of skin, including at least one of the following: minimizes sunbuming, minimizes tanning, and reduces redness.
  • compositions may also have one or more exfoliation promoters.
  • exfoliation promoters that can be used in the present compositions include alpha hydroxy acids (AHA); benzoyl peroxide; beta hydroxy acids; keto acids, such as pyruvic acid, 2-oxopropanoic acid, 2-oxobutanoic acid, and 2- oxopentanoic acid; oxa acids as disclosed in U.S. Patent Nos. 5,847.003 and 5,834,513 (the disclosures of which are incorporated herein by reference); salicylic acid; urea: or any mixtures thereof.
  • AHA alpha hydroxy acids
  • beta hydroxy acids keto acids, such as pyruvic acid, 2-oxopropanoic acid, 2-oxobutanoic acid, and 2- oxopentanoic acid
  • oxa acids as disclosed in U.S. Patent Nos. 5,847.003 and 5,834,513 (the disclosures of which are incorporated here
  • the preferred exfoliation promoters are 3,6,9-trioxaundecanedioic acid, glycolic acid, lactic acid, or any mixtures thereof. (See also, INCl at p. 2205).
  • the composition has about 0.1 weight % to 30 weight %, preferably about 1 weight % to about 15 weight % and more preferably about 1 wt% to about 10 ⁇ vt%, of the exfoliation promoter based on the total weight of the composition.
  • antioxidants functions, among other things, to scavenge free radicals from skin to protect the skin from environmental aggressors.
  • antioxidants that maybe used in the present compositions include compounds having phenolic hydroxy functions, such as ascorbic acid and its derivatives/esters; beta-carotene; catechins; curcumin; ferulic acid derivatives (e.g. ethyl ferulate, sodium ferulate); gallic acid derivatives (e.g. propyl gallate); lycopene; reductic acid; rosmarinic acid; tannic acid; tetrahydrocurcumin; tocopherol and its derivatives; uric acid; or any mixtures thereof.
  • antioxidants are those that have one or more thiol functions (-SH), in either reduced or non-reduced form, such as glutathione, lipoic acid, thiogly colic acid, and other sulfhydryl compounds.
  • the antioxidant may be inorganic, such as bisulfites, metabisulfites, sulfites, or other inorganic salts and acids containing sulfur.
  • Compositions of the present invention may have an antioxidant preferably from about 0.001 wt% to about 10 wt%, and more preferably from about 0.01 ⁇ 1% to about 5 wt%, of the total weight of the composition. (See also, INCI at p. 2184).
  • the composition may also have one or more of the following cosmetic and pharmaceutical active agents, excipients, ingredients, or adjuvants: anesthetics, antibiotics, e.g., erythromycins and tetracyclines, salicylic acids, anti- allergenics, antifungals, antiseptics, anti-irritants, anti-inflammatory agents, antimicrobials, analgesics, nitric oxide synthase inhibitors, insect repellents, self-tanning agents, skin penetration enhancers, skin cooling agents, chelating agents, colorants including dyes, lakes and pigments that may be untreated or chemically surface treated to improve wetability or some other property, demulcents, emollients, emulsifiers, fragrances, humectants, lubricants, skin protectants, moisturizers, pH adjusters, preservatives, stabilizers, surfactants, thickeners, film formers, plasticizers, viscosity
  • anesthetics e.
  • Non-limiting examples of active agents for formulating into the compositions of the invention include those reagents having an effect on the treatment of wrinkles and/or fine lines, in addition to the actives as described, such as keratolytic agents, i.e., an active agent having desquamating, exfoliant, or scrubbing properties, or an active agent which can soften the homy layer of the skin.
  • keratolytic agents i.e., an active agent having desquamating, exfoliant, or scrubbing properties
  • an active agent which can soften the homy layer of the skin include hydroxy acids and retinoids. These agents can be formulated, for example, in amounts of from about 0.0001 % to 5% by weight relative to the total weight of the composition.
  • Suitable hydroxy acids include, for example, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid.
  • Emulsifiers are typically present in the compositions of the invention in an amount of about 0.01 weight % to 30 weight %. by weight and preferably from about 0.1 weight % to 30 weight % by weight relative to the total weight of the composition. However, not all compositions will necessarily include emulsifiers. (See, e.g., INCl at p. 2276-2285).
  • suitable thickening agents include xanthan gum, hydroxypropyl cellulose, hydroxyethyl cellulose, carbomer, gum acacia, Sepigel 305 (available from Seppic Co.. France), and clays such as magnesium aluminum silicate. (See, e.g., INCI at p. 2293-2299).
  • compositions of the present invention may include, and their utility can be enhanced by one or more humectants, such as ureas, pyrrolidone carboxylic acids, amino acids, sodium hyaluronates, certain polyols and other compounds with hygroscopic properties. (See INCI at p. 2244).
  • humectants such as ureas, pyrrolidone carboxylic acids, amino acids, sodium hyaluronates, certain polyols and other compounds with hygroscopic properties.
  • the general activity and mildness to skin of the present topical compositions can also be enhanced by neutralization to pH about 3.5 to about 7.0, mosl preferably from pH about 3.7 to about 5.6.
  • This neutralization is preferably accomplished with one or more of ammonium hydroxide, potassium hydroxide, sodium hydroxide, arginine or other amino acids, and/or triethanolamine.
  • retinoids include, without limitation, retinoic acid (e.g., all-trans or
  • the mesoporous materials, of the present invention may be contained in a cosmetically or dematologically acceptable vehicle, medium, diluent or carrier.
  • the topical composition comprising the loaded or unloaded mesoporous materials may be further formulated according to procedures known in the art to provide cosmetic compositions such as emulsions, gels, creams, lotions, masks, toners, serums, oils, water-in-oil, oil-in-water, water-oil -water triple emulsions having lhe appearance of a cream or gel, microemulsions, ointments, pastes, sticks, cakes, pencils, aerosol, and essences, as well as other topical cosmetic vehicles. It is also contemplated that topical compositions of the present invention can be incorporated into delivery systems such as liposomes and topical patches, tapes, and sprays.
  • compositions may be in the form of vesicular dispersions containing ionic and/or nonionic lipids, as described above. Dosage units suitable for such compositions are formulated according to the conventional knowledge and techniques used in the art.
  • compositions for topical application may be in the form of a protective care composition for the skin, preferably for the face, the neck, the hands, the feet, or other areas of the body.
  • a protective care composition for the skin preferably for the face, the neck, the hands, the feet, or other areas of the body.
  • Non-limiting examples include da)' creams or lotions, night creams or lotions, sunscreen creams, lotions, or oils, body milks, makeup (a foundation), artificial tanning compositions, depilatories, and patches.
  • Diffused transmittance is typically used to quantify soft focus or blurring efficiency.
  • the Color Eye 7000 Spectrophotometer (GretagMagbeth; New Windsor, NY) was used for measuring diffused transmittance.
  • the color eye spectrophotometer allows measurement of films in three different modes: total transmittance. direct transmittance. and reflectance.
  • Diffused transmitiance can be obtained by subtracting direct transmittance from total transmittance. Efficiency of blurring or soft focus effects or the ability to hide lines and wrinkles is believed to be a function of diffused transmittance parameters ( "Quantification of the Soft Focus Effect" Cosmetics & Toiletries; VoI 111, July 1996; pp57).
  • High diffused transmittance is an indication of high soft focus effect or blurring effect, while reflectance is a measure of coverage.
  • the mesoporous material demonstrated a higher percent of enhanced diffused transmittance with reasonably high reflectance at various solid loading concentrations or weight percent when compared to pigment grade TiCh.
  • the pigment grade Ti ⁇ 2 has high reflectance but low diffused transmittance creating a mask-like appearance due to its high reflectance and high coverage properties.
  • the mesoporous T1O 2 is advantageous because it hasa lower reflectance and higher diffused iransmiiiance, thereby providing optimal coverage and blurring effect.
  • mesoporous TiCb would have higher blurring effect of lines, wrinkles, and skin imperfections, while maintaining good coverage when used in a topical cosmetic, for example, a foundation.
  • Using mesoporous materials in a cosmetic would provide a good balance between blurring and coverage.
  • Figure 2 demonstrates film thickness effects on diffused transmittance of films containing mesoporous TiO ⁇ and pigment grade TiO 2 . Al a solid load of 2.5%, mesoporous TiOz had a percent diffused transmittance about 2-3 fold higher than pigment grade TiO 2 at every film thickness tested. The data therefore support that mesoporous TiOa has a more efficient blurring property compared to pigment grade JiOi.
  • mesoporous metal oxide such as TiO 2
  • PE polyethylene
  • silica silica
  • PMMA Polymethylmethacrylate
  • compositions comprising ingredients normally used in formulating foundations may be used.
  • mesoporous TiCh may be used as an alternative to pigment or in conjunction with pigments if so desired.
  • examples of foundation formulations are prepared with and without pigments.

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Abstract

Cette invention concerne des compositions et des méthodes permettant de traiter et d'améliorer l'apparence esthétique d'une surface biologique par modification des propriétés optiques de la surface biologique pour obtenir une apparence naturelle. Les compositions décrites dans cette invention peuvent être appliquées de manière topique sur la surface biologique y compris, entre autres, sur la peau, et en quantité suffisante pour améliorer l'apparence esthétique et naturelle de la surface biologique.
PCT/US2007/084614 2006-12-21 2007-11-14 Compositions de matériaux mésoporeux et méthodes permettant de les utiliser pour améliorer l'apparence de surfaces biologiques Ceased WO2008079543A2 (fr)

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US99976306P 2006-12-21 2006-12-21
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US11/714,516 US20080220026A1 (en) 2007-03-06 2007-03-06 Mesoporous material compositions and methods of their use for improving the appearance of biological surfaces
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010038068A1 (fr) * 2008-09-30 2010-04-08 Intrinsiq Materials Global Limited Compositions de soin capillaire comprenant du silicium poreux
WO2010038066A1 (fr) * 2008-09-30 2010-04-08 Intrinsiq Materials Global Limited Compositions de soin capillaire comprenant du silicium poreux
US9993397B2 (en) 2010-11-23 2018-06-12 Conopco Inc. Composite particles and compositions with composite particles
EP3421097A1 (fr) * 2017-06-26 2019-01-02 L'oreal Composition cosmétique comprenant une matière poreuse ordonnée pour réduire les irrégularités visibles et/ou tactiles de la peau

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2365769A (en) * 2000-08-18 2002-02-27 Secr Defence Skin preparations containing silicon

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010038068A1 (fr) * 2008-09-30 2010-04-08 Intrinsiq Materials Global Limited Compositions de soin capillaire comprenant du silicium poreux
WO2010038066A1 (fr) * 2008-09-30 2010-04-08 Intrinsiq Materials Global Limited Compositions de soin capillaire comprenant du silicium poreux
US9993397B2 (en) 2010-11-23 2018-06-12 Conopco Inc. Composite particles and compositions with composite particles
EP3421097A1 (fr) * 2017-06-26 2019-01-02 L'oreal Composition cosmétique comprenant une matière poreuse ordonnée pour réduire les irrégularités visibles et/ou tactiles de la peau
WO2019002275A1 (fr) * 2017-06-26 2019-01-03 L'oreal Composition cosmétique comprenant un matériau poreux ordonné pour réduire les irrégularités visibles et/ou tactiles de la peau

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