WO2008102783A1 - 発毛促進剤 - Google Patents

発毛促進剤 Download PDF

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Publication number
WO2008102783A1
WO2008102783A1 PCT/JP2008/052781 JP2008052781W WO2008102783A1 WO 2008102783 A1 WO2008102783 A1 WO 2008102783A1 JP 2008052781 W JP2008052781 W JP 2008052781W WO 2008102783 A1 WO2008102783 A1 WO 2008102783A1
Authority
WO
WIPO (PCT)
Prior art keywords
promoter
inhibitor
fgf18
hair growth
hair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/052781
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English (en)
French (fr)
Inventor
Toru Imamura
Miho Kimura
Mitsuko Kawano
Nozomi Tsujino
Akiko Kuramochi
Yuko Oda
Kaori Motomura
Masashi Suzuki
Masahiro Asada
Azusa Kameyama
Sumie Togayachi
Syuichi Oka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institute of Advanced Industrial Science and Technology AIST
Original Assignee
National Institute of Advanced Industrial Science and Technology AIST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institute of Advanced Industrial Science and Technology AIST filed Critical National Institute of Advanced Industrial Science and Technology AIST
Priority to US12/527,694 priority Critical patent/US20100203055A1/en
Priority to EP08720756.9A priority patent/EP2127674B1/en
Priority to JP2009500199A priority patent/JP5360593B2/ja
Publication of WO2008102783A1 publication Critical patent/WO2008102783A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

　毛髪成長を阻害する内在性因子を決定し、当該内在性因子の活性もしくは発現を阻害する物質をスクリーニングして、毛髪成長促進剤、発毛促進剤又は脱毛症治療剤を提供すること。 　FGF18が毛髪成長を阻害することが見出され、FGF18活性阻害物質又はFGF18遺伝子発現阻害物質をスクリーニングして、毛髪成長促進剤、発毛促進剤及び脱毛症治療剤の候補とする方法が開示される。また、FGF18の部分ペプチド、ゴーヤー熱水抽出物などのFGF18活性阻害物質及び／又は発現抑制物質を有効成分として含有する毛髪成長促進剤、発毛促進剤又は脱毛症治療剤が開示される。
PCT/JP2008/052781 2007-02-19 2008-02-19 発毛促進剤 Ceased WO2008102783A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/527,694 US20100203055A1 (en) 2007-02-19 2008-02-19 Hair regrowth promoter
EP08720756.9A EP2127674B1 (en) 2007-02-19 2008-02-19 Use of FGF18 inhibitors as hair regrowth promoter
JP2009500199A JP5360593B2 (ja) 2007-02-19 2008-02-19 発毛促進剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-038223 2007-02-19
JP2007038223 2007-02-19

Publications (1)

Publication Number Publication Date
WO2008102783A1 true WO2008102783A1 (ja) 2008-08-28

Family

ID=39710058

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052781 Ceased WO2008102783A1 (ja) 2007-02-19 2008-02-19 発毛促進剤

Country Status (4)

Country Link
US (1) US20100203055A1 (ja)
EP (1) EP2127674B1 (ja)
JP (2) JP5360593B2 (ja)
WO (1) WO2008102783A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012036259A1 (ja) 2010-09-17 2012-03-22 独立行政法人産業技術総合研究所 毛の成長周期研究モデル動物
JP2012062294A (ja) * 2010-09-17 2012-03-29 National Institute Of Advanced Industrial Science & Technology 毛成長休止期短縮剤
WO2015083375A1 (ja) * 2013-12-02 2015-06-11 オーストリッチファーマ株式会社 脱毛誘発物質を抗原とした抗体、組成物および製造方法
CN115089717A (zh) * 2022-07-20 2022-09-23 深圳大学 转录因子ap-1抑制剂在制备防脱发药物中的应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8445445B2 (en) 2009-09-15 2013-05-21 Five Prime Therapeutics, Inc. Method of promoting hair growth using FGFR4 extracellular domains
WO2011084711A2 (en) 2009-12-17 2011-07-14 Five Prime Therapeutics, Inc. Hair growth methods using fgfr3 extracellular domains
US8481038B2 (en) 2010-11-15 2013-07-09 Five Prime Therapeutics, Inc. Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins
WO2013149191A1 (en) * 2012-03-29 2013-10-03 The Trustees Of Columbia University In The City Of New York Methods for regulating hair growth disorders
CN102675157A (zh) * 2012-04-10 2012-09-19 福州大学 具有血糖调节作用的苦瓜美拉德反应产物及其制备方法
WO2014022655A1 (en) * 2012-08-01 2014-02-06 The Trustees Of Columbia University In The City Of New York Methods for regulating hair growth disorders
EP2735303A1 (en) * 2012-11-23 2014-05-28 Pilosciences Hair growth compositions and methods
KR101951283B1 (ko) * 2017-11-13 2019-02-22 양미경 탈모의 예방 또는 치료용, 또는 발모 또는 육모 촉진용 약학 또는 화장료 조성물
KR102069088B1 (ko) 2018-04-02 2020-01-22 양미경 탈모의 예방 또는 치료용, 또는 발모 또는 육모 촉진용 약학 또는 화장료 조성물

Citations (4)

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Publication number Priority date Publication date Assignee Title
JPH04224522A (ja) 1990-04-27 1992-08-13 Merck & Co Inc 繊維芽細胞増殖因子含有組成物による禿頭症の治療又は予防方法
JP2003176213A (ja) * 2001-12-11 2003-06-24 National Institute Of Advanced Industrial & Technology 育毛剤
JP2006083082A (ja) 2004-09-15 2006-03-30 National Institute Of Advanced Industrial & Technology 毛髪成長促進剤、発毛促進剤及び脱毛症治療剤
JP2006117659A (ja) * 2004-09-27 2006-05-11 Kobayashi Pharmaceut Co Ltd 脱毛改善剤

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Publication number Priority date Publication date Assignee Title
EP2339002A1 (en) * 1996-10-16 2011-06-29 ZymoGenetics, Inc. Fibroblast growth factor homologs
WO2006006270A1 (ja) * 2004-09-27 2006-01-19 Kobayashi Pharmaceutical Co., Ltd. 脱毛改善剤

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
JPH04224522A (ja) 1990-04-27 1992-08-13 Merck & Co Inc 繊維芽細胞増殖因子含有組成物による禿頭症の治療又は予防方法
JP2003176213A (ja) * 2001-12-11 2003-06-24 National Institute Of Advanced Industrial & Technology 育毛剤
JP2006083082A (ja) 2004-09-15 2006-03-30 National Institute Of Advanced Industrial & Technology 毛髪成長促進剤、発毛促進剤及び脱毛症治療剤
JP2006117659A (ja) * 2004-09-27 2006-05-11 Kobayashi Pharmaceut Co Ltd 脱毛改善剤

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See also references of EP2127674A4 *
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SUZUKI S; KATO T; TAKIMOTO H ET AL.: "Localization of rat FGF-5 protein in skin macrophage-like cells and FGF-5S protein in hair follicle: Possible involvement of two Fgf-5 gene products in hair growth cycleregulation", J INVEST DERMATOL, vol. 111, 1998, pages 963 - 972
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YONEDA, A. ET AL.: "Engineering of an FGF-proteoglycan fusion protein with heparin-independent, mitogenic activity", NAT. BIOTEC., vol. 18, no. 6, 2000, pages 641 - 644, XP002993409, DOI: doi:10.1038/76487
ZHANGX ET AL.: "Receptor Specificity of the Fibroblast Growth Factor Family: THE COMPLETE MAMMALIAN FGFFAMILY", J BIOL CHEM, vol. 281, no. 23, 2006, pages 15694 - 15700, XP008121923, DOI: doi:10.1074/JBC.M601252200

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012036259A1 (ja) 2010-09-17 2012-03-22 独立行政法人産業技術総合研究所 毛の成長周期研究モデル動物
JP2012062294A (ja) * 2010-09-17 2012-03-29 National Institute Of Advanced Industrial Science & Technology 毛成長休止期短縮剤
JP5686350B2 (ja) * 2010-09-17 2015-03-18 独立行政法人産業技術総合研究所 毛の成長周期研究モデル動物
WO2015083375A1 (ja) * 2013-12-02 2015-06-11 オーストリッチファーマ株式会社 脱毛誘発物質を抗原とした抗体、組成物および製造方法
JPWO2015083375A1 (ja) * 2013-12-02 2017-03-16 オーストリッチファーマ株式会社 脱毛誘発物質を抗原とした抗体、組成物および製造方法
US9975964B2 (en) 2013-12-02 2018-05-22 Ostrich Pharma Kk Antibody against alopecia-inducing substance as antigen, composition and production method
US10246520B2 (en) 2013-12-02 2019-04-02 Ostrich Pharma Kk Antibody against alopecia-inducing substance as antigen, composition and production method
CN115089717A (zh) * 2022-07-20 2022-09-23 深圳大学 转录因子ap-1抑制剂在制备防脱发药物中的应用
CN115089717B (zh) * 2022-07-20 2023-08-04 深圳大学 转录因子ap-1抑制剂在制备防脱发药物中的应用

Also Published As

Publication number Publication date
US20100203055A1 (en) 2010-08-12
EP2127674A4 (en) 2011-04-27
EP2127674A1 (en) 2009-12-02
JP2013209410A (ja) 2013-10-10
JPWO2008102783A1 (ja) 2010-05-27
EP2127674B1 (en) 2013-04-24
JP5700343B2 (ja) 2015-04-15
JP5360593B2 (ja) 2013-12-04

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