WO2008156331A3 - Nouvelle utilisation de composés de lignane - Google Patents

Nouvelle utilisation de composés de lignane Download PDF

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Publication number
WO2008156331A3
WO2008156331A3 PCT/KR2008/003525 KR2008003525W WO2008156331A3 WO 2008156331 A3 WO2008156331 A3 WO 2008156331A3 KR 2008003525 W KR2008003525 W KR 2008003525W WO 2008156331 A3 WO2008156331 A3 WO 2008156331A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel use
aril
nutmeg
pparγ
extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2008/003525
Other languages
English (en)
Other versions
WO2008156331A2 (fr
Inventor
Jae-Kwan Hwang
Jae Young Lee
Jeong Hwan Kim
Jae-Seok Shim
Hae Ji Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocare Co Ltd
Original Assignee
Biocare Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020080019147A external-priority patent/KR100959557B1/ko
Application filed by Biocare Co Ltd filed Critical Biocare Co Ltd
Publication of WO2008156331A2 publication Critical patent/WO2008156331A2/fr
Publication of WO2008156331A3 publication Critical patent/WO2008156331A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne une nouvelle utilisation de composés de lignane, plus particulièrement, une nouvelle utilisation d'un extrait d'arille de muscade, 2- (4-allyl-2, 6-dimethoxyphenoxy) -1- (4-hydroxy- 3 -methoxyphenyl) -propane, l'austrobailignane 7 ou la licarine E, pour prévenir ou traiter le diabète ou des maladies induites par PPARγ. Le composé susmentionné et l'extrait d'arille de muscade agissent en tant que ligands pour PPARγ, et ils peuvent être utilisés pour prévenir ou traiter des maladies induites par PPARγ parmi lesquelles, entre autres, le diabète et une complication diabétique. Ainsi, 2- (4-allyl-2, 6- dimethoxyphenoxy) -1- (4 -hydroxy-3 -methoxyphenyl) -propane, l'austrobailignane 7 ou la licarine E et l'extrait d'arille de muscade peuvent être utiles en tant qu'agent prophylactique ou thérapeutique pour des maladies induites par PPARγ, parmi lesquelles, entre autres, le diabète et une complication diabétique.
PCT/KR2008/003525 2007-06-20 2008-06-20 Nouvelle utilisation de composés de lignane Ceased WO2008156331A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2007-0060176 2007-06-20
KR20070060176 2007-06-20
KR1020080019147A KR100959557B1 (ko) 2007-06-20 2008-02-29 육두구 가종피 추출 화합물을 유효성분으로 포함하는당뇨병 또는 피피에이알-감마 매개 질환 예방 및 치료용약학적 조성물
KR10-2008-0019147 2008-02-29

Publications (2)

Publication Number Publication Date
WO2008156331A2 WO2008156331A2 (fr) 2008-12-24
WO2008156331A3 true WO2008156331A3 (fr) 2009-02-26

Family

ID=40156812

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/003525 Ceased WO2008156331A2 (fr) 2007-06-20 2008-06-20 Nouvelle utilisation de composés de lignane

Country Status (1)

Country Link
WO (1) WO2008156331A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101062670B1 (ko) * 2009-06-01 2011-09-06 (주)아모레퍼시픽 2,5-비스-아릴-3,4-디메틸테트라하이드로퓨란 리그난을 유효성분으로 포함하는 에이엠피케이의 활성화에 의해 매개되는 비만 관련 질환의 예방 또는 치료용 조성물
CN113440517A (zh) * 2021-06-07 2021-09-28 江南大学 利卡灵b在制备预防或/和治疗非酒精性脂肪肝病药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006273788A (ja) * 2005-03-30 2006-10-12 Kaneka Corp Ｐｐａｒリガンド活性を有する植物由来の組成物
KR20070033938A (ko) * 2005-09-22 2007-03-27 (주)바이오케어 메이스리그난 또는 이의 약제학적으로 허용 가능한 염을유효성분으로 함유하는 ＰＰＡＲα에 의해 매개되는 질환의예방 또는 치료용 조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006273788A (ja) * 2005-03-30 2006-10-12 Kaneka Corp Ｐｐａｒリガンド活性を有する植物由来の組成物
KR20070033938A (ko) * 2005-09-22 2007-03-27 (주)바이오케어 메이스리그난 또는 이의 약제학적으로 허용 가능한 염을유효성분으로 함유하는 ＰＰＡＲα에 의해 매개되는 질환의예방 또는 치료용 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIM, K-J. ET AL.: "Lignans from Myristica Fragrans.", YAKHAK HOEJI., vol. 46, no. 2, 2002, pages 98 - 101 *
LEIGH BROADHURST, C. ET AL.: "Insulin-like Biological Activity of Culinary and Medicinal Plant Aqueous Extracts in Vitro.", J. AGRIC. FOOD. CHEM., vol. 48, 2000, pages 849 - 852, XP002975810 *

Also Published As

Publication number Publication date
WO2008156331A2 (fr) 2008-12-24

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