WO2009007331A2 - Implant biorésorbable - Google Patents

Implant biorésorbable Download PDF

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Publication number
WO2009007331A2
WO2009007331A2 PCT/EP2008/058726 EP2008058726W WO2009007331A2 WO 2009007331 A2 WO2009007331 A2 WO 2009007331A2 EP 2008058726 W EP2008058726 W EP 2008058726W WO 2009007331 A2 WO2009007331 A2 WO 2009007331A2
Authority
WO
WIPO (PCT)
Prior art keywords
bioresorbable
secondary structure
primary structure
primary
implant according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/058726
Other languages
German (de)
English (en)
Other versions
WO2009007331A9 (fr
Inventor
Günter Lob
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RESOIMPLANT GmbH
Original Assignee
RESOIMPLANT GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RESOIMPLANT GmbH filed Critical RESOIMPLANT GmbH
Publication of WO2009007331A2 publication Critical patent/WO2009007331A2/fr
Publication of WO2009007331A9 publication Critical patent/WO2009007331A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body

Definitions

  • the invention relates to a bioresorbable implant which, at least partially, is formed by a bioresorbable polymer, ie a polymer which is degraded in the body of a patient after implantation of the implant.
  • Bioresorbable implants thus represent, for some applications, an alternative to implants, for example made of stainless steel, which either remain permanently in the body or have to be removed again (eg after the healing of bone fractures) in a second operation.
  • the degradation time on the one hand can not be accurately predicted and, on the other hand, ideally should depend on the also not exactly predictable, individual healing process.
  • the present invention aims to provide a solution to this problem.
  • the solution consists in that the bioresorbable implant has a hybrid structure, namely, on the one hand, a supporting primary structure of a bioresorbable polymer and, on the other hand, a secondary structure embedded in the supporting primary structure, which can be influenced from outside the body of a patient when the implant is implanted.
  • the secondary structure can be designed so that it is to be changed by external influence so that it has a higher degradation rate after the change than before the change.
  • the secondary structure can also be chosen so that it can be influenced from the outside in such a way that it releases a substance after the external action at an increased rate, which causes an accelerated degradation (bioresorption) of the primary structure and possibly also of the secondary structure itself.
  • the secondary structure is designed such that, after being changed, it releases water as the substance which causes an accelerated degradation of the primary structure. Since the secondary structure is embedded in the primary structure, water is released in the interior of the primary structure, which degrades the primary structure. This amounts to the fact that the surface of the primary structure, to which their decomposition begins, is significantly increased after external influence, so that the degradation is accelerated.
  • the secondary structure can contain, for example, water-filled microspheres (also called microspheres) which are designed to absorb radiation coming from the outside and consequently to open it, so that the Water can escape from the microspheres and cause hydrolysis of the primary structure from the inside.
  • microspheres also called microspheres
  • the secondary structure may be formed by a bioresorbable polymer that changes its structure under exposure to radiation such that the time constant for bioresorption is shortened.
  • the primary structure or the secondary structure comprises constituents which heat up under the influence of external radiation (for example by absorption of the radiation) and thereby cause a release of a substance which decomposes the primary structure or the secondary structure.
  • the bioresorbable polymer forming the primary structure is a polylactide.
  • FIG. 1 shows, by way of example, a detail of an implant according to the invention with a contiguous primary structure and a secondary structure.
  • the implant 10 has an outer surface 12 and is formed by a cohesive primary structure 14 which is embedded in a secondary structure 16.
  • the primary structure 14 forms a framework which includes interconnected spaces which form the secondary structure.
  • the spaces forming the secondary structure are preferably filled with a material which is different from a material forming the primary structure 14.
  • the material forming the primary structure 14 is preferably polylactide.
  • the material forming the secondary structure 16 contains microparticles 20 which are excitable by external radiation and consequently give off a substance which decomposes the secondary structure and / or the primary structure in an accelerated manner, for example water.
  • the particles may in particular be water-containing microspheres. - A -
  • the surface 12 may be formed by a third material, which thus virtually forms a coating of the implant 10.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un implant biorésorbable doté d'une structure primaire portante en un polymère biorésorbable et d'une structure secondaire incorporée dans la structure primaire portante et sur laquelle, lorsque l'implant est implanté, on peut agir depuis l'extérieur du corps d'un patient de telle sorte que la structure secondaire soit modifiée pour, après modification, pouvoir grâce aux substances propres au corps se décomposer d'elle-même à une vitesse plus élevée qu'avant la modification, ou qui, après la modification, libère à un taux accru une substance qui a pour effet une résorption de la structure primaire.
PCT/EP2008/058726 2007-07-06 2008-07-04 Implant biorésorbable Ceased WO2009007331A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200710031945 DE102007031945A1 (de) 2007-07-06 2007-07-06 Bioresorbierbares Implantat
DE102007031945.4 2007-07-06

Publications (2)

Publication Number Publication Date
WO2009007331A2 true WO2009007331A2 (fr) 2009-01-15
WO2009007331A9 WO2009007331A9 (fr) 2009-04-09

Family

ID=39971113

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/058726 Ceased WO2009007331A2 (fr) 2007-07-06 2008-07-04 Implant biorésorbable

Country Status (2)

Country Link
DE (1) DE102007031945A1 (fr)
WO (1) WO2009007331A2 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8287538B2 (en) 2008-01-14 2012-10-16 Conventus Orthopaedics, Inc. Apparatus and methods for fracture repair
US8906022B2 (en) 2010-03-08 2014-12-09 Conventus Orthopaedics, Inc. Apparatus and methods for securing a bone implant
US8961518B2 (en) 2010-01-20 2015-02-24 Conventus Orthopaedics, Inc. Apparatus and methods for bone access and cavity preparation
US9730739B2 (en) 2010-01-15 2017-08-15 Conventus Orthopaedics, Inc. Rotary-rigid orthopaedic rod
US10022132B2 (en) 2013-12-12 2018-07-17 Conventus Orthopaedics, Inc. Tissue displacement tools and methods
US10918426B2 (en) 2017-07-04 2021-02-16 Conventus Orthopaedics, Inc. Apparatus and methods for treatment of a bone

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19521642C2 (de) * 1995-06-14 2000-11-09 Aesculap Ag & Co Kg Implantat, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung
ATE345359T1 (de) * 1997-12-22 2006-12-15 Metabolix Inc Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten
DE19908753C2 (de) * 1999-02-20 2003-10-02 Jenapharm Gmbh Bioabbaubare, injizierbare Oligomer-Polymer-Zusammensetzung
US6328990B1 (en) * 1999-11-12 2001-12-11 The Trustees Of The University Of Pennsylvania Bioactive, degradable composite for tissue engineering
DE102004035182B4 (de) * 2004-07-14 2008-05-29 Innovent E.V. Technologieentwicklung Implantatmaterial, ein Verfahren zu seiner Herstellung und seine Verwendung
DE102005033101A1 (de) * 2005-07-15 2007-01-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Resorbierbare Polyetherester und ihre Verwendung zur Herstellung von medizinischen Implantaten
US20070203564A1 (en) * 2006-02-28 2007-08-30 Boston Scientific Scimed, Inc. Biodegradable implants having accelerated biodegradation properties in vivo

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Keine Recherche *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8287538B2 (en) 2008-01-14 2012-10-16 Conventus Orthopaedics, Inc. Apparatus and methods for fracture repair
US11399878B2 (en) 2008-01-14 2022-08-02 Conventus Orthopaedics, Inc. Apparatus and methods for fracture repair
US10603087B2 (en) 2008-01-14 2020-03-31 Conventus Orthopaedics, Inc. Apparatus and methods for fracture repair
US9517093B2 (en) 2008-01-14 2016-12-13 Conventus Orthopaedics, Inc. Apparatus and methods for fracture repair
US9788870B2 (en) 2008-01-14 2017-10-17 Conventus Orthopaedics, Inc. Apparatus and methods for fracture repair
US9730739B2 (en) 2010-01-15 2017-08-15 Conventus Orthopaedics, Inc. Rotary-rigid orthopaedic rod
US9848889B2 (en) 2010-01-20 2017-12-26 Conventus Orthopaedics, Inc. Apparatus and methods for bone access and cavity preparation
US8961518B2 (en) 2010-01-20 2015-02-24 Conventus Orthopaedics, Inc. Apparatus and methods for bone access and cavity preparation
US9993277B2 (en) 2010-03-08 2018-06-12 Conventus Orthopaedics, Inc. Apparatus and methods for securing a bone implant
US8906022B2 (en) 2010-03-08 2014-12-09 Conventus Orthopaedics, Inc. Apparatus and methods for securing a bone implant
US10022132B2 (en) 2013-12-12 2018-07-17 Conventus Orthopaedics, Inc. Tissue displacement tools and methods
US10076342B2 (en) 2013-12-12 2018-09-18 Conventus Orthopaedics, Inc. Tissue displacement tools and methods
US10918426B2 (en) 2017-07-04 2021-02-16 Conventus Orthopaedics, Inc. Apparatus and methods for treatment of a bone

Also Published As

Publication number Publication date
WO2009007331A9 (fr) 2009-04-09
DE102007031945A1 (de) 2009-01-08

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