WO2009010871A3 - Nouveaux dérivés hétéroaryle servant d'antagonistes du récepteur a3 de l'adénosine - Google Patents

Nouveaux dérivés hétéroaryle servant d'antagonistes du récepteur a3 de l'adénosine Download PDF

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Publication number
WO2009010871A3
WO2009010871A3 PCT/IB2008/002243 IB2008002243W WO2009010871A3 WO 2009010871 A3 WO2009010871 A3 WO 2009010871A3 IB 2008002243 W IB2008002243 W IB 2008002243W WO 2009010871 A3 WO2009010871 A3 WO 2009010871A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonists
adenosine
receptor
compounds
pyrazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/002243
Other languages
English (en)
Other versions
WO2009010871A2 (fr
Inventor
Christelle Bolea
Sylvain Celanire
Poul Emmanuel Le
Stefania Gagliardi
Anna Rencurosi
Marco Farina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Addex Pharmaceuticals SA
Original Assignee
Addex Pharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0713687A external-priority patent/GB0713687D0/en
Priority claimed from GB0723344A external-priority patent/GB0723344D0/en
Priority claimed from GB0803103A external-priority patent/GB0803103D0/en
Application filed by Addex Pharmaceuticals SA filed Critical Addex Pharmaceuticals SA
Publication of WO2009010871A2 publication Critical patent/WO2009010871A2/fr
Publication of WO2009010871A3 publication Critical patent/WO2009010871A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés de formule (I). X1, X2, X3, X4, Y1, Y2, Y3, Y4, M1, M2, M3, Am et Bn sont définis dans les revendications de l'invention. Les composés de l'invention sont des antagonistes des récepteurs de l'adénosine de sous-type A3 qui servent à traiter les troubles modulés par les récepteurs A3. L'invention concerne également des compositions pharmaceutiques associées et un procédé d'utilisation de tels composés mis en oeuvre dans la fabrication de médicaments, ainsi qu'un procédé d'utilisation de tels composés visant à prévenir et à traiter des maladies dans lesquelles A3 est impliqué.
PCT/IB2008/002243 2007-07-13 2008-07-11 Nouveaux dérivés hétéroaryle servant d'antagonistes du récepteur a3 de l'adénosine Ceased WO2009010871A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0713687.2 2007-07-13
GB0713687A GB0713687D0 (en) 2007-07-13 2007-07-13 New compounds 1
GB0723344A GB0723344D0 (en) 2007-11-28 2007-11-28 Novel compounds 3
GB0723344.8 2007-11-28
GB0803103A GB0803103D0 (en) 2008-02-20 2008-02-20 Novel compounds 3
GB0803103.1 2008-02-20

Publications (2)

Publication Number Publication Date
WO2009010871A2 WO2009010871A2 (fr) 2009-01-22
WO2009010871A3 true WO2009010871A3 (fr) 2009-03-12

Family

ID=40089928

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/002243 Ceased WO2009010871A2 (fr) 2007-07-13 2008-07-11 Nouveaux dérivés hétéroaryle servant d'antagonistes du récepteur a3 de l'adénosine

Country Status (1)

Country Link
WO (1) WO2009010871A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8415345B2 (en) 2008-05-06 2013-04-09 Glaxo SmithKline LLC Benzene sulfonamide thiazole and oxazole compounds
US8604033B2 (en) 2010-01-15 2013-12-10 Addex Pharma S.A. Preparation of 4-amino-thiazoles and 3-amino-1,2,4-thiadiazoles and their use as allosteric modulators of metabotropic glutamate receptors

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0900388D0 (en) 2009-01-12 2009-02-11 Addex Pharmaceuticals Sa New compounds
US20120129897A1 (en) * 2010-11-18 2012-05-24 Joseph Kent Barbay Bis heteroaryl inhibitors of pro-matrix metalloproteinase activation
GB201104267D0 (en) 2011-03-14 2011-04-27 Cancer Rec Tech Ltd Pyrrolopyridineamino derivatives
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor
EP2567959B1 (fr) 2011-09-12 2014-04-16 Sanofi Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
GB201216018D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Pharmacologically active compounds
CN103351339A (zh) * 2013-07-12 2013-10-16 雅本化学股份有限公司 3-氟代烷基-1-取代吡唑-4-羧酸及其制备方法
GB201314452D0 (en) 2013-08-13 2013-09-25 Ostara Biomedical Ltd Embryo implantation
GB201501302D0 (en) 2015-01-27 2015-03-11 Ostara Biomedical Ltd Embryo implantation
WO2017054112A1 (fr) * 2015-09-28 2017-04-06 常州市卜弋科研化工有限公司 Procédé de préparation d'acide 3-fluoroalkyl-1-méthylpyrazole-4-carboxylique
GB201517523D0 (en) 2015-10-05 2015-11-18 Ostara Biomedical Ltd Methods and compositions for managing reproduction
KR102445887B1 (ko) 2016-04-21 2022-09-21 아스트로사이트 파마슈티컬스, 인코포레이티드 신경계 및 심혈관계 병태 치료를 위한 화합물 및 방법
WO2017194517A1 (fr) * 2016-05-10 2017-11-16 Solvay Sa Composition comprenant des acides ou des esters 3-(halogénoalkyle ou formyle)-1h-pyrazole-4-carboxyliques, sa fabrication et son utilisation pour la préparation de carboxamides
ES2676535B1 (es) * 2017-01-20 2019-04-29 Palobiofarma Sl Moduladores de los receptores a3 de adenosina
CN110461822A (zh) * 2017-03-27 2019-11-15 Ａｇｃ株式会社 含卤素吡唑羧酸及其中间体的制造方法
CN108017584B (zh) * 2017-06-20 2021-03-23 南开大学 A3腺苷受体的小分子拮抗剂
IL276358B2 (en) 2018-02-09 2024-11-01 Astrocyte Pharmaceuticals Inc Compounds and methods for treating addiction and related disorders
WO2020106773A1 (fr) * 2018-11-19 2020-05-28 Saint Louis University Traitement du syndrome du côlon irritable

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11158073A (ja) * 1997-09-26 1999-06-15 Takeda Chem Ind Ltd アデノシンａ３拮抗剤
WO2001064674A1 (fr) * 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. Derives de thiazolyle 2,4-disubstitue
WO2007071348A1 (fr) * 2005-12-19 2007-06-28 F. Hoffmann-La Roche Ag Dérivés d’aminopyrazole de type isoquinoléine, leur fabrication et application en tant qu'agents pharmaceutiques pour le traitement du cancer
WO2007076473A2 (fr) * 2005-12-23 2007-07-05 Kalypsys, Inc. Urees pyrimidinyloxy substituees utiles comme inhibiteurs des proteines kinases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11158073A (ja) * 1997-09-26 1999-06-15 Takeda Chem Ind Ltd アデノシンａ３拮抗剤
WO2001064674A1 (fr) * 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. Derives de thiazolyle 2,4-disubstitue
WO2007071348A1 (fr) * 2005-12-19 2007-06-28 F. Hoffmann-La Roche Ag Dérivés d’aminopyrazole de type isoquinoléine, leur fabrication et application en tant qu'agents pharmaceutiques pour le traitement du cancer
WO2007076473A2 (fr) * 2005-12-23 2007-07-05 Kalypsys, Inc. Urees pyrimidinyloxy substituees utiles comme inhibiteurs des proteines kinases

Non-Patent Citations (7)

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Title
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SHELKE, S. N. ET AL: "Synthesis of pyrazolyltriazoles and thiadiazoles by conventional and non-conventional methods", XP002507912, retrieved from STN Database accession no. 2006:1282971 *
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507907, retrieved from STN Database accession no. 255828-23-0 *
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507908, retrieved from STN Database accession no. 255828-22-9 *
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507909, retrieved from STN Database accession no. 255828-21-8 *
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 February 2000 (2000-02-11), XP002507910, retrieved from STN Database accession no. 255828-20-7 *
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ORIENTAL JOURNAL OF CHEMISTRY , 22(2), 369-374 CODEN: OJCHEG; ISSN: 0970-020X, 2006 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8415345B2 (en) 2008-05-06 2013-04-09 Glaxo SmithKline LLC Benzene sulfonamide thiazole and oxazole compounds
US8642759B2 (en) 2008-05-06 2014-02-04 Glaxosmithkline Llc Benzene sulfonamide thiazole and oxazole compounds
US9233956B2 (en) 2008-05-06 2016-01-12 Novartis Ag Benzene sulfonamide thiazole and oxazole compounds
US8604033B2 (en) 2010-01-15 2013-12-10 Addex Pharma S.A. Preparation of 4-amino-thiazoles and 3-amino-1,2,4-thiadiazoles and their use as allosteric modulators of metabotropic glutamate receptors

Also Published As

Publication number Publication date
WO2009010871A2 (fr) 2009-01-22

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