WO2009016855A1 - Procédé empêchant la chute des cheveux et procédé empêchant la dépigmentation capillaire - Google Patents

Procédé empêchant la chute des cheveux et procédé empêchant la dépigmentation capillaire Download PDF

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Publication number
WO2009016855A1
WO2009016855A1 PCT/JP2008/053210 JP2008053210W WO2009016855A1 WO 2009016855 A1 WO2009016855 A1 WO 2009016855A1 JP 2008053210 W JP2008053210 W JP 2008053210W WO 2009016855 A1 WO2009016855 A1 WO 2009016855A1
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WO
WIPO (PCT)
Prior art keywords
preventing hair
depigmentation
hair loss
loss
hair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053210
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English (en)
Japanese (ja)
Inventor
Emi Nishimura
Hiroshi Shimizu
Shintaro Tanimura
Yuko Tadokoro
Daisuke Sawamura
Wataru Nishie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokkaido University NUC
Kanazawa University NUC
Original Assignee
Hokkaido University NUC
Kanazawa University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2007202319A external-priority patent/JP2009035514A/ja
Priority claimed from JP2007218702A external-priority patent/JP2009051753A/ja
Application filed by Hokkaido University NUC, Kanazawa University NUC filed Critical Hokkaido University NUC
Publication of WO2009016855A1 publication Critical patent/WO2009016855A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4741—Keratin; Cytokeratin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A01K2217/206—Animal model comprising tissue-specific expression system, e.g. tissue specific expression of transgene, of Cre recombinase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Immunology (AREA)
  • Birds (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention vise à proposer un agent empêchant la chute des cheveux et un agent empêchant la dépigmentation capillaire. La chute des cheveux ou la dépigmentation capillaire peuvent être empêchées par du collagène de type XVII.
PCT/JP2008/053210 2007-08-02 2008-02-25 Procédé empêchant la chute des cheveux et procédé empêchant la dépigmentation capillaire Ceased WO2009016855A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007-202319 2007-08-02
JP2007202319A JP2009035514A (ja) 2007-08-02 2007-08-02 Ｘｖｉｉ型コラーゲンに関する異常分化抑制剤
JP2007218702A JP2009051753A (ja) 2007-08-24 2007-08-24 Ｘｖｉｉ型コラーゲンに関する脱毛抑制剤及び毛髪の脱色素化抑制剤
JP2007-218702 2007-08-24
JP2007-339302 2007-12-28
JP2007339302 2007-12-28

Publications (1)

Publication Number Publication Date
WO2009016855A1 true WO2009016855A1 (fr) 2009-02-05

Family

ID=40304096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053210 Ceased WO2009016855A1 (fr) 2007-08-02 2008-02-25 Procédé empêchant la chute des cheveux et procédé empêchant la dépigmentation capillaire

Country Status (1)

Country Link
WO (1) WO2009016855A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011012045A (ja) * 2009-06-03 2011-01-20 Kanazawa Univ 色素幹細胞の未分化性維持促進剤
JP2011130725A (ja) * 2009-12-25 2011-07-07 Contig I:Kk Ｌｎａオリゴヌクレオチドとそれを含有する化粧品
EP3403673A4 (fr) * 2016-01-12 2019-12-11 National University Corporation Tokyo Medical and Dental University Composition pour empêcher ou améliorer la chute et le grisonnement des cheveux, et utilisation de cette dernière
CN116640205A (zh) * 2023-05-26 2023-08-25 浙江诸暨聚源生物技术有限公司 重组xvii型胶原蛋白及其表达菌株
CN118415930A (zh) * 2024-03-29 2024-08-02 陕西函得仕生物科技有限公司 一种防脱育发组合物、包含该组合物的精华液及其制备方法
CN120392983A (zh) * 2025-07-07 2025-08-01 苏州拾光医药生物科技有限公司 Xvii型胶原蛋白截断肽及其在防脱发产品中的应用
CN121135866A (zh) * 2025-11-13 2025-12-16 西北大学 一种重组xvii型胶原蛋白及其表达方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005281277A (ja) * 2004-03-31 2005-10-13 Yaizu Suisankagaku Industry Co Ltd 経口摂取用育毛・養毛組成物及び該組成物を含有する飲食品
WO2007004325A1 (fr) * 2005-07-01 2007-01-11 Locomogene, Inc. Preparation proteinique contenant s1-5
JP2007129938A (ja) * 2005-11-09 2007-05-31 Hokkaido Univ ノックアウトマウス

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005281277A (ja) * 2004-03-31 2005-10-13 Yaizu Suisankagaku Industry Co Ltd 経口摂取用育毛・養毛組成物及び該組成物を含有する飲食品
WO2007004325A1 (fr) * 2005-07-01 2007-01-11 Locomogene, Inc. Preparation proteinique contenant s1-5
JP2007129938A (ja) * 2005-11-09 2007-05-31 Hokkaido Univ ノックアウトマウス

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NISHIE, W. ET AL.: "Humanization of autoantigen", NATURE MEDICINE, vol. 13, no. 3, March 2007 (2007-03-01), pages 378 - 383, XP055037249 *
NISHIMURA, E.K. ET AL.: "Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche", SCIENCE, vol. 307, 2005, pages 720 - 724, XP002456150 *
SHINTARO TANIMURA ET AL.: "Shikiso Kansaibo Iji ni Okeru XVII Gata Collagen no Yakuwari", INFLAMMATION AND REGENERATION, vol. 27, no. 4, July 2007 (2007-07-01), pages 428 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011012045A (ja) * 2009-06-03 2011-01-20 Kanazawa Univ 色素幹細胞の未分化性維持促進剤
JP2011130725A (ja) * 2009-12-25 2011-07-07 Contig I:Kk Ｌｎａオリゴヌクレオチドとそれを含有する化粧品
EP3403673A4 (fr) * 2016-01-12 2019-12-11 National University Corporation Tokyo Medical and Dental University Composition pour empêcher ou améliorer la chute et le grisonnement des cheveux, et utilisation de cette dernière
US10702544B2 (en) 2016-01-12 2020-07-07 National University Corporation Tokyo Medical And Dental University Composition for ameliorating loss of hair and graying of hair, and use thereof
US11298372B2 (en) 2016-01-12 2022-04-12 National University Corporation Tokyo Medical And Dental University Composition for ameliorating loss of hair and graying of hair, and use thereof
EP4205750B1 (fr) * 2016-01-12 2025-04-09 Eaderm Co., Ltd. Inhibiteur de nadph oxydase pour supprimer ou améliorer la perte de cheveux ou traiter l'alopécie
CN116640205A (zh) * 2023-05-26 2023-08-25 浙江诸暨聚源生物技术有限公司 重组xvii型胶原蛋白及其表达菌株
CN118415930A (zh) * 2024-03-29 2024-08-02 陕西函得仕生物科技有限公司 一种防脱育发组合物、包含该组合物的精华液及其制备方法
CN120392983A (zh) * 2025-07-07 2025-08-01 苏州拾光医药生物科技有限公司 Xvii型胶原蛋白截断肽及其在防脱发产品中的应用
CN120392983B (zh) * 2025-07-07 2025-10-14 苏州拾光医药生物科技有限公司 Xvii型胶原蛋白截断肽及其在防脱发产品中的应用
CN121135866A (zh) * 2025-11-13 2025-12-16 西北大学 一种重组xvii型胶原蛋白及其表达方法和应用

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