WO2009017193A1 - 服用感の優れたアミノ酸含有顆粒製剤 - Google Patents

服用感の優れたアミノ酸含有顆粒製剤 Download PDF

Info

Publication number
WO2009017193A1
WO2009017193A1 PCT/JP2008/063763 JP2008063763W WO2009017193A1 WO 2009017193 A1 WO2009017193 A1 WO 2009017193A1 JP 2008063763 W JP2008063763 W JP 2008063763W WO 2009017193 A1 WO2009017193 A1 WO 2009017193A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid
amino
granular preparation
containing medicinal
take
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/063763
Other languages
English (en)
French (fr)
Inventor
Mitsuyasu Ida
Nobutaka Ninomiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to KR1020157016192A priority Critical patent/KR101641072B1/ko
Priority to JP2009525448A priority patent/JP5903203B2/ja
Priority to CN200880100710A priority patent/CN101765426A/zh
Priority to EP08791978.3A priority patent/EP2179731B1/en
Publication of WO2009017193A1 publication Critical patent/WO2009017193A1/ja
Anticipated expiration legal-status Critical
Priority to US12/697,563 priority patent/US9301937B2/en
Priority to US14/573,500 priority patent/US9339483B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

　本発明は、従来品より服用感が改善され、速やかに崩壊するアミノ酸含有顆粒製剤を提供することを課題とする。製剤中の顆粒の最大粒径が実質的に１０００μｍ以下であり、かつ、嵩密度が０．５７ｇ／ｍＬ以上の本発明のアミノ酸含有顆粒製剤により、従来のアミノ酸含有顆粒製剤と比し、崩壊性を損なうことなく服用感を著しく改善する。
PCT/JP2008/063763 2007-07-31 2008-07-31 服用感の優れたアミノ酸含有顆粒製剤 Ceased WO2009017193A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1020157016192A KR101641072B1 (ko) 2007-07-31 2008-07-31 복용감이 우수한 아미노산 함유 과립 제제
JP2009525448A JP5903203B2 (ja) 2007-07-31 2008-07-31 服用感の優れたアミノ酸含有顆粒製剤
CN200880100710A CN101765426A (zh) 2007-07-31 2008-07-31 服用感优异的含氨基酸颗粒制剂
EP08791978.3A EP2179731B1 (en) 2007-07-31 2008-07-31 Amino-acid-containing medicinal granular preparation highly easy to take
US12/697,563 US9301937B2 (en) 2007-07-31 2010-02-01 Amino-acid-containing medicinal granular preparation highly easy to take
US14/573,500 US9339483B2 (en) 2007-07-31 2014-12-17 Amino-acid-containing medicinal granular preparation highly easy to take

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007-199875 2007-07-31
JP2007199875 2007-07-31
JP2007-279550 2007-10-26
JP2007279550 2007-10-26
JP2008155594 2008-06-13
JP2008-155594 2008-06-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/697,563 Continuation US9301937B2 (en) 2007-07-31 2010-02-01 Amino-acid-containing medicinal granular preparation highly easy to take

Publications (1)

Publication Number Publication Date
WO2009017193A1 true WO2009017193A1 (ja) 2009-02-05

Family

ID=40304421

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/063763 Ceased WO2009017193A1 (ja) 2007-07-31 2008-07-31 服用感の優れたアミノ酸含有顆粒製剤

Country Status (8)

Country Link
US (2) US9301937B2 (ja)
EP (1) EP2179731B1 (ja)
JP (3) JP5903203B2 (ja)
KR (2) KR101641065B1 (ja)
CN (2) CN101765426A (ja)
MY (2) MY174048A (ja)
TW (1) TWI503128B (ja)
WO (1) WO2009017193A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014205661A (ja) * 2013-03-21 2014-10-30 味の素株式会社 アミノ酸含有顆粒及びその製造方法
JP2015232030A (ja) * 2009-04-01 2015-12-24 ノヴィファーマ ソシエテ アノニム ニトロカテコール誘導体を含む医薬製剤及びその製造方法
WO2017183628A1 (ja) * 2016-04-19 2017-10-26 味の素株式会社 造粒物およびその製造方法
WO2018155435A1 (ja) * 2017-02-21 2018-08-30 Ｅａファーマ株式会社 顆粒製剤

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102908337B (zh) * 2012-10-12 2014-03-05 大连医诺生物有限公司 微囊化氨基酸组合物及其制备方法
CN106420629B (zh) * 2016-10-28 2019-10-11 广州中大南沙科技创新产业园有限公司 支链氨基酸制剂及其制备方法和应用
CN108836948B (zh) * 2018-06-11 2024-04-12 宁波西敦医药包衣科技有限公司 一种利用包衣技术实现营养素可控制释放的产品
ES2960427T3 (es) * 2019-03-05 2024-03-04 Tradichem Ind Services S L L-triptófano de alta densidad, su preparación y usos del mismo
JPWO2021054453A1 (ja) 2019-09-20 2021-03-25

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10305868A (ja) 1997-05-02 1998-11-17 Dainippon Printing Co Ltd 外装材及びそれを用いたスティック状包装体
JPH10305518A (ja) 1997-05-02 1998-11-17 Dainippon Printing Co Ltd 易開封性包材及びそれを用いたスティック状包装体
JPH1170607A (ja) 1997-08-29 1999-03-16 Dainippon Printing Co Ltd スティック状包装体用外装材及びその製造方法
JPH1192403A (ja) * 1997-07-23 1999-04-06 Freunt Ind Co Ltd 単一物質球形粒、該球形粒を含む医薬、食品及びそれらの製造方法
JP3368898B1 (ja) 2002-01-24 2003-01-20 味の素株式会社 分岐鎖アミノ酸含有顆粒の製造方法
JP2003519649A (ja) * 2000-01-10 2003-06-24 ドクター ゲルゲリイ アンド カンパニー インスタント顆粒およびその調製方法
JP2004075600A (ja) * 2002-08-15 2004-03-11 Ogawa & Co Ltd ビタミンｅ含有造粒粉末及び該粉末の製造方法
JP2007169264A (ja) * 2005-11-24 2007-07-05 Ono Pharmaceut Co Ltd 固形製剤および製剤組成物
JP2007182411A (ja) * 2006-01-10 2007-07-19 Nichi-Iko Pharmaceutical Co Ltd ポリカルボフィルカルシウム含有粒剤
JP2008162955A (ja) * 2006-12-28 2008-07-17 Chugai Pharmaceut Co Ltd バリン含有高密度顆粒剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60237054A (ja) * 1984-05-10 1985-11-25 Nippon Kayaku Co Ltd アミノ酸の晶析法
IT1177384B (it) * 1984-12-12 1987-08-26 Boeehringer Biochemia Robin Sp Prodotti dietetici granulari a base di amminoacidi e procedimento per la loro preparazione
JPH01192403A (ja) * 1988-01-28 1989-08-02 Kawasaki Steel Corp 金属ストリップの冷間圧延方法
JPH11279051A (ja) * 1998-03-30 1999-10-12 Nikkiso Co Ltd 透析用剤及びその製造方法
US6337084B1 (en) * 1998-04-24 2002-01-08 Archer Daniels Midland Company Extrusion of amino acid animal feed supplements
US6322788B1 (en) 1998-08-20 2001-11-27 Stanley Arthur Kim Anti-bacterial antibodies and methods of use
JP3233155B1 (ja) * 2000-11-07 2001-11-26 味の素株式会社 分岐鎖アミノ酸含有医薬用顆粒製剤
JP3228289B1 (ja) * 2000-11-16 2001-11-12 味の素株式会社 分岐鎖アミノ酸を含有する医薬用顆粒の製造方法
JP3259731B1 (ja) * 2000-12-06 2002-02-25 味の素株式会社 分岐鎖アミノ酸を含有する医薬用顆粒製剤
JP3682453B2 (ja) * 2003-03-18 2005-08-10 東亜薬品株式会社 分岐鎖アミノ酸含有医薬用顆粒製剤の製造方法
US20100197787A1 (en) 2005-10-12 2010-08-05 Masako Doi Composition for Prevention of Hypoglycemic Condition

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10305868A (ja) 1997-05-02 1998-11-17 Dainippon Printing Co Ltd 外装材及びそれを用いたスティック状包装体
JPH10305518A (ja) 1997-05-02 1998-11-17 Dainippon Printing Co Ltd 易開封性包材及びそれを用いたスティック状包装体
JPH1192403A (ja) * 1997-07-23 1999-04-06 Freunt Ind Co Ltd 単一物質球形粒、該球形粒を含む医薬、食品及びそれらの製造方法
JPH1170607A (ja) 1997-08-29 1999-03-16 Dainippon Printing Co Ltd スティック状包装体用外装材及びその製造方法
JP2003519649A (ja) * 2000-01-10 2003-06-24 ドクター ゲルゲリイ アンド カンパニー インスタント顆粒およびその調製方法
JP3368898B1 (ja) 2002-01-24 2003-01-20 味の素株式会社 分岐鎖アミノ酸含有顆粒の製造方法
JP2003212768A (ja) * 2002-01-24 2003-07-30 Ajinomoto Co Inc 分岐鎖アミノ酸含有顆粒の製造方法
JP2004075600A (ja) * 2002-08-15 2004-03-11 Ogawa & Co Ltd ビタミンｅ含有造粒粉末及び該粉末の製造方法
JP2007169264A (ja) * 2005-11-24 2007-07-05 Ono Pharmaceut Co Ltd 固形製剤および製剤組成物
JP2007182411A (ja) * 2006-01-10 2007-07-19 Nichi-Iko Pharmaceutical Co Ltd ポリカルボフィルカルシウム含有粒剤
JP2008162955A (ja) * 2006-12-28 2008-07-17 Chugai Pharmaceut Co Ltd バリン含有高密度顆粒剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2179731A4

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015232030A (ja) * 2009-04-01 2015-12-24 ノヴィファーマ ソシエテ アノニム ニトロカテコール誘導体を含む医薬製剤及びその製造方法
JP2014205661A (ja) * 2013-03-21 2014-10-30 味の素株式会社 アミノ酸含有顆粒及びその製造方法
WO2017183628A1 (ja) * 2016-04-19 2017-10-26 味の素株式会社 造粒物およびその製造方法
JPWO2017183628A1 (ja) * 2016-04-19 2019-02-21 味の素株式会社 造粒物およびその製造方法
JP7052722B2 (ja) 2016-04-19 2022-04-12 味の素株式会社 造粒物およびその製造方法
WO2018155435A1 (ja) * 2017-02-21 2018-08-30 Ｅａファーマ株式会社 顆粒製剤

Also Published As

Publication number Publication date
JP5903203B2 (ja) 2016-04-13
CN102772370A (zh) 2012-11-14
US9339483B2 (en) 2016-05-17
MY160417A (en) 2017-03-15
JP2017095483A (ja) 2017-06-01
TW200922551A (en) 2009-06-01
EP2179731B1 (en) 2017-06-07
US20150104517A1 (en) 2015-04-16
JP6130795B2 (ja) 2017-05-17
KR20100044236A (ko) 2010-04-29
EP2179731A4 (en) 2013-08-21
EP2179731A1 (en) 2010-04-28
JP2014122229A (ja) 2014-07-03
US9301937B2 (en) 2016-04-05
KR101641072B1 (ko) 2016-07-20
JPWO2009017193A1 (ja) 2010-10-21
KR20150079994A (ko) 2015-07-08
KR101641065B1 (ko) 2016-07-21
CN101765426A (zh) 2010-06-30
MY174048A (en) 2020-03-05
US20100178350A1 (en) 2010-07-15
TWI503128B (zh) 2015-10-11

Similar Documents

Publication Publication Date Title
WO2007093642A3 (fr) Formes pharmaceutiques multimicroparticulaires qui resistent a la decharge immediate du principe actif en presence d'alcool
USD602707S1 (en) Hammock
WO2008101743A3 (de) Pellets mit magensaftresistenter wirkstoff-matrix
WO2007067044A3 (en) Modified active-ingredient-containing pellets/capsules
WO2006084164A8 (en) Gastric retention and controlled release delivery system
WO2009117130A3 (en) Extended release forumulation containing a wax
WO2007146248A3 (en) Stable laquinimod preparations
WO2007090393A3 (de) Pharmazeutische zubereitung auf basis vom mikrotabletten
WO2010066749A3 (en) Ulipristal acetate tablets
WO2008125091A3 (de) Metallfolie
WO2008128775A3 (en) Stabilised pharmaceutical composition containing pregabaline
WO2009092129A8 (en) Delayed release pharmaceutical composition of duloxetine
WO2008052033A3 (en) Ibuprofen composition
USD648937S1 (en) Racquet equipment bag
WO2007144169A3 (en) Entacapone-derivatives
WO2008003050A3 (en) Gallium nitrate formulations
MY160417A (en) Amino-acid-containing medicinal granular preparation highly easy to take
WO2007028512A3 (de) Magnetfeld-gesteuerter wirkstofftransfer für die aerosoltherapie
WO2009149058A3 (en) Modified release niacin formulations
WO2008110374A3 (de) Pellets enthaltend pharmazeutische substanz, verfahren zu deren herstellung und deren verwendung
WO2006103672A3 (en) Spherically shaped substances
EP2196463A4 (en) PREPARATION OF 5,6-DIMETHYLXANTHONE-4-ACETIC ACID, DERIVATIVES DERIVATED THEREOF AND PHARMACEUTICAL FORMULATIONS THEREOF
MY139086A (en) Use of debranched starch in extrusion-spheronization pharmaceutical pellets
GB2443793B (en) Product, method of manufacture and use
WO2012042316A8 (en) Granules

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880100710.4

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08791978

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2009525448

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 12010500239

Country of ref document: PH

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2008791978

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2008791978

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 20107004063

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1145/CHENP/2010

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: PI 2010000475

Country of ref document: MY