WO2009022064A3 - Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

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Publication number
WO2009022064A3
WO2009022064A3 PCT/FR2008/000933 FR2008000933W WO2009022064A3 WO 2009022064 A3 WO2009022064 A3 WO 2009022064A3 FR 2008000933 W FR2008000933 W FR 2008000933W WO 2009022064 A3 WO2009022064 A3 WO 2009022064A3
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WO
WIPO (PCT)
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
containing same
naphthalene derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2008/000933
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English (en)
Other versions
WO2009022064A2 (fr
Inventor
Said Yous
Mohamed Ettaoussi
Ahmed Sabaouni
Pascal Berthelot
Michael Spedding
Philippe Delagrange
Daniel-Henri Caignard
Mark Millan
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Les Laboratoires Servier SAS
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Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002691593A priority Critical patent/CA2691593A1/fr
Priority to EA201000084A priority patent/EA201000084A1/ru
Priority to BRPI0814407A priority patent/BRPI0814407A2/pt
Priority to CN200880022964A priority patent/CN101687772A/zh
Priority to JP2010514038A priority patent/JP2010531860A/ja
Priority to MX2010000001A priority patent/MX2010000001A/es
Priority to AU2008288374A priority patent/AU2008288374B2/en
Priority to US12/452,456 priority patent/US20100137446A1/en
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Priority to EP08827416A priority patent/EP2167457A2/fr
Publication of WO2009022064A2 publication Critical patent/WO2009022064A2/fr
Publication of WO2009022064A3 publication Critical patent/WO2009022064A3/fr
Anticipated expiration legal-status Critical
Priority to ZA2010/00025A priority patent/ZA201000025B/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Composés de formule (I) : dans laquelle : R1 représente alkyle, alkényle, halogénoalkyle, polyhalogénoalkyle, cycloalkyle, cycloalkylalkyle, aryle, arylalkyle, hétéroaryle ou hétéroarylalkyle, R2 représente un atome de fluor ou un groupement alkyle substitué par un ou plusieurs atomes de fluor, Médicaments.
PCT/FR2008/000933 2007-07-02 2008-07-01 Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Ceased WO2009022064A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2008288374A AU2008288374B2 (en) 2007-07-02 2008-07-01 Novel naphthalene derivatives, process for the preparation thereof and pharmaceutical compositions containing same
BRPI0814407A BRPI0814407A2 (pt) 2007-07-02 2008-07-01 derivados naftalênicos, processo de preparação e composições farmacêuticas contendo os mesmos
CN200880022964A CN101687772A (zh) 2007-07-02 2008-07-01 新的萘衍生物、其制备方法和含有它们的药物组合物
JP2010514038A JP2010531860A (ja) 2007-07-02 2008-07-01 新規ナフタレン誘導体、その製造法およびそれを含有する薬学的組成物
MX2010000001A MX2010000001A (es) 2007-07-02 2008-07-01 Derivados de naftaleno novedoso, proceso para la preparacion de los mismos y composiciones farmaceuticas que contienen los mismos.
CA002691593A CA2691593A1 (fr) 2007-07-02 2008-07-01 Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA201000084A EA201000084A1 (ru) 2007-07-02 2008-07-01 Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их
US12/452,456 US20100137446A1 (en) 2007-07-02 2008-07-01 Naphthalene compounds, a process for their preparation and pharmaceutical compositions containing them
EP08827416A EP2167457A2 (fr) 2007-07-02 2008-07-01 Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ZA2010/00025A ZA201000025B (en) 2007-07-02 2010-01-04 New naphthalene compounds,a process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0704748A FR2918370B1 (fr) 2007-07-02 2007-07-02 Nouveaux derives naphtaleniques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR0704748 2007-07-02

Publications (2)

Publication Number Publication Date
WO2009022064A2 WO2009022064A2 (fr) 2009-02-19
WO2009022064A3 true WO2009022064A3 (fr) 2009-04-16

Family

ID=38926225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/000933 Ceased WO2009022064A2 (fr) 2007-07-02 2008-07-01 Nouveaux derives naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (16)

Country Link
US (1) US20100137446A1 (fr)
EP (1) EP2167457A2 (fr)
JP (1) JP2010531860A (fr)
KR (1) KR20100029263A (fr)
CN (1) CN101687772A (fr)
AR (1) AR070006A1 (fr)
AU (1) AU2008288374B2 (fr)
BR (1) BRPI0814407A2 (fr)
CA (1) CA2691593A1 (fr)
EA (1) EA201000084A1 (fr)
FR (1) FR2918370B1 (fr)
MA (1) MA31578B1 (fr)
MX (1) MX2010000001A (fr)
UA (1) UA94827C2 (fr)
WO (1) WO2009022064A2 (fr)
ZA (1) ZA201000025B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2053033A1 (fr) * 2007-10-26 2009-04-29 Bayer Schering Pharma AG Composants à utiliser dans l'imagerie, le diagnostic et/ou le traitement des maladies du système nerveux central ou des tumeurs
CN109761842B (zh) * 2019-02-01 2021-11-30 浙江工业大学 α-F-β-NHAc-羰基化合物的合成方法
CN114605316A (zh) * 2022-03-29 2022-06-10 中山大学 一种β-芳香杂环-γ-三氟甲基胺类化合物及其合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0562956A1 (fr) * 1992-03-27 1993-09-29 Adir Et Compagnie Nouvelles naphtylalkylamines leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2737220B1 (fr) 1995-07-24 1997-09-26 Adir Sequences nucleiques codant pour des recepteurs de la melatonine et leurs applications
FR2762598A1 (fr) * 1997-04-25 1998-10-30 Adir Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennnent
FR2771739B1 (fr) * 1997-11-28 2001-04-20 Adir Nouveaux composes naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP3841628B2 (ja) * 1999-08-20 2006-11-01 武田薬品工業株式会社 経皮吸収剤
FR2890562B1 (fr) * 2005-09-09 2012-10-12 Servier Lab Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0562956A1 (fr) * 1992-03-27 1993-09-29 Adir Et Compagnie Nouvelles naphtylalkylamines leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MAROT C ET AL: "PHARMACOPHORIC SEARCH AND 3D-QSAR COMPARATIVE MOLECULAR FIELD ANALYSIS STUDIES ON AGONISTS OF MELATONIN SHEEP RECEPTORS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 23, 1998, pages 4453 - 4465, XP002172225, ISSN: 0022-2623 *
MATHE-ALLAINMAT M ET AL: "Synthesis of beta--Substituted Naphth-1-yl Ethylamido Derivatives as New Melatoninergic Agonists", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, no. 7, 1999, pages 2945 - 2952, XP002432521, ISSN: 0968-0896 *

Also Published As

Publication number Publication date
FR2918370A1 (fr) 2009-01-09
KR20100029263A (ko) 2010-03-16
EP2167457A2 (fr) 2010-03-31
AU2008288374A1 (en) 2009-02-19
ZA201000025B (en) 2011-04-28
EA201000084A1 (ru) 2010-06-30
CA2691593A1 (fr) 2009-02-19
WO2009022064A2 (fr) 2009-02-19
MX2010000001A (es) 2010-04-21
US20100137446A1 (en) 2010-06-03
MA31578B1 (fr) 2010-08-02
FR2918370B1 (fr) 2009-08-28
BRPI0814407A2 (pt) 2019-09-24
JP2010531860A (ja) 2010-09-30
CN101687772A (zh) 2010-03-31
AU2008288374B2 (en) 2011-08-04
AR070006A1 (es) 2010-03-10
UA94827C2 (ru) 2011-06-10

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