WO2009051220A1 - Aβオリゴマーに特異的に結合する抗体およびその利用 - Google Patents

Aβオリゴマーに特異的に結合する抗体およびその利用 Download PDF

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Publication number
WO2009051220A1
WO2009051220A1 PCT/JP2008/068848 JP2008068848W WO2009051220A1 WO 2009051220 A1 WO2009051220 A1 WO 2009051220A1 JP 2008068848 W JP2008068848 W JP 2008068848W WO 2009051220 A1 WO2009051220 A1 WO 2009051220A1
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WIPO (PCT)
Prior art keywords
oligomer
specifically binding
antibody capable
recognize
soluble
Prior art date
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Ceased
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PCT/JP2008/068848
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English (en)
French (fr)
Inventor
Etsuro Matsubara
Masao Shibata
Tatsuki Yokoseki
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Immunas Pharma Inc
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Immunas Pharma Inc
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Application filed by Immunas Pharma Inc filed Critical Immunas Pharma Inc
Priority to CA2702880A priority Critical patent/CA2702880A1/en
Priority to CN2008801222168A priority patent/CN101965365A/zh
Priority to JP2009538166A priority patent/JPWO2009051220A1/ja
Priority to AU2008312802A priority patent/AU2008312802A1/en
Priority to EP08839297A priority patent/EP2210901A4/en
Publication of WO2009051220A1 publication Critical patent/WO2009051220A1/ja
Priority to US12/762,878 priority patent/US20100260783A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

　本発明者らは生理的分子である可溶性Aβモノマーを認識せず、可溶性Aβオリゴマーのみに特異的なモノクローナル抗体を作製することに成功し、当該抗体がアルツハイマー病に対する診断・治療用モノクローナル抗体として有用であることを見出した。
PCT/JP2008/068848 2007-10-19 2008-10-17 Aβオリゴマーに特異的に結合する抗体およびその利用 Ceased WO2009051220A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2702880A CA2702880A1 (en) 2007-10-19 2008-10-17 Antibody capable of specifically binding to a beta oligomer, and use thereof
CN2008801222168A CN101965365A (zh) 2007-10-19 2008-10-17 能够特异性结合Aβ寡聚体的抗体及其应用
JP2009538166A JPWO2009051220A1 (ja) 2007-10-19 2008-10-17 Ａβオリゴマーに特異的に結合する抗体およびその利用
AU2008312802A AU2008312802A1 (en) 2007-10-19 2008-10-17 Antibody capable of specifically binding to abeta oligomer, and use thereof
EP08839297A EP2210901A4 (en) 2007-10-19 2008-10-17 FOR THE SPECIFIC BINDING TO AN OLIGOMICALLY ABLE ANTIBODY AND ITS USE
US12/762,878 US20100260783A1 (en) 2007-10-19 2010-04-19 Antibody Specific Binding to A Beta Oligomer and the Use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-272015 2007-10-19
JP2007272015 2007-10-19
US8554008P 2008-08-01 2008-08-01
US61/085,540 2008-08-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/533,294 Continuation-In-Part US20100291071A1 (en) 2007-10-19 2009-07-31 Antibody Specific Binding to A-Beta Oligomer and the Use

Publications (1)

Publication Number Publication Date
WO2009051220A1 true WO2009051220A1 (ja) 2009-04-23

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Family Applications (1)

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PCT/JP2008/068848 Ceased WO2009051220A1 (ja) 2007-10-19 2008-10-17 Aβオリゴマーに特異的に結合する抗体およびその利用

Country Status (9)

Country Link
US (1) US20100260783A1 (ja)
EP (1) EP2210901A4 (ja)
JP (1) JPWO2009051220A1 (ja)
KR (1) KR20100115340A (ja)
CN (1) CN101965365A (ja)
AU (1) AU2008312802A1 (ja)
CA (1) CA2702880A1 (ja)
SG (1) SG185316A1 (ja)
WO (1) WO2009051220A1 (ja)

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WO2010119704A1 (en) 2009-04-17 2010-10-21 Immunas Pharma, Inc. Antibodies that specifically bind to a beta oligomers and use thereof
WO2011016238A1 (en) 2009-08-06 2011-02-10 Immunas Pharma, Inc. Antibodies that specifically bind to a beta oligomers and use thereof
WO2011016239A1 (en) 2009-08-06 2011-02-10 Immunas Pharma, Inc. Antibodies that specifically bind to a beta oligomers and use thereof
WO2011016568A1 (ja) 2009-08-07 2011-02-10 協和発酵キリン株式会社 抗アミロイドβオリゴマーヒト化抗体
WO2011016567A1 (ja) 2009-08-07 2011-02-10 協和発酵キリン株式会社 抗アミロイドβオリゴマーヒト化抗体
US8378081B2 (en) 2008-02-08 2013-02-19 Immunas Pharma, Inc. Antibodies that specifically bind to Aβ oligomers and uses thereof
JP2015502551A (ja) * 2011-12-23 2015-01-22 フォルシュングスツェントルム ユーリッヒ ゲゼルシャフ Ａβ凝集体の選択的定量化方法
US9085614B2 (en) 2008-08-01 2015-07-21 Immunas Pharma, Inc. Antibodies that specifically bind to Aβ oligomers and uses thereof
RU2575095C2 (ru) * 2009-08-07 2016-02-10 Киова Хакко Кирин Ко., Лтд. Гуманизированное антитело против олигомера бета-амилоида
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WO2024155876A1 (en) * 2023-01-20 2024-07-25 Mabwell Therapeutics, Inc. ANTI-AMYLOID β PROTOFIBRIL/OLIGOMER ANTIBODIES AND USES THEREOF

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US20100291071A1 (en) * 2008-08-01 2010-11-18 Immunas Pharma, Inc. Antibody Specific Binding to A-Beta Oligomer and the Use
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HUE041391T2 (hu) 2011-06-23 2019-05-28 Biogen Int Neuroscience Gmbh Anti-alfa-szinukleinkötõ molekulák
RU2639537C2 (ru) 2011-10-07 2017-12-21 Ац Иммуне С.А. Фосфоспецифичные антитела, распознающие тау
JP6293731B2 (ja) 2012-04-05 2018-03-14 エーシー イミューン エス．エー． ヒト化タウ抗体
WO2013167681A1 (en) 2012-05-10 2013-11-14 Georg-August-Universität Göttingen CONFORMATIONAL-SPECIFIC ANTIBODIES AGAINST Αβ OLIGOMERS
CN105143258B (zh) 2013-03-15 2020-06-23 Ac免疫有限公司 抗Tau抗体和使用方法
EP2968548B1 (en) * 2013-03-15 2020-09-09 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
WO2017035430A2 (en) * 2015-08-27 2017-03-02 Kolltan Pharmaceuticals, Inc. Anti-alk antibodies and methods for use thereof
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IL272773B2 (en) 2017-08-22 2024-06-01 Biogen Ma Inc Pharmaceutical preparations containing anti-amyloid cell antibodies
KR102710762B1 (ko) 2017-10-25 2024-09-25 얀센 파마슈티칼즈, 인코포레이티드 인산화 타우 펩티드의 조성물 및 이의 용도
US11629184B2 (en) 2018-02-23 2023-04-18 Remd Biotherapeutics, Inc. Calcitonin gene-related peptide (CGRP) antagonist antibodies
CN110818796B (zh) * 2018-08-09 2022-11-08 东莞市朋志生物科技有限公司 一种抗人ca153蛋白的重组抗体
WO2020118293A2 (en) * 2018-12-07 2020-06-11 Georgia Tech Research Corporation Antibodies that bind to natively folded myocilin
AU2020219804A1 (en) 2019-02-08 2021-08-19 Ac Immune S.A. Method of safe administration of phosphorylated Tau peptide vaccine
EA202192891A1 (ru) 2019-04-24 2022-02-04 Янссен Фармасьютикалз, Инк. Гетерологичное введение анти-тау вакцин

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