WO2009060077A3 - Intrauterine deposit - Google Patents

Intrauterine deposit Download PDF

Info

Publication number
WO2009060077A3
WO2009060077A3 PCT/EP2008/065149 EP2008065149W WO2009060077A3 WO 2009060077 A3 WO2009060077 A3 WO 2009060077A3 EP 2008065149 W EP2008065149 W EP 2008065149W WO 2009060077 A3 WO2009060077 A3 WO 2009060077A3
Authority
WO
WIPO (PCT)
Prior art keywords
deposit
frame
uterus
compound
retention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/065149
Other languages
French (fr)
Other versions
WO2009060077A2 (en
Inventor
Graaff Wouter De
Harm Veenstra
Titia Mulders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39155499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009060077(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to ES08848433.2T priority Critical patent/ES2544756T3/en
Priority to NZ58509408A priority patent/NZ585094A/en
Priority to MX2010004685A priority patent/MX2010004685A/en
Priority to PL08848433T priority patent/PL2211794T3/en
Priority to HK11100804.3A priority patent/HK1146890B/en
Priority to DK08848433.2T priority patent/DK2211794T3/en
Priority to RS20150542A priority patent/RS54172B1/en
Priority to HRP20150847TT priority patent/HRP20150847T1/en
Priority to BRPI0818883A priority patent/BRPI0818883A8/en
Priority to US12/740,837 priority patent/US8291910B2/en
Priority to MYPI2010002063A priority patent/MY184694A/en
Priority to CA2703539A priority patent/CA2703539C/en
Priority to CN200880114942.5A priority patent/CN101848689B/en
Priority to EP20080848433 priority patent/EP2211794B1/en
Priority to KR20157001408A priority patent/KR20150016412A/en
Priority to SI200831471T priority patent/SI2211794T1/en
Priority to KR1020107012507A priority patent/KR101536025B1/en
Priority to JP2010532607A priority patent/JP5406844B2/en
Application filed by Organon NV filed Critical Organon NV
Priority to RU2010122904/14A priority patent/RU2503431C2/en
Priority to AU2008324109A priority patent/AU2008324109B2/en
Publication of WO2009060077A2 publication Critical patent/WO2009060077A2/en
Publication of WO2009060077A3 publication Critical patent/WO2009060077A3/en
Priority to IL204995A priority patent/IL204995A/en
Priority to ZA2010/02579A priority patent/ZA201002579B/en
Anticipated expiration legal-status Critical
Priority to IL219479A priority patent/IL219479A/en
Priority to IL219480A priority patent/IL219480A/en
Priority to US13/622,031 priority patent/US20130014763A1/en
Priority to US14/816,582 priority patent/US20150335464A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/142—Wirelike structures, e.g. loops, rings, spirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/142—Wirelike structures, e.g. loops, rings, spirals
    • A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/18—Inserters or removers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/4998—Combined manufacture including applying or shaping of fluent material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/4998—Combined manufacture including applying or shaping of fluent material
    • Y10T29/49982—Coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Surgical Instruments (AREA)

Abstract

An intrauterine system (1) for the retention of a biologically active compoun within the uterus of a female mammal is formed by a frame (16) defining an interior space (20) for receipt of a deposit of the compound (22). The frame has an open structure (18) allowing access to a substantial part of an outer surface of the deposit and the deposit has a rate controlling structure that controls a rate of release of the compound within the Uterus. Retention elements (6) are provided on the frame for retaining the frame within the uterus.
PCT/EP2008/065149 2007-11-07 2008-11-07 Intrauterine deposit Ceased WO2009060077A2 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
AU2008324109A AU2008324109B2 (en) 2007-11-07 2008-11-07 Intrauterine deposit
KR20157001408A KR20150016412A (en) 2007-11-07 2008-11-07 Intrauterine deposit
MX2010004685A MX2010004685A (en) 2007-11-07 2008-11-07 Intrauterine deposit.
PL08848433T PL2211794T3 (en) 2007-11-07 2008-11-07 Intrauterine deposit
HK11100804.3A HK1146890B (en) 2007-11-07 2008-11-07 Intrauterine deposit
DK08848433.2T DK2211794T3 (en) 2007-11-07 2008-11-07 intrauterine DEPOT
RS20150542A RS54172B1 (en) 2007-11-07 2008-11-07 INTERMATERICAL INSERT
HRP20150847TT HRP20150847T1 (en) 2007-11-07 2008-11-07 Intrauterine deposit
BRPI0818883A BRPI0818883A8 (en) 2007-11-07 2008-11-07 INTRA-UTERINE SYSTEM AND METHOD FOR ITS FORMATION
US12/740,837 US8291910B2 (en) 2007-11-07 2008-11-07 Intrauterine deposit
MYPI2010002063A MY184694A (en) 2007-11-07 2008-11-07 Intrauterine deposit
CA2703539A CA2703539C (en) 2007-11-07 2008-11-07 Intrauterine deposit
CN200880114942.5A CN101848689B (en) 2007-11-07 2008-11-07 Intrauterine deposit
EP20080848433 EP2211794B1 (en) 2007-11-07 2008-11-07 Intrauterine deposit
SI200831471T SI2211794T1 (en) 2007-11-07 2008-11-07 Intrauterine deposit
ES08848433.2T ES2544756T3 (en) 2007-11-07 2008-11-07 Intrauterine deposit
NZ58509408A NZ585094A (en) 2007-11-07 2008-11-07 Intrauterine device with form-stable non-eroding deposit of a compound, with frame of open structure to retain deposit
JP2010532607A JP5406844B2 (en) 2007-11-07 2008-11-07 Intrauterine deposit
KR1020107012507A KR101536025B1 (en) 2007-11-07 2008-11-07 Intrauterine deposit
RU2010122904/14A RU2503431C2 (en) 2007-11-07 2008-11-07 Intrauterine carrier
IL204995A IL204995A (en) 2007-11-07 2010-04-11 Intrauterine device for depositing medicine
ZA2010/02579A ZA201002579B (en) 2007-11-07 2010-04-13 Intrauterine deposit
IL219479A IL219479A (en) 2007-11-07 2012-04-30 Intrauterine deposit
IL219480A IL219480A (en) 2007-11-07 2012-04-30 Intrauterine deposit
US13/622,031 US20130014763A1 (en) 2007-11-07 2012-09-18 Intrauterine deposit
US14/816,582 US20150335464A1 (en) 2007-11-07 2015-08-03 Intrauterine deposit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20070120191 EP2057972A1 (en) 2007-11-07 2007-11-07 Intrauterine deposit
EP07120191.7 2007-11-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/740,837 A-371-Of-International US8291910B2 (en) 2007-11-07 2008-11-07 Intrauterine deposit
US13/622,031 Continuation US20130014763A1 (en) 2007-11-07 2012-09-18 Intrauterine deposit

Publications (2)

Publication Number Publication Date
WO2009060077A2 WO2009060077A2 (en) 2009-05-14
WO2009060077A3 true WO2009060077A3 (en) 2009-07-23

Family

ID=39155499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/065149 Ceased WO2009060077A2 (en) 2007-11-07 2008-11-07 Intrauterine deposit

Country Status (31)

Country Link
US (3) US8291910B2 (en)
EP (3) EP2057972A1 (en)
JP (1) JP5406844B2 (en)
KR (2) KR101536025B1 (en)
CN (1) CN101848689B (en)
AR (1) AR070666A1 (en)
AU (1) AU2008324109B2 (en)
BR (1) BRPI0818883A8 (en)
CA (2) CA2703539C (en)
CL (1) CL2008003310A1 (en)
CO (1) CO6270294A2 (en)
CY (1) CY1116818T1 (en)
DK (1) DK2211794T3 (en)
EC (1) ECSP10010219A (en)
ES (2) ES2616145T3 (en)
HK (1) HK1210689A1 (en)
HR (1) HRP20150847T1 (en)
HU (1) HUE025379T2 (en)
IL (3) IL204995A (en)
MX (1) MX2010004685A (en)
MY (2) MY184694A (en)
NZ (2) NZ585094A (en)
PE (2) PE20130816A1 (en)
PL (1) PL2211794T3 (en)
PT (1) PT2211794E (en)
RS (1) RS54172B1 (en)
RU (1) RU2503431C2 (en)
SI (1) SI2211794T1 (en)
TW (1) TWI457115B (en)
WO (1) WO2009060077A2 (en)
ZA (1) ZA201002579B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2057972A1 (en) * 2007-11-07 2009-05-13 N.V. Organon Intrauterine deposit
FI20080523A0 (en) 2008-09-17 2008-09-17 Bayer Schering Pharma Oy inserter
FI20080524A0 (en) 2008-09-17 2008-09-17 Bayer Schering Pharma Oy An inserter
CN102159162B (en) 2008-09-17 2013-04-24 拜耳公司 Inserter
US8568374B2 (en) * 2009-05-04 2013-10-29 Merck Sharp & Dohme B.V. Intrauterine system
US8597262B2 (en) * 2009-07-09 2013-12-03 Ams Research Corporation Apparatus and methods of treatment of pathologic proliferative conditions uterine tissue
JP5992330B2 (en) * 2009-09-29 2016-09-14 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ Intrauterine electronic capsule for administering substances
WO2011117856A1 (en) * 2010-03-21 2011-09-29 Soroker, Eran Intrauterine device and inserter for the same
WO2012088446A1 (en) 2010-12-22 2012-06-28 Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
CA2825464C (en) * 2011-02-08 2019-09-24 Odyssea Pharma S.A. Apparatus for knotting drawstrings of medical devices or medical devices containing drugs
WO2013061341A1 (en) * 2011-10-28 2013-05-02 Sujoy Kumar Guha An improved intra-uterine contraceptive device
WO2014023797A1 (en) * 2012-08-09 2014-02-13 Odyssea Pharma S.P.R.L. Intrauterine device
US10154856B2 (en) * 2013-02-06 2018-12-18 Mark SILLENDER Therapeutic substance transfer catheter and method
DE202013101276U1 (en) * 2013-03-25 2013-04-08 Pfm Medical Ag Device for the introduction of objects
US10781242B2 (en) 2013-09-24 2020-09-22 Medicenna Therapeutics Inc. Interleukin-2 fusion proteins and uses thereof
US10150802B2 (en) 2014-04-24 2018-12-11 The Board Of Trustees Of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
FR3042966B1 (en) 2015-10-30 2017-11-24 Anecova S A RECUPERABLE INTRA-UTERIN DEVICE
JP7433051B2 (en) 2017-06-19 2024-02-19 メディシナ セラピューティクス インコーポレイテッド Uses and methods of IL-2 superagonists, agonists, and fusions thereof
US11571328B2 (en) 2018-04-09 2023-02-07 Medicines360 IUD insertion devices
CN112638400A (en) * 2018-06-25 2021-04-09 泰坦医药品公司 Implant for the release of lipophilic or amphiphilic pharmaceutical substances
TW202131879A (en) * 2020-01-24 2021-09-01 芬蘭商拜耳股份有限公司 An intrauterine system with a locking part
CN112587211A (en) * 2020-11-10 2021-04-02 中国人民解放军空军军医大学 Multifunctional gynecological uterine curettage device
US12582768B2 (en) * 2021-02-22 2026-03-24 Zoetis Services Llc Medicament delivery system, and associated method
US12218610B1 (en) 2023-08-06 2025-02-04 Cnpc Usa Corporation Sensor system with an interior sensor and a piezoelectric power supply

Citations (2)

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Publication number Priority date Publication date Assignee Title
DE2101533A1 (en) * 1970-01-15 1971-09-16 Biological Concepts Inc , New York, NY (V St A ) Device for the dosed delivery of medication
US4102998A (en) * 1972-10-02 1978-07-25 Morton Gutnick Process for the prevention of venereal disease

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US4188951A (en) * 1972-08-17 1980-02-19 Alza Corporation Intrauterine system embracing selected copolymeric membranes for administering beneficial agent
NL173707C (en) 1974-02-14 1984-03-01 Multilan Sa COMPOSITION OF INTRA-UTERINE ANTI-CONCEPTION DEVICE AND ASSOCIATED INSERTS CASE.
US4341728A (en) 1979-12-20 1982-07-27 The Population Council, Inc. Method for making an IUD with shrinking of a medicated attachment onto a support
US4547117A (en) 1983-09-23 1985-10-15 Westinghouse Electric Corp. Nuclear fuel rod bundle drive apparatus
DE4125575C2 (en) 1991-08-02 1997-10-02 Piening Wolf Dietrich Dr Med Intrauterine device
FI97944C (en) * 1994-07-05 1997-03-25 Leiras Oy Device for delivery of active substance
FI97946C (en) * 1994-12-15 1997-03-25 Leiras Oy Depositor intended for setting up a device for intrauterine use
US6476079B1 (en) * 1999-12-23 2002-11-05 Leiras Oy Devices for the delivery of drugs having antiprogestinic properties
CN1289064C (en) * 2001-08-31 2006-12-13 先灵有限责任公司 Drug delivery system
BE1014635A3 (en) 2002-02-12 2004-02-03 Wildemeersch Dirk
EP1400258A1 (en) 2002-09-18 2004-03-24 Schering Oy Pharmaceutical composition delivery device and its manufacturing process
US7833545B2 (en) * 2003-04-29 2010-11-16 The General Hospital Corporation Methods and devices for the sustained release of multiple drugs
JP2006087609A (en) * 2004-09-22 2006-04-06 Olympus Corp Biological tissue acquisition apparatus
FR2881046A1 (en) 2005-01-25 2006-07-28 7 Med Ind Sa Manufacturing method for a hormonal contraceptive tube in which a membrane reservoir is inserted in a holding tube, the reservoir is filled by injection, one end sealed, further filled and then the product polymerized
EP2057972A1 (en) * 2007-11-07 2009-05-13 N.V. Organon Intrauterine deposit

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2101533A1 (en) * 1970-01-15 1971-09-16 Biological Concepts Inc , New York, NY (V St A ) Device for the dosed delivery of medication
US4102998A (en) * 1972-10-02 1978-07-25 Morton Gutnick Process for the prevention of venereal disease

Also Published As

Publication number Publication date
CN101848689A (en) 2010-09-29
HUE025379T2 (en) 2016-02-29
JP5406844B2 (en) 2014-02-05
JP2011502604A (en) 2011-01-27
IL204995A0 (en) 2010-11-30
IL219480A0 (en) 2012-06-28
EP2211794B1 (en) 2015-05-20
AU2008324109A1 (en) 2009-05-14
PE20091159A1 (en) 2009-07-25
RU2010122904A (en) 2011-12-20
CA2703539C (en) 2016-03-22
CA2703539A1 (en) 2009-05-14
WO2009060077A2 (en) 2009-05-14
IL219479A (en) 2015-04-30
ES2616145T3 (en) 2017-06-09
HK1146890A1 (en) 2011-07-22
ECSP10010219A (en) 2010-07-30
DK2211794T3 (en) 2015-08-17
HRP20150847T1 (en) 2015-09-11
US20110017219A1 (en) 2011-01-27
CL2008003310A1 (en) 2009-08-21
IL219480A (en) 2014-11-30
EP2211794A2 (en) 2010-08-04
KR101536025B1 (en) 2015-07-10
TWI457115B (en) 2014-10-21
MX2010004685A (en) 2010-05-19
KR20100102604A (en) 2010-09-24
BRPI0818883A2 (en) 2015-05-05
US20150335464A1 (en) 2015-11-26
BRPI0818883A8 (en) 2016-01-12
MY188590A (en) 2021-12-22
PT2211794E (en) 2015-09-17
KR20150016412A (en) 2015-02-11
US20130014763A1 (en) 2013-01-17
TW200934463A (en) 2009-08-16
NZ601725A (en) 2012-12-21
MY184694A (en) 2021-04-17
NZ585094A (en) 2012-08-31
CN101848689B (en) 2014-03-12
AU2008324109B2 (en) 2013-02-07
ES2544756T3 (en) 2015-09-03
PL2211794T3 (en) 2015-11-30
CA2880300C (en) 2016-05-17
HK1210689A1 (en) 2016-05-06
EP2057972A1 (en) 2009-05-13
EP2942040A1 (en) 2015-11-11
SI2211794T1 (en) 2015-12-31
PE20130816A1 (en) 2013-07-18
ZA201002579B (en) 2011-10-26
US8291910B2 (en) 2012-10-23
RU2503431C2 (en) 2014-01-10
CO6270294A2 (en) 2011-04-20
IL219479A0 (en) 2012-06-28
AR070666A1 (en) 2010-04-28
RS54172B1 (en) 2015-12-31
CA2880300A1 (en) 2009-05-14
EP2942040B1 (en) 2017-01-11
IL204995A (en) 2013-02-28
CY1116818T1 (en) 2017-03-15

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