WO2009063901A1 - クオラムセンシング阻害剤 - Google Patents

クオラムセンシング阻害剤 Download PDF

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Publication number
WO2009063901A1
WO2009063901A1 PCT/JP2008/070583 JP2008070583W WO2009063901A1 WO 2009063901 A1 WO2009063901 A1 WO 2009063901A1 JP 2008070583 W JP2008070583 W JP 2008070583W WO 2009063901 A1 WO2009063901 A1 WO 2009063901A1
Authority
WO
WIPO (PCT)
Prior art keywords
quorum sensing
sensing inhibitor
hydrogen atom
controlling agent
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/070583
Other languages
English (en)
French (fr)
Inventor
Hiroaki Suga
Jun Igarashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Chemical Co Ltd
University of Tokyo NUC
Original Assignee
Otsuka Chemical Co Ltd
University of Tokyo NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Chemical Co Ltd, University of Tokyo NUC filed Critical Otsuka Chemical Co Ltd
Priority to US12/739,554 priority Critical patent/US8507674B2/en
Priority to EP08849623A priority patent/EP2215910A4/en
Priority to JP2009541151A priority patent/JP5649304B2/ja
Publication of WO2009063901A1 publication Critical patent/WO2009063901A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

　本発明は、細菌性病害に対して極めて有効な防除剤を提供する。本発明のクオラムセンシング阻害剤及び農園芸用細菌性病害防除剤は、一般式（１） [式中、Ｒ１はＣ１－５アルキル基又はフェニル基を示し、Ｒ２は水素原子又はＣ１－５アルキル基を示す。但し、Ｒ２が水素原子を示す場合、Ｒ１はメチル基であってはならない。] で表されるピリミジノン化合物を含有する。
PCT/JP2008/070583 2007-11-13 2008-11-12 クオラムセンシング阻害剤 Ceased WO2009063901A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/739,554 US8507674B2 (en) 2007-11-13 2008-11-12 Quorum sensing inhibitor
EP08849623A EP2215910A4 (en) 2007-11-13 2008-11-12 QUORUM-SENSING INHIBITORS
JP2009541151A JP5649304B2 (ja) 2007-11-13 2008-11-12 クオラムセンシング阻害剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007294817 2007-11-13
JP2007-294817 2007-11-13

Publications (1)

Publication Number Publication Date
WO2009063901A1 true WO2009063901A1 (ja) 2009-05-22

Family

ID=40638750

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/070583 Ceased WO2009063901A1 (ja) 2007-11-13 2008-11-12 クオラムセンシング阻害剤

Country Status (5)

Country Link
US (1) US8507674B2 (ja)
EP (1) EP2215910A4 (ja)
JP (1) JP5649304B2 (ja)
TW (1) TW200926986A (ja)
WO (1) WO2009063901A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108210355B (zh) * 2013-12-19 2022-02-18 高露洁-棕榄公司 口腔护理组合物
CN109908017A (zh) 2013-12-19 2019-06-21 高露洁-棕榄公司 口腔护理组合物
US12053486B2 (en) 2018-03-09 2024-08-06 Therazure LLC Compositions for the treatment of infections in feet
CN112512322B (zh) * 2018-04-19 2022-09-06 利达植物研究有限公司 植物防御诱导剂的协同混合物
WO2021007280A1 (en) * 2019-07-08 2021-01-14 Boyce Thompson Institute For Plant Research, Inc. Compositions and methods for modulating microbiomes
CA3150161A1 (en) 2019-08-13 2021-02-18 Darlene E. MCCORD Non-activated, amorphous, ph neutral, two-part bedside-ready clay delivery system that treats pathogen infections in humans and animals
EP4423197A4 (en) 2021-10-25 2025-08-27 Darlene E Mccord COATED MEDICINAL CLAY COMPOSITIONS, PHARMACEUTICAL COMPOSITIONS AND DELIVERY OF CATION SOURCES AND METHODS OF USE THEREOF
CN116267925B (zh) * 2023-03-03 2025-02-25 贵州大学 法尼醇作为农用杀菌剂在植物细菌性病害中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4836193A (ja) 1971-09-17 1973-05-28
US4022897A (en) * 1974-03-04 1977-05-10 E. R. Squibb & Sons, Inc. CNS active compounds
JPS5448795A (en) 1977-08-19 1979-04-17 Chinoin Gyogyszer Es Vegyeszet Pyrazolopyrimidine derivatives and their manufacture
JP2006508929A (ja) * 2002-10-04 2006-03-16 プラナ バイオテクノロジー リミティッド 神経に対し活性な化合物
JP2006512290A (ja) 2002-08-15 2006-04-13 ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク 自己誘導物質類似物質、自己誘導物質アゴニストおよびアンタゴニストのコンビナトリアル・ライブラリー、ならびにその使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE443977B (sv) 1977-05-10 1986-03-17 Chinoin Gyogyszer Es Vegyeszet Forfarande for framstellning av 5(6)-tio-bensimidazolderivat
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
US20020177715A1 (en) * 2000-08-31 2002-11-28 Pesci Everett C. Novel autoinducer molecules and uses therefor
JP4836193B2 (ja) 2006-12-27 2011-12-14 株式会社リコー 画像形成装置及び画像形成方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4836193A (ja) 1971-09-17 1973-05-28
US4022897A (en) * 1974-03-04 1977-05-10 E. R. Squibb & Sons, Inc. CNS active compounds
JPS5448795A (en) 1977-08-19 1979-04-17 Chinoin Gyogyszer Es Vegyeszet Pyrazolopyrimidine derivatives and their manufacture
JP2006512290A (ja) 2002-08-15 2006-04-13 ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク 自己誘導物質類似物質、自己誘導物質アゴニストおよびアンタゴニストのコンビナトリアル・ライブラリー、ならびにその使用方法
JP2006508929A (ja) * 2002-10-04 2006-03-16 プラナ バイオテクノロジー リミティッド 神経に対し活性な化合物

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 85, no. 15, 11 October 1976, Columbus, Ohio, US; abstract no. 108662M, MESZAROS, ZOLTAN ET AL.: "4-Oxo-4H-pyrido[1, 2-a] pyrimidines" page 465; XP008134198 *
FERRARINI P.L. ET AL.: "Synthesis of some 4H- Pyrimidin-4-ones investigated as antimicrobial agents", IL FARMACO, vol. 50, no. 1, 1995, pages 69 - 72, XP009040334 *
MICROBIOLOGY, vol. 143, 1997, pages 3703 - 3711
MOLECULAR MICROBIOLOGY, vol. 54, no. 4, pages 921 - 934
See also references of EP2215910A4
TERESA R. ET AL., APPLIED AND ENVIRONMENTAL MICROBIOLOGY, April 2001 (2001-04-01), pages 1865 - 1873

Also Published As

Publication number Publication date
US20100256369A1 (en) 2010-10-07
JP5649304B2 (ja) 2015-01-07
EP2215910A1 (en) 2010-08-11
TW200926986A (en) 2009-07-01
JPWO2009063901A1 (ja) 2011-03-31
US8507674B2 (en) 2013-08-13
EP2215910A4 (en) 2012-04-04

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