WO2009066457A1 - 脂肪酸系イオン液体を有効成分とする外用剤組成物 - Google Patents

脂肪酸系イオン液体を有効成分とする外用剤組成物 Download PDF

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Publication number
WO2009066457A1
WO2009066457A1 PCT/JP2008/003409 JP2008003409W WO2009066457A1 WO 2009066457 A1 WO2009066457 A1 WO 2009066457A1 JP 2008003409 W JP2008003409 W JP 2008003409W WO 2009066457 A1 WO2009066457 A1 WO 2009066457A1
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WIPO (PCT)
Prior art keywords
external preparation
fatty acid
preparation composition
ionic liquid
active ingredient
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Ceased
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PCT/JP2008/003409
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English (en)
French (fr)
Inventor
Toshikazu Yamaguchi
Kenta Kawai
Katsuhiro Yamanaka
Noboru Tatsumi
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MedRx Co Ltd
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MedRx Co Ltd
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Publication date
Application filed by MedRx Co Ltd filed Critical MedRx Co Ltd
Priority to EP08852335A priority Critical patent/EP2223703A4/en
Priority to US12/734,771 priority patent/US8623387B2/en
Priority to JP2009542480A priority patent/JP5333972B2/ja
Priority to KR1020107013154A priority patent/KR101514342B1/ko
Priority to CA2705965A priority patent/CA2705965A1/en
Priority to CN2008801249743A priority patent/CN101909651B/zh
Priority to AU2008327436A priority patent/AU2008327436B2/en
Publication of WO2009066457A1 publication Critical patent/WO2009066457A1/ja
Anticipated expiration legal-status Critical
Priority to US14/073,123 priority patent/US20140066471A1/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

経皮吸収性の良好な外用剤組成物を提供する。 薬物またはその塩を脂肪酸系イオン液体に溶解させて、薬物の複合イオン組成物を形成させることにより、経皮吸収性に優れた外用剤組成物を作製できる。この外用剤組成物は、液剤、軟膏剤、クリーム剤、硬膏剤等に使用でき、経皮吸収性に優れた製剤品を提供できるようになる。
PCT/JP2008/003409 2007-11-22 2008-11-20 脂肪酸系イオン液体を有効成分とする外用剤組成物 Ceased WO2009066457A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP08852335A EP2223703A4 (en) 2007-11-22 2008-11-20 TOPICAL PREPARATION WITH IONIC LIQUID ON FATTY ACID AS AN ACTIVE SUBSTANCE
US12/734,771 US8623387B2 (en) 2007-11-22 2008-11-20 External preparation composition comprising fatty acid-based ionic liquid as active ingredient
JP2009542480A JP5333972B2 (ja) 2007-11-22 2008-11-20 脂肪酸系イオン液体を有効成分とする外用剤組成物
KR1020107013154A KR101514342B1 (ko) 2007-11-22 2008-11-20 지방산계 이온 액체를 유효성분으로 하는 외용제 조성물
CA2705965A CA2705965A1 (en) 2007-11-22 2008-11-20 External preparation composition comprising fatty acid-based ionic liquid as active ingredient
CN2008801249743A CN101909651B (zh) 2007-11-22 2008-11-20 包括基于脂肪酸的离子型液体作为活性成分的外用制剂组合物
AU2008327436A AU2008327436B2 (en) 2007-11-22 2008-11-20 External preparation composition comprising fatty acid-based ionic liquid as active ingredient
US14/073,123 US20140066471A1 (en) 2007-11-22 2013-11-06 External preparation composition comprising fatty acid-based ionic liquid as active ingredient

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-303784 2007-11-22
JP2007303784 2007-11-22
JP2008-202639 2008-08-06
JP2008202639 2008-08-06

Related Child Applications (2)

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US12/734,771 A-371-Of-International US8623387B2 (en) 2007-11-22 2008-11-20 External preparation composition comprising fatty acid-based ionic liquid as active ingredient
US14/073,123 Division US20140066471A1 (en) 2007-11-22 2013-11-06 External preparation composition comprising fatty acid-based ionic liquid as active ingredient

Publications (1)

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WO2009066457A1 true WO2009066457A1 (ja) 2009-05-28

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ID=40667290

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PCT/JP2008/003409 Ceased WO2009066457A1 (ja) 2007-11-22 2008-11-20 脂肪酸系イオン液体を有効成分とする外用剤組成物

Country Status (8)

Country Link
US (2) US8623387B2 (ja)
EP (2) EP3011954A1 (ja)
JP (2) JP5333972B2 (ja)
KR (1) KR101514342B1 (ja)
CN (2) CN103239721B (ja)
AU (1) AU2008327436B2 (ja)
CA (1) CA2705965A1 (ja)
WO (1) WO2009066457A1 (ja)

Cited By (28)

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WO2011074567A1 (ja) * 2009-12-15 2011-06-23 帝國製薬株式会社 塩基性消炎鎮痛剤含有経皮吸収製剤
US8232265B2 (en) 2005-10-07 2012-07-31 Board Of Trustees Of The University Of Alabama Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
JP2012214411A (ja) * 2011-03-31 2012-11-08 Kobayashi Pharmaceutical Co Ltd 油性製剤
JP2012214412A (ja) * 2011-03-31 2012-11-08 Kobayashi Pharmaceutical Co Ltd 油性製剤
WO2012176668A1 (ja) * 2011-06-20 2012-12-27 久光製薬株式会社 リドカイン含有パップ剤
WO2013035850A1 (ja) * 2011-09-08 2013-03-14 株式会社 ケイ・エム トランスダーム 経皮吸収製剤
EP2570116A1 (en) 2011-09-13 2013-03-20 Nitto Denko Corporation Composition for enhancing transdermal absorption of a drug and patch preparation
EP2570122A1 (en) 2011-09-13 2013-03-20 Nitto Denko Corporation Composition for Enhancing Transdermal Absorption of A Drug and Patch Preparation
EP2570115A1 (en) 2011-09-13 2013-03-20 Nitto Denko Corporation Composition for enhancing transdermal absorption of a drug and patch preparation
JP2013139421A (ja) * 2012-01-04 2013-07-18 Yoichi Akama 皮膚外用鎮痛剤、皮膚穿刺時疼痛軽減剤および皮下静脈の血管拡張剤
WO2013191187A1 (ja) * 2012-06-20 2013-12-27 株式会社メドレックス 薬剤と有機溶媒と親油性膏体基剤と粉体を配合した貼付製剤組成物
WO2014024896A1 (ja) * 2012-08-08 2014-02-13 株式会社メドレックス アゴメラチンを含有する貼付剤組成物
WO2015037639A1 (ja) * 2013-09-11 2015-03-19 株式会社 メドレックス テープ剤の新規な基剤組成物
WO2015129527A1 (ja) * 2014-02-27 2015-09-03 株式会社メドレックス プラミペキソールを含有する神経変性疾患の治療用貼付剤
JP2015526480A (ja) * 2012-08-24 2015-09-10 インテグアールエックス セラピューティクス， エルエルシーＩｎｔｅｇｕｒｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｌｃ 治療剤の経皮送達を増強するための化学組成物および方法
JP2016503802A (ja) * 2012-12-21 2016-02-08 テイコク ファーマ ユーエスエー インコーポレーテッド ホルモン及びその他の薬剤を経皮送達するための組成物及び方法
WO2016068336A1 (ja) * 2014-10-30 2016-05-06 旭化成ケミカルズ株式会社 経皮吸収促進剤及び経皮吸収促進助剤
WO2016121996A1 (ja) * 2015-01-30 2016-08-04 株式会社メドレックス 水性外用剤
JP2016535781A (ja) * 2013-11-03 2016-11-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 経皮薬物送達のためのイオン性液体
JP6161142B1 (ja) * 2015-08-29 2017-07-12 株式会社 メドレックス 酸捕捉剤を含有する貼付製剤
JP2017149782A (ja) * 2015-08-29 2017-08-31 株式会社 メドレックス 経皮吸収組成物
JP2018090539A (ja) * 2016-12-05 2018-06-14 王子ホールディングス株式会社 経皮吸収型製剤
US10828265B2 (en) 2016-12-09 2020-11-10 The Regents Of The University Of California Formulations of propranolol and analogs as an amorphous melt or ionic liquid for transdermal drug delivery
US10912834B2 (en) 2016-08-29 2021-02-09 The Regents Of The University Of California Topical formulations based on ionic species for skin treatment
JPWO2021070893A1 (ja) * 2019-10-11 2021-04-15
WO2021192861A1 (ja) 2020-03-26 2021-09-30 国立大学法人九州大学 イオン液体、溶媒、製剤および経皮吸収剤
JPWO2022030631A1 (ja) * 2020-08-07 2022-02-10
WO2025079694A1 (ja) 2023-10-12 2025-04-17 株式会社 メドレックス 経皮吸収組成物

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CN103239721B (zh) * 2007-11-22 2016-03-16 美德阿利克斯株式会社 包括基于脂肪酸的离子型液体作为活性成分的外用制剂组合物
KR20100127300A (ko) * 2008-03-28 2010-12-03 안게스 엠지 인코포레이티드 전사 인자 디코이를 유효 성분으로 하는 외용제 조성물
WO2010016219A1 (ja) * 2008-08-05 2010-02-11 株式会社メドレックス 塩基性薬効成分の脂肪酸塩、安息香酸塩を含有する外用剤とその製造方法
JP6893086B2 (ja) 2013-03-13 2021-06-23 エーブリー デニソン コーポレイション 接着特性の向上
ES2905771T3 (es) * 2015-01-06 2022-04-12 Cellix Bio Private Ltd Composiciones y procedimientos para el tratamiento de la inflamación y del dolor
CA2931913C (en) * 2015-06-12 2024-03-19 Kemira Oyj Bitumen separation using ionic liquids comprising unsubstituted or substituted primary, secondary or tertiary amines, pyridines, amidines, guanidines and fatty acids and/or resin acids
US10493049B2 (en) * 2016-02-10 2019-12-03 Niracle LLC Applicator-based transdermal drug delivery system for administration of drugs in combination with topical formulations
US20200085770A1 (en) * 2017-06-16 2020-03-19 Medrx Co., Ltd. Anti-Inflammatory and Analgesic Drug for External Use
CN112206222A (zh) * 2018-11-09 2021-01-12 北京德默高科医药技术有限公司 含有布洛芬结构类似物的多层经皮给药系统
CN112755196B (zh) * 2019-11-01 2024-02-27 华东理工大学 多奈哌齐离子液体
JP7525094B2 (ja) * 2020-04-03 2024-07-30 森田薬品工業株式会社 イオン液体を用いたｂｐａ製剤およびｂｐａを構成物質とするイオン液体
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CN101909651B (zh) 2013-11-06
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EP2223703A1 (en) 2010-09-01
EP2223703A4 (en) 2011-01-19
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AU2008327436A1 (en) 2009-05-28
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