WO2009078366A1 - α-リポ酸ナノ粒子およびその調製方法 - Google Patents

α-リポ酸ナノ粒子およびその調製方法 Download PDF

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Publication number
WO2009078366A1
WO2009078366A1 PCT/JP2008/072699 JP2008072699W WO2009078366A1 WO 2009078366 A1 WO2009078366 A1 WO 2009078366A1 JP 2008072699 W JP2008072699 W JP 2008072699W WO 2009078366 A1 WO2009078366 A1 WO 2009078366A1
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WIPO (PCT)
Prior art keywords
lipoic acid
divalent metal
producing
same
aqueous dispersion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/072699
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English (en)
French (fr)
Inventor
Kazuhisa Sugimoto
Hiromi Nishiura
Yoko Yamaguchi
Keiichi Hirata
Yoshiki Kubota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ezaki Glico Co Ltd
Nanoegg Research Laboratories Inc
Original Assignee
Ezaki Glico Co Ltd
Nanoegg Research Laboratories Inc
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Publication date
Application filed by Ezaki Glico Co Ltd, Nanoegg Research Laboratories Inc filed Critical Ezaki Glico Co Ltd
Priority to EP20080863352 priority Critical patent/EP2241314B1/en
Priority to KR1020107015636A priority patent/KR101441523B1/ko
Priority to CN200880126792XA priority patent/CN101945654B/zh
Priority to CA 2707010 priority patent/CA2707010A1/en
Priority to JP2009546249A priority patent/JP4647706B2/ja
Priority to US12/746,795 priority patent/US9079874B2/en
Publication of WO2009078366A1 publication Critical patent/WO2009078366A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

安定なα-リポ酸を提供すること。α-リポ酸ナノ粒子の製造方法であって、α-リポ酸と非イオン性界面活性剤とを含む水性分散液を調製する工程;該水性分散液に、２価金属塩を添加する工程であって、該２価金属塩が、２価金属ハロゲン化物、２価金属酢酸化物または２価金属グルコン酸化物である、工程;および該２価金属塩を添加した水性分散液に、アルカリ金属炭酸化物またはアルカリ金属リン酸化物を添加して、α-リポ酸ナノ粒子を形成させる工程を包含する、方法。
PCT/JP2008/072699 2007-12-14 2008-12-12 α-リポ酸ナノ粒子およびその調製方法 Ceased WO2009078366A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP20080863352 EP2241314B1 (en) 2007-12-14 2008-12-12 Alpha-lipoic acid nanoparticle and method for producing the same
KR1020107015636A KR101441523B1 (ko) 2007-12-14 2008-12-12 α-리포산 나노입자들 및 이의 제조 방법
CN200880126792XA CN101945654B (zh) 2007-12-14 2008-12-12 α-硫辛酸纳米颗粒及其制备方法
CA 2707010 CA2707010A1 (en) 2007-12-14 2008-12-12 .alpha.-lipoic acid nanoparticles and methods for preparing thereof
JP2009546249A JP4647706B2 (ja) 2007-12-14 2008-12-12 α−リポ酸ナノ粒子およびその調製方法
US12/746,795 US9079874B2 (en) 2007-12-14 2008-12-12 α-Lipoic acid nanoparticles and methods for preparing thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-324041 2007-12-14
JP2007324041 2007-12-14

Publications (1)

Publication Number Publication Date
WO2009078366A1 true WO2009078366A1 (ja) 2009-06-25

Family

ID=40795482

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072699 Ceased WO2009078366A1 (ja) 2007-12-14 2008-12-12 α-リポ酸ナノ粒子およびその調製方法

Country Status (7)

Country Link
US (1) US9079874B2 (ja)
EP (1) EP2241314B1 (ja)
JP (2) JP4647706B2 (ja)
KR (1) KR101441523B1 (ja)
CN (1) CN101945654B (ja)
CA (1) CA2707010A1 (ja)
WO (1) WO2009078366A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010137335A1 (ja) * 2009-05-29 2010-12-02 江崎グリコ株式会社 α－リポ酸ナノ粒子を含有する、ターンオーバー促進用組成物
JP2014520541A (ja) * 2011-07-15 2014-08-25 プレイオン 透明な栄養マイクロエマルジョンの配合物
JPWO2012165468A1 (ja) * 2011-05-31 2015-02-23 株式会社ナノエッグ 親油性化合物を高濃度で含有する液晶組成物の製造方法及びその方法によって製造された液晶組成物

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ITMI20111452A1 (it) * 2011-07-29 2013-01-30 Istituto Biochimico Naz Sav Io Srl Soluzione basica di acido alfa-lipoico e suoi usi
KR101504907B1 (ko) * 2013-01-29 2015-03-25 코스맥스 주식회사 알파리포산을 함유하는 비수계 화장료 조성물
ES2873600T3 (es) 2013-02-05 2021-11-03 1Globe Health Inst Llc Nanopartículas biodegradables y clínicamente compatibles como vehículos de suministro de fármacos.
CN103226103B (zh) * 2013-04-04 2015-02-04 哈尔滨师范大学 一种汞离子比色检测探针及其应用方法
JP2015105249A (ja) * 2013-11-29 2015-06-08 富士フイルム株式会社 化粧料
CN103690492A (zh) * 2013-12-16 2014-04-02 常熟富士莱医药化工有限公司 一种硫辛酸颗粒的制备方法
JP2016088902A (ja) * 2014-11-07 2016-05-23 ポーラ化成工業株式会社 徐放担体
US10729661B2 (en) 2014-12-19 2020-08-04 Sekisui Chemical Co., Ltd. Preparation
WO2016160436A1 (en) * 2015-03-27 2016-10-06 Andrew Teng Tiny particles for control-release and method of manufacturing the same
EP3421131A1 (en) 2017-06-30 2019-01-02 Blink AG A sample cartridge for incubating and/or analyzing a dispersion of particles, cells or droplets
JP2019069912A (ja) * 2017-10-06 2019-05-09 株式会社シャネル化粧品技術開発研究所 非水系皮膚外用組成物およびその製造方法
CN108553458B (zh) * 2018-04-25 2020-06-30 四川大学 一种抗肿瘤纳米药物
AU2019334555B2 (en) 2018-09-05 2025-02-20 Renapharma AB An iron containing composition and use thereof
US20210369648A1 (en) * 2018-10-06 2021-12-02 Biotheravision Llc Cysteamine zinc complex and method of using a cysteamine zinc complex
US10799455B1 (en) 2019-11-11 2020-10-13 King Abdulaziz University Micellles containing alpha lipoic acid as a transdermal drug delivery system
JP7333751B2 (ja) * 2019-12-20 2023-08-25 ライオン株式会社 ヒト抗菌ペプチド産生促進剤
CN114010522B (zh) * 2021-12-22 2023-10-13 郑州大学 一种硫辛酸混合胶束及其制备方法和应用
CN116637203B (zh) * 2022-02-15 2026-03-03 四川大学 硫辛酸纳米粒子在制备氧化应激相关疾病治疗药物中的应用
CN116637184B (zh) * 2022-02-15 2025-11-07 四川大学 一种金属-硫辛酸纳米复合物及其制备方法和应用
CN115844892B (zh) * 2022-09-21 2024-04-19 中国药科大学 二硫键修饰的纳米聚集体及其制备方法和应用
CN115957345B (zh) * 2023-01-10 2024-10-11 北京百替生物技术有限公司 一种用于变应性鼻炎治疗的pH响应性靶向纳米递送系统及其制备方法和应用
CN116270459B (zh) * 2023-02-06 2025-03-25 湖北工业大学 一种雷公藤红素前药递送明胶胶束及其制备方法
CN116998482B (zh) * 2023-08-04 2025-08-01 天津农学院 一种纳米农药及其制备方法
CN117186058B (zh) * 2023-08-21 2026-05-15 江苏同禾药业有限公司 一种硫辛酸纳米粒子及其制备方法

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Cited By (3)

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Publication number Priority date Publication date Assignee Title
WO2010137335A1 (ja) * 2009-05-29 2010-12-02 江崎グリコ株式会社 α－リポ酸ナノ粒子を含有する、ターンオーバー促進用組成物
JPWO2012165468A1 (ja) * 2011-05-31 2015-02-23 株式会社ナノエッグ 親油性化合物を高濃度で含有する液晶組成物の製造方法及びその方法によって製造された液晶組成物
JP2014520541A (ja) * 2011-07-15 2014-08-25 プレイオン 透明な栄養マイクロエマルジョンの配合物

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KR101441523B1 (ko) 2014-09-17
JP4647706B2 (ja) 2011-03-09
CA2707010A1 (en) 2009-06-25
EP2241314A4 (en) 2012-08-08
US9079874B2 (en) 2015-07-14
US20110065781A1 (en) 2011-03-17
KR20100101660A (ko) 2010-09-17
EP2241314A1 (en) 2010-10-20
JPWO2009078366A1 (ja) 2011-04-28
CN101945654B (zh) 2012-06-27
JP5547612B2 (ja) 2014-07-16

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