WO2009079412A3 - Inhibiteurs de transcriptase inverse - Google Patents

Inhibiteurs de transcriptase inverse Download PDF

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Publication number
WO2009079412A3
WO2009079412A3 PCT/US2008/086703 US2008086703W WO2009079412A3 WO 2009079412 A3 WO2009079412 A3 WO 2009079412A3 US 2008086703 W US2008086703 W US 2008086703W WO 2009079412 A3 WO2009079412 A3 WO 2009079412A3
Authority
WO
WIPO (PCT)
Prior art keywords
reverse transcriptase
transcriptase inhibitors
inhibitors
hiv
enzyme inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/086703
Other languages
English (en)
Other versions
WO2009079412A2 (fr
Inventor
Aleksandr Shaginian
Samedy Ouk
Jean-Michel Vernier
Anthony B Pinkerton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ardea Biociences Inc
Original Assignee
Ardea Biociences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biociences Inc filed Critical Ardea Biociences Inc
Priority to ES08862480T priority Critical patent/ES2389752T3/es
Priority to EP08862480A priority patent/EP2220091B1/fr
Priority to CA2709176A priority patent/CA2709176C/fr
Publication of WO2009079412A2 publication Critical patent/WO2009079412A2/fr
Publication of WO2009079412A3 publication Critical patent/WO2009079412A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des inhibiteurs d'enzyme innovants. Selon certains modes de réalisation, les inhibiteurs d'enzyme sont des inhibiteurs de transcriptase inverse, en particulier des inhibiteurs de la transcriptase inverse du VIH. L'invention concerne également des compositions les contenant et leurs procédés d'utilisation. En conséquence, les composés et les compositions décrits dans la description sont utiles pour l'inhibition in vitro et in vivo de la transcriptase inverse du VIH en tant que procédé de traitement ou de prévention du VIH, du sida ou des affections apparentées.
PCT/US2008/086703 2007-12-14 2008-12-12 Inhibiteurs de transcriptase inverse Ceased WO2009079412A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES08862480T ES2389752T3 (es) 2007-12-14 2008-12-12 Inhibidores de la transcriptasa inversa
EP08862480A EP2220091B1 (fr) 2007-12-14 2008-12-12 Inhibiteurs de transcriptase inverse
CA2709176A CA2709176C (fr) 2007-12-14 2008-12-12 Inhibiteurs de transcriptase inverse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1398307P 2007-12-14 2007-12-14
US61/013,983 2007-12-14

Publications (2)

Publication Number Publication Date
WO2009079412A2 WO2009079412A2 (fr) 2009-06-25
WO2009079412A3 true WO2009079412A3 (fr) 2009-08-20

Family

ID=40788899

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/086703 Ceased WO2009079412A2 (fr) 2007-12-14 2008-12-12 Inhibiteurs de transcriptase inverse

Country Status (6)

Country Link
US (2) US8207178B2 (fr)
EP (1) EP2220091B1 (fr)
AR (1) AR071739A1 (fr)
CA (1) CA2709176C (fr)
ES (1) ES2389752T3 (fr)
WO (1) WO2009079412A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8933227B2 (en) * 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
JP5539518B2 (ja) 2009-08-14 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ２−アミノ−５−トリフルオロメチルピリミジン誘導体の位置選択的調製
EP2616441B1 (fr) 2010-09-17 2019-08-07 Purdue Pharma L.P. Composés de pyridine et ses utilisations
CN103517990A (zh) 2010-10-07 2014-01-15 通用医疗公司 癌症生物标志物
ES2450944T3 (es) * 2011-06-01 2014-03-25 Ratiopharm Gmbh Composición y comprimido que comprenden raltegravir
EP2780007A4 (fr) * 2011-11-18 2015-07-29 Avexa Ltd Polythérapie avec apricitabine et pi
US10004721B2 (en) * 2012-10-23 2018-06-26 Cipla Limited Pharmaceutical antiretroviral composition
WO2014079545A1 (fr) * 2012-11-20 2014-05-30 Ktb Tumorforschungsgesellschaft Mbh Dérivés de thioéther utilisés en tant qu'inhibiteurs de protéines kinases
WO2014100071A2 (fr) * 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Pyrrolopyrimidines substituées en tant qu'inhibiteurs de hdm2
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
WO2015162515A1 (fr) * 2014-04-25 2015-10-29 Pfizer Inc. Composés hétéroaromatiques et leur utilisation comme ligands de la dopamine d1
WO2015162518A1 (fr) 2014-04-25 2015-10-29 Pfizer Inc. Composes hetero-aromatiques et leur utilisation comme ligands d1 de la dopamine
EP3760208B1 (fr) 2014-06-25 2024-05-29 The General Hospital Corporation Ciblage de hsatii (human satellite ii)
EP3778605A3 (fr) 2015-02-13 2021-03-10 Dana Farber Cancer Institute, Inc. Inhibiteurs de lrrk2 et leurs méthodes de production et d'utilisation
CN106188060A (zh) * 2015-04-29 2016-12-07 厦门大学 嘧啶并吡咯类化合物、其制备方法、药用组合物及其应用
US10729691B2 (en) 2015-06-26 2020-08-04 Kadmon Corporation, Llc Treatment of infectious diseases with glucose uptake inhibitors
US10273248B2 (en) 2015-06-26 2019-04-30 Kadmon Corportion, LLC Glucose uptake inhibitors
US20210213041A1 (en) 2018-02-06 2021-07-15 The General Hospital Corporation Repeat rna as biomarkers of tumor immune response
CN109053591A (zh) * 2018-07-04 2018-12-21 复旦大学 含联苯结构的二芳基嘧啶类衍生物及其制备方法和用途
CN110437253A (zh) * 2019-08-06 2019-11-12 复旦大学 含联苯结构的二芳基嘧啶并环化合物及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043394A1 (fr) * 1999-01-26 2000-07-27 Ústav Experimentální Botaniky Av Cr Derives heterocycliques d'azote substitue et leur utilisation pharmaceutique
WO2005028479A2 (fr) * 2003-09-25 2005-03-31 Janssen Pharmaceutica N.V. Derives de purine servant a inhiber la replication du vih
WO2006122003A2 (fr) * 2005-05-05 2006-11-16 Ardea Biosciences, Inc. Diaryl-purine, -azapurines et -deazapurines inhibiteurs non nucleosidiques de la transcriptase inverse utilises dans le traitement du vih

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1129096T3 (da) 1998-11-12 2003-09-15 Neurocrine Biosciences Inc CRF-receptorantagonister og fremgangsmåder, der er relateret dertil
WO2000037471A1 (fr) * 1998-12-23 2000-06-29 Neurogen Corporation 2-amino-9-alkylpurines: ligands pour recepteurs cerebraux gaba
YU25500A (sh) * 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
PL227577B1 (pl) 2003-02-07 2017-12-29 Janssen Pharmaceutica Nv Zastosowanie pochodnych pirymidyny do wytwarzania leku do zapobiegania zakażeniu wirusem HIV oraz kompozycja farmaceutyczna
EP1772454A4 (fr) 2004-07-23 2009-02-25 Mitsubishi Tanabe Pharma Corp Composé bicyclique azoté
US8153640B2 (en) 2004-10-29 2012-04-10 Tibotec Pharmaceuticals Ltd. HIV inhibiting bicyclic pyrimdine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043394A1 (fr) * 1999-01-26 2000-07-27 Ústav Experimentální Botaniky Av Cr Derives heterocycliques d'azote substitue et leur utilisation pharmaceutique
WO2005028479A2 (fr) * 2003-09-25 2005-03-31 Janssen Pharmaceutica N.V. Derives de purine servant a inhiber la replication du vih
WO2006122003A2 (fr) * 2005-05-05 2006-11-16 Ardea Biosciences, Inc. Diaryl-purine, -azapurines et -deazapurines inhibiteurs non nucleosidiques de la transcriptase inverse utilises dans le traitement du vih

Also Published As

Publication number Publication date
ES2389752T3 (es) 2012-10-31
US8207178B2 (en) 2012-06-26
EP2220091B1 (fr) 2012-07-25
AR071739A1 (es) 2010-07-14
CA2709176A1 (fr) 2009-06-25
US20090162319A1 (en) 2009-06-25
CA2709176C (fr) 2013-02-05
US8372852B2 (en) 2013-02-12
EP2220091A4 (fr) 2011-04-27
US20120277206A1 (en) 2012-11-01
WO2009079412A2 (fr) 2009-06-25
EP2220091A2 (fr) 2010-08-25

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