WO2009083267A3 - Steroid-17,17-lactol-derivat, dessen verwendung und das derivat enthaltende arzneimittel - Google Patents

Steroid-17,17-lactol-derivat, dessen verwendung und das derivat enthaltende arzneimittel Download PDF

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Publication number
WO2009083267A3
WO2009083267A3 PCT/EP2008/011160 EP2008011160W WO2009083267A3 WO 2009083267 A3 WO2009083267 A3 WO 2009083267A3 EP 2008011160 W EP2008011160 W EP 2008011160W WO 2009083267 A3 WO2009083267 A3 WO 2009083267A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivative
derivatives
steroid
lactol
medicament containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/011160
Other languages
English (en)
French (fr)
Other versions
WO2009083267A2 (de
Inventor
Ulrich Klar
Joachim Kuhnke
Rolf Bohlmann
Jan HÜBNER
Sven Ring
Thomas Frenzel
Frederik Menges
Steffen Borden
Hans Peter Muhn
Katja Prelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Schering Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Publication of WO2009083267A2 publication Critical patent/WO2009083267A2/de
Publication of WO2009083267A3 publication Critical patent/WO2009083267A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/001—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class spiro-linked
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die Erfindung betrifft Steroid-17, 17-Lactol-Derivate mit der allgemeinen chemischen Formel (I) sowie deren tautomere Formen mit der allgemeinen chemischen Formel (Ia), wobei R4, R6a, R6b, R7, R15, R16a, R16b, R18, R22 und Z die in Anspruch 1 angegebenen Bedeutungen haben, sowie deren Solvate, Hydrate, Stereoisomere und Salze. Die Erfindung betrifft außerdem die Verwendung dieser Derivate zur Herstellung eines Arzneimittels zur oralen Kontrazeption und zur Behandlung von prä-, peri- und postmenopausalen Beschwerden sowie Arzneimittel, die derartige Derivate enthalten. Die erfindungsgemäßen Derivate weisen eine gestagene und in bevorzugten Fällen zusätzlich eine antimineralkorticoide und neutrale bis leicht androgene Wirkung auf.
PCT/EP2008/011160 2007-12-29 2008-12-23 Steroid-17,17-lactol-derivat, dessen verwendung und das derivat enthaltende arzneimittel Ceased WO2009083267A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007063499.6 2007-12-29
DE102007063499A DE102007063499A1 (de) 2007-12-29 2007-12-29 Steroid-17,17-Lactol-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
WO2009083267A2 WO2009083267A2 (de) 2009-07-09
WO2009083267A3 true WO2009083267A3 (de) 2009-09-11

Family

ID=40679345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/011160 Ceased WO2009083267A2 (de) 2007-12-29 2008-12-23 Steroid-17,17-lactol-derivat, dessen verwendung und das derivat enthaltende arzneimittel

Country Status (2)

Country Link
DE (1) DE102007063499A1 (de)
WO (1) WO2009083267A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012059594A1 (en) 2010-11-04 2012-05-10 Bayer Pharma Aktiengesellschaft Mineralcorticoid receptor antagonists for the treatment of corticoid-induced obesity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277089A1 (de) * 1987-01-23 1988-08-03 Schering Aktiengesellschaft 11 Beta-alkinyl-estrene und -estradiene, deren Herstellung und diese enthaltende pharmezeutische Präparate
WO2006072467A1 (de) * 2004-12-30 2006-07-13 Schering Aktiengesellschaft 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische präparate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1183500B (de) 1962-10-12 1964-12-17 Schering Ag Verfahren zur Herstellung von alpha, beta-Methylenketonen der Steroidreihe
GB1193951A (en) 1966-05-19 1970-06-03 Herchel Smith 03-C2-4 Alkyl-Gonane Compounds
US3705179A (en) 1971-03-15 1972-12-05 American Home Prod Antiandrogenic steroids
NL7701384A (nl) 1977-02-10 1978-08-14 Akzo Nv Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks.
DE2922500A1 (de) 1979-05-31 1980-12-04 Schering Ag 6 beta .7 beta
DE3402329A1 (de) 1984-01-20 1985-08-01 Schering AG, 1000 Berlin und 4709 Bergkamen 6,6-ethylen-15,16-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US5646136A (en) 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
DE19651000A1 (de) 1996-12-01 1998-06-04 Schering Ag Oxyiminopregnancarbolactone

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277089A1 (de) * 1987-01-23 1988-08-03 Schering Aktiengesellschaft 11 Beta-alkinyl-estrene und -estradiene, deren Herstellung und diese enthaltende pharmezeutische Präparate
WO2006072467A1 (de) * 2004-12-30 2006-07-13 Schering Aktiengesellschaft 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische präparate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOHNS, WILLIAM F. ET AL: "Steroidal spirolactols (17-22)", JOURNAL OF ORGANIC CHEMISTRY, vol. 32, no. 7, 1966, pages 2099 - 2105, XP002531252 *

Also Published As

Publication number Publication date
WO2009083267A2 (de) 2009-07-09
DE102007063499A1 (de) 2009-07-02

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