WO2009087647A1 - Formulation stabilisée de concentré d'iode et d'eau, utile pour une protection contre des troubles liés à une carence en iode - Google Patents

Formulation stabilisée de concentré d'iode et d'eau, utile pour une protection contre des troubles liés à une carence en iode Download PDF

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Publication number
WO2009087647A1
WO2009087647A1 PCT/IN2008/000619 IN2008000619W WO2009087647A1 WO 2009087647 A1 WO2009087647 A1 WO 2009087647A1 IN 2008000619 W IN2008000619 W IN 2008000619W WO 2009087647 A1 WO2009087647 A1 WO 2009087647A1
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Prior art keywords
iodine
formulation
water
stabilized
alkali
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Ceased
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PCT/IN2008/000619
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English (en)
Inventor
Gadde Ramachandraiah
David Livingston
Amjad Hussain
Dipak Balvantrai Shukla
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Council of Scientific and Industrial Research CSIR
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Council of Scientific and Industrial Research CSIR
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Publication of WO2009087647A1 publication Critical patent/WO2009087647A1/fr
Anticipated expiration legal-status Critical
Priority to ZA2010/05263A priority Critical patent/ZA201005263B/en
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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/18—Iodine; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a stabilized iodine-water concentrate formulation useful for iodinating drinking water for protection against iodine deficiency disorders.
  • the present invention relates to a stabilized iodine-water concentrate formulation useful for iodinating drinking water for protection against iodine deficiency disorders, wherein the said formulation comprising iodine, and deionized water containing edible chemicals selected from the group consisting of alkali carbonate, alkali iodide and alkali iodate.
  • iodization of edible materials like iodised salt, iodised oil (capsule and injections), iodised water, iodised bread, and iodized Soya sauce, iodoform compounds used in dairy and poultry, and certain food additives (World Health Organization. 1994. Iodine and health: A statement by WHO, WHO/NUT/94.4).
  • the iodization of salt is done either by spraying potassium iodate or potassium iodide in amounts that ensure a minimum intake of 150 ⁇ g iodine/day/person. Both of these forms of iodine are absorbed as iodide ions and are completely bio-available (ICCIDD/MI/UNICEF/WHO, 1995. Salt iodization for the elimination of iodine deficiency).
  • salt iodization has not been successful for a number of reasons.
  • the limitations of salt iodization are that it is a cumbersome process and the process steps involved in it unnecessarily enhances the cost of salt.
  • Iodine loss occurs as a result of improper packaging, humidity and moisture, and transport in open trucks and railway wagons exposed to sunlight.
  • higher levels of iodine are used during the production of iodized salt. Losses during the cooking process are also accountable which vary from 20 percent to 40 percent depending on the type of cooking used (Salt iodization for the elimination of iodine deficiency, ICCIDD/MI/UNICEF/WHO, 1995).
  • the iodine content of salt at the production level should be monitored with proper quality assurance programmes (WHO/UNICEF/ICCIDD, 1992. "Indicators for assessing Iodine Deficiency Disorders and their control through salt iodization" Report of a Joint Consultation, World Health Organization, Geneva. November 1992: Document WHO/NUT/94.6).
  • the iodide or iodate used in iodised salt manufactory are not. readily adsorbed in the human body unless otherwise they are converted in to more easily adsorbable iodine form.
  • iodide requires extra one-electron oxidation while iodate needs extra five-electron reduction in an acidic atmosphere as prevailing in human stomach for the conversion to elemental iodine.
  • Oxidizing agents like oxygen or its equivalent and reducing agents like ascorbic acid present in vitamin-C are being utilized in this process.
  • the iodide or iodate will merely go waste in excreta.
  • R. S. Khisamov et al. have disclosed the iodine-saturated ion-exchange resin useful for disinfection and iodination of mineral, drinking water.
  • the disadvantages of this method are that it requires a costly resin and the treatment of resin with a solution containing Kl and I 2 is crucial. Moreover, the stepwise dispensing of a calculated amount of I 2 needs special skills to maintain the weight concentration of I 2 lower than that in the aqueous solution and to decrease the resin loss.
  • the method of iodination of drinking water with this resin is only adaptable to make bottled water on industrial scale or municipality level. A little portion of such iodinated water is really utilized for the cause it was made leaving the major portion for other domestic usages. Thus a major portion of iodine is being wasted.
  • the major disadvantage of this process is that the resin decomposition and iodine loses occur when chlorine disinfected water is used (L Samson and I. Czegeny Egeszsegtudomany, 2001 , 45(1 ), 88-90).
  • the process for producing a pentaiodide ion-exchange resin is carried out at a temperature between 40 and 50° C.
  • the saturation of a triiodide resin into a pentaiodide one is achieved by dosing a calculated amount of crystalline iodine for 3 to 5 hours while continuously mixing the same, and by allowing the resin to stand in an aqueous solution for 40 to 65 hours.
  • the disadvantages of this method are that it requires a costly resin and the iodination process requires skills and time consuming.
  • the inventors identified the need for a stabilized iodine-water concentrate formulation, useful for iodinating drinking water for the protection against iodine deficiency disorders, which obviates the drawbacks of the said citations.
  • the main object of the present invention is to provide a stabilized iodine-water concentrate formulation useful for iodinating drinking water for protection against iodine deficiency disorders, wherein the said formulation comprising iodine, and deionized water containing edible chemicals selected from the group consisting of alkali carbonate, alkali iodide and alkali iodate, wherein concentration of iodine in the said formulation being in the range of 0.1- 0.4% (w/v), alkali carbonate being in the range of 0.1-0.51% (w/v), alkali iodide being in the range of 0.09 -0.45% (w/v) and alkali iodate being in the range of 0.02- 0.1 1 % (w/v).
  • Yet another object of the present invention is to provide a process for the preparation of the stabilized iodine-water concentrate formulation useful for iodinating drinking water for protection against iodine deficiency disorders.
  • Still another object of the present invention is to provide the use of the stabilized iodine-water concentrate formulation useful for iodinating drinking water for protection against iodine deficiency disorders. .
  • Yet another object of the present invention is to lower the elemental iodine content and to provide a stabilized iodine-water concentrate formulation, wherein the iodine in the said formulation is not in the elemental form and hence not harmful for use.
  • the present invention describes a stabilized iodine-water concentrate formulation useful for iodinating drinking water for protection against iodine deficiency, disorders, wherein the said formulation comprising iodine, and deionized water containing edible chemicals selected from the group consisting of alkali carbonate, alkali iodide, alkali iodate and a mixture thereof, wherein the iodine in the said formulation is not in the elemental form and hence not harmful for use.
  • the present invention provides a stabilized iodine-water concentrate formulation useful for iodinating drinking water for protection against iodine deficiency disorders, wherein the said formulation comprising iodine, and deionized water containing edible chemicals selected from the group consisting of alkali carbonate, alkali iodide alkali iodate and a mixture thereof, wherein concentration of iodine in the said formulation being in the range of 0.0 - 0.4% (w/v), alkali carbonate being in the range of 0.1-0.51% (w/v), alkali iodide being in the range of
  • alkali iodate being in the range of 0.02- 0.1 1% (w/v).
  • the said formulation is characterized by total iodine content ranging between 10OOppm - 4000ppm and pH in the range of 8- 1 1.
  • the quantity of the said formulation required for mixing with 10 - 15 liters of drinking water is 0.1 ml - 0.3 ml.
  • the iodine in the said formulation is not in the elemental form and hence not harmful for use.
  • the said edible chemicals are being used for stabilizing the said formulation.
  • the said edible chemicals are being used for lowering the free iodine content of the said formulation up to 0.1- 0.5% (w/v).
  • the said formulation remains stable at least up to 9 - 15 months at temperature ranging between 2O 0 C - 4O 0 C in open or closed condition.
  • a process for preparing the stabilized iodine-water concentrate formulation comprising the following steps of:
  • step (b) heating the mixture as obtained from step (a) at a temperature range of 40 -55 0 C for a time period ranging between 1 hr - 1 Vi hrs;
  • step (c) cooling the heated mixture as obtained from step (b) to room temperature (20 0 C - 4O 0 C) and storing the same in a closed vessel for 12 - 24 hours in dark;
  • step (d) filtering the formulation as obtained from step (c) to obtain the desired stabilized iodine-water concentrate useful for iodinating drinking water for protection against iodine deficiency disorders.
  • the present invention provides a stabilized iodine-water concentrate formulation useful for iodinating drinking water for protection against iodine . deficiency disorders, wherein the said formulation comprising iodine, and deionized water containing edible chemicals selected from the group consisting of alkali carbonate, alkali iodide, alkali iodate and a mixture thereof, wherein concentration of iodine in the said formulation being in the range of 0.0- 0.4% (w/v), alkali carbonate being in the range of 0.1-0.51% (w/v), alkali iodide being in the range of 0.09 -0.45% (w/v) and alkali iodate being in the range of 0.02-0.11% (w/v).
  • the elemental iodine rapidly dissolves in excess alkali carbonates solution and stabilized itself in the form of corresponding iodide and iodate salts.
  • the stable iodine-water solution is prepared by dissolving alkali iodide and alkali iodates in a required composition in excess corresponding alkali carbonate.
  • the iodides and iodates present in the final solution obtained from either iodine-alkali carbonates or the mixture of the iodide and iodate salts react readily with each other and generate again the elemental iodine in a fairly acidic conditions of
  • the stable iodine-water concentrate was prepared in a 500 ml conical flask with a single ground joint neck. Alkali carbonate (2 -10 g) was dissolved in about 200 ml de-ionized water. To it 1-4 g of iodine was added and heated to 40-50° Celsius on a hot water bath for 30 to 45 min to obtain a pale yellow solution. The solution was cooled to room temperature, stored for 12-24 h in a dark place to get a colorless solution and filtered over a Whatman-40 filter paper and finally diluted to 1 liter to get the desired formulation of stable iodine-water concentrate.
  • the iodine-water concentrates thus obtained were analyzed for the total iodine composition by volumetric procedure using standard sodium thiosulfate (Na2S2O3) and 10 ml of 2 N sulfuric acid and starch as an indicator (A. I. Vogel A Text-Book of Quantitative Inorganic Analysis, 3rd ed., The English Language Book Society, Longman, London 1969, 349).
  • Na2S2O3 sodium thiosulfate
  • 10 ml of 2 N sulfuric acid and starch as an indicator
  • the iodization of drinking water is achieved using the said iodine-water concentrate formulation in the household level to protect against iodine deficiency related disorders.
  • the use of elemental iodine is in a non- harmful form, which is easily and quickly absorbed along with the food materials to react further in human metabolism reactions without the need of external oxidizing/reducing agents, unlike the iodide and iodate ions which will go waste in absence of external agents in the excreta;
  • the used non-harmful form of iodine will readily be released in fairly acidic condition from the components of the properly diluted solution, within the stomach after consumption, keeping the food contents same;
  • improvement of human metabolism is achieved by reducing the quantity of reducing agent or Vitamin-C in the food consumed.
  • the stable iodine-water concentrate is prepared in a 500 ml ground jointed conical flask by adding 1.2 g iodine in about 200 ml deionized water containing 2.5 g sodium carbonate at room temperature and heating on a hot water bath at 40 degree Celsius. The heating is continued for one and half hour with frequent stirring to get a clear pale yellow solution.
  • the flask is then removed from the hot water bath, cooled to room temperature, stoppered, wrapped with a black paper and stored for 24 hours in a dark place. The color faded slowly and became colorless.
  • the solution is filtered through Whattman filter paper, diluted to 1 liter with deionised water and bottled as stable iodine-water concentrate for its ready use. The total iodine content is measured as 1 190ppm, while the alkalinity of sodium carbonate is measured as 1985ppm.
  • EXAMPLE 2 The stable iodine-water concentrate is prepared in a 500 ml ground jointed conical flask by adding 1.8 g iodine in about 200 ml deionized water containing 3.6 g sodium carbonate at room temperature and heating on a hot water bath at 40 degree Celsius. The heating is continued for one and half hour with frequent stirring to get a clear pale yellow solution. The flask was then removed from the hot water bath, cooled to room temperature, stoppered, wrapped with a black paper and stored for 24 hours in a dark place. The color faded slowly and became colorless. The solution was filtered through Whattman filter paper, diluted to one liter with deionized water and bottled as stable iodine-water concentrate for its ready use. The total iodine content is measured as 1790ppm, while the alkalinity of sodium carbonate is measured as 2840ppm.
  • the stable iodine-water concentrate was prepared in a 500 ml ground jointed conical flask by adding 4 g iodine in about 200 ml deionized water containing 8.0 g sodium carbonate at room temperature and heating on a hot water bath at 45 degree Celsius. The heating is continued for one and half hour with frequent stirring to get a clear pale yellow solution. The flask was then removed from the hot water bath, cooled to room temperature, stoppered, wrapped with a black paper and stored for 24 hours in a dark place. The color faded slowly and became colorless. The solution was filtered through Whattman filter paper, diluted to one liter with deionized water and bottled as stable iodine-water concentrate for its ready use. The total iodine content was measured as 3980ppm, while the alkalinity of sodium carbonate is measured as 6300ppm.
  • the stable iodine-water concentrate was prepared in a 500 ml ground jointed conical flask by adding 2 g iodine in about ' 200 ml deionized water containing 4.0 g sodium carbonate at room temperature and heating on a hot water bath at 45 degree Celsius. The heating is continued for one and half hour with frequent stirring to get a clear pale yellow solution.
  • the flask was then removed from the hot water bath, cooled to room temperature, stoppered, wrapped with a black paper and stored for 24 hours in a dark place. The color faded slowly and became colorless.
  • the solution was filtered through Whattman filter paper, diluted to one liter with deionized water and bottled as stable iodine-water concentrate for its ready use. The total iodine content was measured as 1985ppm, while the alkalinity of sodium carbonate is measured to be 3153ppm.
  • iodized water concentrate was prepared in a 500 ml ground jointed conical flask by dissolving 1.31 g potassium iodide, 0.34 g potassium iodate in about 200 ml deionized water containing 1.56 g potassium carbonate on a hot water bath at 50 degree Celsius. The heating is continued for one and half hour with frequent shaking to get a clear solution. The flask was then removed from the hot water bath and cooled to room temperature. The solution was filtered through Whattman filter paper, diluted to one liter with deionized water and bottled as stable iodine-water concentrate for its ready use. The total iodine content was measured as 1 198ppm, while the total alkalinity of potassium carbonate as 1555ppm.
  • iodized water concentrate was prepared in a 500 ml ground jointed conical flask by dissolving 1.18 g potassium iodide, 0.31 g potassium iodate in about 200 ml deionized water containing 1.2 g sodium carbonate on a hot water bath at 50 degree Celsius. The heating is continued for one and half hour with frequent shaking to get a clear solution. The flask was then removed from the hot water bath and cooled to room temperature. The solution was filtered through Whattman filter paper, diluted to one liter with deionized water and bottled as stable iodine-water concentrate for its ready use. The total iodine content is measured as 1 198ppm, while the total alkalinity of sodium carbonate is measured as 1 190ppm.
  • EXAMPLE 7 The preparation of iodized water concentrate was prepared in a 500 ml ground jointed conical flask by dissolving 1.18 g potassium iodide, 0.31 g potassium iodate in about 200 ml deionized water containing 1.2 g sodium carbonate on a hot water bath at 50 degree Celsius. The heating is continued for one and half hour with frequent shaking to get a clear solution. The flask was then removed from the hot water bath and cooled to room temperature. The solution was filtered through Whattman filter paper, diluted to one liter with deionized water and bottled as stable iodine-water concentrate for its ready use. The total iodine content was measured as 1 198ppm while the .total alkalinity of sodium carbonate has been measured as 1 189ppm.
  • iodized water concentrate was prepared in a 500 ml ground jointed conical flask by dissolving 4.36 g potassium iodide, 1.12 g potassium iodate in about 200 ml deionized water containing 4 g sodium carbonate on a hot water bath at 50 degree Celsius. The heating is continued for one and half hour with frequent shaking to get a clear solution. The flask was then removed from the hot water bath and cooled to room temperature. The solution was filtered through Whattman filter paper, diluted to one liter with deionized water and bottled as stable iodine-water concentrate for its ready use. The total iodine content was measured as 3985ppm while the total alkalinity of sodium carbonate is measured as 3958ppm.
  • the stable iodine-water concentrate was prepared in a 500 ml ground jointed conical flask by adding 1.8 g iodine in about 200 ml deionized water containing 4.8 g potassium carbonate at room temperature and heating on a hot water bath at
  • the heating is continued for one and half hour with frequent stirring to get ⁇ clear pale yellow solution.
  • the flask was then removed from the hot water bath, cooled to room temperature, stoppered, wrapped with a black paper and stored for 24 hours in a dark place.
  • the iodine color faded slowly and became colorless.
  • the solution was filtered through Whattman filter paper, diluted to one liter with deionized water and bottled as stable iodine-water concentrate for its ready use.
  • the total iodine content was measured as 1793 ppm while the alkalinity as potassium carbonate 3735 ppm.
  • the stable iodine-water concentrate was prepared in a 500 ml ground jointed conical flask by adding 1.2 g iodine in about 200 ml deionized water containing 6.57 g cesium carbonate at room temperature and heating on a hot water bath at 40 degree Celsius. The heating is continued for one and half hour with frequent stirring to get a clear pale yellow solution.
  • the flask was then removed from the hot water bath, cooled to room temperature, stoppered, wrapped with a black paper and stored for 24 hours in a dark place. The color faded slowly and became colorless.
  • the solution was filtered through Whattman filter paper, diluted to 1 liter with deionised water and bottled as stable iodine-water concentrate for its ready use. The total iodine content was measured as 1 189 ppm while the alkalinity as cesium carbonate 5185 ppm.
  • the main advantages of the present invention are as following: 1.
  • the present iodized water concentrate has inbuilt oxidizing and reducing agents and hence do not require any external material to liberate absorbable iodine.
  • the present iodized water concentrate readily gives easily absorbable iodine when it comes into a fairly acidic atmosphere.
  • Addition of two to ten drops of this iodized water concentrate measuring 0.1 to 0.5 ml is required to iodinate 10-15 liters of house hold drinking water sufficient to 4-5 members including children for a day consumption to control the iodine deficiency related disorders. 4.
  • the iodized water concentrate overcomes all the difficulties involved in the preparation and transportation of iodized materials like iodized salt, iodized oil etc. 9.
  • the iodized water concentrate is quite stable with shelve life more than a year without any iodine loss.
  • the present iodized water concentrate is economical to use for the consumer with assurance and confidence.

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Abstract

La présente invention concerne une formulation stabilisée de concentré d'iode et d'eau destinée à une protection contre des troubles liés à une carence en iode par iodation de l'eau potable. La formulation contient de 0 à 0,4 % d'iode, de 0,1 à 0,51 % de carbonate alcalin, de 0,09 à 0,45 % d'iodure alcalin et de 0,02 à 0,11 % d'iodate alcalin.
PCT/IN2008/000619 2008-01-07 2008-09-26 Formulation stabilisée de concentré d'iode et d'eau, utile pour une protection contre des troubles liés à une carence en iode Ceased WO2009087647A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ZA2010/05263A ZA201005263B (en) 2008-01-07 2010-07-23 A stabilized iodine-water concentrate formulation useful for protection against iodine deficiency disorders

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Application Number Priority Date Filing Date Title
IN59DE2008 2008-01-07
IN059/DEL/2008 2008-01-07

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WO2009087647A1 true WO2009087647A1 (fr) 2009-07-16

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10034899B2 (en) 2013-11-27 2018-07-31 BioPharmX, Inc. Solid oral dosage form for breast symptoms

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4858560A (en) * 1987-01-07 1989-08-22 Toyo Jozo Co., Ltd. Method of breeding poultry for food
WO1991011117A2 (fr) * 1990-02-05 1991-08-08 Board Of Regents, The University Of Texas System Complements alimentaires comprenant des vitamines et des sels mineraux
US5885592A (en) * 1997-10-29 1999-03-23 Symbollon Corporation Methods and pharmaceutical compositions for oral delivery of molecular iodine
WO2000050046A1 (fr) * 1999-02-26 2000-08-31 Symbollon Corporation Composition pharmaceutique orale stabilisee contenant de l'iodure et de l'iodate et procede associe
EP1044689A1 (fr) * 1998-01-06 2000-10-18 Fujisawa Pharmaceutical Co., Ltd. Preparations solides a base d'iodophore et procede de fabrication correspondant
GB2362880A (en) * 1998-12-16 2001-12-05 Vasily Nikolaevich Melnichenko Method for the iodination of water and beverages

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4858560A (en) * 1987-01-07 1989-08-22 Toyo Jozo Co., Ltd. Method of breeding poultry for food
WO1991011117A2 (fr) * 1990-02-05 1991-08-08 Board Of Regents, The University Of Texas System Complements alimentaires comprenant des vitamines et des sels mineraux
US5885592A (en) * 1997-10-29 1999-03-23 Symbollon Corporation Methods and pharmaceutical compositions for oral delivery of molecular iodine
EP1044689A1 (fr) * 1998-01-06 2000-10-18 Fujisawa Pharmaceutical Co., Ltd. Preparations solides a base d'iodophore et procede de fabrication correspondant
GB2362880A (en) * 1998-12-16 2001-12-05 Vasily Nikolaevich Melnichenko Method for the iodination of water and beverages
WO2000050046A1 (fr) * 1999-02-26 2000-08-31 Symbollon Corporation Composition pharmaceutique orale stabilisee contenant de l'iodure et de l'iodate et procede associe

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
QUEIROZ C A D S ET AL: "Synthesis and thermoanalytical characterization of samarium peroxocarbonate", JOURNAL OF ALLOYS AND COMPOUNDS, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 374, no. 1-2, 14 July 2004 (2004-07-14), pages 401 - 404, XP004514972, ISSN: 0925-8388 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10034899B2 (en) 2013-11-27 2018-07-31 BioPharmX, Inc. Solid oral dosage form for breast symptoms

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