WO2009095583A3 - Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale - Google Patents

Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale Download PDF

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Publication number
WO2009095583A3
WO2009095583A3 PCT/FR2009/050081 FR2009050081W WO2009095583A3 WO 2009095583 A3 WO2009095583 A3 WO 2009095583A3 FR 2009050081 W FR2009050081 W FR 2009050081W WO 2009095583 A3 WO2009095583 A3 WO 2009095583A3
Authority
WO
WIPO (PCT)
Prior art keywords
preventing
epithelial origin
treating cancerous
aminopeptidase inhibitors
azaindole compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2009/050081
Other languages
English (en)
Other versions
WO2009095583A2 (fr
Inventor
Pierre Roux
Marion De Toledo
Jean-Paul Leonetti
Christelle Anguille
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to EP09706702A priority Critical patent/EP2234610A2/fr
Priority to CA2712339A priority patent/CA2712339A1/fr
Priority to US12/812,501 priority patent/US20110046154A1/en
Priority to CN2009801053395A priority patent/CN101951905A/zh
Priority to JP2010542670A priority patent/JP2011509982A/ja
Publication of WO2009095583A2 publication Critical patent/WO2009095583A2/fr
Publication of WO2009095583A3 publication Critical patent/WO2009095583A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Utilisation d'un composé choisi parmi un composé inhibiteur d'aminopeptidase et un composé aza-indole pour la fabrication d'un médicament destiné à la prévention ou au traitement des métastases cancéreuses chez l'homme ou l'animal.
PCT/FR2009/050081 2008-01-22 2009-01-21 Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale Ceased WO2009095583A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP09706702A EP2234610A2 (fr) 2008-01-22 2009-01-21 Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale
CA2712339A CA2712339A1 (fr) 2008-01-22 2009-01-21 Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale
US12/812,501 US20110046154A1 (en) 2008-01-22 2009-01-21 Use of aminopeptidase inhibitors or azaindole compounds for preventing or treating cancerous metastases from epithelial origin
CN2009801053395A CN101951905A (zh) 2008-01-22 2009-01-21 氨肽酶抑制剂或氮杂吲哚化合物用于预防或治疗上皮来源的癌转移的用途
JP2010542670A JP2011509982A (ja) 2008-01-22 2009-01-21 上皮起源からのガン転移を防ぎ又は処置する為のアミノペプチダーゼインヒビター又はアザインドール化合物の使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0850389A FR2926463B1 (fr) 2008-01-22 2008-01-22 Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale
FR0850389 2008-01-22

Publications (2)

Publication Number Publication Date
WO2009095583A2 WO2009095583A2 (fr) 2009-08-06
WO2009095583A3 true WO2009095583A3 (fr) 2010-03-11

Family

ID=39708890

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2009/050081 Ceased WO2009095583A2 (fr) 2008-01-22 2009-01-21 Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale

Country Status (7)

Country Link
US (1) US20110046154A1 (fr)
EP (1) EP2234610A2 (fr)
JP (1) JP2011509982A (fr)
CN (1) CN101951905A (fr)
CA (1) CA2712339A1 (fr)
FR (1) FR2926463B1 (fr)
WO (1) WO2009095583A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10640457B2 (en) 2009-12-10 2020-05-05 The Trustees Of Columbia University In The City Of New York Histone acetyltransferase activators and uses thereof
EP2654428B1 (fr) 2010-12-22 2018-02-14 The Trustees of Columbia University in the City of New York Modulateurs de l'histone acétyltransférase et leurs utilisations
CN102212511A (zh) * 2011-03-31 2011-10-12 山东大学 定点突变的嗜热菌f3因子重组蛋白及其应用
CN105541806A (zh) * 2015-12-25 2016-05-04 中国药科大学 巴比妥酸类化合物、制备方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002039990A2 (fr) * 2000-11-14 2002-05-23 Novartis Ag Methode de criblage de composes antiproliferatifs et methode permettant d'inhiber une croissance tumorale
EP1382349A1 (fr) * 2001-04-27 2004-01-21 Nippon Kayaku Kabushiki Kaisha Immunotherapie supplementaire pouvant etre utilisee apres une ablation pulmonaire liee a un cancer

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US6987113B2 (en) * 1997-06-11 2006-01-17 Sugen, Inc. Tyrosine kinase inhibitors
DE10348023A1 (de) * 2003-10-15 2005-05-19 Imtm Gmbh Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
KR100875870B1 (ko) * 2004-10-14 2008-12-26 에프. 호프만-라 로슈 아게 항암제로서의 신규 아자인돌 티아졸리논
WO2006050076A1 (fr) * 2004-10-29 2006-05-11 Janssen Pharmaceutica, N.V. Composes de pyrrolyle fusionnes substitues par pyrimidinyle et utiles dans le traitement des troubles induits par la kinase
US7371862B2 (en) * 2005-11-11 2008-05-13 Pfizer Italia S.R.L. Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002039990A2 (fr) * 2000-11-14 2002-05-23 Novartis Ag Methode de criblage de composes antiproliferatifs et methode permettant d'inhiber une croissance tumorale
EP1382349A1 (fr) * 2001-04-27 2004-01-21 Nippon Kayaku Kabushiki Kaisha Immunotherapie supplementaire pouvant etre utilisee apres une ablation pulmonaire liee a un cancer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
COTE L ET AL: "Studies on nicotinamide derivatives.", JOURNAL OF BACTERIOLOGY APR 1951, vol. 61, no. 4, April 1951 (1951-04-01), pages 463 - 467, XP002560848, ISSN: 0021-9193 *
FUJII H ET AL: "Human Melanoma Invasion and Metastasis Enhancement by High Expression of Aminopeptidase N/CD13", CLINICAL & EXPERIMENTAL METASTASIS, XX, XX, vol. 13, no. 5, 1 January 1995 (1995-01-01), pages 337 - 344, XP002977602, ISSN: 0262-0898 *
KUSHNER S ET AL: "Experimental chemotherapy of tuberculosis; substituted nicotinamides.", THE JOURNAL OF ORGANIC CHEMISTRY NOV 1948, vol. 13, no. 6, November 1948 (1948-11-01), pages 834 - 836, XP002560847, ISSN: 0022-3263 *
SHEREMETEV, A.B. ET AL: "Synthesis of secondary and tertiary aminofurazans", RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 53, no. 3, 2004, pages 596 - 614, XP002550405 *
YONEDA J ET AL: "INHIBITION OF TUMOR INVASION AND EXTRACELLULAR MATRIX DEGRADATION BY UBENIMEX (BESTATIN)", CLINICAL & EXPERIMENTAL METASTASIS, XX, XX, vol. 10, no. 1, 1 January 1992 (1992-01-01), pages 49 - 59, XP009030476, ISSN: 0262-0898 *

Also Published As

Publication number Publication date
EP2234610A2 (fr) 2010-10-06
JP2011509982A (ja) 2011-03-31
FR2926463B1 (fr) 2010-08-13
WO2009095583A2 (fr) 2009-08-06
FR2926463A1 (fr) 2009-07-24
CN101951905A (zh) 2011-01-19
US20110046154A1 (en) 2011-02-24
CA2712339A1 (fr) 2009-08-06

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