WO2009098404A8 - Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation - Google Patents

Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation Download PDF

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Publication number
WO2009098404A8
WO2009098404A8 PCT/FR2008/001661 FR2008001661W WO2009098404A8 WO 2009098404 A8 WO2009098404 A8 WO 2009098404A8 FR 2008001661 W FR2008001661 W FR 2008001661W WO 2009098404 A8 WO2009098404 A8 WO 2009098404A8
Authority
WO
WIPO (PCT)
Prior art keywords
macromolecules
amphiphilic molecules
nanoparticles based
preparing nanoparticles
functional amphiphilic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2008/001661
Other languages
English (en)
Other versions
WO2009098404A2 (fr
WO2009098404A3 (fr
Inventor
Philippe Barthelemy
Michel Camplo
Nathalie Campins
Bruno Chauffert
Florence Bouyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aix Marseille Universite
Universite Victor Segalen Bordeaux 2
Universite de Bourgogne
Original Assignee
Universite Victor Segalen Bordeaux 2
Universite de la Mediterranee Aix Marseille II
Universite de Bourgogne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Victor Segalen Bordeaux 2, Universite de la Mediterranee Aix Marseille II, Universite de Bourgogne filed Critical Universite Victor Segalen Bordeaux 2
Priority to CA2706812A priority Critical patent/CA2706812A1/fr
Priority to CN2008801260085A priority patent/CN101932310B/zh
Priority to JP2010535425A priority patent/JP5719594B2/ja
Priority to US12/745,670 priority patent/US20110059180A1/en
Priority to EP08872219A priority patent/EP2231132A2/fr
Publication of WO2009098404A2 publication Critical patent/WO2009098404A2/fr
Publication of WO2009098404A3 publication Critical patent/WO2009098404A3/fr
Publication of WO2009098404A8 publication Critical patent/WO2009098404A8/fr
Anticipated expiration legal-status Critical
Priority to US14/208,978 priority patent/US9533049B2/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/242—Gold; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne un procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles, éventuellement en présence d'au moins un colipide, permettant Pencapsulation d'agents thérapeutiques, en particulier d'agents anti-tumoraux, et leur utilisation pour le transport et la vectorisation d'agents thérapeutiques, en particulier d'agents anti-tumoraux.
PCT/FR2008/001661 2007-11-30 2008-11-28 Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation Ceased WO2009098404A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2706812A CA2706812A1 (fr) 2007-11-30 2008-11-28 Procede de preparation de nanoparticules a base de molecules ou macromolecules amphiphiles fonctionnelles et leur utilisation
CN2008801260085A CN101932310B (zh) 2007-11-30 2008-11-28 制备基于官能两亲分子或者大分子的纳米颗粒的方法和其用途
JP2010535425A JP5719594B2 (ja) 2007-11-30 2008-11-28 機能性両親媒性の分子又は巨大分子を基とするナノ粒子の調製方法及びその使用
US12/745,670 US20110059180A1 (en) 2007-11-30 2008-11-28 Method for Preparing Nanoparticles Based on Functional Amphiphilic Molecules or Macromolecules, and the Use Thereof
EP08872219A EP2231132A2 (fr) 2007-11-30 2008-11-28 Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation
US14/208,978 US9533049B2 (en) 2007-11-30 2014-03-13 Method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, and the use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR07/08399 2007-11-30
FR0708399A FR2924430B1 (fr) 2007-11-30 2007-11-30 Procede de preparation de nanoparticules a base de molecules ou macromolecules amphiphiles fonctionnelles et leur utilisation

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/745,670 A-371-Of-International US20110059180A1 (en) 2007-11-30 2008-11-28 Method for Preparing Nanoparticles Based on Functional Amphiphilic Molecules or Macromolecules, and the Use Thereof
US14/208,978 Division US9533049B2 (en) 2007-11-30 2014-03-13 Method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, and the use thereof

Publications (3)

Publication Number Publication Date
WO2009098404A2 WO2009098404A2 (fr) 2009-08-13
WO2009098404A3 WO2009098404A3 (fr) 2009-11-12
WO2009098404A8 true WO2009098404A8 (fr) 2010-01-28

Family

ID=39638675

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2008/001661 Ceased WO2009098404A2 (fr) 2007-11-30 2008-11-28 Procédé de préparation de nanoparticules à base de molécules ou macromolécules amphiphiles fonctionnelles et leur utilisation

Country Status (7)

Country Link
US (2) US20110059180A1 (fr)
EP (1) EP2231132A2 (fr)
JP (3) JP5719594B2 (fr)
CN (1) CN101932310B (fr)
CA (1) CA2706812A1 (fr)
FR (1) FR2924430B1 (fr)
WO (1) WO2009098404A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945946B1 (fr) * 2009-05-29 2011-08-26 Univ Victor Segalen Bordeaux 2 Formulations a compartiments multiples a base de molecules ou macromolecules amphiphiles fonctionnelles
ES2660752T3 (es) * 2014-10-06 2018-03-26 Universite de Bordeaux Compuestos de bola-anfifílicos y sus usos para aplicaciones biomédicas
EP3085360A1 (fr) 2015-04-20 2016-10-26 Universite De Bordeaux Compositions de nanovecteurs à base de lipide chargées avec des nanoparticules métalliques et agent thérapeutique
JP2019532027A (ja) 2016-08-17 2019-11-07 ソルスティス バイオロジクス，リミティッド ポリヌクレオチド構築物
WO2019006455A1 (fr) 2017-06-30 2019-01-03 Solstice Biologics, Ltd. Auxiliaires de phosphoramidites chiraux et leurs procédés d'utilisation
EP3502684A1 (fr) 2017-12-22 2019-06-26 Universite De Bordeaux Procédé de détection d'ions métalliques dans des solutions aqueuses au moyen de composés nucléolipides
EP3505178A1 (fr) 2017-12-29 2019-07-03 Universite De Bordeaux Formulations de gel de bio-encres comprenant un composé à base de nucléolipides
FR3078064A1 (fr) 2018-02-22 2019-08-23 Universite de Bordeaux Procede de decontamination d'un milieu liquide aqueux contenant des micropolluants
KR20220044816A (ko) * 2019-08-12 2022-04-11 인티그레이티드 나노테라퓨틱스 아이엔씨. 하전 물질 전달을 위한 지질, 이의 제형 및 그 제조 방법
KR20250123805A (ko) * 2022-12-13 2025-08-18 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 친유성 단량체를 포함하는 올리고뉴클레오티드 및 비-간 전달에서의 용도
WO2024140624A1 (fr) * 2022-12-27 2024-07-04 Suzhou Abogen Biosciences Co., Ltd. Composés lipidiques et compositions de nanoparticules lipidiques
WO2024240125A1 (fr) * 2023-05-22 2024-11-28 Suzhou Abogen Biosciences Co., Ltd. Composés lipidiques et compositions de nanoparticules lipidiques

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
JPH0696590B2 (ja) * 1985-04-16 1994-11-30 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシウリジン−３′−ホスフエ−ト誘導体およびその塩
DK86988A (da) * 1987-02-25 1988-08-26 Takeda Chemical Industries Ltd Liposompraeparat og anvendelse deraf
US6001817A (en) * 1998-01-12 1999-12-14 Unitech Pharmaceuticals, Inc. Pharmaceutical composition comprised of cisplatin, and processes for making and using same
GB9813535D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
WO2001032139A2 (fr) * 1999-11-05 2001-05-10 Seed Capital Investment-2 (Sci-2) B.V. Procede de formulation de substances a hydrosolubilite et lipophilie faibles et formulation ainsi obtenue
EP1459724B1 (fr) * 2001-12-28 2013-11-20 Terumo Kabushiki Kaisha Systeme de sac sanguin et procede d'inactivation de micro-organismes pathogenes
FR2869616B1 (fr) * 2004-04-29 2008-10-24 Univ D Avignon Et Des Pays Du Nouveaux composes amphiphiles, leur procede de preparation et leurs applications notamment a la transfection
EA016838B1 (ru) * 2005-06-07 2012-07-30 Йельский Университет Способы лечения рака и других заболеваний или патологических состояний с применением клевудина (lfmau) и телбивудина (ldt)
FR2945946B1 (fr) * 2009-05-29 2011-08-26 Univ Victor Segalen Bordeaux 2 Formulations a compartiments multiples a base de molecules ou macromolecules amphiphiles fonctionnelles

Also Published As

Publication number Publication date
JP2017014243A (ja) 2017-01-19
US20140308343A1 (en) 2014-10-16
WO2009098404A2 (fr) 2009-08-13
JP6280167B2 (ja) 2018-02-14
WO2009098404A3 (fr) 2009-11-12
CA2706812A1 (fr) 2009-08-13
US9533049B2 (en) 2017-01-03
FR2924430A1 (fr) 2009-06-05
CN101932310B (zh) 2013-11-13
US20110059180A1 (en) 2011-03-10
FR2924430B1 (fr) 2010-03-19
JP2015044815A (ja) 2015-03-12
JP2011504920A (ja) 2011-02-17
CN101932310A (zh) 2010-12-29
EP2231132A2 (fr) 2010-09-29
JP5719594B2 (ja) 2015-05-20

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