WO2009100164A2 - Elément d’étanchéité antimicrobien - Google Patents

Elément d’étanchéité antimicrobien Download PDF

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Publication number
WO2009100164A2
WO2009100164A2 PCT/US2009/033126 US2009033126W WO2009100164A2 WO 2009100164 A2 WO2009100164 A2 WO 2009100164A2 US 2009033126 W US2009033126 W US 2009033126W WO 2009100164 A2 WO2009100164 A2 WO 2009100164A2
Authority
WO
WIPO (PCT)
Prior art keywords
antimicrobial
sealing element
antimicrobial agent
opening
polymeric resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/033126
Other languages
English (en)
Other versions
WO2009100164A3 (fr
Inventor
Ivan Wei-Kang Ong
Donald P. Satchell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microban Products Co
Original Assignee
Microban Products Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microban Products Co filed Critical Microban Products Co
Publication of WO2009100164A2 publication Critical patent/WO2009100164A2/fr
Publication of WO2009100164A3 publication Critical patent/WO2009100164A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • C09K3/10—Materials in mouldable or extrudable form for sealing or packing joints or covers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0058—Biocides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2200/00—Chemical nature of materials in mouldable or extrudable form for sealing or packing joints or covers
    • C09K2200/06—Macromolecular organic compounds, e.g. prepolymers
    • C09K2200/0615—Macromolecular organic compounds, e.g. prepolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C09K2200/0617—Polyalkenes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2200/00—Chemical nature of materials in mouldable or extrudable form for sealing or packing joints or covers
    • C09K2200/06—Macromolecular organic compounds, e.g. prepolymers
    • C09K2200/0615—Macromolecular organic compounds, e.g. prepolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C09K2200/0635—Halogen-containing polymers, e.g. PVC
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D23/00—General constructional features
    • F25D23/08—Parts formed wholly or mainly of plastics materials
    • F25D23/082—Strips
    • F25D23/087—Sealing strips

Definitions

  • the present invention relates to a sealing element for a container or the like, and more particularly to an antimicrobial sealing element and to articles fitted therewith.
  • Containers and the like having a lid covering an opening frequently employ a gasket or other sealing means around the periphery of the opening. Whether the lid is detached or hinged, it is advantageous in some applications to provide for separation of air, liquid, moisture and/or temperature between the container's interior and the environment.
  • a household appliance such as a refrigerator has a flexible gasket material affixed near the perimeter of the main opening(s). The gasket serves to retain cooled air inside the refrigerator volume and prevent exchange of air between the interior and outside. A gasket also may help prevent odors from entering or escaping the refrigerator.
  • a front-loading washing (laundry) machine or dishwasher typically has a pliable polymer material likewise affixed about the perimeter of the major aperture. In these examples, retention of water within the appliance's inner space is the primary goal.
  • a cooler or a food storage container (such as a glass jar, polymeric container, or companion lid therefor) likewise can be equipped with a sealing gasket to act as an air barrier and thereby thermally insulate the contents.
  • a sealing gasket to act as an air barrier and thereby thermally insulate the contents.
  • FIG. 1 is a perspective-view diagram of a conventional refrigerator appliance.
  • FIG. 2 is a perspective-view diagram of a conventional passive thermal cooler.
  • FIG. 3 is a perspective-view diagram of a conventional gasket as might be found in the refrigerator of FIG. 1.
  • FIG. 4 is a perspective-view diagram of a conventional gasket as might be found in the cooler of FIG. 2.
  • microbe or "microbial” should be interpreted to encompass any of the microscopic organisms commonly studied by microbiologists. Such organisms include, but are not limited to, bacteria and fungi as well as other single-celled organisms such as mold, mildew and algae. Viral particles and other infectious agents are also included in the term microbe.
  • antimicrobial includes biostatic activity, i.e., where the proliferation of microbiological species is reduced or eliminated, and true biocidal activity where microbiological species are killed. For ease of discussion, this detailed description may make reference to bacteria and antibacterial agents. This method of presentation should not be interpreted as limiting the scope of the invention in any way.
  • the term "efficacy,” as used herein, is defined as the characteristic of inhibiting the growth and/or proliferation of a microbe on a substrate.
  • non-metallic as used herein means antimicrobial agents, other than quaternary ammonium compounds, that do not contain or utilize metal ions such as, for example, silver or copper.
  • the present antimicrobial sealing element is a durable polymeric article comprising a first polymeric resin and a first antimicrobial agent incorporated therein. The antimicrobial agent is substantially inert with respect to the polymeric resin and present within the polymeric resin in an amount sufficient to confer persistent antimicrobial properties upon the polymer of the sealing element.
  • an antimicrobial agent can be substantially uniformly dispersed within the polymeric resin, such that an article manufactured using the antimicrobial polymeric resin exhibits antimicrobial properties for the life of the article.
  • the antimicrobial agent can be disposed in a heterogeneous manner within the polymeric material of the sealing element.
  • a typical refrigerator 10 includes body 102 defining interior volume 104 accessible through opening 106.
  • Door 108 is typically sized to fit over and thereby cover opening 106, and gasket 1 10 provides an airtight seal when door 108 is closed.
  • Gasket 110 can be disposed on body 102, door 108, or both.
  • the appliance may have a plurality of openings, with separate doors dedicated to each, a common door covering multiple openings, or other design choices. The fundamental point is that an opening exists which can be covered, and that the seal between the cover (e.g. door) and the appliance body is effected at least in part by way of a sealing element, such as a gasket.
  • cooler 20 (FIG. 2), which typically includes body 202 at least partially defining internal volume 204.
  • Conventional opening 206 is covered by door 208.
  • Cooler 2 may in some embodiments be equipped with gasket 210, usually located at the periphery of opening 206, either on body 202 or door 208.
  • flexible gasket 1 10 conventionally has a construction along the lines of the non-limiting example shown in FIG. 3.
  • One feature common to, but not required of, such gaskets is that they can mate successfully with each of the door and appliance body surfaces.
  • Such mating can be facilitated by a flexible structure, accomplished here by way of pleats or an "accordion" shape.
  • a pleated/accordion structure confers flexibility and aids gasket 1 10 in aligning with the surface to be mated.
  • a magnetic element 1 12 can be disposed in gasket 1 10 to further provide positive mating with a magnetic mating surface (e.g. metal refrigerator wall defining the periphery of the opening).
  • this pleating need not be present.
  • sealing element 210 (FIG. 4) can have a simpler cross-sectional geometric profile and achieve its sealing purpose via pliancy and/or tack of the polymer (e.g. silicone).
  • the airtightness of the seal may be effected by mechanical pressure between mating surfaces.
  • a latch can secure door 108, 208 to the perimeter of the device's opening 106, 206.
  • a single antimicrobial agent is incorporated into the polymeric resin from which the sealing element is constructed.
  • a suitable antimicrobial agent can be organic or inorganic in nature.
  • the concentration of the antimicrobial agent can vary depending on the specific polymer used for the sealing element, the specific antimicrobial agent selected, and against which microbes protection is sought.
  • a sealing element can have a plurality of antimicrobial agents disposed therein. Selection of the members of the plurality of antimicrobial agents generally is based upon the nature of the desired antimicrobial protection (e.g. bacteria, fungi (either broadly, or mold or mildew specifically)), the compatibility of the agents with the polymer from which the element is constructed, the inter-compatibility of the antimicrobial agents, known synergies of the compounds, and the like.
  • Suitable organic antimicrobial agents include 2-phenylphenol; poly(hexamethylene biguanide) hydrochloride; 3,4,4'-trichlorocarbanilide; pyrithione and salts thereof (e.g.
  • 2,4,4'- trichloro-2'-hydroxydiphenyl ether which is a diphenyl ether (bis-phenyl) derivative, is particularly efficacious.
  • the combination of 2-phenylphenol and 2,4,4'-trichloro-2'-hydroxydiphenyl ether previously has been reported to exhibit synergistic effects.
  • Isothiazolone-based compounds also are useful in the present sealing element, including without limitation 1 ,2-benzisothiazolin-3-one (CAS
  • Particularly preferred isothiazolinones include, but are not limited to, 2-n-octyl-4-isothiazolin-3-one and N-butyl-1 , 2 benzisothiazolin-3-one.
  • Additional antimicrobial agents suitable for use in the polymeric resin of the sealing element disclosed herein include diiodomethyl p- tolylsulfone; zinc and sodium pyrithiones; azoles (such as propiconazoles); titanium dioxide; and barium metaborate monohydrate.
  • azoles should be interpreted to include any of the “azole” antimicrobial agents known to those skilled the art.
  • Particularly preferred azoles include, but are not limited to, propiconazole and tebuconazole and mixtures of these two agents. Mixtures of these two agents have been shown elsewhere to have a synergistic effect that translates to improved efficacy at lower concentrations of agents.
  • Inorganic antimicrobial agents include, without limitation, metal- based antimicrobial agents such as silver, copper, or zinc compounds in various forms (e.g. zeolite, amorphous glass, sol-gel, and other ion- exchange formulations).
  • Compounding additives in addition to the antimicrobial agent, can include: surface active agents such as wetting agents, surfactants, de- aeratants, and defoamers; anti-blocking agents; catalysts such as PTSA (para-toluene sulfonic acid), MSA (methane sulfonic acid), oxalic acid, ammonium nitrate and ammonium chloride; fillers; pigments; dielectric modifiers; glossing agents; and dyes.
  • surface active agents such as wetting agents, surfactants, de- aeratants, and defoamers
  • anti-blocking agents catalysts such as PTSA (para-toluene sulfonic acid), MSA (methane sulfonic acid), oxalic acid, ammonium nitrate and ammonium chloride
  • fillers pigments; dielectric modifiers; glossing agents; and dyes.
  • a sealing element conventionally is manufactured by extrusion or co-extrusion, although other methods of manufacture can be employed.
  • An advantage of the present antimicrobial sealing element is that it can be produced by conventional methods without perturbation of the antimicrobial property.
  • Prototypes of the second embodiment disclosed herein were constructed of flexible polyvinyl chloride ("PVC").
  • PVC flexible polyvinyl chloride
  • the gasket body has an extended longitudinal axis, a width, and a height.
  • the antimicrobial composition employed was Microban Additive ZO8, the active ingredients of which are substantially equal amounts of zinc pyrithione and N-butyl-1 ,2-benzisothiazolin-3-one.
  • the Additive ZO8 was formulated into a PVC masterbatch at a concentration of 5% based on the weight of PVC masterbatch polymer. The Additive ZO8-containing masterbatch then was added to unadulterated PVC polymer to make experimental sealing elements.
  • the masterbatch letdown rates were selected to achieve the targeted final concentrations of ZO8 in the polymer of the sealing element, as shown in the data tables, below. After letdown, for example, a sample containing 1.0% ZO8 would contain 5000 ppm zinc pyrithione and 5000 ppm N-butyl-1 ,2-benzisothiazolin-3-one.
  • Prototype sealing elements were manufactured with Microban Additive ZO8 as described herein, and preliminary physical inspection was undertaken. The assessment of the antimicrobial sealing elements confirmed that the antimicrobial agents did not interfere with the extrusion process, nor did its presence affect other additives (e.g. colorant, plasticizer). The manufactured sealing element prototype showed no perturbation in strength or pliability of the polymer. No unusual appearance or discoloration was observed. [0045] ANTIMICROBIAL EFFICACY [0046] EXAMPLE 2
  • OBPA was used at its conventional addition level of 25 ppm. It can be seen that the untreated sealing element and the conventional gasket with OPBA created no zones of inhibition. In contrast, the ZO8-treated gasket sealing elements demonstrated strong antibacterial efficacy against both S. aureus and K. pneumoniae.
  • EXAMPLE 3 The antifungal efficacy was evaluated for prototype sealing elements manufactured of polypropylene with Microban Additive ZO8. Quantitative and qualitative test methodologies were employed, as detailed below. [0053] Samples were plated against Aspergillus niger (a common household black mold) using the AATCC 30 Part III test, an aggressive 7- day antifungal evaluation where the test samples are exposed to high levels of fungal spores. In this case, the samples each were placed on an agar bed, then 10O ⁇ l of a suspension of Aspergillus niger (>10 5 /ml) was evenly spread over the sample area and the agar. The plates were incubated for four days at 20 Q C — optimal conditions for the spores to germinate.
  • test plates were removed from the humid incubation chamber, and the samples were evaluated for fungal attack and encroachment. Each sample was run in triplicate; the mean results of the evaluation are given in TABLE 2.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Sealing Material Composition (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

L'invention concerne un élément d'étanchéité antimicrobien, tel qu'un joint d'étanchéité statique pour un appareil ou un contenant de stockage, qui peut être constitué d'une résine polymère façonnée pour s'associer avec une périphérie d'une ouverture de surface. La résine polymère contient un ou plusieurs agents microbiens, permettant d'obtenir une efficacité antimicrobienne durable sans perturber les propriétés physiques et esthétiques de l'élément d'étanchéité.
PCT/US2009/033126 2008-02-04 2009-02-04 Elément d’étanchéité antimicrobien Ceased WO2009100164A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2603708P 2008-02-04 2008-02-04
US61/026,037 2008-02-04

Publications (2)

Publication Number Publication Date
WO2009100164A2 true WO2009100164A2 (fr) 2009-08-13
WO2009100164A3 WO2009100164A3 (fr) 2009-11-12

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012076529A1 (fr) * 2010-12-07 2012-06-14 Sanitized Ag Procédé de traitement antimicrobien de tissus avec des compositions d'adhésif fusible, compositions d'adhésif fusible et leur utilisation
EP2749167A1 (fr) * 2012-12-28 2014-07-02 Sanitized AG Formulation destinée à l'équipement antimicrobien de compositions à base de chlorure de polyvinyle
WO2014102228A1 (fr) * 2012-12-28 2014-07-03 Sanitized Ag Formulation d'apprêt antimicrobien de compositions polymériques
WO2015040642A1 (fr) * 2013-09-19 2015-03-26 B.B.S. S.P.A. Procédé pour préparer une matière polymère antibactérienne pour des applications alimentaires
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
WO2019086259A1 (fr) * 2017-11-06 2019-05-09 Arcelik Anonim Sirketi Joint de porte
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1961666B (zh) * 2001-01-04 2011-06-22 拜奥特罗尔股份有限公司 抗微生物组合物
DE10146189A1 (de) * 2001-05-25 2002-11-28 Lg Electronics Inc PVC Zusammensetzungen für die Dichtungen von Kühlschränken

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012076529A1 (fr) * 2010-12-07 2012-06-14 Sanitized Ag Procédé de traitement antimicrobien de tissus avec des compositions d'adhésif fusible, compositions d'adhésif fusible et leur utilisation
EP2749167A1 (fr) * 2012-12-28 2014-07-02 Sanitized AG Formulation destinée à l'équipement antimicrobien de compositions à base de chlorure de polyvinyle
WO2014102228A1 (fr) * 2012-12-28 2014-07-03 Sanitized Ag Formulation d'apprêt antimicrobien de compositions polymériques
WO2015040642A1 (fr) * 2013-09-19 2015-03-26 B.B.S. S.P.A. Procédé pour préparer une matière polymère antibactérienne pour des applications alimentaires
US11039619B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11464232B2 (en) 2014-02-19 2022-10-11 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11470847B2 (en) 2014-02-19 2022-10-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11751570B2 (en) 2014-02-19 2023-09-12 Corning Incorporated Aluminosilicate glass with phosphorus and potassium
US12121030B2 (en) 2014-02-19 2024-10-22 Corning Incorporated Aluminosilicate glass with phosphorus and potassium
WO2019086259A1 (fr) * 2017-11-06 2019-05-09 Arcelik Anonim Sirketi Joint de porte

Also Published As

Publication number Publication date
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