WO2009106972A2 - Composition dentaire destinée à désensibiliser, désinfecter et protéger la dentine exposée - Google Patents

Composition dentaire destinée à désensibiliser, désinfecter et protéger la dentine exposée Download PDF

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Publication number
WO2009106972A2
WO2009106972A2 PCT/IB2009/000372 IB2009000372W WO2009106972A2 WO 2009106972 A2 WO2009106972 A2 WO 2009106972A2 IB 2009000372 W IB2009000372 W IB 2009000372W WO 2009106972 A2 WO2009106972 A2 WO 2009106972A2
Authority
WO
WIPO (PCT)
Prior art keywords
composition
disinfecting
substance
desensitizing
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2009/000372
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English (en)
Other versions
WO2009106972A3 (fr
Inventor
Alessandro Tosetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ITALMED Srl
Original Assignee
ITALMED Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ITALMED Srl filed Critical ITALMED Srl
Publication of WO2009106972A2 publication Critical patent/WO2009106972A2/fr
Publication of WO2009106972A3 publication Critical patent/WO2009106972A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers

Definitions

  • the present invention relates to dentistry, more precisely it relates to a composition for treating dentinal hypersensitivity and for disinfecting and protecting the teeth and the periodontium. Brief description of the prior art
  • Dentinal hypersensitivity is a symptom that is frequently referred to in odontostomatologic anamnesis.
  • the patient refers a bothersome trouble which occurs by taking hot, cold, sweet and slightly acid food, as well as by toothbrushing .
  • Dentine is a tooth part which is radially crossed by many dentinal tubules, which contains dentinal fluid, and are peripherally coated with enamel (in coronal dentine) and by cementum (in radicular dentine) , such that they are substantially impervious.
  • Nerve fibres are also radially arranged between dentine and pulp, which is densely innerved as well. Some of these nerve fibres cross a layer that is called predentine and have an end at the true beginning of the dentinal tubules. Therefore, apart from a few micrometres thick layer, dentine is in large part free from nerve fibres.
  • dentinal hypersensitivity occurs when a cavity is made to receive dental filling, in case of changing the cavity-liner, or when creating a dental stump for implanting prosthetic elements; they also occur after scaling and root planning operations and after whitening treatments. Dentinal hypersensitivity is observed, in particular, after that a permanent tooth filling has been completed, as in the case of amalgam or composite tooth fillings.
  • Dentinal hypersensitivity often occurs in the presence of periodontal diseases due to periodontal tissue detachment, which is accompanied by gingival recession and tooth neck exposition.
  • gingival recession and tooth neck exposition the exposition of the junction between enamel and cementum, as well as the cementum exposition, softens the exposed cementum and/or the dentine, causing hypersensitivity.
  • dentinal sensitivity can be considerably reduced by occluding the dentinal tubules orifices, such that their conductance is reduced.
  • substances are known, as potassium nitrate, chloride and oxalate, as well as eugenol, that are adapted to reduce the dentinal sensitivity, via a so-called depolarising effect, i.e.
  • insoluble salts such as calcium phosphate, hydroxyapatite, colloidal silica, etc.
  • glass ionomer cement and resins of various kinds can also be used.
  • the most popular are laser or the use of a pulsed ultrasonic sealer, which cause the production of a consistent amount of smear layer debris that subsequently occlude the tubules.
  • dentine desensitizing is carried out by means of chemical tubules occlusion techniques, or by means of physical techniques that prevent the dentinal fluids from moving inside the dentinal tubules, or by means of depolarizing substances.
  • composition which is suitable for depolarizing dentinal nerve fibres. It is also a feature of the invention to provide such a composition, which offers protection against metalloproteinase of the collagen that is present in the hybrid layer of the dentine that has been pre-treated with ortho-phosphoric acid.
  • composition which has a high desensitizing/ protective response and therefore a long lasting adhesive stability.
  • the substance that causes a precipitation within the dentinal tubules of a calcium- containing substance is selected from the group comprised of:
  • the precipitated calcium-containing substance can be selected from the group comprised of: calcium oxalate, calcium fluoride, or a combination thereof .
  • the composition comprises, furthermore, a disinfecting substance.
  • the disinfecting substance is a cationic disinfecting substance .
  • the cationic disinfecting substance is selected from the group comprised of : benzalkonium chloride, benzethonium chloride, chlorhexidine , cetrimide, cetylpyridinium chloride, chlorhexidine gluconate.
  • the soluble fluorine salt is selected from the group comprised of: potassium fluoride, sodium fluoride, sodium monofluorophosphate , potassium monofluorophosphate, amine fluoride, or a combination thereof .
  • the acrylic polymer is HEMA (2- hydroxyethylmetacrylate) .
  • the pharmaceutical composition allows to overcome the above-described drawbacks, due to the moderate effectiveness of the commonly used desensitizing substances.
  • the solution may have the following weight proportions : HEMA 5-40%,
  • dental compositions for desensitizing, disinfecting and protecting the exposed dentine .
  • EXAMPLE 1 A desensitizing, disinfecting and protecting composition that provides the use of a solution based on chlorhexidine gluconate and oxalic acid together with HEMA and Potassium fluoride; the composition is packaged in 0,5 ml PE single-dose ampoules or in 5 ml glass small vials, equipped with dropper, and has the following weight proportions:
  • Oxalic acid 3% Chlorhexidine gluconate 2%, 2-hydroxyethylmetacrylate (HEMA) 35%, Potassium fluoride 2%, Depurated water up to 100%.
  • HEMA 2-hydroxyethylmetacrylate
  • EXAMPLE 2 A desensitizing, disinfecting and protecting composition that provides the use of a solution based on chlorhexidine gluconate and oxalic acid together with HEMA; the composition is packaged in 0,5 ml PE single-dose ampoules or in 5 ml glass small vials, equipped with dropper, and has the following weight proportions:
  • a desensitizing, disinfecting and protecting composition that provides the use of a solution based on chlorhexidine gluconate and oxalic acid together with HEMA; the composition is packaged in 0,5 ml PE single-dose ampoules or in 5 ml glass small vials, equipped with dropper, and has the following weight proportions: Oxalic acid 3%, Chlorhexidine gluconate 2%, 2-hydroxyethylmetacrylate (HEMA) 35%, Ethyl alcohol 30%,
  • a desensitizing, disinfecting and protecting composition that provides the use of a solution based on chlorhexidine gluconate and potassium fluoride together with HEMA; the composition is packaged in 0,5 ml PE single-dose ampoules or in 5 ml glass small vials, equipped with dropper, and has the following weight proportions :
  • a desensitizing, disinfecting and protecting composition that provides the use of a solution based on chlorhexidine gluconate and potassium oxalate together with HEMA; the composition is packaged in 0,5 ml PE single-dose ampoules or in 5 ml glass small vials, equipped with dropper, and has the following weight proportions : Potassium oxalate 3%,
  • compositions are used in a desensitizing, disinfecting and protective treatment, as described below:
  • the composition is particularly indicated for treating a composite dental filling preparation, but, more in general, it can be used to treat any dental regions which exhibit enamel erosion or wear, or in patients who are affected by a gingival recession, in which the junction between enamel and cementum is exposed.
  • the composition can also be applied on dental prosthetic stumps, after scaling and root planning, or after a whitening treatment.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dental Preparations (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition destinée à désensibiliser, désinfecter et protéger la dentine exposée, comprenant une substance provoquant la précipitation d'une substance contenant du calcium dans les tubulis dentinaires, en particulier de l'acide oxalique, de l'oxalate de potassium ou un sel de fluor, et un polymère acrylique (de préférence 2-hydroxyéthylmétacrylate) pour stabiliser la substance contenant du calcium précipitée. La composition présente une efficacité supérieure à celle des substances de désensibilisation d'usage commun car elle permet aux cristaux insolubles d'oxalate de calcium et de fluorure de calcium d'adhérer profondément à l'intérieur des tubulis dentinaires. La présence d'une substance désinfectante améliore également l'efficacité de la composition. Des substances désinfectantes cationiques présentent en particulier une efficacité de désensibilisation lorsqu'elles sont appliquées sur la dentine exposée car elles réduisent la plaque bactérienne et limitent ainsi les produits de réaction et de dégradation de la plaque bactérienne qui pourraient sinon pénétrer dans les tubulis dentinaires qui sont perméables en raison de l'exposition de la dentine.
PCT/IB2009/000372 2008-02-26 2009-02-26 Composition dentaire destinée à désensibiliser, désinfecter et protéger la dentine exposée Ceased WO2009106972A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITFI2008A000034 2008-02-26
ITFI20080034 ITFI20080034A1 (it) 2008-02-26 2008-02-26 Composizione odontoiatrica per la desensibilizzazione disinfezione e protezione della dentina esposta.

Publications (2)

Publication Number Publication Date
WO2009106972A2 true WO2009106972A2 (fr) 2009-09-03
WO2009106972A3 WO2009106972A3 (fr) 2009-10-22

Family

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Family Applications (1)

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PCT/IB2009/000372 Ceased WO2009106972A2 (fr) 2008-02-26 2009-02-26 Composition dentaire destinée à désensibiliser, désinfecter et protéger la dentine exposée

Country Status (2)

Country Link
IT (1) ITFI20080034A1 (fr)
WO (1) WO2009106972A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITFI20120250A1 (it) * 2012-11-19 2014-05-20 Italmed Srl Composizione ad uso odonotiatrico per la preservazione del legame resina-dentina
WO2015065968A1 (fr) * 2013-10-28 2015-05-07 The Procter & Gamble Company Compositions de soins bucco-dentaires pour la désensibilisation des dents
US20180153789A1 (en) * 2015-04-17 2018-06-07 Lg Household & Health Care Ltd. Oral composition
WO2022165467A1 (fr) * 2021-02-01 2022-08-04 The Procter & Gamble Company Composition orale comprenant de l'acide oxalique

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659751A (en) * 1983-01-10 1987-04-21 American Dental Association Health Foundation Simplified method for obtained strong adhesive bonding of composites to dentin, enamel and other substrates
US5693315A (en) * 1996-06-10 1997-12-02 Abco Trust Mammal tooth treating composition
ITFI980051A1 (it) * 1998-03-06 1999-09-06 Italmed Di Galli Giovanna E Pa Composizione ad uso odontoiatrico per la desensibilizzazione della dentina esposta
US6096292A (en) * 1998-07-28 2000-08-01 Block Drug Company, Inc. Polymeric desensitizing compositions
JP2004506663A (ja) * 2000-08-21 2004-03-04 ブロック　ドラッグ　カンパニー　インコーポレイテッド 過敏性歯のための歯科用組成物
JP5004381B2 (ja) * 2001-04-03 2012-08-22 日本ゼトック株式会社 口腔用組成物
US20060183081A1 (en) * 2004-09-27 2006-08-17 Al Bevilacqua Tooth bleaching system and method
US20070258916A1 (en) * 2006-04-14 2007-11-08 Oregon Health & Science University Oral compositions for treating tooth hypersensitivity

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITFI20120250A1 (it) * 2012-11-19 2014-05-20 Italmed Srl Composizione ad uso odonotiatrico per la preservazione del legame resina-dentina
WO2015065968A1 (fr) * 2013-10-28 2015-05-07 The Procter & Gamble Company Compositions de soins bucco-dentaires pour la désensibilisation des dents
AU2014342543B2 (en) * 2013-10-28 2017-03-09 The Procter & Gamble Company Oral care compositions for tooth desensitizing
US9717665B2 (en) 2013-10-28 2017-08-01 The Procter & Gamble Company Tooth desensitizing oral care compositions, devices, and methods
RU2670432C2 (ru) * 2013-10-28 2018-10-23 Дзе Проктер Энд Гэмбл Компани Композиции для ухода за полостью рта для десенсибилизации зубов
US10231913B2 (en) 2013-10-28 2019-03-19 The Procter & Gamble Company Tooth desensitizing oral care compositions, devices, and methods
US20180153789A1 (en) * 2015-04-17 2018-06-07 Lg Household & Health Care Ltd. Oral composition
US11103441B2 (en) * 2015-04-17 2021-08-31 Lg Household & Health Care Ltd. Oral composition
WO2022165467A1 (fr) * 2021-02-01 2022-08-04 The Procter & Gamble Company Composition orale comprenant de l'acide oxalique
CN116887805A (zh) * 2021-02-01 2023-10-13 宝洁公司 包含草酸的口腔组合物
AU2022214550B2 (en) * 2021-02-01 2025-04-17 The Procter & Gamble Company Oral composition comprising oxalic acid

Also Published As

Publication number Publication date
ITFI20080034A1 (it) 2009-08-27
WO2009106972A3 (fr) 2009-10-22

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